Ukuba kukho umntu kusapho lwakho, mhlawumbi umama wakho othandekayo, utata, okanye umakhulu, onesifo se-Alzheimer's, siyazi ukuba kunokuba buhlungu kangakanani. Kubuhlungu kakhulu ukubona inkumbulo yomntu omthandayo iphela kancinci kancinci. Nangona kunjalo, phakathi kwale meko inzima, sithetha ngeendaba ezizisa ithemba elincinci. Olu asilonyango olupheleleyo lwesi sifo, kodwa lunokuba linyathelo elibalulekileyo phambili.
Zithini ezi ndaba zintsha?
Kutshanje, iphaneli yeengcebiso ye-US Food and Drug Administration (FDA) ngazwinye inike imvume kunyango olutsha lwe-Alzheimer's. Igama leyeza yi
-donanemab . Liyacetyiswa kwizigulana
ezikwinqanaba lokuqala lesi sifo. Ukuvunywa kwale phaneli yeengcebiso kuthetha ukuba kukho ithuba elikhulu lokuba i-FDA iza kunika imvume epheleleyo kule chiza kungekudala. Oku kuyinto enkulu ngokwenene, kuba ukufika konyango olutsha lwesifo esibi njenge-Alzheimer's lithemba elikhulu.
Isebenza njani iDonanemab?
Kulungile, masibone ukuba eli yeza lisebenza njani. Oku kunzima kancinci, kodwa ndiza kukuchaza ngokulula. I-Donanemab luhlobo lweyeza elibizwa ngokuba
yi-monoclonal antibody . Ngamafutshane, yiproteni ekhethekileyo eyenziwe kwilebhu ukuhlasela ithagethi ethile kusetyenziswa iindawo ezithile zenkqubo yethu yokuzikhusela komzimba. Yintoni ithagethi yale yeza? Zii
-amyloid plaques , ezicingelwa ukuba zingunobangela omkhulu wesifo se-Alzheimer. Njengokuba umhlwa ukhula kwimibhobho yethu yamanzi, ezi plaques zakha phakathi kweeseli zemithambo-luvo ebuchotsheni kwaye ziphazamisane nomsebenzi wazo. Into eyenziwa yi-Donanemab kukuchonga ezi plaques kwaye zincede ekuzisuseni.
Into ebalulekileyo kukuba oku akuyonyango lwesifo. Nangona kunjalo, kunokucothisa isantya esiba sibi kakhulu ngaso isifo. Oku kuthetha ukuba kunokunceda isigulana sigcine inkumbulo yaso kunye nokukwazi ukwenza imisebenzi yemihla ngemihla ixesha elide.
Lisebenza kangakanani eli yeza?
Ngokweziphumo zovavanyo lwezonyango ezapapashwa kunyaka ophelileyo, olu nyango
lunokunciphisa izinga esi sifo esiba mandundu ngalo kwiinyanga ezimbalwa.Kuye kwenzeka. Oku kulinganiswa ngovavanyo olulinganisa ubuchule bengqondo bezigulane (umz., inkumbulo, ukusombulula iingxaki) kunye nendlela abazenza kakuhle ngayo imisebenzi yemihla ngemihla (umz., ukuqhuba, ukuphatha imali). Ezinye iingcali zibiza ezi ziphumo njengeziphumo eziphantsi okanye "eziqhelekileyo". Oko kuthetha ukuba awunakulindela umahluko omkhulu koku. Kodwa kulungile nokuba isifo sinokuncitshiswa kwiinyanga ezimbalwa nje, kunokuba sibe sibi ngaphandle konyango. Ngokuphathelele indlela unyango olunikwa ngayo, iyeza linikwa izigulane nyanga zonke ngemithambo yegazi (i-infusion). Abo bathathe inxaxheba kuvavanyo banikwe olu nyango malunga nonyaka onesiqingatha.
Kukho iingenelo kunye neengozi ezinkulu.
Njengalo naliphi na iyeza elinamandla, i-donanemab ineengenelo kunye nemiphumo emibi kunye neengozi. Kubalulekile ukuqonda amacala omabini ngaphambi kokuba wenze isigqibo.
| Iinzuzo | Iingozi kunye nokungalungi |
|---|
| Ukunciphisa izinga esi sifo siba sibi ngalo. | Iziphumo ebezingalindelekanga ezinzulu: Kukho umngcipheko wokudumba kwengqondo okanye ukopha kwengqondo. |
| Ukunceda ukugcina inkumbulo kunye nokukwazi ukwenza imisebenzi yemihla ngemihla ixesha elide. | Ngexesha lovavanyo lweklinikhi, kuye kwaxelwa ukuba kukho ukufa kwabantu abathathu okunxulunyaniswa nolu nyango. |
| Ukujolisa kwiiplaque ezikwingqondo ezibangela esi sifo. | Ixabiso eliphezulu: Ngokwezibalo zaseMelika, iindleko zonyango zonyaka zingaba malunga ne-$6,600 (phantse i-rupees zaseSri Lanka ezizigidi ezi-2). |
| Ukuzisa ithemba elitsha kwizigulana ezine-Alzheimer kunye neentsapho zazo. | Kufuneka ndize esibhedlele inyanga nenyanga ukuze ndifumane unyango kwaye ndifakelwe amayeza ngemithambo yegazi. |
Nangona zonke ezi zinto ziqwalaselweyo, iphaneli yeengcebiso ye-FDA ekugqibeleni yagqiba kwelokuba
iingenelo zale yeza zingaphezulu kweengozi zayo.Oko kukuthi, ukuba inikwa izigulana ezifanelekileyo, phantsi kweliso elifanelekileyo, iingenelo ziba nkulu.
Ingaba le kuphela iyeza elitsha elifumanekayo?
Hayi. Kukho elinye iyeza elisebenza ngendlela efanayo. Libizwa ngokuba yi
-lecanemab . Elo yeza likwasebenza ngokujolisa kwiiplatelets eziqokelelana engqondweni. Lafumana imvume ye-FDA ngoJulayi 2023. I-Donanemab linyathelo elinye kolo hambo. Imibutho ephambili ye-Alzheimer's kwihlabathi inethemba elikhulu kunyango olutsha olufana nolu. Bathi, "Okukhona unyango oluvunyiweyo olufana nolu luvela, kokukhona amathuba okuba izigulane zifanelekele olu nyango abe makhulu. Kwenziwa inkqubela phambili ecacileyo ngokubhekiselele kunyango." Okwangoku, izigidi zabantu kwihlabathi liphela zinesifo se-Alzheimer's. Akukabikho ndlela yokuthintela okanye yokunyanga ngokupheleleyo esi sifo. Ke ngoko, amayeza afana ne-donanemab zizinto ezibalulekileyo kakhulu kolo hambo lude.
Umyalezo Wokuya Ekhaya
- I-Donanemab liyeza elitsha eliza kuvunywa ukunyanga amanqanaba okuqala esifo sika-Alzheimer .
- Oku akunakunyanga esi sifo, kodwa kunokuthoba isantya apho iimpawu ziba mandundu kangangeenyanga ezimbalwa .
- Kunye neenzuzo zolu nyango, kukwakho neengozi ezinkulu , ezinje ngokudumba kobuchopho nokopha .
- Isigqibo sokuthatha eli yeza okanye ukungalisebenzisi kufuneka senziwe emva kwengxoxo enzulu nogqirha wakho malunga nemeko yesigulana kunye neengozi zaso, nasemva kokuqwalasela ngononophelo izinto ezilungileyo nezingalunganga.
- Kulungile ukwazi unyango olutsha olufana nolu, kodwa qiniseka ukuba ucela iingcebiso kugqirha ofanelekileyo ngaphambi kokuba wenze naziphi na izigqibo.
Isifo sika-Alzheimer, i-donanemab, isifo sobuchopho, ukulahlekelwa yinkumbulo, i-dementia, unyango olutsha, i-antibody ye-monoclonal
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