I-Kerendia inceda abo banesifo seswekile kunye nesifo sezintso (CKD)

Siyazi ukuba abantu abanesifo seswekile basengozini yezinye iingxaki zempilo ezininzi , kuquka iingxaki zezintso nezentliziyo. Nangona kukho amayeza ahlukeneyo okunciphisa lo mngcipheko, abantu abaninzi abanesifo seswekile banokufumana isifo sezintso esingapheliyo (CKD) ngokuhamba kwexesha. Ukuba unesifo seswekile kunye ne-CKD, usenokuba neengxaki zempilo ezinzulu. Nangona kunjalo, iyeza elibizwa ngokuba yiKerendia, elavunywa ngo-2021, linokunceda ukunciphisa ezi ngozi kwabanye abantu.

I-Kerendia ibanceda njani abantu abanesifo seswekile kunye nesifo sezintso?

Ukuba unesifo seswekile sohlobo lwesibini, amanqanaba aphezulu eswekile egazini ngokuhamba kwexesha anokonakalisa amalungu ahlukeneyo emzimbeni. Oku kuchaphazela izintso kubantu abaninzi. Izintso ezonakeleyo ngale ndlela azikwazi ukusebenza kakuhle. Le meko ibizwa ngokuba yiChronic Kidney Disease (CKD) . Ngokuhamba kwexesha, le meko iya isiba mandundu kancinci kancinci kwaye inokukhokelela ekusileleni kwezintso. Amanqanaba aphezulu eswekile egazini nawo ayonakalisa intliziyo nemithambo yegazi (inkqubo yentliziyo). Oku kwandisa umngcipheko weemeko ezinzima ezifana nestroke, ukuhlaselwa yintliziyo, kunye nokungaphumeleli kwentliziyo. Ngenxa yokuba izintso zingasebenzi kakuhle, abantu abane-CKD nabo banokuba nesifo sentliziyo. Ngoko ke, umntu onesifo seswekile, i-CKD, kunye nesifo sentliziyo xa zidibene usemngciphekweni omkhulu wokufa. Ngokulawula iswekile yegazi lakho kunye noxinzelelo lwegazi, unokunciphisa umonakalo entliziyweni yakho, kwimithambo yegazi, nakwizintso. Kodwa ngelixa usenza njalo, kukho amayeza anokunceda ukukhusela izintso zakho ekonakaleni okungakumbi. I-Kerendia yenye yeza ezikhethekileyo. I-Kerendia isebenza ngendlela eyahlukileyo kancinci ukuthintela umonakalo entliziyweni yakho nakwizintso. Isithako esisebenzayo kule pilisi yi- finerenone . Isebenza ngokuvala i-receptor ebizwa ngokuba yi-mineralocorticoid receptor (MR) kwizintso zakho, entliziyweni, nakwimithambo yegazi. Le receptor ye-MR inokuba nokusebenza kakhulu kubantu abanesifo seswekile. Ngokuvimba le receptor, i-Kerendia inceda izintso zakho ukuba zisuse i-sodium (ityuwa) egazini lakho. Ikwanceda ekunciphiseni ukudumba kunye namanxeba (fibrosis) entliziyweni yakho nakwimithambo yegazi. Xa uyithatha ixesha elide, unokunciphisa umngcipheko weengxaki zempilo ezinzulu.

Ndingayisebenzisa njani le yeza?

I-Kerendia yipilisi enokuthatyathwa kube kanye ngemini nokuba utye okanye ungenakutya. Ukuba unengxaki yokuginya ipilisi yonke, ungayityumza uyixube namanzi amancinci okanye ukutya okuthambileyo okufana ne-applesauce. Nangona kunjalo, kufuneka uyithathe kwangoko emva kokuyixuba. Emva kokuba uqale ukuthatha i-Kerendia, ugqirha wakho uya kujonga amanqanaba akho e-potassium egazini rhoqo. Ke ngoko, kufuneka uqiniseke ukuba uya kuvavanyo lwegazi yonke imihla ugqirha wakho akuxelele ukuba uyenze. Ngokuxhomekeke kumanqanaba akho e-potassium egazini, ugqirha wakho unokukucebisa ukuba wonyuse okanye unciphise idosi yeyeza, okanye uyeke ukuthatha iyeza kangangeentsuku ezimbalwa. Ukuba uphosa idosi, yithathe ngokukhawuleza xa ukhumbula. Kodwa kuphela ukuba ingaphakathi kosuku lwedosi ephosakeleyo. Ukuba ukhumbula usuku olulandelayo, musa ukuthatha idosi ephosakeleyo. Ukuthatha idosi ephindwe kabini kunokunyusa umngcipheko weziphumo ebezingalindelekanga.

Zeziphi iimvavanyo ezenziweyo kweli yeza?

Ngoku usenokuba uzibuza ukuba eli yeza lithembeke kangakanani kwaye ngubani olisebenzisileyo. Makhe sijonge izifundo ezenziweyo kulo. Kuye kwenziwa iimvavanyo ezimbini ezinkulu ukuze kubonwe ukuba iKerendia ikhuselekile kwaye isebenza kangakanani kubantu abadala abanesifo seswekile kunye ne-CKD. Ubudala obuqhelekileyo babathathi-nxaxheba kwezi zilingo yayimalunga neminyaka engama-64.

Ulwazi olubalulekileyo malunga nabo bathathe inxaxheba kuvavanyo:

• Bonke babenesifo seswekile sohlobo lwesibini kunye ne-CKD .
• Nangona abanye babekhe bafunyaniswa benesifo sentliziyo ngaphambili, akukho namnye owayeneempawu ngexesha lovavanyo.
• Wonke umntu wayesebenzisa amayeza athile awayefanele ukukhusela izintso .
• Ama-97% asebenzisa amayeza okulawula iswekile egazini .
• Iyeza leKerendia lithelekiswa ne -placebo , ipilisi yobuxoki engenasiphumo. Akukho mntu wayesazi ukuba bafumana iyeza lokwenyani okanye ipilisi yobuxoki.

Olunye lwale mvavanyo lulinganise ukuba zingaphi iingxaki ezinkulu zezintso ezenzekayo ngelixa kusetyenzwa eli yeza. Oko kukuthi:

• Abantu abanesifo sezintso esinzima kakhulu.
• Abantu abanengxaki yezintso.
• Abantu abasweleke ngenxa yeengxaki zezintso.

Olunye uvavanyo lulinganise ukuba zingaphi iziganeko ezinzulu zentliziyo nezemithambo yegazi ezenzekileyo. Oko kukuthi:

• Abantu abakhe baba nestroke okanye isifo sentliziyo .
• Abantu abalaliswe esibhedlele ngenxa yesifo sentliziyo.
• Abantu abasweleke ngenxa yeengxaki zentliziyo.

Zithini iziphumo zovavanyo?

Iingxaki zezintso: Kolu phando, oluthathe malunga neminyaka eyi-2.5, abantu abathathe iKerendia babeneengxaki ezimbalwa zezintso kunabo bathathe i-placebo. Oku kuthetha ukuba abanye abantu babengenamathuba amaninzi okufumana iingxaki ezinkulu zezintso, ezifana nokungasebenzi kakuhle kwezintso, ukungasebenzi kakuhle kwezintso, okanye ukufa ngenxa yesifo sezintso. Iingxaki zentliziyo: Kolu phando, oluthathe malunga neminyaka eyi-3.5, abantu abathathe iKerendia babeneengxaki ezimbalwa ezinkulu zentliziyo kunabo bathathe i-placebo. Oku kuthetha ukuba abanye abantu babengenamathuba amaninzi okufumana iingxaki ezinkulu zentliziyo, ezifana nestroke, ukuhlaselwa yintliziyo, ukulaliswa esibhedlele ngenxa yesifo sentliziyo, okanye ukufa.

Iziphumo ebezingalindelekanga kunye nendlela yokuzilawula?

Njengayo nayiphi na iyeza, iKerendia inokubangela ezinye iziphumo ebezingalindelekanga. Eyona iphambili kukunyuka kwamanqanaba e-potassium egazini. Yiyo loo nto ugqirha wakho eza kujonga igazi lakho rhoqo. Usenokungaziva mahluko mkhulu xa usebenzisa eli yeza. Oku kungenxa yokuba umsebenzi walo ophambili kukunciphisa izinga lomonakalo wangaphakathi. Ke ngoko, nokuba uzive ungcono, ungayeki ukulisebenzisa ngaphandle kwengcebiso kagqirha wakho. I-Kerendia, i-finerenone, isifo seswekile, isifo sezintso, isifo sezintso esingapheliyo, i-CKD, isifo sentliziyo, eSri Lanka