Ngaba uhlala uziva udiniwe kwaye ungenabomi? Esinye sezizathu zoku kusenokuba kukungabikho kwegazi emzimbeni, imeko ebizwa ngokuba yi-anemia ngokwezonyango. Xa le anemia isenzeka ngenxa yeemeko ezithile zonyango, kusenokufuneka utofelwe igazi rhoqo. Ngoko ke, namhlanje siza kuthetha ngeyeza elitsha eliye laziswa kwihlabathi liphela ukunyanga ezo meko. Igama lelo yeza yiReblozyl.
Luhlobo luni lonyango iReblozyl?
I-Reblozyl liyeza elavunywa ngo-2019. Ngokuchanekileyo, likwiqela lamayeza abizwa ngokuba yi-``erythroid maturation agents (EMA)''. Kulungile, kulungile, elo gama lisenokuvakala liyinkimbinkimbi. Ngamafutshane, eli yeza linceda iiseli ezibomvu zegazi eziveliswa kumongo wethu wethambo ukuba "zivuthwe", oko kukuthi, zibe ziiseli ezikhulileyo nezisempilweni. Eli yeza lisetyenziswa kakhulu ukunyanga i-anemia ebangelwa zizifo ezithile zegazi. Ingakumbi kubantu abadala abanezi zifo zimbini: 1.
I-Beta-thalassemia: Abantu abafuna utofelo-gazi rhoqo ngenxa yesi simo. 2.
I-Myelodysplastic Syndromes (MDS): Oku kwaziwa nangokuba yi-bone
marrow failure. Ke ngoko, i-Reblozyl ikwanikwa abantu abafuna utofelo-gazi rhoqo.
Masifunde okungakumbi malunga ne-beta-thalassemia kunye ne-MDS.
Ukuba uyaqonda kancinci ngezi zifo zimbini, kuya kuba lula ukuqonda indlela elisebenza ngayo iyeza leReblozyl.
- I-Beta-thalassemia: Cinga ngeeseli ezibomvu zegazi ezisegazini lethu njengezithuthi ezithwala ioksijini. Ioksijini ekule moto ifakwa kwiproteni ebizwa ngokuba yi-hemoglobin . Umntu one-beta-thalassemia akavelisi ngokwaneleyo le proteni ye-hemoglobin. Ngoko ke iiseli emzimbeni azifumani ioksijini eziyidingayo. Yiyo loo nto iimpawu ezifana nokudinwa rhoqo kunye nokuphaphatheka zisenzeka.
- I-Myelodysplastic syndrome (MDS): Olu luhlobo lomhlaza oluqala kumongo wethambo. Umongo wethambo ngumzi-mveliso owenza iiseli zethu zegazi (iiseli ezibomvu, iiseli ezimhlophe, kunye neeplatelets). Kumntu one-MDS, ukuveliswa kwale mveliso kuyaphazamiseka. Oku kuthetha ukuba ukuveliswa kweeseli zegazi ezisempilweni neziphuhlileyo kuyancitshiswa.
Kuzo zombini ezi meko, ingxaki ephambili kukuncipha kwenani leeseli ezibomvu zegazi ezisempilweni nezisebenzayo, oko kuthetha ukubaI-anemia iyenzeka.
I-Reblozyl isebenza ngokunceda iiseli ezibomvu zegazi ezingakhuli kakuhle ukuba zikhule kakuhle. Oku kwandisa inani leeseli ezibomvu zegazi ezisempilweni, kwandisa amanqanaba e-hemoglobin, kwaye kuphucula amandla omzimba okuthwala ioksijini. Ngenxa yoko,
unokufuna utofelo-gazi oluncinci rhoqo.
Kodwa khumbula oku: I-Reblozyl ayithathi indawo yotofelo-gazi. Lunyango nje olunceda ekunciphiseni isidingo.
Linikwa njani eli yeza?
I-Reblozyl ayilo pilisi onokuyisebenzisa ekhaya. Yinaliti enikwa
rhoqo emva kweeveki ezi-3 . Le naliti inikwa ngugqirha okanye umongikazi oqeqeshiweyo kwiofisi kagqirha wakho, kwikliniki, okanye esibhedlele.
- Apho unganikela khona ugonyo: Olu gonyo ludla ngokunikezelwa phantsi kwesikhumba sengalo, ithanga, okanye isisu, ngaphantsi kwegxalaba.
- Ukufumana isitofu ngexesha: Kubaluleke kakhulu ukuya kufumana isitofu ngosuku olunye ugqirha akunike lona. Ukuba uphoswe lusuku, fowunela ugqirha ngoko nangoko uze ucele ingcebiso ngosuku olulandelayo.
- Idayari yeempawu: Kungcono ukubhala phantsi iimpawu zakho (ezifana nokudinwa kunye nesiyezi ) kwincwadi okanye kwifowuni yakho yonke imihla. Oku kuya kwenza kube lula ukuchazela ugqirha wakho indlela amayeza akuchaphazela ngayo.
Umlinganiselo wamayeza oza kunikwa uya kugqitywa ngugqirha wakho ngokusekwe kubunzima bakho kunye nendlela umzimba wakho osabela ngayo kumayeza.
Zithini iziphumo ebezingalindelekanga? Ungazijongana njani nazo?
Njengayo nayiphi na iyeza, iReblozyl inokubangela ezinye iziphumo ebezingalindelekanga. Asinguye wonke umntu ozifumanayo, kodwa kubalulekile ukuba uzazi. Itheyibhile engezantsi idwelisa ezinye zeziphumo ebezingalindelekanga eziqhelekileyo kunye nendlela yokuzilawula.
| Imiphumela | Indlela yokulawula |
|---|
| Ukudinwa kakhulu, isiyezi, ukungakwazi ukulawula umzimba | Kuphephe ukuqhuba okanye ukusebenzisa oomatshini abanzima ude wazi kakuhle ukuba eli yeza likuchaphazela njani. |
| Intloko ebuhlungu, iintlungu zemisipha okanye amalungu | Buza ugqirha wakho ngeepilisi zokuthomalalisa iintlungu ezinokunceda ekunciphiseni ezi mpawu. Xelela ugqirha wakho ukuba iimpawu zakho aziphucuki okanye ziya zisiba mandundu. |
| Isicaphucaphu, iintlungu zesisu, urhudo (i-flatulence) | Zama ukutya ukutya okuncinci kunokutya ukutya okuninzi. Yitya ukutya okungeyondlwantyala njengesonka, ii-crackers, kunye nerayisi. Sela amanzi amaninzi. Ukuba ezi mpawu ziya zisiba mandundu okanye aziphucuki, xelela ugqirha wakho. |
| Igazi elonyukayo | Kubalulekile ukuzilolonga nokwamkela ukutya okunempilo okufana ne-DASH. Jonga uxinzelelo lwakho lwegazi rhoqo. Ukuba uxinzelelo lwakho lwegazi luphezulu kune-180/120 mmHg, yiya kwiSebe leNgxamiseko (ETU) ngoko nangoko. |
| Ubunzima bokuphefumla, Ukusabela kwi-aleji | Buza ugqirha wakho kwangaphambili malunga neempawu ze-allergy (umz., ukurhawuzelela kwesikhumba, ukurhawuzelela, ukudumba kobuso, ukuphefumla kancinci). Ukuba ufumana naziphi na kwezi mpawu, fowunela ugqirha wakho ngoko nangoko okanye uye kwiSebe leNgxamiseko (ETU) elikufutshane . |
| Ukuqokelelana kolwelo emzimbeni (i-edema) | Ukuba ubona ukudumba ezandleni zakho, ezinyaweni, okanye emzimbeni, xelela ugqirha wakho. Nguye oza kukunika unyango olufunekayo. |
Ngaba kukho iingxaki ngamanye amayeza?
Ewe. Ukusebenzisa iReblozyl kunokubangela iingxaki ukuba uthatha amanye amayeza athile. Ngokukodwa, ukuba usebenzisa unyango lokutshintshwa kweehomoni ngexesha lokuya exesheni okanye iipilisi zokulawula ukuzalwa, umngcipheko wokuqhekeka kwegazi unokwanda.
Ngoko ke, qiniseka ukuba uxelela ugqirha wakho ngayo yonke imithi oyithathayo, kuquka leyo ichazwe ngoogqirha, amayeza athengiswa ngaphandle kwemvume kagqirha, iivithamini, amayeza esintu, kunye neemveliso zemifuno .
Umyalezo Wokuya Ekhaya
- I-Reblozyl liyeza elitsha elinikwa njengejekiseni lokunyanga i-anemia ebangelwa ziimeko ezibizwa ngokuba yi-beta-thalassemia kunye ne-MDS.
- Oku kunceda kakhulu ukuba iiseli ezibomvu zegazi ezingavuthwanga zikhule kakuhle.
- Eli yeza linokunciphisa isidingo sokutofelwa igazi rhoqo, kodwa alithathi indawo yokunikela ngegazi.
- Olu gonyo lunikwa ngugqirha okanye umongikazi rhoqo emva kweeveki ezi-3.
- Iziphumo ezingalindelekanga ezifana nentloko ebuhlungu, ukudinwa, kunye nentlungu yemisipha zinokubakho. Thetha nogqirha wakho ngazo naziphi na iimpawu ezingaqhelekanga.
- Kubalulekile ukwazisa ugqirha wakho ngazo zonke ezinye iziyobisi ozisebenzisayo.
I-Reblozyl, i-Anemia, i-Beta-Thalassemia, i-Myelodysplastic Syndromes, i-MDS, utofelo-gazi, i-Luspatercept, i-hemoglobin
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