Ngaba ngamanye amaxesha uziva ngathi amehlo akho ayadinwa njengoko imini iqhubeka, ulwimi lwakho luyadideka xa uthetha, okanye amalungu akho omzimba ayaphelelwa ngamandla? Oku kusenokungabi ngenxa yokudinwa nje kuphela. Namhlanje sithetha ngemeko ekhethekileyo ebizwa ngokuba yi- 'Myasthenia Gravis ' ebangela ezi mpawu kunye nonyango olutsha olusetyenzisiweyo kuyo. Kubaluleke kakhulu ukuqaphela oku.
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Yintoni kanye kanye iMyasthenia Gravis?
Ngamafutshane, i-myasthenia gravis yimeko engapheliyo apho inkqubo yokuzikhusela yomzimba wethu, inkqubo yokuzikhusela komzimba, ihlasela ngempazamo iiseli zethu eziphilileyo. Oku kubizwa ngokuba sisifo sokuzikhusela komzimba.
Khawuthelekelele, umyalezo othunyelwa usuka engqondweni yethu uhamba ngemithambo-luvo uze ufikelele kwisihlunu, esiza kusebenza emva koko. Indawo yokudibana kwemithambo-luvo phakathi kwemithambo-luvo kunye nesihlunu yonakele kwesi sifo. Amanye ama-antibodies aveliswa yinkqubo yethu yokuzikhusela afikelela kule ndawo yokudibana aze athintele ukuhamba kwemiyalezo. Ngenxa yoko , isihlunu siqala ukuba buthathaka kancinci kancinci .
Iindidi ezimbini eziphambili zee-antibodies ezibangela le ngxaki yi -anti- acetylcholine receptor (AChR) kunye ne -anti-muscle-specific tyrosine kinase (MuSK) . Ugqirha wakho uza kukuchazela ezi zinto.
Ziziphi iimpawu eziqhelekileyo zesi sifo?
Ezi mpawu zinokwahluka kumntu nomntu. Kwakhona, okukhona usebenzisa izihlunu ngakumbi, kokukhona ziba buthathaka. Itheyibhile engasezantsi idwelisa ezinye zezona mpawu zixhaphakileyo.
| Uphawu | Inkcazo |
|---|---|
| Iinkophe ezigobileyo | Ukugoba okungalawulekiyo kweliso elinye okanye omabini. Abanye abantu banokubona amabini. |
| Utshintsho kwimbonakalo yobuso | Ukubuthathaka kwemisipha ebusweni nasemhlathini kunokubangela utshintsho kwizinto ezifana nokuncuma nokubonakalisa umsindo. |
| Ubuthathaka kwiingalo, emilenzeni, nakwiminwe | Ubunzima bokwenza imisebenzi yemihla ngemihla efana nokuphakamisa into ethile, ukukama iinwele, okanye ukuhamba. |
| Ubunzima bokuginya | Ukuziva ngathi uyakrwitshwa xa uginya ukutya okanye isiselo. |
| Ubunzima bokuthetha | Utshintsho kwilizwi xa uthetha, luvakala ngathi uthetha ngempumlo yakho, okanye intetho ebotshelelwe lulwimi. |
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Check Availability →Isebenza njani iyeza elitsha iRystiggo?
I-Rystiggo (Rozanolixizumab-noli) liyeza elitsha elivunyiweyo lokunyanga i-myasthenia gravis. Likwiqela lamayeza abizwa ngokuba yi-neonatal Fc receptor (FcRn) blockers.
Ngoku masibone ukuba oku kusebenza njani. Njengoko benditshilo ngaphambili, unobangela wesi sifo zii-antibodies eziyingozi (AChR kunye neMuSK) egazini lethu. Into eyenziwa yiRystiggo kukujonga ezi antibodies ziyingozi kunye nokukhawulezisa ukususwa kwazo emzimbeni wethu.
Ngamafutshane, eli yeza lisebenza njengesihluzo esicoca igazi lethu kwaye sinciphise inani lee-antibodies ezimbi ezibangela isifo.
Xa ubungakanani bezi antibodies buncipha, ukuphazamiseka kokudluliselwa kwesignali phakathi kwemithambo-luvo kunye nemisipha kuyancipha. Ngenxa yoko, amandla emisipha ayanda kwakhona kwaye iimpawu ziyalawulwa.
Ingaba eli yeza lilungile kubo bonke abantu?
Hayi. I-Rystigmo ivunyiwe kuphela ukuba isetyenziswe kwizigulana zabantu abadala abane-myasthenia gravis abaye bavavanywa ii-antibodies ze-AChR okanye ze-MuSK egazini labo. Abantu abangenazo ezi antibodies basenokungancedi kweli yeza. Ke ngoko, ugqirha wakho uya kugqiba ukuba olu nyango lukulungele na.
Lunikwa njani unyango kwaye zithini iziphumo ebezingalindelekanga?
Eli yeza lidla ngokunikezelwa njengenaliti kwizicubu ezingaphantsi kwesikhumba esibhedlele okanye eklinikhi. Eli yeza lidla ngokunikezelwa kwindawo engaphantsi kwesisu.
- Umjikelo wonyango:Olu gonyo ludla ngokunikezelwa kube kanye ngeveki kangangeeveki ezi-6. Oku kubizwa ngokuba ngumjikelo wonyango. Emva koko, ungahlala ungenalo unyango okwethutyana uze uqale umjikelo omtsha ukuba kuyimfuneko. Konke oku kugqitywa ngugqirha wakho.
- Isilumkiso: Uza kugcinwa phantsi kweliso likagqirha malunga nemizuzu eli-15 emva kokufakwa inaliti, njengoko ngamanye amaxesha kunokuvela iimpembelelo ze-allergy.
| Umngcipheko/isiphumo esibi | Okufanele ukwenze noko ukwaziyo |
|---|---|
| Iimeko apho kufuneka wazise ugqirha wakho ngoko nangoko | |
| Iintsholongwane Ezisebenzayo | Ukuba uneempawu ezinje ngomkhuhlane, iintlungu zomzimba, ukukhohlela, i-phlegm, ubunzima bokuphefumla, okanye urhudo, xelela ugqirha wakho kwangoko ngaphambi okanye ngexesha lonyango. Unyango lunokufuneka luhlehliswe de usulelo luphele. |
| Iziphumo ebezingalindelekanga eziqhelekileyo | |
| Intloko ebuhlungu | Oku kudla ngokuba yinto encinci. Ukuba inzima okanye iyaqhubeka, xelela ugqirha wakho. |
| Isicaphucaphu kunye norhudo | Oku kuqhelekile kwiiveki zokuqala zonyango. Sela amanzi amaninzi kwaye utye ukutya okungeyondlwantyala (irayisi, iibhanana). Ukuba kuyaqhubeka, xelela ugqirha wakho. |
| Iimpendulo kwindawo yokujova | Kunokubakho ukubomvu, ukurhawuzelela, kunye nokudumba kwindawo yokujova. Oku kungancitshiswa ngokutshintsha indawo yokujova endaweni yokujova kwindawo enye ngalo lonke ixesha. |
Ngaba kukho iingxaki ngamanye amayeza kunye neegonyo?
Ewe, loo nto ibaluleke kakhulu.
- Iigonyo: Ezinye iigonyo azinakunikwa ngaphambi okanye ngexesha lonyango ngeRystiggo. Ngoko ke, xelela ugqirha wakho kwangaphambili malunga nazo naziphi na iigonyo ozifumanayo.
- Amanye amayeza: Amanye amayeza owasebenzisayo, ingakumbi unyango olunxulumene nomzimba olufana ne -Intravenous Immunoglobulin (IVIg) , kunye nama-antibodies e-monoclonal , asenokusebenzisana ne-Rystiggo.
Ngoko ke, kubalulekile ukuxelela ugqirha wakho ngayo yonke imithi oyithathayo (kuquka iivithamini kunye neemveliso zezityalo) ngaphandle kokufihla nantoni na.
Uyazi njani ukuba iyeza liyasebenza?
Kwiiveki ezimbalwa emva kokuqala iRystiggo, uza kuqala ukuziva izihlunu zakho ziqina kwaye iimpawu zakho ziya ziphucuka. Nangona kunjalo, nokuba iimpawu zakho ziya ziphucuka, ungaze uyeke ukuthatha amayeza ngaphandle kwengcebiso kagqirha wakho. Ukwenza njalo kunokubangela ukuba iimpawu zakho zibuye. Soloko uthetha nogqirha wakho ngemeko yakho.
Umyalezo Wokuya Ekhaya
- I-Myasthenia Gravis sisifo apho amajoni ethu omzimba ahlasela izihlunu zethu.
- I-Rystigmo lunyango olutsha lwesi sifo. Inceda ukususa ii-antibodies eziyingozi ezibangela esi sifo emzimbeni.
- Olu nyango alufanelekanga kuye wonke umntu. Ugqirha wakho uza kugqiba ukuba oku kulungile na kuwe ngokujonga ukuba ngaba une-AChR okanye i-MuSK antibodies egazini lakho.
- Ukuba ubonakalisa iimpawu zosulelo ezifana nomkhuhlane kunye nokukhwehlela ngexesha lonyango, yazisa ugqirha wakho ngoko nangoko.
- Kubaluleke kakhulu ukuxelela ugqirha wakho ngazo zonke ezinye iziyobisi ozisebenzisayo.
- Kuphephe ukuyeka amayeza anikwe ngugqirha ngaphandle kwengcebiso kagqirha nangasiphi na isizathu.
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