Ngaba unesifo esibizwa ngokuba yiMyasthenia Gravis (MG)? Ngoko mhlawumbi uyazi kakuhle ukuba bubunzima obungakanani obu buthathaka bemisipha, ukugoba kwamehlo, ubunzima bokuthetha, kunye nokuginya obunokuba yingxaki ebomini bakho. Kuya kufuneka usebenzise amayeza amaninzi ahlukeneyo ukulawula le meko. Kodwa into enye onokonwaba ngayo kukuba kutshanje, kuye kwaveliswa amayeza amatsha okunyanga esi sifo. Namhlanje, siza kuthetha ngeZilbrysq, inaliti entsha enokusetyenziswa ekhaya.
Okokuqala, masibone ukuba yintoni iMyasthenia Gravis (MG).
Ngamafutshane, iMyasthenia Gravis (MG) yimeko yokuzikhusela komzimba. Oku kuthetha ukuba inkqubo yokuzikhusela yomzimba wethu, okanye inkqubo yokuzikhusela yomzimba, ngempazamo iqala ukuhlasela iiseli zethu eziphilileyo.
Khawuthelekelele ukuba ingqondo yethu ithumela umyalezo kwisihlunu ukuze 'sinciphe'. Lo myalezo uhamba ngemithambo-luvo. Indawo apho imithambo-luvo kunye nezihlunu zidibana khona ifana 'nekhonkco'. Siyibiza ngokuba yi-neuromuscular junction. Kule khonkco, kukho 'ii-receptors' ezikhethekileyo ezifumana umyalezo wemithambo-luvo. Kwi-MG, inkqubo yethu yomzimba yokuzikhusela ihlasela ezi receptors ezibizwa ngokuba yi-'acetylcholine receptors'. Emva koko umyalezo ovela engqondweni awumkelwa ngokufanelekileyo yimisipha. Ngenxa yoko, izihlunu ziyadinwa ngokukhawuleza kwaye zibe buthathaka.
Ayingabo bonke abantu abane-MG abafumana iimpawu ezifanayo. Abanye abantu baqala ngequbuliso iimpawu , ngelixa abanye benokwanda kancinci kancinci kweempawu ngokuhamba kweminyaka. Ngamanye amaxesha kunokubakho amaxesha okuxolelwa (xa iimpawu ziphela).
| Iimpawu Eziqhelekileyo zeMyasthenia Gravis (MG) | |
|---|---|
| Inxalenye yomzimba echaphazelekayo | Iimpawu ezinokwenzeka |
| Izihlunu zamehlo | Umbono ophindwe kabini, amehlo ajiyileyo. |
| Izihlunu zobuso nomlomo | Ukungathethi kakuhle xa uthetha, ubunzima bokuhlafuna nokuginya ukutya, utshintsho kwilizwi, kunye nobunzima bokulawula imbonakalo yobuso. |
| Intamo, iingalo kunye nemilenze | Ubunzima bokuhamba, ukungakwazi ukusebenzisa izandla neminwe ngokuqhelekileyo, ubunzima bokubamba intloko ime nkqo. |
| Inkqubo yokuphefumla | Abanye abantu (malunga nama-20%) banokuhlangabezana nemeko engxamisekileyo, enzima, nehlala isongela ubomi ebizwa ngokuba yi-"myasthenic crisis". Le yimeko engxamisekileyo efuna unyango olukhawulezileyo. |
Ingxaki ye-'Myasthenic' yimeko engxamisekileyo apho izihlunu zokuphefumla ziba buthathaka kwaye ungakwazi ukuphefumla. Inokubangelwa lusulelo, uxinzelelo, okanye amayeza athile. Ukuba oku kuyenzeka, kubalulekile ukuya kwicandelo lezonyango elikufutshane (ETU) ngoko nangoko.
Isebenza njani iyeza iZilbrysq?
Injongo ephambili yokunyanga i-MG kukubuyisela ukudluliselwa kwemiyalezo yemithambo-luvo nge-acetylcholine receptor. Amayeza anjenge-pyridostigmine (Mestinon), ii-steroids ezifana ne-prednisone, kunye ne -immunosuppressants asetyenziswa kakhulu ukwenza oku.
I-Zilbrysq ikwiqela elitsha lamayeza asebenza ngendlela eyahlukileyo. Siwabiza ngokuba 'zii-complement inhibitors'.
Uyakhumbula xa ndandisithi inkqubo yethu yokuzikhusela komzimba ihlasela izihlunu zethu? Kukho into ebizwa ngokuba yi-"complement pathway" edlala indima ebalulekileyo kule nkqubo yokuhlasela. Into eyenziwa yiZilbrysq kukuthintela umsebenzi wale nkqubo yokuxhasa. Emva koko inkqubo yokuzikhusela komzimba inciphisa ukuhlaselwa okuyingozi kwii-receptors. Ngenxa yoko, imiyalezo yemithambo-luvo iqala ukuya kwizihlunu ngokufanelekileyo kwakhona, kwaye amandla ezihlunu aphucuka kwakhona.
Ngaba iZilbrysq ingasetyenziswa ngumntu wonke oneMG?
Hayi, ayinguye wonke umntu onokukwazi. Eli yeza livunyiwe kuphela kubantu abane-antibody ethile ebizwa ngokuba yi-"anti-acetylcholine receptor antibody" egazini labo. Uninzi lwabantu abane-MG (malunga ne-80%-90%) banale antibody. Kodwa ukuba awunayo le nto egazini lakho, eli yeza lisenokungabi luncedo kangako. Ke ngoko, ngaphambi kokuba uqale ukusela eli yeza, ugqirha wakho uya kwenza uvavanyo olukhethekileyo lwegazi ukujonga ukuba unayo na le antibody.
Ulisebenzisa njani eli yeza?
I-Zilbrysq liyeza elenziwe ngolwelo elifakwa phantsi kolusu yonke imihla. Lingafakwa ethangeni, esiswini, okanye ngasemva kwengalo engasentla.
- Indawo yokugcina: Eli yeza lifanele ligcinwe efrijini.
- Ngaphambi kokusetyenziswa: Susa isitofu efrijini imizuzu engama-30-45 ngaphambi kokusifaka kwinaliti uze usivumele sifikelele kubushushu begumbi. Oku kuya kunciphisa ukungonwabi ngexesha lokusifaka.
- Uqeqesho: Xa uqala ukufumana eli yeza, ugqirha wakho okanye umongikazi uza kukubonisa indlela yokulifaka ngqo. Kubaluleke kakhulu ukulifaka ngqo njengoko kuyalelwe ukuze ufumane idosi efanelekileyo. Ukuba kukho into ongaqinisekanga ngayo, buza ugqirha wakho kwakhona.
Izinto ezikhethekileyo ekufuneka uzazi ngaphambi kokuba uqalise amayeza
Le yinxalenye ebaluleke kakhulu, ngoko ke nikela ingqalelo enzulu.
Eli yeza linokunyusa umngcipheko wezifo ezinzulu, ingakumbi izifo ze -meningococcal. Ngenxa yale ngozi, eli yeza lifumaneka kuphela ngenkqubo yokhuseleko ekhethekileyo ebizwa ngokuba yi-Zilbrysq REMS program. Wena nogqirha wakho kufuneka nibhalise kule nkqubo.
Njengenxalenye yale nkqubo, ugqirha wakho uza kukufundisa ngezifo ze-meningococcal, indlela yokuzithintela, indlela yokuzibona iimpawu, kunye nokubaluleka kokufuna iingcebiso zonyango ngoko nangoko ukuba kuvela iimpawu.
- Ukugonywa: Ukunciphisa umngcipheko wokosuleleka, ugqirha wakho uya kuqinisekisa ukuba ufumene imijovo ye-meningococcal ubuncinane iiveki ezimbini ngaphambi kokuba uqale iZilbrysq. Ukuba kufuneka uqale amayeza ngokukhawuleza kwaye awukagonywa, kuya kufuneka uthathe amayeza okubulala iintsholongwane de kube kusebenze umjovo.
- Ikhadi Lokhuseleko: Uza kunikwa 'iKhadi Lokhuseleko Lwesigulane' elikhethekileyo. Kufuneka uligcine eli khadi ngamaxesha onke. Kubalulekile ukuligcina nawe ngelixa usela amayeza, kunye neenyanga ezimbini emva kokuyeka amayeza. Ungalibonisa eli khadi nakweyiphi na enye ugqirha onyangayo.
Iziphumo ebezingalindelekanga kunye nendlela yokuzilawula?
Njengayo nayiphi na iyeza, iZilbrysq inokubangela ezinye iziphumo ebezingalindelekanga, kodwa uninzi lwazo lunokulawulwa.
| Imiphumela | Indlela yokulawula |
|---|---|
| Iimpendulo kwindawo yokufaka inaliti (ukuba bomvu, ukurhawuzelela, ukudumba) | Musa ukuhlaba kwindawo enye yonke imihla, kodwa tshintsha indawo. Sebenzisa ezinye iindawo ezifana nethanga, isisu, nengalo engentla. Musa ukuhlaba kwiindawo ezineenxeba, imivumbo, ukudumba, okanye amanxeba. |
| Usulelo lweebhaktheriya (impumlo, umphimbo, imiphunga) | Ezi zinokuthintelwa ngokufumana imigonyo efunekayo. Hlamba izandla zakho rhoqo. Hlala kude nabantu abagulayo. |
| I-Pancreatitis | Ugqirha wakho uza kuvavanya igazi lakho ngaphambi kokuba aqalise amayeza. Ukuba ufumana iintlungu eziqatha esiswini sakho esingaphezulu (esiphuma emqolo wakho), tsalela umnxeba ugqirha wakho ngoko nangoko. |
| Umngcipheko wezifo ezidluliselwa ngesondo ezifana ne-gonorrhea | Eli yeza linokunyusa kancinci umngcipheko wezifo ezidluliselwa ngesondo ezifana ne-gonorrhea. Kubalulekile ukwenza isondo esikhuselekileyo (umz., ukusebenzisa ikhondom) kwaye uhlolwe rhoqo. Thetha nogqirha wakho ngale nto. |
Ndingalindela iziphumo nini?
Ukuba iZilbrysq ikulungele, ungabona ukuphucuka kweempawu zakho kwiveki yokuqala yokuqalisa amayeza. Uninzi lwabantu lubona iziphumo ezilungileyo kwinyanga yokuqala.
Ibaluleke kakhulu:Musa ukuyeka ngequbuliso ukuthatha eli yeza okanye naliphi na elinye iyeza le-MG ngaphandle kokuthetha nogqirha wakho. Musa ukwenza njalo nokuba iimpawu zakho ziyaphucuka. Kungenjalo, isifo sinokuba mandundu ngakumbi.
Ukuba awuboni tshintsho kwiimpawu zakho emva kokusela iyeza kangangenyanga okanye ezimbini, thetha nogqirha wakho. Uza kuthetha nawe ngezinye iindlela zonyango.
Umyalezo Wokuya Ekhaya
- I-Zilbrysq (iZilucoplan) yinaliti entsha yemihla ngemihla efakwa phantsi kwesikhumba kwizigulana ezifanelekileyo ezineMyasthenia Gravis (MG).
- Oku kusebenza ngokuthintela 'inkqubo yokuncedisa', eyinxalenye yenkqubo yokuzikhusela komzimba, nokunciphisa umonakalo kwizihlunu.
- Eli yeza lingasetyenziswa kuphela ngabantu abane-antibody ebizwa ngokuba yi-'anti-AChR antibody' egazini labo.
- Ngenxa yomngcipheko wokosuleleka kakhulu, eli yeza lifumaneka kuphela phantsi kwenkqubo ekhethekileyo ebizwa ngokuba yinkqubo ye-REMS. Kuyimfuneko ukufumana i-meningococcal vaccine ngaphambi kokuba uqalise iyeza.
- Hlala ugcina 'iKhadi loKhuseleko lweSigulana' olinikiweyo.
- Musa ukuyeka ukuthatha naliphi na iyeza le-MG okanye utshintshe idosi ngaphandle kwengcebiso kagqirha.
- Musa ukuba neentloni zokuthetha nogqirha wakho ngayo nayiphi na imiphumo okanye iingxaki onokuba nazo.
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