Ngaba une-asthma enzima? Ngaba usahlaselwa rhoqo nangona usebenzisa i-inhaler yakho kunye namanye amayeza? Ngaba udiniwe kukungalali kakuhle ebusuku kwaye ungakwazi ukwenza nemisebenzi emincinci? Ngabo banengxaki yiyo kuphela abaziyo ukuba kunzima kangakanani ukuphila ne-asthma enzima ukuyilawula. Kodwa ungoyiki, ngokuhambela phambili kwesayensi yezonyango, unyango olutsha ngoku luye lwanceda. Namhlanje, siza kuthetha ngonyango olutsha noluphucukileyo. Lo nguTezspire.
Eli yeza elibizwa ngokuba yiTezspire lisebenza njani ngokwenene?
Kulungile, masiqale siqonde ngokulula ukuba kwenzeka ntoni emizimbeni yethu xa sine-asthma. I-asthma yimeko apho iindlela zethu zomoya, okanye ii-windpipes, zivuvukala, zidumbe, kwaye zibe novelwano. Xa into ethile ene-allergy (umzekelo, uthuli, umsi) ingena emzimbeni, ezi ndlela zomoya ziba ncinci kwaye kuba nzima ukuphefumla.
Ngokwesiqhelo, sisebenzisa iintlobo ezimbini eziphambili zamayeza ukunyanga isifo sesifuba. Elinye ngamayeza okulawula isifo sesifuba. La asetyenziswa yonke imihla ukulawula isifo sesifuba nokuthintela ukuhlaselwa. Elinye uhlobo ngamayeza okuhlangula . La asetyenziselwa ukunciphisa ngokukhawuleza iimpawu xa kuvela uhlaselo lwesifo sesifuba.
I-Tezspire liyeza elongezelelweyo kwiyeza lokulawula elisele ulisebenzisa. Linceda ekuthinteleni ukuhlaselwa sisifo sesifuba, hayi iyeza 'lokuhlangula' onokulisebenzisa xa unalo.
Ngamafutshane, iTezspire liyeza elenziwe ngohlobo oluthile lweproteni. Ngokuchanekileyo, oku kubizwa ngokuba yi- (monoclonal antibody) . Umzimba wethu unekhemikhali ebizwa ngokuba yi- (Thymic Stromal Lymphopoietin - TSLP) . Le TSLP yeyona nto ibangela ukudumba (ukudumba) kunye nobuthathaka obungafunekiyo kwiindlela zomoya. Iyeza leTezspire lithintela isenzo saloo khemikhali ebizwa ngokuba yi-TSLP. Xa i-TSLP ivaliwe, ukudumba kunye nokuncitshiswa kweendlela zomoya kuyancitshiswa kwaye iimpawu ze-asthma zilawulwa ngcono.
Ufumanise njani ukuba eli yeza lisebenza kangakanani?
Ngaphambi kokuba naliphi na iyeza elitsha lifike kwimarike, kwenziwa izifundo ezinkulu zeklinikhi ukuze kuqinisekiswe ukuba likhuselekile na ukusetyenziswa ebantwini kwaye nokuba liyasebenza ngokwenene na. Izifundo ezibini eziphambili zenziwe ngeTezspire.
Abathathi-nxaxheba kolu phononongo yayingabantu abaneminyaka eli-12 nangaphezulu abane -asthma enzima . Oko kukuthi, abo babehlaselwa rhoqo yi-asthma nto leyo eyayifuna iipilisi ze-steroid okanye ukulaliswa esibhedlele.
Olu phando lujolise ikakhulu kwizinto ezininzi:
- Ukwanda kwe-Asthma: Sijonge ukuba ukuhlaselwa si-asthma kuye kwehla kangakanani emva kokuthatha amayeza.
- Umsebenzi wemiphunga : Uvavanyo olukhethekileyo lulinganisa ubungakanani bomoya onokukhutshwa ngamandla ngomzuzwana omnye. Oku kubizwa ngokuba yiForced Expiratory Volume ngomzuzwana omnye - FEV1 .
- Ulawulo lweempawu: Kusetyenziswa iphepha lemibuzo elikhethekileyo (`Imibuzo yoLawulo lweSifo soMphefumlo 6` okanye i-ACQ-6 ), izigulane nazo zahlolwa ukuze kubonwe ukuba iimpawu zazo zilawulwa kakuhle kangakanani na.
Ezi zifundo zaziquka abantu abavela kwiintlanga ezahlukeneyo kunye neemvelaphi ezahlukeneyo, kodwa abantu abatshayayo kunye nabo banezinye izifo zokuphefumla ababandakanywanga kwezi zifundo.
Zithini iziphumo zolu phando?
Abathathi-nxaxheba kolu phononongo baqhubeka nokusela amayeza abo aqhelekileyo okulawula i-asthma (umz. ii-corticosteroids eziphefumliweyo ). Elinye iqela lanikwa i-Tezspire vaccine, ngelixa elinye iqela lanikwa i-placebo . I-placebo yinto ebonakala ngathi yeyeza kodwa ayinayo nayiphi na iyeza esebenzayo. Isetyenziselwa ukulinganisa ngokuchanekileyo imiphumo yeyeza lokwenyani.
Iziphumo ekupheleni kweeveki ezingama-52, oko kukuthi, unyaka, ziyakhuthaza ngokwenene.
- Xa kuthelekiswa neqela le-placebo, abo bafumene iTezspire babenokwehla kwama-56% ukuya kuma-72% kwi-asthma exacerbations (ukuhlaselwa).
- Kwakhona, umsebenzi wemiphunga , oko kukuthi, i-FEV1, unyuke malunga ne-0.13 yeelitha kwabo bathathe iTezspire.
- Ngokwemibuzo ye-ACQ-6, ama-86% abo bathatha iTezspire baxele ukuba iimpawu zabo ziphucukile, xa kuthelekiswa nama-77% kwiqela le-placebo.
Ezi ziphumo zibonisa ngokucacileyo ukuba iTezspire lunyango olusebenzayo kakhulu lokulawula isifo sombefu esiqatha. Kodwa khumbula ukuba iziphumo zophando azifani kuye wonke umntu. Iziphumo zakho zinokwahluka.
Ungayifumana njani iTezspire? Ungayisebenzisa njani?
Ukuba isifo sakho sesifuba kunzima ukusilawula kwaye unomdla kwiTezspire, ungathetha nogqirha wakho wosapho okanye ingcali yemiphunga ngayo. Ukuba ugqirha wakho ugqiba kwelokuba eli yeza lifanelekile kwimeko yakho, uza kwenza amalungiselelo afunekayo ukuze ulifumane.
I-Tezspire yinaliti efakwa ngaphantsi kwesikhumba enikwa rhoqo kwiiveki ezi-4.Oku kudla ngokunikezelwa eofisini kagqirha, ekliniki, okanye esibhedlele. Ngamanye amaxesha, ugqirha wakho unokugqiba kwelokuba kukhuselekile kwaye kufanelekile ukuba uzinike isitofu ekhaya. Ukuba kunjalo, ugqirha wakho okanye umongikazi oqeqeshiweyo uya kukufundisa indlela yokunika isitofu ngokufanelekileyo.
Kubalulekile: Ungaze uyeke ukuthatha amayeza e-asthma owasebenzisayo ngoku, ingakumbi ii-steroids, ngaphandle kwengcebiso kagqirha wakho. I-Tezspire liyeza elongezelelweyo kuphela.
Iziphumo ebezingalindelekanga kunye nezinto ekufuneka uzazi
Njengayo nayiphi na imithi, iTezspire inokubangela iziphumo ebezingalindelekanga ezincinci kwaye ngamanye amaxesha ezibi kakhulu. Kubalulekile ukuzazi ezi zinto.
| Isiphumo/umngcipheko | Inkcazo kunye namanyathelo aza kuthathwa |
|---|---|
| Iziphumo ebezingalindelekanga eziqhelekileyo | Umphimbo obuhlungu, iintlungu zamalungu, kunye nentlungu yomqolo. Ezi aziqhelekanga ukuba zimbi kakhulu. Kodwa ukuba ukhathazekile, xelela ugqirha wakho. |
| Iimpendulo kwindawo yokujova | Ububomvu, ukudumba, okanye iintlungu zinokwenzeka kwindawo efakwe kuyo inaliti. Oku kungancitshiswa ngokuthatha inaliti efrijini iyure ngaphambi kokuba ifakwe kwaye uyifake kwindawo eyahlukileyo ngalo lonke ixesha. |
| Iimpendulo Ezinzima Zokwaliwa Yi-Allergic | Iimpawu ezinje ngobunzima bokuphefumla, ukudumba kobuso/imilebe, ukubetha kwentliziyo ngokukhawuleza, kunye nokurhawuzelela kunokwenzeka. Le yimeko engxamisekileyo! Yeka ukuthatha amayeza ngoko nangoko kwaye uye kwiSebe lezeMpilo eziNgxamisekileyo (ETU) lesibhedlele esikufutshane. |
| Amathuba osulelo | Oku kunokuchaphazela inkqubo yomzimba yokuzikhusela, nto leyo eyenza ukuba ingakwazi ukulwa nezifo ezithile, ingakumbi izifo ze-helminth ezibangelwa zizinambuzane . Ukuba unentsholongwane enjalo, kufuneka inyangwe ngaphambi kokuba uqale iTezspire. |
| Isitofu | Musa ukufumana izitofu ezinciphileyo ngelixa usela eli yeza. Buza ugqirha wakho malunga nokuba zeziphi izitofu omele uzifumane ngaphambi kokuba uqale iTezspire. |
| Umngcipheko wesifo sentliziyo | Kolunye uphando, abantu abasebenzisa iTezspire babenomngcipheko ophezulu kancinci weziganeko zentliziyo, ezifana nokuhlaselwa yintliziyo kunye nokubetha kwentliziyo, xa kuthelekiswa nabo bathatha i-placebo. Thetha nogqirha wakho ngale nto ukuba usengozini yesifo sentliziyo. |
| Ukukhulelwa kunye nokuncancisa | Akukho datha yaneleyo okwangoku malunga nokhuseleko lokusebenzisa iTezspire ngexesha lokukhulelwa okanye lokuncancisa. Ukuba uceba ukukhulelwa, ukhulelwe, okanye uncancisa, xelela ugqirha wakho ngoko nangoko. |
Khumbula, iTezspire ayiloyeza 'lokuhlangula' onokulisebenzisa xa uhlaselwa sisifo sesifuba. Liyeza elinceda ukulawula isifo sakho sesifuba ixesha elide.
Ngaba kukho iingxaki ngamanye amayeza?
Ngokolwazi lwangoku, iTezspire ayibikwanga ukuba ibangela ukudibana okukhulu namanye amayeza. Nangona kunjalo, kungcono ukuxelela ugqirha wakho ngawo onke amayeza, iivithamini, kunye nezongezo ozithathayo. Soloko ubuza ugqirha wakho ngaphambi kokuba uqalise naliphi na iyeza elitsha.
Ukuba ukrokrela ukuba ukhe waba nesiphumo esibi esivela kweli yeza, nokuba awuqinisekanga ngokupheleleyo ukuba sibangelwa yiTezspire, ungayixela kwiZiko loLwazi lweePoisons kwiSibhedlele sikaZwelonke saseColombo . Olu lwazi luya kuba lubaluleke kakhulu ekuqokeleleni ulwazi oluthe kratya malunga neli yeza kwixesha elizayo.
Umyalezo Wokuya Ekhaya
- I-Tezspire lunyango olongezelelweyo lwesifo sesifuba esibi kubantu abadala abaneminyaka engaphezu kwe-12 ubudala abangalawulwayo lunyango lwangoku.
- Olu lugonyo olunikwa rhoqo emva kweeveki ezi-4 kwaye lunceda ekuthinteleni ukuhlaselwa sisifo sesifuba, alulonyango 'lokuhlangula' olusetyenziswa xa kukho imeko engxamisekileyo.
- Ngaphambi kokuba uqale olu nyango, xoxa ngononophelo ngeengenelo kunye neengxaki zalo nogqirha wakho.
- Kuphephe ukuyeka naliphi na iyeza le-asthma olisebenzisayo ngoku ngaphandle kwengcebiso kagqirha.
- Ukuba ufumana iimpawu ezinobungozi ze-allergy ezifana nobunzima bokuphefumla kunye nokudumba kobuso, yiya kwiSebe lezeMpilo eziNgxamisekileyo (ETU) lesibhedlele esikufutshane ngoko nangoko.
- Yazisa ugqirha wakho ngayo nayiphi na imiphumo emibi okanye naziphi na iingxaki ohlangabezana nazo.
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