Umuthi Wokugomela i-Brentuximab Vedotin: Okudingeka Ukwazi

Ingabe odokotela bakho banqume ukukunikeza wena noma othile omaziyo umjovo obizwa ngokuthi i-Brentuximab Vedotin ukuze welaphe isimo somdlavuza njenge-lymphoma? Uma kunjalo, namuhla sizoxoxa ngalo muthi, ukuthi usebenza kanjani, imiphumela yawo engase ibe yingozi, kanye nezinto okudingeka uzazi. Njengoba lo muthi uyinkimbinkimbi, kubalulekile ukuthi ucace ngalezi zinto.

Uhlobo luni lomuthi iBrentuximab Vedotin?

Kalula nje, i-Brentuximab Vedotin iwumuthi wokugomela okhethekile osetshenziselwa ukwelapha uhlobo lomdlavuza olubizwa ngokuthi i-Lymphoma. Lokhu kungenxa yokuthi kukhona iphrotheni ekhethekile esiza amangqamuzana omdlavuza ukuba akhule, ahlukane, futhi ande. Ngokuyivala leyo phrotheni, lo muthi usiza ekumiseni ukusabalala kwamangqamuzana omdlavuza, noma okungenani ukuyinciphisa. Ukuze kube sobala, lo muthi unikezwa amangqamuzana omdlavuza (ukwelashwa okuqondiwe). Igama lomkhiqizo wawo odumile yi -ADCETRIS . Ngezinye izikhathi, udokotela wakho angasebenzisa lo muthi nakwezinye izimo. Ngakho-ke uma unemibuzo, kungcono ukubuza udokotela wakho noma usokhemisi.

Yiziphi izinto okudingeka uzitshele ithimba lakho lezokwelapha ngaphambi kokuthatha lo muthi?

Ngaphambi kokuthi uqale lo muthi, udinga ukutshela ithimba lakho lokunakekela izinto ezithile ngokucacile. Ngoba lolo lwazi luzobasiza banqume ukuthi lo muthi ukulungele yini nokuthi bawunikeza kanjani. Ungafihli lutho, ngisho nento encane kakhulu. Uma unezinye zalezi zimo, qiniseka ukuthi ubatshela:

• Isifo sikashukela : Uma unesifo sikashukela.
• Isifo sezinso : Uma kukhona inkinga noma isifo ezinso .
• Isifo sesibindi : Uma kukhona inkinga noma isifo esibindini.
• Inani lamaseli amhlophe egazini eliphansi: Uma uke watholakala ukuthi unamaseli amhlophe egazini lakho. Lawa amaseli alwa nezifo emzimbeni wethu.
• Isifo samaphaphu : Uma unesifo samaphaphu , isibonelo , ubunzima bokuphefumula .
• Izinkinga zemizwa : Uma unezinzwa ezinyaweni zakho, umuzwa wokucasuka, noma ezinye izinkinga zemizwa (njenge-peripheral neuropathy).
• Ukungezwani komzimba: Uma uke waba nokusabela kokungezwani komzimba kulo muthi, i-Brentuximab Vedotin, noma yimuphi omunye umuthi owusebenzisile esikhathini esidlule, noma yikuphi ukudla, noma yimaphi amadayi, noma yiziphi izithasiselo.
• Ukukhulelwa noma ukuzama ukukhulelwa: Uma ukhulelwe noma uhlela ukuba nomntwana maduze nje.
• Ukuncelisa: Uma uncelisa ingane yakho.

Uma lezi zinto zishiwo kahle, ithimba lezokwelapha lingakwelapha ngokuphephile.

Ngingakunika kanjani lo muthi?

Lomuthi unikezwa njengomjovo emthanjeni (ngokufakwa nge-intravenous noma nge-IV infusion). Lomuthi uvame ukunikezwa ngabasebenzi bezokwelapha abaqeqeshwe esibhedlela noma emtholampilo womdlavuza. Lokhu kusho ukuthi awukwazi ukuwuthatha uwuyise ekhaya uwusebenzise.

Ingabe lo muthi unganikezwa izingane ezincane?

Yebo, kwezinye izimo ezikhethekile, lo muthi unganikezwa izingane ezineminyaka engu-2 ubudala . Kodwa-ke, kumele kulandelwe izinyathelo zokuphepha ezikhethekile. Uma ingane yakho inikezwe lo muthi, khuluma nodokotela wakho ngokucophelela bese uthola imininingwane.

Kwenzekani uma uphuza umuthi omningi kakhulu?

Uma ucabanga ukuthi uphuze kakhulu lo muthi ngephutha, shayela isikhungo sokulawula ubuthi noma igumbi lezimo eziphuthumayo ngokushesha.

Okubalulekile: Lo muthi unikezwe wena kuphela. Ungawubelani nanoma ubani nganoma yisiphi isizathu.

Kuthiwani uma ngiphuthelwa umthamo wemithi?

Uzonikezwa usuku nesikhathi esithile sokuthola lo muthi wokugoma. Kubaluleke kakhulu ukuya uyothola umuthi wokugoma ngalezo zinsuku. Uma ngesizathu esithile ungakwazi ukuya ngosuku oluhleliwe, shayela ithimba lakho lezempilo ngokushesha bese ubazisa.

Yiziphi ezinye izinto ezingasebenzisana nalo muthi?

Kunemithi ethile engabangela izinkinga uma ithathwa nge-Brentuximab Vedotin. Ngakho-ke, kufanele utshele udokotela wakho ngayo yonke imithi oyithathayo, okuhlanganisa amavithamini, imithi yamakhambi, kanye nezithasiselo zokudla. Eminye imithi okungafanele ithathwe nalo muthi ihlanganisa:

• I-Bleomycin

Futhi, kunezinye izinto ezingasebenzisana nalo muthi:

• I-Ketoconazole
• I-Rifampin
• I-St. John's Wort - Lena isitshalo sendabuko esisetshenziswa abanye abantu.

Lolu hlu aluphelele. Ngakho-ke, tshela udokotela wakho ngayo yonke imithi oyithathayo, nokuthi uyabhema, uphuza utshwala, noma usebenzisa ezinye izidakamizwa. Ezinye izinto zingathinta indlela lo muthi osebenza ngayo.

Yini okufanele uyiqaphele lapho uthatha lo muthi?

Isimo sakho sizoqashwa eduze odokotela bakho ngenkathi uthatha lo muthi. Futhi, kufanele uqaphele ngezinye izinto.

• Ukuhlolwa kwegazi: Kuzodingeka ukuthi uhlolwe igazi njalo (ukuhlolwa kwegazi) ngenkathi uthatha lo muthi. Lokhu kwenzelwa ukuhlola ukuthi umuthi uwuthinta kanjani umzimba wakho nokuthi ngabe kukhona yini imiphumela emibi.
• Ingozi yokutheleleka: Ungase ube sengozini enkulu yokuthola izifo, ikakhulukazi izifo, ngenkathi uthatha lo muthi. Ngakho-ke, uma uhlangabezana nanoma yiziphi izimpawu zomkhuhlane, njengomkhuhlane, ukubanda, umphimbo obuhlungu, noma ezinye izimpawu ezifana nomkhuhlane , ungaziphilisi futhi ufune iseluleko sezokwelapha ngokushesha. Zama ukugwema izindawo lapho abantu begula khona ngangokunokwenzeka.
• I-Progressive Multifocal Leukoencephalopathy (PML): Lokhu kungase kuzwakale kusabisa, kodwa kubalulekile ukwazi. Kwabanye abantu, lo muthi ungabangela ukutheleleka okukhulu kobuchopho (Progressive Multifocal Leukoencephalopathy - PML). Lokhu akuvamile kakhulu, kodwa kungaba yingozi. Ngakho-ke uma unezimpawu, njengokushintsha kombono, inkinga yokucabanga, inkinga yokukhuluma, noma inkinga yokuhamba noma ukuma , tshela ithimba lakho lezokwelapha ngokushesha. Uma ungakwazi ukufinyelela kubo, thola olunye usizo lwezokwelapha ngokushesha.
• Ushukela ophezulu egazini: Lo muthi ungabangela ukwanda koshukela egazini lakho. Le ngozi iphezulu kubantu asebenesifo sikashukela kakade. Ngakho-ke, buza ithimba lakho lezokwelapha ngezindlela zokulawula amazinga kashukela egazini lakho.
• Ukukhulelwa nokuncelisa:
• Ungakhulelwa ngenkathi uthatha lo muthi futhi izinyanga eziyisithupha ngemva kokuyeka umuthi. Lokhu kubaluleke kakhulu, ngoba lo muthi ungalimaza kakhulu ingane esibelethweni.
• Ngakho-ke, kubalulekile ukusebenzisa izindlela zokuvimbela inzalo ezifanele phakathi nalesi sikhathi. Khuluma nodokotela wakho mayelana nokuthi yiziphi izindlela zokuvimbela inzalo ezifanele wena nomlingani wakho.
• Uma ucabanga ukuthi wena noma umlingani wakho kungenzeka ukuthi nikhulelwe, tshela udokotela wakho ngokushesha.
• Ungancelisi ingane ngesikhathi uthatha lo muthi.
• Ukuzala: Lo muthi ungathinta ukuzala, okusho ukungabi nabantwana. Uma unenkinga ngalokhu, khuluma nethimba lakho lezokwelapha.

Yimiphi imiphumela emibi engaba khona yalo muthi?

Njenganoma yimuphi umuthi, i-Brentuximab Vedotin ingabangela imiphumela emibi. Eminye iyingozi, eminye ayibi kakhulu. Into ebaluleke kakhulu ukutshela udokotela wakho ngokushesha uma ubona noma yini engavamile.

Imiphumela emibi okufanele ibikwe kudokotela ngokushesha:

Uma uhlangabezana nanoma yiziphi zalezi zimpawu, shayela ithimba lakho lezokwelapha ngokushesha okukhulu:

• Ukusabela kokungezwani komzimba: Ukuqubuka kwesikhumba, ukulunywa, amaqhubu, ukuvuvukala kobuso, izindebe, ulimi kanye nomphimbo.
• Izinkinga zesiyezi kanye nokuxhumana:Isiyezi, ukulahlekelwa yibhalansi noma ukuhlangana, ukudideka, kanye nobunzima bokukhuluma.
• Amazinga aphezulu kashukela egazini (i-Hyperglycemia): Ukuzizwa womile kakhulu, udinga ukuchama njalo, uzizwa ukhathele ngendlela engavamile, umbono ofiphele.
• Izimpawu zokutheleleka: umkhuhlane, ukubanda, ukukhwehlela, umphimbo obuhlungu, amanxeba angapholi, ubuhlungu noma ubunzima bokuchama, kanye nokungakhululeki okuvamile.
• Izimpawu zokulimala kwesibindi: Ubuhlungu ohlangothini olungaphezulu kwesokudla lwesisu, ukulahlekelwa yisifiso sokudla, isicanucanu, indle enombala okhanyayo, umchamo ophuzi noma onsundu omnyama, ukuphuzi kwesikhumba namehlo (i-jaundice), kanye nokukhathala okungavamile.
• Izimpawu zamaseli abomvu aphansi: ukuzizwa ukhathele ngendlela engavamile, isiyezi, ikhanda elibuhlungu, ubunzima bokuphefumula.
• Izimpawu zokulimala kwamaphaphu: ubunzima bokuphefumula, ukukhwehlela, igazi esikhwehleni, ubuhlungu besifuba, umkhuhlane.
• Ubuhlungu, ukuqaqamba, noma ukuba ndikindiki ezandleni noma ezinyaweni: Lokhu kungaba uphawu lwe-peripheral neuropathy.
• I-Pancreatitis: Ubuhlungu obukhulu besisu (lokhu kungase kuphumele emhlane, futhi ubuhlungu bungase bube bubi kakhulu ngemva kokudla noma lapho uhamba), umkhuhlane, isicanucanu, nokuhlanza.
• Ukusabela kwesikhumba: Ukubomvu, ukuqubuka, ukuxebuka kwesikhumba, nezinto ezifanayo kungenzeka ngaphakathi emlonyeni.
• Izimpawu zokopha esiswini: indle enegazi noma ephuzile, kanye nokuhlanza igazi elifana nekhofi eligayiwe noma elinsundu.
• Ubuhlungu obukhulu besisu obungazelelwe: Ubuhlungu obukhulu besisu obungazelelwe, uhudo olunegazi, umkhuhlane, isicanucanu, nokuhlanza.
• I-Tumor Lysis Syndrome (TLS): Lokhu kwenzeka lapho amangqamuzana omdlavuza ephuka ngokushesha kakhulu. Izimpawu zifaka: isicanucanu, ukuhlanza, uhudo, ukuncipha kokuchama, umchamo omnyama, ukukhathala okungavamile, ukudideka, ukudikiza kwemisipha noma ubuhlungu, ukushaya kwenhliziyo okusheshayo noma okungajwayelekile, kanye nobuhlungu bamalunga.
• Ukuphuka noma ukuphuma kwegazi okungavamile: Ukuphuka kalula, ubunzima bokumisa ukuphuma kwegazi.

Imiphumela emibi evame ukungadingi ukunakekelwa kwezokwelapha (kodwa kufanele ibikwe kudokotela uma iqhubeka noma ikhathaza):

Le miphumela emibi ngokuvamile ayibi mibi kakhulu. Kodwa-ke, uma iqhubeka noma ikukhathaza kakhulu, tshela ithimba lakho lezokwelapha.

• Ukukhwehlela
• Uhudo
• Ukukhathala
• Ubuhlungu bamalunga
• Isicanucanu
• Ubuhlungu besisu
• Ukuhlanza

Lolu hlu alufaki yonke imiphumela emibi engaba khona. Uma ubona noma yini engavamile, buza udokotela wakho ngayo. Ungabika futhi imiphumela emibi ku-FDA (Food and Drug Administration) ngokushayela ku-1-800-FDA-1088.

Ngingawugcina kanjani lo muthi?

Njengoba lo muthi unikezwa esibhedlela noma emtholampilo, akudingeki uwuyise ekhaya uwugcine. Ngakho akudingeki ukhathazeke ngawo.

Okokugcina, izinto ezibaluleke kakhulu okufanele uzikhumbule (Umyalezo Wokuya Ekhaya)

Kulungile, ngakho-ke sesikhulume kakhulu nge-Brentuximab Vedotin. Ekuphetheni, nazi izinto ezibaluleke kakhulu okudingeka uzikhumbule:

• Lona umuthi okhethekile olawula ukukhula kwamaseli omdlavuza.
• Qiniseka ukuthi utshela udokotela wakho ngezinye izimo zakho zezokwelapha kanye nemithi oyiphuzayo.
• Zivikele ezifweni ngenkathi uthatha imithi futhi uqaphele noma yiziphi izimpawu ezingavamile.
• Landela imiyalelo mayelana nokukhulelwa nokuncelisa ngokucophelela.
• Uma unemibuzo noma ukungabaza, ungesabi ukubuza ithimba lezokwelapha. Bakhona ukuzokusiza.

Lokhu kwelashwa kungaba nzima, kodwa awuwedwa. Sikufisela amandla! I-Brentuximab Vedotin, i-Lymphoma, Ukwelashwa Komdlavuza, Imithi Yomdlavuza, Imiphumela Engemihle, i-ADCETRIS