Ingabe uhlushwa ukunyakaza komzimba okungalawuleki? (Tardive Dyskinesia & Chorea) - Ake sixoxe nge-Ingrezza!

Ukuqhaqhazela kwamalungu akho noma ukushintsha kobuso bakho ngaphandle kokulawula kwakho kungaba yinto engakhululekile neze. Kungenza kube nzima ukwenza imisebenzi yansuku zonke noma ngisho nokuxhumana nabantu abane. Abantu abaningi bacindezelekile ngenxa yezimo ezinjalo. Uma wena noma othile oseduze nawe eke wabhekana nalokhu, lesi sihloko sizoba sibaluleke kakhulu kuwe.

Ziyini i-Tardive Dyskinesia ne-Chorea?

Kalula nje, lezi yizimo ezimbili zezokwelapha ezenzekayo ezihlobene nokunyakaza kwemizimba yethu.

I-Tardive Dyskinesia (TD): Lesi yisimo lapho sizwa khona ukunyakaza komzimba okungahleliwe, ikakhulukazi ubuso nezitho zomzimba. Lokhu kungafaka phakathi ukuvela kolimi ngaphandle kokuzikhethela, ukushaya izindebe, ukucwayiza kwamehlo, noma ukugxumagxuma kwezitho zomzimba. Lesi simo singaba umphumela omubi wokusetshenziswa isikhathi eside kwemithi ethile yokulwa nokuphazamiseka kwengqondo noma eminye imithi yesisu.

I-Chorea: Lokhu ukuphazamiseka kokunyakaza okubangelwa yisimo sofuzo esibizwa ngokuthi i-Huntington 's Disease . Esifweni sikaHuntington, amangqamuzana ezinzwa ebuchosheni ayabhujiswa kancane kancane. Lokhu kubangela izinkinga ngokucabanga, ukulawula imizwa, kanye nokunyakaza komzimba. I-Chorea ibangela ukunyakaza okungalawulwa kwezandla, izinyawo, nobuso.

Umuthi i-Ingrezza usiza ukulawula ukunyakaza okungalawuleki okwenzeka kuzo zombili izimo. Kodwa khumbula, i-Ingrezza ayilaphi ezinye izimpawu zesifo sikaHuntington (njengezinkinga zokucabanga).

Isebenza kanjani isidakamizwa i-Ingrezza?

Ukuze siqonde lokhu, sidinga kuqala ukwazi ngesithunywa esincane samakhemikhali ebuchosheni bethu. Igama laso yi -Dopamine . Uma sikhuluma iqiniso, i-Dopamine iyi-neurotransmitter. Le Dopamine ibaluleke kakhulu ekulawuleni ukunyakaza kwemizimba yethu.

Cabanga ukuthi kwenzekani uma ubuchopho bethu buthumela i-dopamine eningi kakhulu? Njengompompi wamanzi ovula ngokushesha kakhulu, kukholelwa ukuthi lapho izimpawu ze-dopamine zanda, imizimba yethu iba yinto engazikhetheli .

Nakhu okwenziwa yi-Ingrezza. Ihlose iphrotheni ebuchosheni bethu ebizwa nge -VMAT2 (vesicular monoamine transporter 2) . Le phrotheni yiyona esiza ekukhipheni i-dopamine. Ngokulawula umsebenzi we-VMAT2, i-Ingrezza yehlisa ukudluliswa kwe-dopamine ngokweqile. Kufana nokuvula impompi kancane. Ngenxa yalokho, ukunyakaza okungalawulwa kuncipha kancane kancane.

Ngingawusebenzisa kanjani lo muthi?

I-Ingrezza umuthi oza ngesimo se-capsule. Ungathathwa nokudla noma ngaphandle kokudla. Udokotela wakho uzokunikeza lo muthi. Ungalokothi uthathe umthamo ongaphezu noma ongaphansi komthamo udokotela wakho akutshela ukuthi uwuthathe.

Umthamo ojwayelekile ubhalwe kuthebula elingezansi, kodwa udokotela wakho angashintsha lokhu kuye ngesimo sakho.

Indlela Yokuthatha I-Ingrezza Sprinkle Capsule

Abanye abantu banenkinga yokugwinya ama-capsule. Kulabo bantu, kukhona uhlobo olukhethekile olubizwa ngokuthi "Ingrezza Sprinkle." Nansi indlela yokuyisebenzisa:

1. Vula i-capsule ngokucophelela bese ufaka izinhlamvu ezincane zemithi (ama-sprinkle) ngaphakathi esipunini sokudla okuthambile njenge-applesauce, i-yogurt, noma i-pudding.

2. Ungawuhlafuni noma uwuchoboze lo muthi .

3. Yidla isipuni sonke sokudla okuxutshwe nomuthi ngokushesha .

4. Bese uphuza ingilazi yamanzi (cishe ama-240 ml).

5. Ungalokothi uhlanganise lo muthi nobisi noma amanzi.

Wazi kanjani ukuthi umuthi uyasebenza?

Ngokwezifundo zezokwelapha, ungabona ukuthuthuka kwezimpawu zingakapheli amasonto amabili nje uqale i-Ingrezza. Uzoqaphela ukuthi lokho kunyakaza komzimba okungalawulwa kuyehla kancane kancane.

Udokotela wakho uzokuqala ngomthamo ophansi bese elungisa umthamo njengoba kudingeka ukuze abone ukuthi umzimba wakho usabela kanjani. Ngakho-ke kungathatha isikhathi ukubona imiphumela emihle kakhulu. Uma unomuzwa wokuthi izimpawu zakho azithuthuki noma ziya ziba zimbi kakhulu, tshela udokotela wakho ngokushesha. Angase alungise umthamo, engeze omunye umuthi, noma akushintshele komunye umuthi uma kudingeka.

Imiphumela emibi engaba khona nokuthi ungayiphatha kanjani?

Njenganoma yimuphi umuthi, i-Ingrezza ingabangela imiphumela emibi, yize kungebona bonke abantu abayitholayo.

• Imiphumela emibi evame kakhulu phakathi kweziguli ezine-tardive dyskinesia (TD) yile:
• Ukozela

• Imiphumela emibi evamile phakathi kweziguli ze-Chorea:
• Ukozela
• Ukuqubuka kwesikhumba (ama-Hives)
• Ukuqhuma kwesikhumba
• Inkinga yokulala

Ubhekana kanjani nalezi zinto?

• Ukozela: Gwema imisebenzi edinga ukuqapha, njengokushayela noma ukusebenzisa imishini, uze wazi kahle ukuthi lo muthi uthinta kanjani wena.
• Ukuqubuka kwesikhumba noma amaqhubu: Lokhu kungaba izimpawu zokusabela kokungezwani komzimba. Uma lokhu kwenzeka, shayela udokotela wakho ngokushesha, noma uye egumbini lezimo eziphuthumayo esibhedlela esiseduze (i-ETU).
• Ukungalali: Kunezinto ongazenzela zona. Ukunciphisa ukudla kwakho iziphuzo ezine-caffeine njengekhofi, itiye, ne-cola, ukujwayela ukulala nokuvuka ngesikhathi esifanayo nsuku zonke, ukugcina igumbi lakho lokulala limnyama, kanye nokunciphisa ukusebenzisa kwakho amafoni namathebulethi ngaphambi kokulala kungasiza.

Ukusebenzisana Kwezidakamizwa

Uma usebenzisa i-Ingrezza, kubaluleke kakhulu ukutshela udokotela wakho ngayo yonke eminye imithi oyithathayo, ngisho namavithamini, ngoba eminye imithi ingasebenzisana ne-Ingrezza.

• I-Monoamine oxidase inhibitors (MAOIs):Lena imithi esetshenziselwa ukwelapha ukucindezeleka noma isifo sikaParkinson. Le mithi ye-MAOI ayivunyelwe ngokuphelele ukuthathwa ne-Ingrezza.
• I-Digoxin: Lona umuthi osetshenziselwa ukwelapha ukwehluleka kwenhliziyo kanye nokushaya kwenhliziyo okungajwayelekile. Ukuthatha i-Ingrezza ne-Digoxin kungakhuphula izinga le-Digoxin egazini lakho, okubangela imiphumela emibi. Udokotela wakho uzohlola igazi lakho futhi anciphise umthamo wakho we-Digoxin uma kudingeka.
• Ama-CYP3A4 kanye nama-CYP2D6 inhibitors/inducers: Lawa ngamagama ezokwelapha ayinkimbinkimbi kancane. Asebenza ezinhlotsheni ezahlukene zemithi. Into elula nephephile ongayenza ukutshela udokotela wakho ngayo yonke imithi oyithathayo. Uzokwenza noma yiziphi izinguquko ezidingekayo.