Kuyini i-Mantle Cell Lymphoma? Ake sixoxe ngakho!

Ungase ungaqapheli nokuthi ngezinye izikhathi kuba nezimpi ezithule ezenzeka emizimbeni yethu. Isibonelo, i-Mantle Cell Lymphoma (MCL) umdlavuza ongavamile oqala emangqamuzaneni ethu amhlophe egazi abizwa ngokuthi ama-lymphocyte. Empeleni uhlobo lwe-lymphoma olubizwa ngokuthi i-non-Hodgkin lymphoma. Ake sixoxe ngalokhu kalula, ngendlela ongayiqonda.

I-mantle cell lymphoma (MCL) ikhula kanjani? Kwenzekani emzimbeni?

Cabanga nje, lo mdlavuza obizwa ngokuthi i-MCL uqala ukusabalala kancane kancane emzimbeni ekuqaleni. Kodwa ngemva kwesikhashana, ungakhula ngokushesha ngokuzumayo. Lokhu kusakazeka kakhulu kulo lonke uhlelo lwethu lwe-lymphatic. Uhlelo lwe-lymphatic luhlobo loketshezi emzimbeni wethu kanye nenethiwekhi yemithambo ethwala lolo ketshezi. Kufana nohlelo olususa imfucuza emzimbeni wethu. Lapho lesi sifo siba sibi kancane , la maseli omdlavuza angaphuma kuma-lymph node asakazekele egazini lethu, emnkantsheni, futhi ngezinye izikhathi ngisho nasezindaweni ezifana nohlelo lokugaya ukudla.

Okubalulekile, umuntu one-MCL angaba nezikhathi zokuyekelela, futhi angaba nokuphinda abuye. Lokhu kungenzeka izikhathi eziningi. Nakuba ukwelashwa kungeke kuphulukise ngokuphelele i-MCL, kungasiza ekwandiseni isikhathi sokuyekelela.

I-Mantle cell lymphoma ingumdlavuza ongavamile kakhulu . Ithinta cishe umuntu oyedwa kwabangu-200,000. Nakuba noma ubani engaba nalo mdlavuza, abantu abaneminyaka ephakathi kuka-60 no-70 basengozini enkulu kancane.

Yiziphi izinhlobo ze-mantle cell lymphoma (MCL)?

Kunezinhlobo ezimbili eziyinhloko ze-MCL: 1. I-MCL yakudala: Lolu uhlobo oluvame kakhulu. Luqala kuma-lymph node bese lusakazekela kwezinye izingxenye zomzimba. Ngokuvamile luhlobo olunolaka kakhulu. 2. I-MCL engaguquki ye-leukaemic: Lolu hlobo luvame ukubandakanya amangqamuzana e-spleen ne-lymphoma akhulisiwe egazini nasemongweni wethambo. Lukhula kancane kunohlobo lwakudala.

Ziyini izimpawu zalesi sifo? Uzibona kanjani?

Izimpawu ze-MCL zingahluka kumuntu nomuntu. Ngezinye izikhathi zingabonakala njengezimpawu zesifo esivamile, ngakho-ke ungase ungacabangi ukuthi umdlavuza. Yingakho i-MCL ivame ukutholakala sekwephuzile, lapho lesi sifo sesivele sisakazekile. Ungase ungabi nazo nhlobo izimpawu. Kodwa-ke, uma unezimpawu, zingafaka:

• Ukuphuka
• Ikhanda elibuhlungu
• Ukuzizwa ukhathele ngaso sonke isikhathi ( Ukukhathala )
• Imfiva
• Ukuvuvukala kwesisu
• Isifiso sokudla
• NgobusukuUkujuluka
• Ama-lymph node avuvukele (njengasentanyeni, emakhwapheni, embotsheni)
• Ukuzizwa ubuthakathaka
• Ukwehlisa isisindo ngaphandle kwesizathu

Ungesabi i-MCL ngoba nje unalezi zimpawu. Kodwa uma lezi zimpawu ziqhubeka, kungcono ukubona udokotela .

Yini ebangela i-mantle cell lymphoma (MCL)?

Esikhathini esiningi, i-MCL ibangelwa ukuguquka kwezakhi zofuzo kwezinye zezakhi zethu zofuzo. Lokhu kuguquka kushintsha indlela amangqamuzana ethu e-B, uhlobo lwe-lymphocyte, asebenza ngayo. Abacwaningi abazi kahle ukuthi kungani lokhu kuguquka kwenzeka. Kodwa nakhu okwenzekayo: 1. Amaseli e-B angaguquki ngendlela engavamile akhiqiza iphrotheni eningi kakhulu ebizwa ngokuthi i-cyclin D1. Le phrotheni isiza amaseli e-B ukuba akhule. 2. Ukukhiqizwa ngokweqile kwale phrotheni ye-cyclin D1 kubangela ukuthi amaseli e-B ahlukane futhi azalane ngendlela engalawuleki. 3. Amaseli ahlukana ngokungalawuleki ahlangana ndawonye ukuze akhe izimila.

Yiziphi izinkinga zalesi simo?

Njengoba i-mantle cell lymphoma iqhubeka, izinkinga ezifana nalezi:

• Ukopha kwamathumbu
• Ubende obuqhekekile
• I-Tumor lysis syndrome (inkinga ebangelwa ukuwohloka okusheshayo kwamangqamuzana omdlavuza)

I-mantle cell lymphoma (MCL) itholakala kanjani?

Uma udokotela wakho esola ukuthi une-MCL, cishe uzokwenza izivivinyo eziningana.

• Ukuhlolwa kwelebhu: Lokhu kungafaka phakathi ukubalwa kwegazi okuphelele (i-CBC), iphaneli ephelele ye-metabolic (i-CMP), ukuhlolwa kwe-LDH, noma ukuhlolwa kwezinga le-uric acid. Odokotela bavame ukusola uma bebona ukwanda kwenani lama-lymphocyte ekuhlolweni kwegazi.
• Ukuhlolwa kwezicubu: Udokotela wakho angase akuncome ukuthi kwenziwe i-lymph node biopsy noma i-bone marrow biopsy ukuqinisekisa ukuthi akhona yini amangqamuzana omdlavuza. Isampula yezicubu ihlolwa ngudokotela wezifo.
• Ukuhlolwa kwezithombe: Lokhu kuhlolwa kusiza ukubona ukuthi umdlavuza ususakazeke kangakanani. Kuye ngokuthi umdlavuza ukuphi, kungadingeka ukuthi wenze i-colonoscopy, i-CT scan, i-EGD (esophagogastroduodenoscopy), noma i-PET scan.

Uma imiphumela yokuhlolwa kwegazi ingajwayelekile, udokotela wakho uzokuxilonga futhi akubuze ngezimpawu zakho. Bangase bazizwe nezindawo ezifana nentamo yakho namakhwapha ukuze babone ukuthi ama-lymph node akho avuvukele yini.

Yiziphi izigaba ze-mantle cell lymphoma (MCL)?

Odokotela bahlukanisa lesi sifo ngezigaba ngokusekelwe ekutheni sesisabalale kangakanani. Basebenzisa uhlelo olukhethekile olubizwa ngokuthi i-Mantle Cell Lymphoma International Prognostic Index (MIPI). Lokhu kunikeza umbono ocacile wokuthi isiguli singalindela ukuphila isikhathi esingakanani. Ngokuvamile, lesi sifo sivame ukubuya ezigabeni zakamuva kunasezigabeni zokuqala. Isigaba sinqunywa ukuthi umdlavuza ususabalale kangakanani:

• Isigaba I: Kunqunyelwe ku-lymph node eyodwa noma ezimbalwa endaweni efanayo.
• Isigaba II: Sesisabalale kuma-lymph node amabili noma ngaphezulu ohlangothini olufanayo lwe-diaphragm yakho.
• Isigaba III: Sesisabalale kuzo zombili izinhlangothi ze-diaphragm, noma ku-spleen kanye nama-lymph node angaphezu kwe-diaphragm.
• Isigaba IV: I-Mantle cell lymphoma isisabalale ezindaweni ezikude emzimbeni, noma kwezinye izindawo ezingezona ama-lymph node.

Iphathwa kanjani i-mantle cell lymphoma (MCL)?

Ukwelashwa kwe-MCL akufani kuwo wonke umuntu. Ukwelashwa okufanele kuncike ezicini ezifana nokuthi umdlavuza ukuphi nokuthi ukhula ngokushesha kangakanani. Nazi ezinye zezindlela zokwelapha ezitholakalayo ze-MCL:

• Ukwelashwa ngamakhemikhali: Imithi enikezwa ukubhubhisa amangqamuzana omdlavuza.
• Ukwelashwa nge-immunotherapy: Ukwelashwa okuvuselela amasosha omzimba wakho ukuze alwe nomdlavuza.
• Ukwelashwa ngemisebe: Ukubhubhisa amangqamuzana omdlavuza kusetshenziswa imisebe enamandla aphezulu.
• Ukwelashwa okuqondiwe: Imithi eqondisa ama-molecule athile asiza amangqamuzana omdlavuza ukukhula nokusabalala.
• Ukufakelwa kwamaseli e-stem: Ukufakelwa kwamaseli e-stem aphilile ukuze kuthathelwe indawo umongo wethambo onesifo.

Ungase ufanelekele ezinye zalezi zindlela zokwelapha, futhi ungase ungafanelekeli ezinye.

Uma une-MCL, kungumqondo omuhle futhi ukucabangela izivivinyo zemitholampilo ezihlola ukwelashwa okusha. Lezi zindlela zokwelapha ezintsha zingase zingayiqedi ngokuphelele i-MCL, kodwa zingase zikunike isikhathi esengeziwe sokuphila impilo ejabulisayo nengenazo izimpawu. Buza udokotela wakho ngalokhu.

Ingabe i-mantle cell lymphoma (MCL) ingavinjelwa?

Ngeshwa, i-MCL ayinakuvinjelwa. Ukuthi nje unalesi sifo akusho ukuthi wenze noma yini engalungile. Abacwaningi basazama ukuthola ukuthi kungani izakhi zofuzo emizimbeni yethu zishintsha (zishintsha) ngezindlela ezibangela umdlavuza njenge-MCL.

Impilo injani nge-mantle cell lymphoma (MCL)?

I-Mantle cell lymphoma akuyona uhlobo lwe-lymphoma olungelapheka ngokuphelele. Kodwa-ke, kunezindlela zokwelapha ezingakusiza ukuthi uphumule ngokuphelele. Ukuba sempumuzweni akusho ukuthi umdlavuza usuphelile ngokuphelele. I-MCL ingaphinde ibuyele emuva ezinyangeni noma eminyakeni kamuva. Isikhathi ohlala ngaso ekuphumuleni nge-MCL singase sibe sifushane. Kodwa-ke, izindlela zokwelapha ezintsha eziqondiwe ziboniswe ukuthi ziyanda ngalesi sikhathi. Khuluma nodokotela wakho ukuze ufunde kabanzi mayelana nokubikezela kwakho.

Izinga lokusinda

Izinga lokusinda kweminyaka emihlanu ye-mantle cell lymphoma licishe libe ngu-50%. Lokhu kusho ukuthi cishe ingxenye yabantu abatholakale benalesi sifo basaphila eminyakeni emihlanu ngemva kokuxilongwa.

Kodwa khumbula, la mazinga okusinda ayizilinganiso nje. Awakutsheli ukuthi uzophila isikhathi esingakanani noma ukuthi uzosabela kanjani kunoma yikuphi ukwelashwa. Kungcono ukukhuluma nodokotela wakho ukuze uthole ukuthi la mazinga asebenza kanjani kuwe.

Uzinakekela kanjani?

Kubaluleke kakhulu ukuzinakekela ngokomzimba, ngokwengqondo nangokomzwelo uma uphila ne-mantle cell lymphoma. Nazi ezinye iziphakamiso ezingakusiza:

• Yamukela imizwa yakho: Ukucindezela imizwa efana nokudabuka nokwesaba ngeke kuyenze iphele. Ukuqonda nokuvumela imizwa yakho ukuthi ibonakale kuyisinyathelo sokuqala sokuthola ukwesekwa okudingayo.
• Thola ukwesekwa: Kuyasiza ukujoyina iqembu lokusekelana nabantu abadlula kokuhlangenwe nakho okufanayo. Buza udokotela wakho ngamaqembu endaweni yakini noma ku-inthanethi.
• Lawula ukucindezeleka: Thola izindlela zokuphumula. Zama izivivinyo zokucabanga, njengokuzindla.
• Qala inqubo: Umjikelezo wokululama nokubuyela emuva kwesifo ungenza konke kuzwakale kudidekile. Ukusungula inqubo yemisebenzi yakho yansuku zonke nokunamathela kuyo kungakusiza ukuthi uthole ukulawula okuthile.
• Khuluma nomeluleki: Kubalulekile ukunakekela impilo yakho yengqondo. Umeluleki noma uchwepheshe wezokwelapha angakusiza ukubhekana nemizwa eyinkimbinkimbi.

Kufanele ubonane nini nodokotela?

Uma welashwa i-mantle cell lymphoma, kuzodingeka ubone udokotela wakho njalo. Bazoqapha isimo sakho futhi bakusize uphathe imiphumela emibi yokwelashwa kwakho. Uma isifo sakho sesiphelile, kuzodingeka ubone udokotela wakho ngezikhathi ezithile (ukulandelela). Buza udokotela wakho ukuthi kufanele ube nalezi zikhathi zokuqokwa kangaki. Uma une-mantle cell lymphoma (MCL), uphila nokungaqiniseki kwesifo esingasoze saphela ngempela. Ungase ukhathazeke kaningi ngokuthi lesi sifo sizophinde sibuye yini. Noma ungase uzibuze ukuthi ukwelashwa kulungile yini kuwe. Kuvamile ukuzwa le mizwa. Kodwa uma lokhu kukhathazeka kukuvimbela ekujabuleleni impilo, qiniseka ukuthi ukhuluma nodokotela wakho . Bangakudlulisela ezinsizeni ezingakusiza ohambweni lwakho.

Ekugcineni, umyalezo okufanele uwuthathe uye ekhaya:

I-Mantle cell lymphoma (MCL) ingaba yigama elithusayo. Kodwa-ke, kubalulekile ukuqaphela, ukunaka izimpawu, nokufuna iseluleko sezokwelapha ngesikhathi esifanele. Khumbula, awuwedwa. Ngokwelashwa okufanele nokusekelwa, uzothola amandla okubhekana nalesi simo. Unganqikazi ukwabelana nganoma yimiphi imibuzo noma ukukhathazeka onakho nodokotela wakho. I-Mantle Cell Lymphoma, Umdlavuza, Umdlavuza Wegazi, Uhlelo Lwe-Lymphatic, Izimpawu, Ukwelashwa