Kuvamile ukukhohlwa izinto ezincane njengoba sikhula. Izinto ezifana nokuthola ukuthi izihluthulelo zethu zikuphi noma ukuthi izibuko zethu zikuphi, azenzeki kubazali bethu kuphela, kodwa ngezinye izikhathi nathi siyakwenza lokho. Kodwa lapho lokho kukhohlwa kukhula kancane kancane, futhi sikhohlwa izingane zethu, igama lethu, idolobhana lethu, ngisho nendlela eya ekhaya, akukwenzi yini ukuthi imizimba yethu ithuthumele? Namuhla sizokhuluma ngalesi 'sifo sokukhohlwa' esibi okungekho noyedwa kithi othanda ukusizwa, noma
i-dementia njengoba ibizwa kanjalo ngokwezokwelapha. Lesi sihloko simayelana nocwaningo lwakamuva oluletha ithemba elincane ekwesabeni lesi sifo.
Kuyini lokhu okusha okutholiwe?
Ucwaningo olubaluleke kakhulu lusanda kushicilelwa ephephabhukwini lesayensi elidumile emhlabeni wonke elithi 'Nature Aging'. Ngokusho kwaleli thimba locwaningo, ngokuhlaziya amaprotheni athile egazini lomuntu, kungenzeka ukubikezela amathuba okuba lowo muntu abe nesifo sokulahlekelwa yingqondo eminyakeni engaba yi-10-15. Cabanga nje, kuhle kangakanani ukwazi into efana nale
ngisho neminyaka eyishumi ngaphambi kokuba kuvele izimpawu? Odokotela bakubiza ngokuthi "ukutholwa kusenesikhathi okukhulu". Njengamanje, ayikho ikhambi lokulahlekelwa yingqondo. Kodwa-ke, uma sazi ukuthi lesi sifo singase sifike kusenesikhathi, singenza okuningi ukulawula noma ukubambezela ukukhula kwalesi sifo. Isibonelo, sinesikhathi sokwenza izinguquko endleleni yokuphila futhi siqale ukwelashwa okuthile njengoba kunqunywe udokotela.
Kalula nje, kufana nokuthola isibikezelo sezulu ngaphambi kokuba kufike isiphepho. Kusinika isikhathi sokusilungiselela.
Lokhu kuhlolwa kwegazi kusebenza kanjani?
Ukuze siqonde lokhu, sidinga kuqala ukucabanga ngemizimba yethu. Imizimba yethu iyimishini eyinkimbinkimbi kakhulu. Kunamakhemikhali ahlukahlukene adlulisa imiyalezo phakathi kwezingxenye ezahlukene zalo mshini.
Amaprotheni ayisinye sezithunywa ezibalulekile. Ikakhulukazi, amaprotheni e-plasma egazini atshela okuningi ngempilo yomzimba wethu. Lokho okwenziwe yilolu cwaningo ukuhlaziya amaprotheni anjalo angaba ngu-1,500 egazini nokuhlonza iphethini ethile yamaprotheni ekhombisa ingozi yokuwohloka komqondo. Ngalokhu, baqinisekisile ngokwengeziwe ubudlelwano phakathi kwamaprotheni amathathu atholakale ngaphambilini. Bathole nephrotheni entsha ebaluleke kakhulu kulokhu kubikezela. Ake sibone ukuthi ayini lawa maprotheni nokuthi athini etafuleni elingezansi.
| Amaprotheni | Kalula nje, kusho ukuthini lokhu? |
|---|
| I-GFAP | Lokhu kuhlobene nomonakalo noma ukuvuvukala ebuchosheni. Ku-dementia, amazinga ale phrotheni ayashintsha njengoba amangqamuzana obuchopho elimala. |
| I-NEFL | Le phrotheni iqoqana egazini lapho amaseli ezinzwa zobuchopho (ama-neurons) onakele. Lokhu kuwuphawu lokubhujiswa kwamaseli ezinzwa. |
| I-GDF15 | Le phrotheni iyanda ngezikhathi zokucindezeleka ezahlukahlukene emzimbeni. Kutholakale nokuthi iyanda ngesikhathi sezinqubo ezihlobene nokuwohloka komqondo. |
| I-LTBP2 (esanda kutholakala) | Lokhu kungukutholwa kwakamuva nokunamandla kakhulu kwalolu cwaningo. Le phrotheni ibonise ukunemba okuphezulu kakhulu ekubikezeleni ingozi yokuwohloka komqondo. |
Kunembile kangakanani lokhu?
Impumelelo yangempela yalolu cwaningo akukhona ukuthi babheke iphrotheni eyodwa kuphela. Bahlanganise ulwazi oluvela kwamanye amaprotheni ukuze bakhe isibikezelo esinembile kakhudlwana.
Cabanga nje, lokho okwenziwe yilaba bacwaningi kufana nomseshi ongabheki nje ubufakazi obubodwa, kodwa kunalokho oqoqa ubufakazi obuningi bese efika esiphethweni.
Futhi, uma
iminyaka yomuntu, ubulili, izinga lemfundo , kanye nokuba khona kwe-gene
`APOE4` kufakwa kule datha yamaprotheni, ukunemba kokubikezela kuyanda kakhulu. I-`APOE4` iyi-gene ekhulisa ingozi yokuthola isifo i-Alzheimer's. Kodwa-ke, akuwona wonke umuntu onalesi gene ozohlakulela lesi sifo, futhi akuwona wonke umuntu ongenaso. Kuyisici esiyingozi nje.
Ingabe i-Dementia iyisifo esifanayo?
Cha. I-Dementia akuyona isifo esisodwa, kodwa igama elijwayelekile leqoqo lezimpawu. Njengoba nje "umkhuhlane" ungaba nezimbangela eziningi. Kunezimbangela eziningana eziyinhloko ze-dementia. 1.
Isifo se-Alzheimer's:Lolu uhlobo oluvame kakhulu lwe-dementia. Lubangelwa ukufa kancane kancane kwamangqamuzana obuchopho kanye nokwakheka kwamaprotheni angajwayelekile (ama-plaque nama-tangles) ebuchosheni. Kufana nokuthi ukuxhumana ebuchosheni kuyagqwala. 2.
I-Vascular Dementia: Isimo esibangelwa ukulimala kwemithambo yegazi ehambisa igazi ebuchosheni. Isibonelo, lesi simo singase senzeke lapho ukugeleza kwegazi ezingxenyeni zobuchopho kuphazamiseka ngenxa yokushaywa yimithambo emincane eminingi. Kunjengokungathi 'ugesi' unqanyuliwe kwezinye izingxenye zobuchopho. Esinye isici esikhethekile salokhu kuhlolwa kwegazi okusha ukuthi akukwazi nje ukubikezela ingozi ye-dementia ngokujwayelekile, kodwa futhi kubikezela ingozi yesifo i-Alzheimer's kanye ne-vascular dementia ngokwahlukana. Lokhu kuzoba kubaluleke kakhulu ekuhleleni ukwelashwa esikhathini esizayo.
Imikhawulo yalolu cwaningo kanye nekusasa lethu
Njengakuzo zonke ucwaningo, kunemikhawulo ethile kulolu. Okuyinhloko ukuthi abahlanganyeli kulolu cwaningo kwakungabantu abamhlophe abaningi abahlala e-UK. Ngakho-ke, kudingeka ucwaningo olwengeziwe ukuze kubonwe ukuthi le miphumela isebenza kahle kangakanani kubantu base-Asia abafana nathi. Futhi, lokhu kusesesigabeni socwaningo.
Awukwazi ukucela udokotela wakho ukuthi akunike lolu vivinyo kusasa ekuseni. Kodwa ngokusho kwabacwaningi, izingxoxo seziqalile kakade ukuthuthukisa ukuhlolwa okutholakala kwezentengiselwano okusekelwe kule miphumela. Lokhu kusho ukuthi lokhu kungaba ngokoqobo eminyakeni embalwa ezayo.
Into ebalulekile ukuthi, ngenkathi sizwa izindaba ezinethemba kangaka, asikhohlwa ukuthi yini esingayenza njengamanje. Ukudla ukudla okulinganiselayo, ukuzivocavoca njalo , ukulawula umfutho wegazi nesifo sikashukela , kanye nokwenza imisebenzi ebeka ubuchopho inselele (isib. ukufunda izincwadi, ukuxazulula amaphazili) kuyizindlela ezinhle kakhulu zokunciphisa ingozi ye-dementia .
Uma wena noma othandekayo wakho enezinkinga zokukhumbula, ungesabi
ukukhuluma nodokotela womndeni wakho. Umlayezo Wokuya Nawe Ekhaya
- Ucwaningo olusha lusikisela ukuthi ukuhlolwa kwegazi kungase kukwazi ukubona i-dementia eminyakeni eyi-10-15 ngaphambi kokuba kuvele izimpawu.
- Le ndlela isekelwe ekuhlaziyeni amazinga amaprotheni amaningana athile egazini (amaprotheni e-plasma).
- Ukuhlonza kusenesikhathi ingozi yesifo kuyindlela enhle yokwenza izinguquko endleleni yokuphila ukulawula ukuqhubeka kwalesi sifo, nokulungiselela ukwelashwa kwesikhathi esizayo.
- Lokhu kusesesigabeni socwaningo futhi akukafinyeleli ekusetshenzisweni kwezokwelapha.
- Uma wena noma othile oseduze nawe enezinkinga zokukhumbula, kubaluleke kakhulu ukuxoxa ngakho nodokotela wakho.
ukuwohloka komqondo, isifo sika-Alzheimer, ukuwohloka komqondo kwemithambo yegazi, ukuhlolwa kwegazi, ukutholwa kusenesikhathi, ukulahlekelwa yinkumbulo, impilo yobuchopho
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