Ukucindezeleka akulula njengoba kubonakala. Ukuphila nakho kuvame ukuba yinselele. Kuthatha abanye abantu isikhathi ukuthola ukwelashwa okufanele. Ngezinye izikhathi, umuthi owodwa ungase unganikezi impumuzo ephelele. Kunesizathu salokho. Ake sikuqonde lokhu kusukela ekuqaleni.
Kungani ukucindezeleka kwenzeka? Umuthi ofana neRexulti ungasiza kanjani?
Kalula nje, ku-Major Depression Disorder (MDD), amazinga amakhemikhali athile ebuchosheni bethu ayancipha. Siwabiza ngokuthi ama-neurotransmitter. Kungenzeka ukuthi uke wezwa nge-serotonin ne-dopamine . Lawa yizithunywa zamakhemikhali eziyinhloko ezilawula izinto ezifana nendlela esicabanga ngayo, esihlela ngayo, esizizwa sijabule ngayo, esinaka ngayo, kanye nendlela esilala ngayo. Ngakho-ke uma lokhu kuncishisiwe, kuvela izimpawu zokucindezeleka.
Ama-antidepressant avame ukunikezwa ukusiza ekubuyiseleni la mazinga amakhemikhali. Kodwa ngezinye izikhathi, noma ngabe le mithi inganciphisa izimpawu, ingashiya izimpawu ezinzima kakhulu ukuba zingasebenzi empilweni yansuku zonke. Abanye abantu basabela kancane ekwelashweni. Lokhu kubizwa ngokuthi ukucindezeleka okumelana nokwelashwa.
Yilapho odokotela befaka khona omunye umuthi emuthini okhona njengamanje. Lokhu kubizwa ngokuthi ukwelashwa okungeziwe . Okusho ukuthi, umuthi onikezwa "ukusiza" ukwelashwa kwamanje, "ukukhulisa" ukusebenza kwawo.
I-Rexulti (i-brexpiprazole) ingenye yemithi engeziwe enjalo. Le mithi ingeyesigaba semithi ebizwa ngokuthi ama-antipsychotics esizukulwane sesibili. Le mithi emisha inemiphumela emibi embalwa, njengokuthuthumela, ukuqina kwemisipha, kanye nokukhuluphala, kunemithi emidala. I-Rexulti isebenza ngokulawula amakhemikhali obuchopho ngendlela ehlukile, inciphisa izimpawu ngenkathi futhi inciphisa ingozi yemiphumela emibi.
I-Rexulti isebenza kanjani emzimbeni?
I-Rexulti isebenza kakhulu ngokwandisa amazinga e-dopamine kanye ne-serotonin ebuchosheni. Ngokukhethekile, lo muthi ubopha kuma-receptor athile ebuchosheni futhi usize ekukhululeni i-dopamine ebambekile. Uphinde uvuselele isenzo se-serotonin, esingasiza ekuthuthukiseni isimo sengqondo futhi sinciphise izimpawu zokucindezeleka.
Ngingawusebenzisa kanjani lo muthi?
I-Rexulti iyiphilisi oliphuza kanye ngosuku. Lingathathwa nokudla noma ngaphandle kokudla. Ngokuvamile liqala ngomthamo ophansi kakhulu, cishe uhhafu we-milligram (0.5mg). Udokotela wakho uzobe esekhulisa umthamo kancane kancane kuye ngokuthi umzimba wakho usabela kanjani, eminye imithi oyiphuzayo, nokuthi izinso zakho noma isibindi sakho zisebenza kahle kangakanani. Umthamo omkhulu wokucindezeleka ungama-milligram angu-3 (3mg) ngosuku.
Into ebaluleke kakhulu ukulandela imiyalelo kadokotela wakho ngqo. Ukuthatha imithi yakho ngesikhathi esifanele nsuku zonke kuyindlela kuphela yokulinganisela i-chemistry yobuchopho bakho, ukulawula izimpawu zakho, nokusebenza kahle.
Khumbula, lo muthi awukuphulukisi ngokushesha. Kungathatha amasonto ambalwa ukuqaphela ushintsho ezimpawini zakho. Ngakho-ke, ukusebenzisa umuthi njalo kuyisihluthulelo sempumelelo.
Izifundo zithini ngempumelelo yalo muthi?
Kuye kwenziwa izifundo ezimbili ezinkulu ukuthola ukuthi i-Rexulti iphumelela futhi iphephile kangakanani ekucindezelekeni. Kulezi zifundo, iqembu elilodwa labantu lanikwa i-Rexulti kanti elinye iqembu lanikwa i-placebo. Lokhu kwavumela abacwaningi ukuthi balinganise imiphumela yangempela yalo muthi.
Ngokusho kwemiphumela yalezi zifundo, ngemva kwamasonto ayi-6, iningi labantu abathatha i-Rexulti ngaphezu kwemithi yabo evamile yokucindezeleka babenezimpawu zokucindezeleka eziphakathi nendawo kuya kwezincane.
Ithebula elingezansi limane libonisa imiphumela. Uma amaphuzu ephansi, izimpawu ziba zimbi kakhulu.
| Ithimba | Izinga lokucindezeleka ekuqaleni (isilinganiso samaphuzu) | Izinga lokucindezeleka ngemva kwamasonto ayi-6 (isilinganiso samaphuzu) | Umehluko kumaphuzu (ukuthuthuka) |
|---|---|---|---|
| Isifundo 1: I-Placebo (iphilisi eliyimbumbulu) | 27.3 | 22.1 | -5.2 |
| Isifundo 1: I-Rexulti 2 mg | 26.9 | 18.5 | -8.4 |
| Isifundo 2: I-Placebo (iphilisi eliyimbumbulu) | 26.5 | 20.2 | -6.3 |
| Isifundo 2: I-Rexulti 1 mg | 26.5 | 18.9 | -7.6 |
| Isifundo 2: I-Rexulti 3 mg | 26.5 | 18.2 | -8.3 |
Njengoba ubona kulezi zifundo, labo abathatha iRexulti babe nokuthuthuka okukhulu ezimpawini zabo. Lezi zifundo ziqinisekisile nokuthi ikhono labo lokusebenza empilweni yansuku zonke, nomndeni, emphakathini, nasemsebenzini/esikoleni, lithuthukile.
Ngingazi kanjani ukuthi umuthi uyasebenza?
Phakathi namasonto noma izinyanga ezimbalwa, uzoqala ukubona intuthuko enkulu ezimpawini zakho. Umndeni wakho nabangani bakho nabo bazobona umehluko kuwe.
- Isimo sengqondo esithuthukisiwe
- Amandla noma isisusa esengeziwe
- Ukulala okungcono
- Unentshisekelo emisebenzini obuyijabulela.
- Ukukhathazeka noma ukukhathazeka okunciphile
- Ukwanda kwesifiso sokudla
- Ukugxila okungcono
Lezi zinguquko azenzeki ngobusuku obubodwa. Zenzeka kancane kancane. Ngakho-ke, kubalulekile ukulandelela izinguquko ezimpawu zakho. Isikhathi osidingayo ukuthatha ukwelashwa siyahlukahluka kuye ngomuntu nomuntu. Abanye abantu bayakudinga isikhathi esifushane, kanti abanye bayakudinga isikhathi eside.
Into ebaluleke kakhulu ukungayeki ukuthatha imithi yakho ngaphandle kokukhuluma nodokotela wakho ngoba ucabanga ukuthi izimpawu zakho ziya ngokuba ngcono. Uma wenza kanjalo, izimpawu zakho zingase zibe zimbi kakhulu futhi. Uma ungazizwa ungcono ngemva kwezinyanga ezimbalwa, tshela udokotela wakho ngalokho futhi.
Imiphumela emibi nokuthi ungayiphatha kanjani?
Imiphumela emibi evame kakhulu ye-Rexulti ukukhuluphala, ukozela, isiyezi, izimpawu ezifana nomkhuhlane, kanye nokungahlaliseki (ukungakwazi ukuhlala uthule). Lokhu akwenzeki kuwo wonke umuntu, kodwa kuvame ukuncipha ngokuhamba kwesikhathi.
| Umphumela ongemuhle | Lokho ongakwenza |
|---|---|
| Ukwanda kwesisindo, ukwanda kwe-cholesterol/ushukela | Yamukela indlela yokuphila enempilo. Vivinya umzimba, engeza imifino, izithelo, kanye nenyama engenamafutha ekudleni kwakho. Nciphisa uwoyela, usawoti, kanye noshukela. Udokotela wakho uzohlola njalo isisindo sakho, umfutho wegazi, i-cholesterol, kanye namazinga kashukela. |
| Ukozela noma isiyezi | Uma uzizwa ulele, thatha umuthi ngaphambi kokulala ebusuku. Vuka kancane uhleli noma ulele. Gwema ukushayela uze wazi ukuthi umuthi uthinta kanjani wena. |
| Ukungaphumuli (Akathisia) | Lokhu kubhekisela emzweni wokungakwazi ukuhlala endaweni eyodwa nokuzulazula nje. Ukuzivocavoca okulula njengokuhamba nokwelula umzimba kungasiza. Thulisa ingqondo yakho ngezinto ezifana nokuzivocavoca kokuphefumula nokuzindla. Nciphisa izinto ezifana nekhofi, itiye, ne-cola, njengoba zingandisa lo muzwa. |
| Ukungabekezeleli ukushisa | Lomuthi unganciphisa ikhono lomzimba lokuzipholisa. Gwema ukushisa okukhulu kanye nokuphelelwa amanzi emzimbeni. Gqoka izingubo ezilula futhi uphuze amanzi amaningi. |
| Ukuphazamiseka kwesisu, ukuqunjelwa, umlomo owomile | Thatha umuthi kanye nokudla. Uma umlomo wakho woma, phuza amanzi amancane njalo, munce ama-ice cubes, noma uhlafune i-gum engenashukela. Uma uqunjelwa, phuza amanzi amaningi futhi udle ukudla okune-fiber eningi (ukolweni, ubhontshisi, izithelo). |
Lezi yizinto ezivame kakhulu ukwenzeka. Uma noma yikuphi kwalokhu kungakhululeki kuqhubeka noma kuba kubi kakhulu, qiniseka ukuthi utshela udokotela wakho.
Ingabe kungaba nezinkinga ngeminye imithi? (Ukusebenzisana kwezidakamizwa)
Yebo. Eminye imithi ingakhuphula noma yehlise ukusebenza kahle kweRexulti, noma yandise ingozi yemiphumela emibi, uma ithathwa neRexulti. Isibonelo, eminye imithi elwa namagciwane (isb. i-ketoconazole), eminye imithi elwa namagciwane (isb. i-clarithromycin), eminye imithi yokucindezeleka (isb. i-fluoxetine, i-paroxetine), ngisho nejusi lamagilebhisi kungashintsha imiphumela yeRexulti.
Ngakho-ke, kubaluleke kakhulu ukutshela udokotela wakho ngayo yonke imithi, amavithamini, kanye nemikhiqizo yamakhambi oyithathayo, ukuze akwazi ukulungisa umthamo we-Rexulti ukuze uvumelane nawe.
Yiziphi izivivinyo okufanele zenziwe ngesikhathi sokwelashwa?
Udokotela wakho uzokwenza izivivinyo ezithile ukuze aqaphe impilo yakho ngaphambi kokuba uqale ukuthatha imithi nangesikhathi uyithatha.
- Isisindo sakho, ukuphakama, kanye nobubanzi besinqe sakho.
- Ukubalwa kwegazi okuphelele (i-CBC).
- Ukuhlolwa kwe-cholesterol yegazi nokuzila ukudla kanye noshukela (Ukuhlolwa kwephrofayili yamafutha okuzila ukudla kanye noshukela egazini).
- Ukushaya kwegazi.
- Ukuhlolwa kwe-AIMS ukuhlola ukunyakaza okungajwayelekile (isb., ukunyakaza kwezitho okungahleliwe).
Lezi zivivinyo ziyindlela kuphela yokwazi kahle ukuthi umuthi uzowuthinta kanjani umzimba wakho.
Umlayezo Wokuya Nawe Ekhaya
- I-Rexulti umuthi "ongeziwe" onikezwa ngaphezu kwemithi esivele isetshenziswa yokucindezeleka, ukuze kuthuthukiswe ukusebenza kwayo.
- Lokhu kusebenza ngokulinganisela amakhemikhali asebuchosheni ahlobene nenjabulo kanye nenjabulo.
- Thatha umuthi njalo, ngesilinganiso esinqunyiwe, njengoba kunqunywe udokotela wakho.
- Ngisho noma izimpawu zakho ziba ngcono, gwema ukuyeka imithi ngaphandle kokubonisana nodokotela wakho.
- Qaphela imiphumela emibi efana nokukhuluphala, ukozela, kanye nokungahlaliseki. Uma kukuphazamisa, khuluma nodokotela wakho.
- Kubalulekile ukwazisa udokotela wakho ngayo yonke eminye imithi, amavithamini, kanye nemithi yendabuko oyithathayo.
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