So wowɔ nsɛmmisa bi fa ENA Panel (Extractable Nuclear Antigen Panel) mogya mu nhwehwɛmu no ho? Momma yɛne Nirogi Lanka nsusuw ho kɛkɛ!

So woasusuw ho pɛn sɛ ebia wo nipadua no ankasa ahobammɔ nhyehyɛe—asraafo a na wɔpɛ sɛ wɔbɔ wo ho ban fi nyarewa ho—betumi adwene atu afra na afi ase atow ahyɛ w’ankasa wo ntini a ɛte apɔw no so da bi anaa? Eyi ne nea yɛfrɛ no nyarewa a nipadua no tumi ko tia nyarewa . Sɛ eyi ba a, nnuruyɛfo taa de mogya mu nhwehwɛmu titiriw bi a wɔfrɛ no ENA panel di dwuma de hu nea ɛrekɔ so ne nea enti a ɛrekɔ so ankasa. Ɛnnɛ, wɔ Nirogi Lanka no, momma yɛnka Extractable Nuclear Antigen (ENA) Panel no ho asɛm wɔ ɔkwan a ɛnyɛ den na ɛnyɛ den sɛ yɛbɛte ase so.

Dɛn ankasa ne ENA sɔhwɛ?

Sɛ yɛbɛka no tiawa a, ENA panel yɛ mogya mu nhwehwɛmu a wɔde hu sɛ ebia wo nipadua no mu nkwammoaa a ɛte apɔw no de wɔn ani asi wo nipadua mu nkwammoaa a ɛte apɔw so anaa. Momma yɛnbubu mu. Susuw wo nipadua mu ahoɔden a ɛko tia nyarewa no ho sɛ ɔman no ahobammɔ asraafo. Asraafo titiriw bi a wɔfrɛ wɔn antibodies na ɛwɔ mu . Wɔn adwuma ne sɛ wobehu ɔyare mmoawa te sɛ mmoawa ne mmoawa a wɔbɔ mmɔden sɛ wɔbɛba wo nipadua mu na wɔako atia. Ntuafo biara wɔ agyiraehyɛde soronko bi wɔ ne ani a ɛka kyerɛ wo nipadua mu tumi a ɛko tia nyarewa no sɛ, “Meyɛ ɔtamfo”—wɔ nnuruyɛ mu no, yɛfrɛ eyi antigen . Wo nipadua mu nkwammoaa a ɛko tia nyarewa no hu saa nnuru a ɛko tia nyarewa yi na ɛma ɛyɛ nea ɛnyɛ hwee. Ɛyɛ nhyehyɛe a ɛyɛ nwonwa, a ɛyɛ pɛpɛɛpɛ yiye, ɛnte saa? Nanso, ɛtɔ mmere bi a nhyehyɛe yi di mfomso. Eyi ne nea ɛkɔ so wɔ nyarewa a nipadua no tumi ko tia nyarewa mu . Wo nipadua no fi ase yɛ nnuru a ɛko tia protein afã horow pɔtee bi a ɛwɔ wo nkwammoaa a ɛwɔ apɔwmuden no nucleus mu (wɔfrɛ eyinom nuklea antigens a wotumi yi fi mu ). Ɛte sɛ w’ankasa ahobammɔ asraafo a wɔdan wɔn ho tia ɔman mma a wɔahyɛ da abɔ wɔn ho ban no titiriw. ENA sɔhwɛ no boa nnuruyɛfo ma wohu w’ankasa antigens no mu nea saa antibodies yi reto ahyɛ wɔn so no pɛpɛɛpɛ. Eyi boa wo duruyɛfo ma wosi tebea ahorow a nipadua no tumi ko tia nyarewa no so dua anaasɛ ɔpow.

Bere bɛn na wɔhyɛ sɛ wɔnyɛ ENA nhwehwɛmu?

Ɛnyɛ obiara na ohia ENA sɔhwɛ. Ebia wo duruyɛfo bɛkamfo biako akyerɛ wo wɔ tebea pɔtee bi mu:

• Sɛ woda yare bi a nipadua no tumi ko tia nyarewa adi (te sɛ nkwaa mu yaw , ɔbrɛ a emu yɛ den , anaa honam ani nsɛm) na woahu sɛ wowɔ Antinuclear Antibody (ANA) nhwehwɛmu no mu a . ANA sɔhwɛ no yɛ adwinnade titiriw a wɔde hwehwɛ nyarewa a nipadua no tumi ko tia nyarewa . Sɛ ɛsan ba a ɛyɛ papa a, wɔde ENA panel no di dwuma sɛ nea edi akyi de tew nea ɛde ba pɔtee no so.
• Sɛ woanyinsɛn na wonim sɛ wowɔ Lupus a . Wɔ tebea horow a ɛtete saa mu no, wo nipadua mu nkwammoaa a ɛko tia nyarewa no betumi atwa awotwaa no mu na ebetumi de neonatal lupus aba akokoaa no mu. Esiane sɛ eyi betumi de nsɛnnennen te sɛ koma a ɛyɛ den aba nti, ebia wo duruyɛfo bɛkamfo ENA nhwehwɛmu pɔtee bi akyerɛ de ahwɛ tebea no so.

Tebea horow bɛn na ENA nhwehwɛmu betumi aboa ma wɔahu?

ENA sɔhwɛ no hwehwɛ nnuru ahorow a ɛko tia nyarewa, a emu biara ne ɔyare pɔtee bi a nipadua no tumi ko tia nyarewa no wɔ abusuabɔ. Tebea horow a ɛtaa ba no bi ne:

• Lupus (Lupus a Ɛyɛ Nhyehyɛe/SLE) .
• Sjögren yare a ɛma obi nya ɔyare no
• Ntini a ɛka bom a wɔadi afra (MCTD) .
• Scleroderma (Akisikuru a ɛma nipadua no yɛ mmerɛw) .
• Polymyositis a ɛwɔ nipadua no mu
• Dermatomyositis a ɛma nipadua no nya honam ani yare

Esiane sɛ ɛsono sɛnea tebea horow yi mu biara da adi nti, wo duruyɛfo no bɛkyerɛ ENA mu aba no ase aka wo nipadua mu sɛnkyerɛnne ahorow ho na ama wahu yare no pɛpɛɛpɛ.

Ɔkwan bɛn so na wɔyɛ ENA sɔhwɛ no?

Ɛyɛ adeyɛ a ɛyɛ tẽẽ. Obi a ɔyɛ aduruyɛdan mu ɔbenfo bɛboaboa mogya ketewaa bi afi ntini bi a ɛwɔ wo nsa mu mu, na afei wɔayɛ mu nhwehwɛmu wɔ aduruyɛdan mu. Wɔ aduruyɛdan mu no, mfiridwumayɛfo de nnuru titiriw bi a wɔde hyɛ agyirae di dwuma . Sɛ nnuru pɔtee a ɛko tia nyarewa no wɔ wo mogya mu a, saa agyiraehyɛde ahorow yi bata ho na “ɛhyerɛn” anaasɛ ɛsakra kɔla. Eyi ne ɔkwan a lab no si so dua sɛ wɔwɔ hɔ. Ɛyɛ aduruyɛ mu mfiridwuma a ɛkɔ anim yiye!

Nnuru a ɛko tia nyarewa bɛn na ENA nhwehwɛmu no hwehwɛ?

Mpɛn pii no, ENA sɔhwɛ bi hwehwɛ nipadua mu nkwammoaa a ɛko tia nyarewa a ɛyɛ adwuma wɔ antigens pɔtee anan kosi asia a ɛwɔ yɛn nkwammoaa mu no ho. Antibody biara ne autoimmune tebea horow wɔ abusuabɔ. Sɛ nhwɛso no, nnuru bi a ɛko tia nyarewa no yɛ nea ɛfa Lupus ho kɛse, bere a afoforo ne Sjögren yare no wɔ abusuabɔ kɛse. Wo duruyɛfo de n’adwene besi nnuru pɔtee a ɛko tia nyarewa a ɛfa wo ayaresabea sɛnkyerɛnne ahorow ho kɛse no so.

So ahosiesie bi ho hia ma ENA sɔhwɛ?

Asɛmpa bi ni: mpɛn pii no wunhia ahosiesie titiriw biara ma ENA sɔhwɛ. Wubetumi adi, anom, na woanom nnuru a wotaa de di dwuma sɛnea ɛsɛ. Ɛyɛ papa bere nyinaa sɛ wo ne wo duruyɛfo besi eyi so dua sɛnea ɛbɛyɛ a wubenya awerɛhyem ara kwa.

Dɛn na ɛsɛ sɛ mehwɛ kwan wɔ sɔhwɛ no mu?

Sɛnea yɛaka no, oduruyɛfo, ɔyarehwɛfo, anaa lab technician de ade ketewaa bi bɛtwe mogya afi ntini bi a ɛwɔ wo basa mu mu. Ebia wobɛte nka sɛ woabɔ wo kakra anaasɛ wo ho nyɛ wo dɛ, nanso ɛkyɛ sikɔne kakraa bi pɛ. Sɛ wo ho yeraw wo wɔ nnade ho a, sɛ wobɛhwɛ baabi foforo bere a woreyɛ saa no betumi aboa wo.

So asiane ahorow bi wɔ ENA sɔhwɛ no mu?

Asiane ahorow a ɛbata ENA nhwehwɛmu ho no sua koraa . Nanso, sɛnea ɛte wɔ mogya a wɔtwe biara ho no, nsɛm nketenkete betumi aba:

• Sɛ ɛyɛ den sɛ wobenya ntini bi a, ebia ebehia sɛ mfiridwumayɛfo no sɔ hwɛ bɛboro pɛnkoro.
• Ebia nnipa binom bɛte nka sɛ wɔn ti ayɛ wɔn yaw anaasɛ wɔatotɔ piti .
• Ebia wubenya akuru nketenkete anaa mogya ketewaa bi a ɛbɛboaboa wo honam ani (a wonim no sɛ hematoma ).
• Wɔ tebea horow a ɛntaa nsi koraa mu no, ɔyare mmoawa betumi aba wɔ baabi a wɔatow no.
• Ankorankoro binom betumi anya mogya mmoroso bere a wɔayi ade no awie no.

Sɛ wuhu saa sɛnkyerɛnne ahorow yi bi a, yɛ komm na bɔ nnuruyɛfo no amanneɛ ntɛm ara. Sɛ ɛba sɛ aduruyɛ mu tebea a egye ntɛmpɛ bi si a, yɛsrɛ wo frɛ 911 anaa kɔ dwumadibea a ɛbɛn wo a wɔhwɛ ntɛmpɛ so.

Ɔkwan bɛn so na wɔkyerɛ sɔhwɛ mu aba no ase?

Wɔtaa bɔ sɔhwɛ mu aba ho amanneɛ sɛ ɛnyɛ papa , a ɛkyerɛ sɛ Positive , anaa borderline (a wɔsan frɛ no equivocal ) ne akwan a wɔtaa fa so bɔ nea efi mu ba yi ho amanneɛ. Nkyɛmu a ɛyɛ daa no betumi ayɛ soronko kakra a egyina aduruyɛdan a ɛyɛ wo nhwehwɛmu no so. Esiane eyi nti, ɛsɛ sɛ wo laboratory amanneɛbɔ no de reference range pɔtee a ɛfa wo results ho no ka ho bere nyinaa.

• Nea efii mu bae pa kyerɛ sɛ wohuu antibody pɔtee no wɔ wo mogya mu.
• Nea enye a efi mu ba kyerɛ sɛ na nnuru a ɛko tia antigens a ɛfa ho no nni wo mogya mu anaasɛ na ɛwɔ dodow a wontumi nhu.

Sɛ me ENA nhwehwɛmu no yɛ papa a, so ɛno kyerɛ sɛ mewɔ Lupus?

Dabi, sɔhwɛ biako pɛ a efi mu ba no ntumi nsi tebea bi te sɛ Lupus so dua koraa.

Eyi yɛ nsonsonoe a ɛho hia yiye. ENA nhwehwɛmu a ɛyɛ papa no nkyerɛ sɛ wowɔ Lupus ara kwa. Sɛ nhwɛso no, nnipa pii a wɔwɔ Sjögren yare no mu nhwehwɛmu hu sɛ wɔwɔ anti-SSA ne anti-SSB antibodies. Nanso, wobetumi ahu saa nnuru koro yi ara a ɛko tia nyarewa yi nso wɔ nnipa a wɔwɔ Lupus anaa ayaresa mu tebea afoforo mu. Enti, wo duruyɛfo no bedu baabi a wobehu sɛ wowɔ yare no denam wo ENA nhwehwɛmu no aba a ɔbɛhwehwɛ mu aka wo yare no ho sɛnkyerɛnne ne nhwehwɛmu afoforo a wɔde hu yare (te sɛ ANA, CRP, anaa ESR) ho no so.

Bere bɛn na ɛsɛ sɛ me ne me duruyɛfo di akyi?

Sɛ wowɔ nsɛmmisa anaa nsɛm bi a ɛhaw wo wɔ wo nhwehwɛmu no mu aba ho a, yɛsrɛ wo hwɛ hu sɛ wo ne wo duruyɛfo bɛbɔ ho nkɔmmɔ. Bio nso, sɛ wote ɛyaw, wo ho wosow, anaasɛ wohu sɛnkyerɛnne a ɛkyerɛ sɛ nsu retu wɔ baabi a wɔtwee wo mogya no, anaasɛ wunya ɔyare bi ho sɛnkyerɛnne te sɛ atiridiinini a, yɛsrɛ wo kɔ adwumayɛbea a wɔhwɛ ntɛmpɛ so anaa kɔ adwumayɛbea a wɔhwɛ ntɛmpɛ so ntɛm ara.

Nsonsonoe bɛn na ɛda ANA sɔhwɛ ne ENA sɔhwɛ ntam?

Eyi yɛ asɛmmisa a wɔtaa bisa. Momma yɛnhwɛ nsonsonoe a ɛwɔ mu no. Susuw ANA (Antinuclear Antibody) sɔhwɛ no ho te sɛ adwinnade a wɔde hwehwɛ nneɛma mu wɔ ɔkwan a ɛkɔ akyiri so a polisifo de di dwuma. Ɛhwɛ asɛmmisa a ɛtrɛw yi: “So autoimmune ho asɛm bi a ɛda adi wɔ ha?” Ɛkyerɛ sɛ ebia nnuru a ɛko tia nuklea wɔ wo mogya mu ne dodow a ɛwɔ wo mogya mu anaa. ENA (Extractable Nuclear Antigen) sɔhwɛ no yɛ adwuma te sɛ nhwehwɛmu titiriw a wɔde di akyi. Sɛ ANA nhwehwɛmu no yɛ papa a, yɛde ENA nhwehwɛmu no di dwuma de kɔ akyiri: “Sɛ asɛm bi wɔ hɔ a, dɛn ankasa na ɛyɛ?Protein (antigen) pɔtee bɛn na ɛwɔ wo nipadua mu a saa nipadua mu nkwammoaa a ɛko tia nyarewa yi de wɔn ani asi so?” ENA sɔhwɛ no yɛ pɔtee kɛse sen ANA sɔhwɛ no. Nnipa pii a wɔwɔ autoimmune tebea horow no benya ANA a ɛyɛ papa. Nanso, nnipa binom a wɔwɔ apɔwmuden a wonni yare a nipadua no tumi ko tia nyarewa nso betumi anya ANA a ɛyɛ papa (wɔ saa tebea no mu no, wɔn ENA nhwehwɛmu no taa yɛ nea enye). Eyi nti na nnuruyɛfo hyɛ sɛ wɔnyɛ ENA nhwehwɛmu na ama wɔaboaboa nsɛm pii ano bere a ANA nhwehwɛmu ma wonya nea ɛyɛ papa no.

Nea etwa to no, nneɛma a ɛsɛ sɛ yɛkae

Extractable Nuclear Antigen (ENA) panel no yɛ sɔhwɛ a ɛho hia a ɛma wo duruyɛfo no nya nsɛm pii fa nnuru a ɛko tia nyarewa a ebia ɛde n’ani si w’ankasa nkwammoaa so na ɛboa ma wo sɛnkyerɛnne ahorow no ba no ho.

Nhwehwɛmu biako biara nni hɔ a ebetumi ahu yare bi a nipadua no tumi ko tia nyarewa no ankasa.

Wo duruyɛfo no bɛka abom ahwɛ wo ENA aba, wo sɛnkyerɛnne ahorow, ne nhwehwɛmu afoforo de ahu yare no pɛpɛɛpɛ. Enti, sɛ wowɔ nsɛmmisa bi fa nea efi mu ba anaa sɛnea ɛka w’akwahosan nhyehyɛe ho a, yɛsrɛ wo ntwentwɛn wo nan ase sɛ wubebisa wo duruyɛfo a ɔwɔ Nirogi Lanka. Eyi bɛboa wo ma woate sɛnea wohwɛ wo no yiye. ENA nhwehwɛmu, nyarewa a nipadua no tumi ko tia nyarewa, antibodies, antigens, Lupus, mogya mu nhwehwɛmu, ANA nhwehwɛmu