Kodi nthawi zambiri mumamva kupweteka kwachilendo m'thupi? Tiyeni tiphunzire zambiri za (Systemic Mastocytosis) iyi!

Kodi nthawi zina mumamva mawanga ofiira komanso oyabwa pakhungu lanu? Kapena mumamva kupweteka m'mimba komanso mutu womwe umangobwera ndi kutha? Ngati zinthuzi zimachitika mobwerezabwereza, mwina ndi vuto losowa lotchedwa ``Systemic Mastocytosis'' lomwe tikambirane lero. Musadandaule, iyi si matenda omwe amakhudza anthu ambiri. Koma ndikofunikira kudziwa izi.

Ndiye, kodi "Systemic Mastocytosis" iyi ndi chiyani?

Mwachidule, `(Systemic Mastocytosis)` ndi matenda osowa kwambiri okhudzana ndi magazi athu. Chomwe chimachitika pamenepa ndi chakuti mtundu wapadera wa selo wotchedwa `(Mast cells)` m'thupi mwathu umakula modabwitsa. Taganizirani, maselo a mast awa ali ngati asilikali ang'onoang'ono m'thupi mwathu. Ndiwo omwe, monga gawo la chitetezo chathu chamthupi, amazindikira ndikulimbana ndi olowa m'malo akunja (monga majeremusi, zinthu zomwe zimayambitsa ziwengo, ndi zina zotero). Wolowa m'malo achilendo wotere akabwera, maselo a mast awa amatulutsa mankhwala monga `(Histamine)`. `(Histamine)` iyi ndiyo imayambitsa zizindikiro za ziwengo (monga kufiira, kuyabwa, kutupa). Nthawi zambiri, maselo a mast amasiya kutulutsa `(Histamine)` iyi ntchito ikatha. Komabe, m'thupi la munthu yemwe ali ndi `(Systemic Mastocytosis)`, maselo a mast osazolowerekawa amakula kwambiri ndipo amamasula `(Histamine)` mosalekeza. Zili ngati wina wasiya pompo yamadzi kenako n’kuiwala kuizima. Ichi ndichifukwa chake timapitiriza kukhala ndi zizindikiro zonga ziwengo. Zingakhudze khungu lathu lokha, komanso ziwalo zathu zamkati monga chiwindi, ndulu, ndi matumbo. Matendawa, otchedwa ``Systemic Mastocytosis,'' akuti amakhudza anthu 13 okha pa anthu 100,000 aliwonse padziko lapansi. Izi zikutanthauza kuti ndi osowa kwambiri. Komabe, anthu omwe ali ndi vutoli ali pachiwopsezo chachikulu cha anaphylaxis ( chomwe chimayambitsa ziwengo mwadzidzidzi, zomwe zimawopseza moyo). Nthawi zambiri, ``Systemic Mastocytosis'' imathanso kusanduka khansa. Madokotala sangathe kuchiza matendawa kwathunthu. Komabe, pali mankhwala omwe angakuthandizeni kuwongolera zizindikiro zanu ndikukhala moyo wabwinobwino.

Kodi mitundu ikuluikulu ya `(Systemic Mastocytosis)` ndi iti?

Pali mitundu isanu ndi umodzi ikuluikulu ya ``Systemic Mastocytosis``. Imakhudza ife m'njira zosiyanasiyana. Kawirikawiri, maselo a mast omwe muli nawo m'thupi lanu amakhala osazolowereka, m'pamene mumakhala ndi mwayi waukulu wopeza mavuto. Tiyeni tiwone mitundu imeneyo: 1. Mtundu wokulira pang'onopang'ono (``Indolent systemic mastocytosis``):

• Uwu ndi mtundu wofala kwambiri. Monga mtengo womwe umakula pang'onopang'ono, zingatenge zaka kuti zizindikiro ziwonekere. Chiwerengero cha maselo osazolowereka chimawonjezeka pakapita nthawi. Izi zingayambitse zizindikiro pakhungu, chiwindi , ndulu , ndi m'mimba (monga matumbo).

2. Mtundu wopita patsogolo pang'ono (`Systemic smoldering mastocytosis`):

• Mu mtundu uwu, maselo osazolowereka a mast amasonkhana m'chiwindi ndi ndulu. Pakapita nthawi, izi zingayambitse chiwindi kapena ndulu kutupa. Taganizirani izi ngati zomwe zimachitika nyumba yaying'ono ikadzaza kwambiri.

3. Mtundu womwe umabwera ndi matenda ena a magazi (`Systemic mastocytosis yokhala ndi neoplasm yogwirizana`):

• Anthu omwe ali ndi mtundu uwu akhoza kukhala ndi matenda ena okhudzana ndi magazi, monga myeloproliferative neoplasms ndi myelodysplastic syndrome . Mtundu uwu umakhudza pafupifupi munthu m'modzi mwa asanu omwe ali ndi Systemic Mastocytosis.

4. Mtundu woopsa (`Aggressive systemic mastocytosis`):

• Izi ndi zoopsa kwambiri chifukwa zingakhudze mafupa (kumene maselo a magazi amapangidwa) ndi mafupa. Maselo osazolowereka amatha kukula mkati mwa mafupa, kuwafooketsa ndikupangitsa kuti asweke mosavuta.

5. Mtundu umene umasanduka leukemia (`Mast cell leukemia`):

• Kawirikawiri, Systemic Mastocytosis imatha kukhala matenda otchedwa Mast Cell Leukemia . Uwu ndi mtundu wa Acute Myeloid Leukemia (AML) .

6. Mtundu wa chotupa (`Mast cell sarcoma`):

• Apa ndi pamene zotupa (zotupa) zopangidwa kuchokera ku maselo osazolowereka a mast cell zimawononga minofu yosiyanasiyana m'thupi. Anthu ochepa kwambiri omwe ali ndi ``Systemic Mastocytosis`` amakhala ndi vutoli lotchedwa ``Mast cell sarcoma``.

Kodi zizindikiro za matendawa (Systemic Mastocytosis) ndi ziti?

Zizindikiro zimatha kusiyana malinga ndi munthu. Zimatengera komwe maselo osazolowereka a mast cell amakhala ambiri m'thupi. Mwachitsanzo, ngati muli ndi maselo ambiri a mast cell m'mimba mwanu, mutha kukhala ndi zilonda zam'mimba komanso kupweteka m'mimba. Komanso, ngati maselo a mast cell asonkhana m'mafupa anu, zimatha kusokoneza kupanga kwa maselo amagazi. Nazi zizindikiro zodziwika bwino:

• Kuchepa kwa magazi ( kusowa magazi m'thupi )
• Kupweteka kwa mafupa
• Kutuluka magazi ambiri (monga magazi ambiri ochokera pachilonda chaching'ono)
• Kumva kutopa nthawi zonse (` Kutopa` )
• Khungu loyera
• Kugunda kwa mtima
• Ziphuphu (zoyabwa, zotupa pakhungu )
• Khungu loyabwa
• Kusintha kwa maganizo kapena kuvutika maganizokuvutika maganizo
• Mawanga akuda, oyabwa pakhungu (`Urticaria pigmentosa`)

Nthawi zina, anthu omwe ali ndi Systemic Mastocytosis amatha kukumana ndi zizindikiro zingapo nthawi imodzi. Madokotala amatcha izi kuti "mastocytosis attack" kapena "flare."

Chofunika: Si aliyense amene ali ndi zizindikiro zimenezi amene ali ndi `(Systemic Mastocytosis).` Komabe, ngati muli ndi zizindikiro zingapo izi nthawi imodzi, ndipo zikupitirira, muyenera kuonana ndi dokotala kuti akupatseni upangiri.

Nchifukwa chiyani `(Systemic Mastocytosis)` iyi imachitika?

Kafukufuku wapeza kuti pafupifupi 80% ya anthu omwe ali ndi `(Systemic Mastocytosis)` ali ndi `KIT gene variant` . Jini iyi ya `KIT` imathandiza mitundu ina ya maselo m'thupi lathu, makamaka maselo amagazi ndi mast cells, kukula. Jini iyi imachitika titatenga pakati m'mimba. Izi zikutanthauza kuti siilandira cholowa.

Kodi ndi zinthu ziti zomwe zimakulitsa kapena kuyambitsa matendawa (`Zoyambitsa`)?

Zinthu zambiri zingayambitse zizindikiro za "Systemic Mastocytosis." Si aliyense amene amakhudzidwa ndi zinthu zomwezo. Komabe, pali zinthu zingapo zomwe zimachitika kawirikawiri:

• Mowa
• Zakudya zokometsera
• Mankhwala ena: Mwachitsanzo , NSAIDs ( mankhwala ochepetsa ululu), opumulitsa minofu, ndi mankhwala oletsa ululu.
• Kuchita masewera olimbitsa thupi ndi kuchita masewera olimbitsa thupi ( kwa ena okha)
• Kulumidwa ndi tizilombo (makamaka nyerere, mavu, ndi njuchi)
• Kupsinjika maganizo kapena thupi
• Kukanda kapena kukangana pakhungu lanu
• Kusintha kwadzidzidzi kwa kutentha (monga kudumphira mwadzidzidzi m'madzi ozizira)

Ngati muli ndi matendawa, ndikofunikira kwambiri kufunsa dokotala wanu zofooka zanu ndi zomwe muyenera kupewa.

Kodi mumazindikira bwanji matendawa molondola? (Kuzindikira)

Mukapita kwa dokotala, chinthu choyamba chomwe angachite ndikukupimitsani thupi. Adzakufunsani za zizindikiro zanu ndi matenda aliwonse omwe mudadwalapo kale. Kenako, angachite chimodzi kapena zingapo mwa izi kuti adziwe ngati muli ndi Systemic Mastocytosis:

• Kuyezetsa magazi: Izi zimayesa kuchuluka kwa tryptase m'magazi mwanu. Tryptase ndi enzyme yapadera yomwe mast cells amatulutsa akamayankha ku zinthu zakunja.
• Kufufuza mafupa: Yang'anani ngati mafupa awonongeka.
• Kufufuza za mafupa: Izi zimaphatikizapo kutenga chitsanzo cha mafupa anu ndikuwayesa kuti awone ngati pali maselo achilendo a mast omwe ali mmenemo, komanso angati.
• Mayeso a majini: Yang'anani kusintha kwa majini a `KIT` omwe atchulidwa kale.

Kodi imachiritsidwa bwanji?

Madokotala amachiritsa matenda a Systemic Mastocytosis poletsa zizindikiro ndi mavuto ena. Mwachitsanzo, ngati muli ndi asidi wambiri m'mimba, angakupatseni mankhwala oletsa asidi a H2 (mtundu wa mankhwala oletsa asidi). Ngati kuchepa kwa magazi m'thupi ndi chifukwa cha matendawa, adzachiritsidwa. Nazi zina mwa njira zazikulu zothandizira:

• Mankhwala oletsa kutupa: Amachepetsa zizindikiro za khungu monga kuyabwa ndi kufiira.
• Corticosteroids: Amachepetsa kutupa ndi kutupa m'thupi.
• Ma Bisphosphonates: Amathandiza kulimbitsa mafupa ngati ali ofooka.
• Chithandizo cholunjika: Izi zimaphatikizapo kuyang'ana puloteni inayake yomwe imapezeka m'maselo osazolowereka a mast.
• Chemotherapy: Izi zimagwiritsidwa ntchito pokhapokha ngati Systemic Mastocytosis yasanduka khansa.
• Kuchotsa splenectomy: Ngati ndulu yatupa kwambiri, ikhoza kuchotsedwa opaleshoni.
• Kusamutsa mafupa: Izi zimachitika kwa anthu omwe ali ndi matenda oopsa kwambiri, kapena omwe ali kumapeto.

Kumbukirani: Ngati muli ndi Systemic Mastocytosis, nthawi zonse muyenera kunyamula EpiPen . EpiPen ndi mankhwala omwe angagwiritsidwe ntchito nthawi yomweyo ngati pali vuto lalikulu la ziwengo, monga Anaphylaxis yomwe yatchulidwa pamwambapa.

Kodi "Systemic Mastocytosis" iyi singapewedwe?

Monga tafotokozera kale, ``Systemic Mastocytosis`` imayamba chifukwa cha kusintha kwa majini. Chifukwa chake, sizingatheke kuletsa kukula kwake. Komabe, mutha kuwongolera matendawa popewa ``zoyambitsa`` zomwe zimawonjezera zizindikiro.

Kodi munthu amene ali ndi `(Systemic Mastocytosis)` ali ndi tsogolo lotani?

Izi zimatengera mtundu wa `(Systemic Mastocytosis)` womwe muli nawo. Anthu omwe ali ndi mtundu wokulira pang'onopang'ono (`Indolent systemic mastocytosis`) nthawi zambiri amatha kuwongolera matendawa bwino ndi chithandizo. Akhoza kukhala ndi moyo wabwinobwino. Komabe, anthu omwe ali ndi mitundu ina yoopsa akhoza kukhala ndi moyo wautali pang'ono. Komabe, `(Systemic Mastocytosis)` amatha kuchiritsidwa kwathunthu ndi chithandizo chotchedwa ``Bone marrow transplant``. Komabe, madokotala amapereka chithandizo chimenecho kwa anthu omwe ali pamlingo wovuta kwambiri wa matendawa.

Kodi ndimadzisamalira bwanji ndikakhala ndi `(Systemic Mastocytosis)`?

Kudziwa zomwe zimayambitsa zizindikiro zanu ndikuzipewa ndiye chinthu chofunikira kwambiri chomwe mungachite mukakhala ndi Systemic Mastocytosis. Ngati muli ndi vutoli, dziwani izi:

• Nthawi zonse tengani EpiPen. Chitani mwamsanga ngati muli ndi vuto lalikulu la ziwengo.
• Dziwani bwino zomwe zimayambitsa vutoli ndipo pewani momwe mungathere.
• Pewani kupsinjika maganizo. Yesetsani kusinkhasinkha kapena njira zina zoganizira bwino.
• Valani chibangili cha chenjezo cha zachipatala chomwe chili ndi mndandanda wa mankhwala omwe simungamwe. Izi ndizofunikira kwambiri chifukwa zimathandiza madokotala kudziwa vuto lanu ngati simungathe kulankhula mwadzidzidzi.

Ndiyenera kupita kwa dokotala liti?

Ngati muli ndi matenda a Systemic Mastocytosis, muyenera kupita kwa dokotala wanu kuti akakuwoneni nthawi zonse. Komanso, onetsetsani kuti mwauza dokotala wanu ngati mukupeza zizindikiro zatsopano, kapena ngati zizindikiro zanu zikukulirakulira.

Ndi mafunso ati omwe ndiyenera kufunsa dokotala?

Popeza Systemic Mastocytosis ndi matenda osowa, mungakhale ndi mafunso ambiri. Nazi mafunso ena oti mufunse dokotala wanu:

• Kodi ndili ndi mtundu wanji wa ``Systemic Mastocytosis''?
• Ndi zizindikiro zina ziti zomwe zingasonyeze kuti vuto langa likuipiraipira?
• Ndi mankhwala ati omwe alipo kwa mtundu wanga?
• Kodi chithandizochi chidzathetsa zizindikiro zanga zonse?
• Kodi pali mayeso aliwonse azachipatala omwe ndingatenge nawo mbali?

Kupezeka ndi matenda a Systemic Mastocytosis ndi chinthu chosintha moyo. Muyenera kupita kwa dokotala nthawi zonse, kuyezetsa magazi, ndikuphunzira kuzindikira ndikupewa zomwe zimayambitsa matendawa. Kukhala ndi vutoli ndi kusintha kwakukulu. Chifukwa chake, khalani ndi ubale wabwino ndi dokotala wanu. Alipo kuti akuthandizeni. Adzakupatsani chidziwitso ndi magulu othandizira omwe angakuthandizeni. Izi zidzakuthandizani kupanga zisankho zokhudzana ndi thanzi lanu.

Pomaliza, zinthu zoti muzikumbukira (Uthenga Wopita Nawo Kunyumba)

Chabwino, takambirana zambiri za `(Systemic Mastocytosis)`, sichoncho? Kumbukirani, ngakhale kuti iyi ndi matenda osowa, ndikofunikira kwambiri kudziwa za iyo.

Chofunika kwambiri ndikuonana ndi dokotala ngati muli ndi zizindikiro izi. Ngati matendawa apezeka msanga, chithandizo chimayamba ndipo zizindikiro zake zitha kuthetsedwa.

Simuli nokha. Madokotala anu, achibale anu, ndi anzanu alipo kuti akuthandizeni. Mukadziwa zambiri zoyenera ndikutsatira malangizo a dokotala wanu, mutha kukhala bwino ndi vutoli. Khalani chete ndipo ganizirani bwino!