Unonzwawo kuvaviwa mumuviri wako wese nguva nenguva here? Chiso chako nemutsipa zvinoshanduka kuva zvitsvuku here wonzwa sekunge uri kunzwa kupisa? Une kurwadziwa nemudumbu, dzungu, uye moyo unomhanya? Kunyangwe uchifunga kuti zvinhu izvi zvinongova allergies, dzimwe nguva panogona kunge paine chimwe chirwere chiri shure kweizvi, chatisati tanzwa zvakawanda nezvacho. Nhasi tiri kutaura nezvechimwe chirwere chisingawanzoitiki, Systemic Mastocytosis. Usazvidya moyo, ngatinzwisise izvi zviri nyore.
Chii chinonzi systemic mastocytosis?
Zvichitaurwa zviri nyore, ichi chirwere chinokonzerwa nekuwedzera kusingawanzoitiki kwerudzi rwesero rinonzi
'mast cells' mumuviri wedu. Mast cells rudzi rwemachenu eropa. Funga nezvemast cell aya semasoja ari muimmune system yedu. Basa rawo guru nderekutidzivirira kubva kuzvirwere uye kutibatsira kuporesa
patinokuvara . Asi muchirwere ichi, mast cell aya anoungana akawandisa uye asingawanzoitiki munhengo dzakasiyana-siyana dzakadai seganda redu,
mumongo wemapfupa , mapfupa, uye ura. Chii chinoitika ipapo? Nekuda kwechimwe chikonzero, mast cell aya akawandisa anongoerekana ashanda uye anoburitsa huwandu hwakawanda hwemakemikari senge
'histamine' mumuviri. Ndipo panotanga kuoneka zviratidzo zvandambotaura, zvakaita sekubuda ropa, kuvaviwa,
uye eczema .
Mune zvimwe zviitiko zvakakomba, izvi zvinogona kukura kuita allergy inouraya inonzi anaphylaxis . Izvi zvinokonzeresa emergency. Muzviitiko zvakadaro, unofanira kuenda kuchipatara nekukurumidza. Unofanirawo kushandisa epinephrine auto- injector kana chiremba wako akakurudzira .
Chii chinokonzera chirwere ichi?
Vanhu vazhinji vanoshamisika kana ichi chirwere chinogara nhaka. Asi ichi hachisi chirwere chinogara nhaka. Kazhinji, chinoitika
mujini rinonzi KIT, rinowanikwa mumasero edu emasero.Zvinokonzerwa nekuchinja-chinja kusingatarisirwi (mutation). Jini iri rinobatsira kugadzira puroteni inodzora kukura kwemasero. Saka kana izvi zvachinja, masero emuviri anotanga kukura zvisingadzoreki. Kunyangwe zviratidzo izvi zvichigona kuoneka pazera ripi zvaro, zvinonyanya kuitika kuvanhu vakuru, kunyanya
pakati pemakore makumi mana nemakumi mashanu .
Zvinokonzera zviratidzo zvinowedzera
Havasi vese vane chirwere ichi vanowana zviratidzo zvakafanana. Zvakare, zvinhu zvinokonzera zviratidzo zvinogona kusiyana kubva pamunhu kusvika pamunhu. Zvisinei, zvimwe zvezvinhu zvinowanzo kukonzera zvinosanganisira izvi zvakanyorwa patafura iri pazasi. Zvakakosha kuziva nezvazvo.
| Zvinokonzera zviratidzo zvinowedzera | Tsananguro |
|---|
| Doro | Kunyanya zvinhu zvakaita sewaini tsvuku. |
| Chikafu chine zvinonhuhwirira | Zvikafu zvine mhiripiri nemhiripiri. |
| Kuchinja kwekupisa | Kungoerekana wasangana nechando chakanyanya kana kupisa kwakanyanya. |
| Kurumwa nezvipembenene | Zvinhu zvakaita sekuruma nyuchi negonye. |
| Kushungurudzika kana kuzvidya mwoyo | Kushushikana kwemuviri kana kwepfungwa. |
| Mimwe mishonga | Aspirin, opioid, uye NSAIDs zvinoderedza marwadzo. |
| Kuvhiyiwa uye kubaiwa majekiseni | Kushushikana usati wavhiyiwa uye mushure mekuvhiyiwa uye mamwe marudzi ejekiseni. |
Zvakakoshawo kuyeuka kuti dzimwe nguva zviratidzo zvinogona kuoneka pasina chikonzero chaicho.
Ndezvipi zviratidzo zvikuru zvechirwere ichi?
Kune mhando shanu huru dzeSystemic Mastocytosis. Chiremba wako achakuyedza uye achakuudza kuti une rudzii.
- Indolent Systemic Mastocytosis (ISM): Iyi ndiyo mhando inonyanya kuwanikwa uye isinganyanyi kuoma. Chirwere ichi chinokura zvishoma nezvishoma uye hachikonzeri kukuvara kwakanyanya kwenhengo.
- Kusvuta kweSystemic Mastocytosis (SSM): Yakanyanya kuoma kupfuura ISM. Zviratidzo zvacho zvakanyanya uye zvinogona kukanganisa nhengo dzemuviri nekufamba kwenguva.
- Systemic Mastocytosis ine Associated Hematological Neoplasm (SM-AHN): Muchiitiko ichi, mastocytosis inoperekedzwa nechimwe chirwere chine chekuita neropa (semuenzaniso leukemia ).
- Aggressive Systemic Mastocytosis (ASM): Rudzi urwu runokura nekukurumidza uye runogona kukuvadza nhengo dzakadai sechiropa, chirebvu, nemapfupa.
- Mast Cell Leukemia (MCL): Iyi ndiyo mhando isingawanzoonekwi uye yakanyanya kuipa. Kune huwandu hwakawanda hwemasero emasero mumongo wemapfupa neropa.
Zviratidzo zvaunoona zvinoenderana nerudzi rwechirwere chaunacho uye kuti masero emuviri wako akanyanya kuwanda. Heano mamwe ezviratidzo zvakajairika:
- Kukwenya, mapundu , kusviba
- Kurwadziwa kwemudumbu, kuzvimba, manyoka
- Kusvotwa kana kurutsa
- Musoro uye kuneta
- Kurova kwemoyo nekukurumidza
- Kuderera kweropa, dzungu, kurasikirwa nepfungwa
- Kuzvimba kwechiropa, chirebvu, uye ma lymph nodes
- Anemia nemamiriro ekubuda ropa
- Kupera simba kwemapfupa (Osteoporosis)
- Mupfungwa, mamiriro ezvinhu akadai sekuomerwa nekuisa pfungwa pachinhu chimwe chete, kuzvidya mwoyo nguva nenguva, kana kuora mwoyo.
Nzira yekuziva chirwere ichi? (Kuongororwa)
Chiremba wako achatanga akubvunza nezvezviratidzo zvako uye oita bvunzo yemuviri. Zvadaro, vanogona kukurudzira bvunzo dzinoverengeka kuti vasimbise chirwere ichi:
- Kuongororwa kweganda: Kachikamu kadiki keganda kanotorwa kubva panzvimbo yakakanganiswa koongororwa nemaikorosikopu kuti vaone kana paine masero akawanda eganda.
- Kuongororwa kweBone Morrow Biopsy: Chiremba weropa anoshandisa tsono diki kutora sampuli diki yebonde rako oiongorora.
- Kuongororwa kweropa neweti:Kuverengwa kweropa kwakazara (CBC) kunogonawo kushandiswa kutarisa zvimwe zvirwere, zvakaita seanemia.
- Kuongororwa kweMajini: Ropa kana kuti tissue sampuro inoongororwa kuti ione kana paine shanduko dziri mujini reKIT rataurwa kare.
- Kuongororwa kwemifananidzo: X-rays, ultrasound, uye CT scans zvinogona kubatsira kuona kusasimba kwemapfupa uye kuzvimba kwenhengo dzakadai sechiropa nespleen.
- Endoscopy kana Colonoscopy: Chubhu yakatetepa ine kamera yakabatanidzwa pairi inoshandiswa kuongorora mukati medumbu kana ura kuti ione kana paine zvisina kumira zvakanaka, zvakaita semaronda.
Ndezvipi zviri kurapwa?
Chiremba achasarudza hurongwa hwekurapa zvichienderana nezviratidzo zvako, nhengo dzakakanganiswa, uye rudzi rwechirwere.
- Mishonga inorwisa mabhakitiriya: Mishonga iyi inobatsira kudzora zvinhu zvakaita sekuvaviwa kweganda, kutsvuka, uye dumbu.
- Epinephrine: Homoni inoshandiswa kana paine allergy yakanyanya (anaphylaxis).
- Proton Pump Inhibitors: Dzivisa acid yemudumbu uye uderedze zvinhu zvakaita sekuzvimba kwemudumbu.
- Zvigadzikiso zveMast Cell: Mishonga inomisa kuburitswa kwehistamine kubva mumasero emast.
- MaSteroids: Anogona kubatsira nezvirwere zveganda nekufema.
- Kurapa Kwakanangana: Mishonga inonanga jini kana puroteni chaiyo inobatanidzwa nechirwere ichi. Iyi inogona kudiwa kuvanhu vane zviratidzo zvakakomba.
- Kurapa nemakemikari: Kurapa uku kunogona kudiwa kana chirwere ichi chiri kupararira nekukurumidza uye chichikonzera kukuvara kwakanyanya kwenhengo dzemuviri.
- Kudyara Masero Emuviri: Sarudzo yekurapa inoonekwa mune zvisingawanzoitiki.
Mharidzo Yekuenda Nayo Kumba
- Systemic Mastocytosis chirwere chisingawanzoitiki chinokonzerwa nekuwedzera kusingawanzoitiki kwemasero emasero.
- Zviratidzo zvinogona kuwedzerwa nezvinhu zvakaita sedoro, chikafu chine mhiripiri, uye kushushikana. Ziva uye dzivisa zvinhu zvinokonzera kuti zviratidzo zvako zviwedzere.
- Izvi zvingasava kungova allergy chete. Kana zviratidzo zvikaramba zviripo, iva nechokwadi chekuona chiremba uye kuongororwa kwakakodzera.
- Pane njodzi yekurwara zvakanyanya (anaphylaxis). Gara uine epinephrine auto-injector kana chiremba wako akakurudzira kuti ishande.
- Kunyange hazvo chirwere ichi chisingarapike zvachose, kurapwa kunogona kudzora zviratidzo zvikuru uye kubvumira vanhu kurarama hupenyu hwakajairika.
- Zvakakosha kuti pfungwa dzako dzirambe dzakasimba paunenge uchirarama nechirwere chakadai kwenguva refu. Tsvaga rutsigiro kubva kumhuri, shamwari, kana mapoka ekutsigira.
Systemic Mastocytosis, mast cells, mapundu eganda, anaphylaxis, anaphylaxis, KIT gene, histamine
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