Ngaba uhlala uphathwa ziintlungu zamalungu , iintlungu zomqolo , okanye iintlungu eziqatha eziza nokuya exesheni? Emva koko sithatha ngokukhawuleza i- painkiller . Kodwa ubusazi na ukuba kukho iintlobo ezahlukeneyo zezi ntlungu? Namhlanje siza kuthetha ngohlobo lwe-painkiller oluthatha indawo ekhethekileyo phakathi kwazo, kwaye lusebenza ngendlela eyahlukileyo kancinci. Loo nto yi -COX-2 inhibitors .
Ngamafutshane, ziintoni ezi COX-2 Inhibitors?
Ii-COX-2 inhibitors ngokwenene liqela lamayeza athomalalisa iintlungu kwaye anciphise ukudumba (ukudumba). Igama lezonyango leli qela yi-NSAIDs, elimele iiNonsteroidal Anti-inflammatory Drugs. Amayeza afana ne -Ibuprofen , i-Naproxen , kunye ne-Diclofenac ohlala usiva ngawo nawo akwiqela elibizwa ngokuba yi-NSAIDs .
Nangona kunjalo, olu hlobo luthile, olubizwa ngokuba yi-COX-2 inhibitors, lusebenza emzimbeni ngendlela eyahlukileyo kancinci kune-NSAIDs zemveli esizaziyo sonke. Makhe sijonge ukuba lo mahluko uyintoni.
Eli yeza lisebenza njani emzimbeni? Liyindlela emangalisayo kakhulu!
Ukuze sikuqonde oku, kufuneka siqale siqonde iintlobo ezimbini zee-enzymes emizimbeni yethu. Ezi zii -enzymes ze-COX-1 kunye ne-COX-2 . Zombini ezi enzymes zivelisa iikhemikhali emizimbeni yethu ezibizwa ngokuba zii-prostaglandins . Ezi prostaglandins zezona zizathu ziphambili zokuba sive iintlungu, ukudumba (ukudumba), kunye nomkhuhlane.
Khawuthelekelele oku: Kukho abasebenzi ababini ngaphakathi kumzi-mveliso ababizwa ngokuba ngumzimba wethu.
- I-COX-1 (umsebenzi wokuqala): Le ngomnye umsebenzi olungileyo. Yenza ii-prostaglandins ezibangela iintlungu nokudumba. Kodwa ukongeza koko, yenza izinto ezimbini ezibaluleke kakhulu . Enye kukukhusela ulwelo lwesisu namathumbu ethu kwi-asidi yesisu. Enye kukuncedisa kwinkqubo yokuqunjelwa kwegazi.
- I-COX-2 (Umsebenzi 2): Le yingxaki yokwenyani. Umsebenzi wayo ophambili kukwenza ii-prostaglandins ezibangela iintlungu kunye nokudumba.
Ngoku khangela, xa sithatha amayeza okudambisa iintlungu (ii-NSAID ezingakhethiyo) ezifana ne-Ibuprofen kunye ne-Diclofenac, amayeza ayayeka omabini la mayeza. Emva koko, ngenxa yokuba i-COX-2 iyekiwe, iintlungu kunye nokudumba ziyancitshiswa. Kodwa ngenxa yokuba umsebenzi olungileyo, oko kukuthi, i-COX-1, iyekiwe, ukhuselo lwesisu luyalahleka , kwaye amathuba okuba ne-gastritis, ukudumba kwesisu, kunye nezilonda ziyanda.
Kodwa, olu hlobo lwamayeza abizwa ngokuba yi-COX-2 inhibitors lukrelekrele kakhulu. Aya ngqo kumsebenzi onengxaki, oko kukuthi, i-enzyme ye-COX-2 . Avumela umsebenzi olungileyo (COX-1) ukuba enze umsebenzi wawo. Ngoko ke umonakalo esiswini mncinci kakhulu. Le yeyona nzuzo inkulu yolu hlobo lwamayeza.
Zeziphi iimeko ezisetyenziselwa i-COX-2 inhibitors?
Oogqirha bacebisa olu hlobo lwamayeza ukulawula iintlungu ezincinci ukuya kweziphakathi kunye nokudumba okubangelwa ziimeko ezahlukeneyo zonyango.
| Imeko yezonyango | Ingcaciso elula |
|---|---|
| I-Osteoarthritis | Intlungu nokuqina okubangelwa kukuguguleka kwamalungu njengoko sikhula. |
| Irheumatoid arthritis | Isifo esibangela ukudumba kunye nentlungu emalungeni ngenxa yokusebenza kwenkqubo yomzimba yokuzikhusela. |
| Isifo samathambo solutsha | I-arthritis kubantwana abancinci. |
| I-Ankylosing Spondylitis | Isifo apho amalungu, ikakhulu emgogodleni, avuvukala aze adibane ngokuhamba kwexesha. |
| Intlungu ngexesha lokuya exesheni (iDysmenorrhea) | Intlungu ebuhlungu esiswini ngexesha lokuya exesheni. |
| Ukulimala okwethutyana, njengokulimala kwezemidlalo | Kwimeko yokukruneka, ukutsalwa kwemisipha, njl. |
Ukongeza, ugqirha wakho unokukunika eli yeza kwiimeko ezifana ne-gout kunye ne-migraine.
Zithini iingozi kunye nemiphumo emibi yokusebenzisa ii-COX-2 Inhibitors?
Nangona zinciphisa iziphumo ebezingalindelekanga zesisu, izithinteli ze-COX-2 azingomayeza angenabungozi kwaphela. Kunokubakho iingozi ezithile , ingakumbi xa zisetyenziswa ngeedosi eziphezulu kwaye ixesha elide .
Iingozi eziphambili
- Ukuhlaselwa sisifo sentliziyo kunye nestroke: Kufunyenwe ukuba ii-COX-2 inhibitors zinxulunyaniswa nomngcipheko okhulayo kancinci wokuhlaselwa sisifo sentliziyo kunye nestroke. Lo mngcipheko mkhulu ngakumbi kubantu abasele benesifo sentliziyo okanye izinto ezinokubangela eso sifo. Ngenxa yesi sizathu, ezinye ii-COX-2 inhibitors, ezifana ne-`Rofecoxib (Vioxx®)` kunye ne-`Valdecoxib (Bextra®)`, zisusiwe kwimarike.
- Iingxaki zesisu namathumbu: Nangona umonakalo wesisu unciphile, awupheli ngokupheleleyo. Abanye abantu banokuba nokopha kunye nezilonda .
Iziphumo ebezingalindelekanga eziqhelekileyo
| Uhlobo lwesiphumo esibi | Iimpawu ezinokwenzeka |
|---|---|
| Inkqubo yokugaya ukutya | Ukudumba, urhudo, ukuqhina, isicaphucaphu, isisu esibuhlungu, iintlungu zesifuba. |
| Intliziyo kunye nemithambo yegazi | Uxinzelelo lwegazi oluphezulu, iintlungu zesifuba, ukuhlaselwa yintliziyo, isifo sohlangothi. |
| Izintso | Ukungasebenzi kakuhle kwezintso, ukuqokelelwa kwamanzi emzimbeni kunye nokudumba (i-edema). |
| Inkqubo yemithambo-luvo | Intloko ebuhlungu, isiyezi. |
Ngubani ongafanele athathe ii-COX-2 Inhibitors?
Ugqirha wakho uza kujonga imbali yakho yempilo epheleleyo ukuze abone ukuba eli yeza likulungele na. Kufuneka uphephe ukulisebenzisa eli yeza ukuba unenye yezi meko zilandelayo:
- Ukuba ukhe waba nestroke ngaphambili.
- Ukuba usandul’ ukwenza okanye uza kwenza utyando lwe-coronary artery bypass .
- Ukuba unesifo sezintso esibi okanye isifo sesibindi .
- Ukuba ukhe wahlaselwa sisifo sesifuba ngaphambili okanye wasabela kakhulu kwi-allergy xa usebenzisa enye i-NSAID, i-aspirin, okanye i-sulfa antibiotic.
- Ukuba ukwiinyanga ezintathu zokugqibela zokukhulelwa .
- Ukuba ungumama oncancisayo (thetha nogqirha wakho ngale nto).
Ufanele uye nini kugqirha ngoko nangoko?
Ukuba ufumana naziphi na iimpawu ezilandelayo ngelixa usebenzisa eli yeza, musa ukulibazisa kwaye ubone ugqirha wakho ngoko nangoko okanye uye kwiSebe lezeMpilo eziNgxamisekileyo (ETU) elikufutshane.
- Iimpawu zengxaki yesibindi: umchamo omnyama, ukudinwa kakhulu, ukutyheli kolusu okanye amehlo, indle ekhanyayo, isisu esibuhlungu.
- Iimpawu zokopha: ukuhlanza igazi okanye ukuhlanza okufana nekofu, ukuphuma kwegazi kwindle (indle emnyama okanye ebomvu), ukuphuma kwegazi kumchamo, ukuphuma kwegazi kwiintsini, ukugruzuka okungaqhelekanga kwesikhumba.
- Iimpawu zengxaki yezintso: ukungakwazi ukuchama, utshintsho kubungakanani bomchamo oveliswayo, ukunyuka kobunzima ngequbuliso.
- Iimpawu ze-allergy enzima: ukurhawuzelela okanye ukurhawuzelela kwesikhumba, ukurhawuzelela, ubunzima bokuphefumla, ukudumba kobuso, imilebe, okanye ulwimi.
- Iimpawu zokuhlaselwa yintliziyo: iintlungu zesifuba, ukuphefumla nzima, iintlungu eziphuma emhlathini okanye egxalabeni.
- Iimpawu zestroke: ukungaziva mnandi kwelinye icala lomzimba, ubunzima bokuthetha, ukugoba kobuso.
Umyalezo Wokuya Ekhaya
- Ii-COX-2 inhibitors ziluhlobo olukhethekileyo lwamayeza angenabungozi kangako esiswini njengee-painkillers eziqhelekileyo (ii-NSAIDs). Iintlobo ezisetyenziswa kakhulu eSri Lanka yiCelecoxib kunye ne-Etoricoxib.
- Ezi azinazo zonke iingozi, ingakumbi kuba zinokunyusa umngcipheko wokuhlaselwa sisifo sentliziyo kunye nesifo sohlangothi.
- Ungaze usebenzise eli yeza livela kwikhemesti ngaphandle kwemvume kagqirha.
- Soloko usebenzisa idosi ephantsi ecetyiswa ngugqirha wakho, ixesha elifutshane kangangoko .
- Ukuba uneemeko ezifana nesifo sentliziyo, isifo sezintso, isifo sesibindi, okanye isifo se-gastritis, kubalulekile ukuxelela ugqirha wakho ngaphambi kokuba usebenzise eli yeza.
- Hlala uqaphela iimpawu ezilumkisayo ezikhankanyiweyo apha ngasentla. Ukuba kukho naziphi na iingxaki, funa ingcebiso kagqirha ngokukhawuleza.
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