Ngaba ukhe waphawula ngequbuliso utshintsho ekuboneni kwakho, iintlungu zamehlo, okanye ukungabi nanto okanye ubuthathaka kwimilenze yakho? Isenokuba yinto eyahlukileyo. Namhlanje sithetha ngemeko engaqhelekanga kakhulu kwilizwe lethu, kodwa kubaluleke kakhulu ukuba uyiqaphele. Eso yiNeuromyelitis Optica Spectrum Disorder , okanye i-NMOSD ngamafutshane. Esi sisifo sokuzikhusela komzimba esichaphazela kakhulu amehlo akho kunye nomqolo.
Yintoni i-NMOSD? Isebenza njani i-Enspryng?
Ngamafutshane, i-NMOSD kuxa inkqubo yomzimba wakho yokuzikhusela, inkqubo esikhusela kwizifo, iqala ngempazamo ukuhlasela iiseli zakho eziphilileyo. Ngokukodwa, umzimba wakho uqala ukwenza ii-antibodies ezichasene neproteni ethile kwinkqubo yakho yemithambo-luvo ebizwa ngokuba yi-'aquaporin-4 (AQP4).'
Olu hlaselo lubangela ukudumba, okanye ukudumba, okujikeleze umthambo wakho wokubona (umthambo othwala imiyalezo phakathi kweliso lakho nengqondo yakho) kunye nomthambo womqolo. Njengoko oku kuqhubeka, kunokukhokelela ekulahlekelweni kokubona kunye nobunzima bokuhamba.
Akukho nyango lwe-NMOSD okwangoku. Unyango lujolise kakhulu ekunciphiseni ukudumba, ukulawula iimpawu , kunye nokuthintela ukuphinda kubuye isifo.
Kulapho i-Enspryng ingena khona. I-Enspryng liyeza elitsha lebhayoloji. Eli yeza linokunceda ukuthintela i-NMOSD ukuba ingabuyi, ingakumbi ukuba une-anti-AQP4 antibodies esithethe ngayo ngaphambili egazini lakho.
I-Enspryng isebenza ngokuvala enye iproteni emzimbeni wethu ebizwa ngokuba yi-``interleukin-6 (IL-6).`` Kuba le proteni ebizwa ngokuba yi-IL-6 ikwabandakanyeka ekuvuvukeni okubangelwa zii-anti-APQ4 antibodies. Ngoko ke xa i-IL-6 ivaliwe, ukuvuvuka kuyancitshiswa, iimpawu ziyalawulwa, kwaye isifo sinokuncitshiswa.
| Indawo echaphazelekayo kunye nemeko yayo | Iimpawu ezinokuvakala |
|---|---|
| I-Optic Neuritis |
|
| I-Myelitis eguquguqukayo |
Ndingayisebenzisa njani le yeza?
I-Enspryng yinaliti efakwa ngaphantsi kwesikhumba . Idla ngokunikezelwa esiswini esisezantsi okanye embindini wethanga.
- Iinaliti zokuqala ezintathu kufuneka zinikwe rhoqo emva kweeveki ezimbini.
- Emva koko, kufuneka uyibethe kube kanye ngenyanga.
Kubaluleke kakhulu ukukhumbula iintsuku ezichanekileyo ekufuneka uzifake kuzo ezi naliti. Beka isikhumbuzi kwikhalenda okanye kwifowuni yakho. Ukuba uphoswe yinaliti, ngokuqinisekileyo kuya kufuneka uthethe nogqirha wakho malunga nento omawuyenze ngokulandelayo.
Ungakhathazeki, ugqirha wakho uza kukufundisa indlela yokuzijova, indawo oza kuyijova kuyo, kunye nendlela yokutshintsha indawo yolusu ngalo lonke ixesha. Hlamba izandla zakho kakuhle ngaphambi kokuba ujove.
Ndingaligcina njani iyeza?
Eli yeza lifanele ligcinwe efrijini . Kodwa ungaligcini efrijini. Kwakhona, ungalishukumisi iyeza. Likhuphe iyeza imizuzu engama-30 ngaphambi kokuba ulifake uze ulivumele lifikelele kubushushu begumbi. Ungaze ulifudumeze iyeza kwi-microwave okanye ngamanzi ashushu.
Kubalulekile ukuthetha nogqirha wakho malunga naluphi na ugonyo omele ulufumane ngelixa usebenzisa i-Enspryng. Amanye amachiza awacetyiswa xa usebenzisa la mayeza.
Luphandwe njani olu yeza?
Kuye kwenziwa izifundo ezibini eziphambili ukujonga ukhuseleko kunye nokusebenza kakuhle kwe-Enspryng. Ezi zithelekisa i-Enspryng ne-placebo, iyeza elingenaso isithako esisebenzayo. Kulapho ke sinokuthi sibone khona ukuba ichiza liluncedo okanye liyingozi.
Bonke abathathi-nxaxheba kolu phononongo babene-NMOSD, imbali yokubuyela umva, kunye namanqaku aphakathi kwe-0 kunye ne-6.5 kwi-Expanded Disability Status Scale (EDSS), isikali esilinganisa inqanaba labo lokukhubazeka. (Amanqaku e-EDSS angama-0 athetha ukuba akukho kukhubazeka, ama-6.5 athetha ukuba kukho umda othile ekuhambeni.)
Olu phando lujonge kakhulu ukuba kwathatha ixesha elingakanani ukuba esi sifo sibuye. Ukongeza, kwajongwa utshintsho kwi-'Visual Analog Scale (VAS)', elinganisa iintlungu, kunye ne-'Functional Assessment of Chronic Illness Therapy (FACIT)', elinganisa ukudinwa.
Zithini iziphumo zophando?
Kuzo zombini izifundo, izigulane ezisebenzisa i-Enspryng bezinokuphinda zibuyele umva okumbalwa kakhulu kunezo zithatha i-placebo. Oku kuthetha ukuba i-Enspryng inokunciphisa iimpawu zakho kunye nenani lokuphinda zibuyele umva.
Nangona kunjalo, izigulane ezingenazo ii-anti-AQP4 antibodies azizange zizuze kakhulu kwi-Enspryng xa kuthelekiswa ne-placebo.
| Amanqanaba okubuyela umva kwizigulane ezine-anti-AQP4 antibodies | ||
|---|---|---|
| Uphando | Udidi lwe-Enspryng | Iqela le-Placebo |
| Uphando 1 (Enspryng kuphela) | I-20% ibuyele kwisimo sayo sangaphambili | Ama-43% abuyele kwisimo sawo sengqondo |
| Isifundo sesi-2 (Ukusebenzisa amayeza ngamanye) | Ama-30% abuyele kwisimo sawo | I-50% ibuyele umva |
Kodwa khumbula, ezi ziziphumo zophando. Iziphumo zakho zinokwahluka. Wena nogqirha wakho nifanele nigqibe kunye ukuba eli yeza likulungele na kwaye ngaba iingenelo zingaphezulu kweengozi.
Ungazilawula njani iziphumo ebezingalindelekanga xa zisenzeka?
Iziphumo ebezingalindelekanga eziqhelekileyo zale mithi kukwasulelwa yimpumlo nomqala, intloko ebuhlungu, isicaphucaphu, ukurhawuzelela kolusu, isifo sesisu, ukudinwa, kunye nentlungu emalungeni okanye emalungeni. Xelela ugqirha wakho ukuba unayo nayiphi na kwezi.
Iintsholongwane
Kukho umngcipheko okhulayo kancinci wokufumana usulelo oluqhelekileyo okanye olunzima ngelixa usebenzisa i-Enspryng. Xelela ugqirha wakho ukuba unyangelwa usulelo. Kwakhona, xelela ugqirha wakho ngoko nangoko ukuba unezinye zeempawu ezilandelayo:
- Umkhuhlane, iintlungu zomzimba, umkhuhlane, umphimbo obuhlungu, ukukhwehlela okungapheliyo
- Ubomvu okanye ukudumba kolusu
- Ukuphazamiseka kwesisu, urhudo
- Ukutsha xa uchama okanye ukusoloko ufuna ukuchama
Urhawuzelelo
Xelela ugqirha wakho ukuba unesirhawu xa usebenzisa iyeza. Ukuba isirhawu sisasazeka emzimbeni wonke ngequbuliso, yiya kwigumbi likaxakeka lesibhedlele (ETU) ngoko nangoko.
Ezi azizo zodwa iziphumo ebezingalindelekanga. Ukuba uneempawu ezikukhathazayo, thetha nogqirha wakho ngazo.
Zeziphi iimvavanyo ekufuneka zenziwe ngaphambi kokuba kuqalwe unyango nangexesha lonyango?
Ngaphambi kokuba uqale i-Enspryng, ugqirha wakho uza kwenza uvavanyo lwegazi oluninzi ukujonga ukusebenza kwesibindi sakho, i-hepatitis B, isifo sephepha, okanye ezinye izifo. Olu vavanyo lunokufuneka luphindwe ngexesha lonyango. Ngoko ke kubaluleke kakhulu ukuba uvavanyo lwakho lwenziwe ngexesha.
Ngaba kukho iingxaki ngamanye amayeza?
Akukho ntsebenziswano inkulu ibikiweyo phakathi kwe-Enspryng nokutya okanye amanye amayeza. Nangona kunjalo, kubalulekile ukuxelela ugqirha wakho malunga nawo onke amayeza owasebenzisayo (kuquka amayeza ezinye izifo, iivithamini, amayeza emifuno, kunye nezongezo). Oku kunokunceda ukuthintela naziphi na iziphumo ebezingalindelekanga.
Umyalezo Wokuya Ekhaya
- I-NMOSD yimeko engaqhelekanga kodwa enzulu apho amajoni akho omzimba ahlasela amehlo akho kunye nomqolo.
- I-Enspryng liyeza elitsha elinceda ekunciphiseni ukuphinda-phinda isifo, ingakumbi kwizigulana ezine-anti-AQP4 antibodies.
- Olu luhlaselo phantsi kolusu. Kubalulekile ukufumana uqeqesho olufanelekileyo kugqirha wakho.
- Yazisa ugqirha wakho ngoko nangoko malunga nazo zonke ezinye iziyobisi ozisebenzisayo kunye nazo naziphi na iziphumo ebezingalindelekanga ezenzeka ngexesha lonyango.
- Ungaze uyeke unyango okanye utshintshe umthamo ngaphandle kwengcebiso kagqirha wakho.
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