⚡ Interactive Clinical Tool
Renal function (eGFR)
Measure kidney function based on creatinine value
Eli yeza iJynarque libanceda njani abaguli be-ADPKD?
Ngamafutshane, i-ADPKD sisifo semfuza esidluliselwa kwizizukulwana ngezizukulwana . Esi sisifo apho ii-cysts ezininzi ezizaliswe lulwelo (ii-cysts) zenzeka khona kwizintso. Ekuhambeni kwexesha, ezi cysts ziyakhula, zitshintsha imilo yezintso kwaye zibe nkulu kakhulu kunesiqhelo. Ekugqibeleni, izintso azisakwazi ukwenza umsebenzi wazo wokucoca igazi ngokufanelekileyo. Amaxesha amaninzi, ezi mpawu azibonakali kubantu abancinci, kodwa zibonakala phakathi kweminyaka engama-30 nama-50. Uphawu oluqhelekileyo luxinzelelo lwegazi oluphezulu . Intlungu kwizintso nayo inokubakho. Oku kunokubangelwa kusulelo kwizintso okanye kwindlela yomchamo, ii-cysts eziqhekekileyo, okanye amatye ezintso. Phantse wonke umntu one-ADPKD ekugqibeleni uba nesifo sezintso esingapheliyo (CKD). Esi sisifo esiba mandundu kancinci kancinci. Makhe sibone ukuba zeziphi izigaba zaso.| Isigaba se-CKD | Imeko ilula. |
|---|---|
| Amanqanaba 1 kunye nelesi-2 | Eli lixesha lokuqala. Izintso zisasebenza kakuhle, ngoko ke azisoloko zikho iimpawu. |
| Amanqanaba 3 kunye ne-4 | Okwangoku, ukusebenza kwezintso kuye kwehla kakhulu. Iimpawu ziqala ukubonakala kuba azikwazi ukucoca igazi ngokufanelekileyo. |
| Inqanaba lesi-5 | Eli linqanaba lokugqibela. Izintso azikwazi ukusebenza ngokupheleleyo (Ukusilela Kwezintso). Ngaphandle kwe-dialysis okanye ukufakelwa kwezintso, inokuba yingozi ebomini. |
I-Jynarque isebenza ngendlela eyahlukileyo. Imizimba yethu inehomoni ebizwa ngokuba yi-(vasopressin). Kwizigulane ze -ADPKD , le homoni ithumela imiqondiso kwizintso ukuze zenze ii-cysts ezingaphezulu. Isithako esisebenzayo kwi-Jynarque, (tolvaptan), sithintela loo miqondiso ukuba ingafikeleli kwizintso. Oku kunciphisa ukwakheka kwee-cysts ezintsha kunye nokukhula kwee-cysts ezindala. Oku kuvumela izintso ukuba zisebenze kakuhle ixesha elide.
Ingaba eli yeza alifanelekanga kuye wonke umntu?
Ewe, iJynarque ayifanelekanga kubo bonke abaguli. Kubalulekile ukuxelela ugqirha wakho ngazo zonke iimeko zakho zonyango zangaphambili nezangoku , ingakumbi:- Ukuba uneengxaki zesibindi.
- Ukuba unezinga eliphantsi okanye eliphezulu le-sodium egazini lakho.
- Ukuba unengxaki yokuchama (umz. amatye ezintso , ukuvaleka komchamo).
- Ukuba awuziva unxaniwe okanye unengxaki yokusela amanzi imini yonke.
✨ Clinical nutrition
Verified Partner
Clinical vitamins and nutritional supplements
Clinically proven high quality vitamins, minerals and immune nutritional supplements.
Check Availability →Indlela yokusebenzisa eli yeza?
I-Jynarque yipilisi ethathwa kabini ngemini. Ingathathwa ngaphambi okanye emva kokutya. Ixesha lokuthatha le pilisi libaluleke kakhulu.| Idosi | Ixesha elithathiweyo |
|---|---|
| Idosi yokuqala (kusasa) | Yithathe kwangoko xa uvuka kusasa. Le yeyona dosi iphezulu. |
| Idosi yesibini (emva kwemini) | Thatha idosi yokuqala kanye emva kweeyure ezisi-8 emva kwedosi yokugqibela. (Umzekelo, ukuba uyithatha ngo-8 kusasa, thatha elandelayo ngo-4 emva kwemini). Le yidosi ephantsi. |
Kubaluleke kakhulu: Ngelixa usela eli yeza, ugqirha wakho uza kukucela ukuba wenze uvavanyo lwegazi (uvavanyo lomsebenzi wesibindi) ngamaxesha athile ukuze ujonge ukusebenza kwesibindi sakho . Kubalulekile ukuba uye kwezi mvavanyo kwiintsuku ezicwangcisiweyo. Ngokuxhomekeke kwiziphumo, umthamo wakho unokufuneka uncitshiswe, umiswe iintsuku ezimbalwa, okanye uyekwe ngokupheleleyo.Ukuba uphoswe yidosi, ungayithathi. Yitsibe idosi ongayithathiyo uze uthathe idosi yakho elandelayo ngexesha elicwangcisiweyo. Kubalulekile ukulandela ishedyuli ngqo, kwangoko nje ukuba uvuke kusasa nasemva kweeyure ezisi-8. Kungcono ukuseta i-alamu kwifowuni yakho ukuze ukhumbule idosi yesibini.
Zithini iimvavanyo ngempumelelo yale yeza?
Kuye kwenziwa izifundo ezibini ezinkulu ukuze kuhlolwe ukhuseleko kunye nokusebenza kakuhle kwesiyobisi iJynarque.Izigulane ze-CKD ezikwinqanaba lokuqala (inqanaba loku-1 okanye lesi-2)
Kolu phononongo, izinga lokwanda kwezintso kwabo bathathe iJynarque linciphile kakhulu xa lithelekiswa nabo bathathe i-placebo. Ukuchaneka, izinga lokwanda kwezintso kwabo bathathe iJynarque linciphile malunga nama-49% xa lithelekiswa nabo bathathe i-placebo. Oku kuthetha ukuba umonakalo kwizintso ulawulwe kakhulu. Ukongeza, abo bathathe iJynarque nabo abazange bave nentlungu ingako enxulumene nezintso.Izigulane ze-CKD ezikwinqanaba lokugqibela (inqanaba lesi-3 okanye lesi-4)
Kweli qela lezigulana, izinga lokusebenza kwezintso kakubi kwabo bathathe iJynarque lalicotha kancinci kunakwabanye. Oku kuthetha ukuba eli yeza linokunceda ukugcina ukusebenza kwezintso zabo ixesha elide, kwanabo banesifo esibi kakhulu.Iziphumo ebezingalindelekanga kunye nendlela yokuzilawula?
Kukho iziphumo ebezingalindelekanga xa usebenzisa iJynarque, kwaye kubalulekile ukuba uzazi.- Ukuchama rhoqo: Le yeyona miphumo ixhaphakileyo. Oku kunokubangela ukuba ufune ukuya kwindlu yangasese rhoqo, emini nasebusuku. Ukuze unciphise ukungonwabi ebusuku, thatha idosi yesibini ngexesha elinye, ungadluli emva kwemini.
- Ukuphelelwa ngamanzi emzimbeni: Kukho umngcipheko wokuphelelwa ngamanzi emzimbeni kuba umzimba ulahlekelwa ngamanzi amaninzi. Ukuthintela oku, sela amanzi amaninzi imini yonke, ungalindi ude uzive unxaniwe . Sela amanzi ngoko nangoko xa uziva unxaniwe. Ukuphelelwa ngamanzi emzimbeni kunokubangela amanqanaba aphezulu esodium egazini. Ukuba ufumana iimpawu ezinje ngesiyezi, ubuthathaka , ukudinwa kakhulu, ukutyhafa, okanye ukubetha kwentliziyo okungaqhelekanga , yazisa ugqirha wakho ngoko nangoko.
Ngaba kukho iingxaki ngamanye amayeza okanye ukutya?
Ewe, nalo ngumcimbi obaluleke kakhulu.- Amanye amayeza: I-Jynarque isenokusebenzisana namanye amayeza. Amanye amayeza anokunyusa iziphumo ebezingalindelekanga ze-Jynarque, ngelixa amanye anokunciphisa ukusebenza kakuhle kwe-Jynarque. Ngoko ke, qiniseka ukuba uxelela ugqirha wakho malunga nawo onke amayeza owasebenzisayo (kuquka iivithamini kunye namayeza esintu).
- Ukutya: Musa ukutya igrapefruit okanye usele ijusi yegrapefruit ngelixa usebenzisa eli yeza. Igrapefruit inyusa izinga leJynarque emzimbeni, nto leyo enyusa umngcipheko weziphumo ebezingalindelekanga. Esi siphumo sinokwenzeka nokuba utya igrapefruit nangaliphi na ixesha losuku, kungekhona xa usebenzisa eli yeza, ngoko ke ziphephe ngokupheleleyo igrapefruit.
Ingaba ikho indlela ekhethekileyo yokufumana eli yeza?
I-Jynarque liyeza elinamandla angaqhelekanga okubangela umonakalo kwisibindi. Ngenxa yale ngozi, eli yeza lifumaneka kuphela phantsi kwenkqubo ekhethekileyo ebizwa ngokuba yiNkqubo ye-REMS . Kufuneka ubhalise kule nkqubo ngaphambi kokuba uqale ukusela eli yeza. Kuya kufuneka wenze uvavanyo lwegazi ukujonga ukusebenza kwesibindi sakho. Kuya kufuneka uqhubeke nokwenza olu vavanyo lwegazi rhoqo emva kokuba uqale ukusela eli yeza. Kubalulekile ukuba uqhubeke uthatha olu vavanyo ukuba ufuna ukuqhubeka nokusela eli yeza. Ugqirha wakho uya kukuchazela ngakumbi ngale nto.Umyalezo Wokuya Ekhaya
- I-ADPKD sisifo esidluliselwa kwilifa esibangela ukuba kubekho amatye ezintso, nto leyo enokubangela ukuba izintso zingasebenzi kakuhle.
- I-Jynarque (iTolvaptan) liyeza elikhethekileyo elinceda ekucothiseni ukukhula kwezi thumba zezintso.
- Eli yeza alifanelekanga kuye wonke umntu. Xelela ugqirha wakho ngazo zonke iimeko zakho zempilo.
- Sela amayeza ngexesha elifanelekileyo, ngedosi efanelekileyo. Musa ukulibazisa uvavanyo lwegazi ukuze ujonge ukusebenza kwesibindi sakho.
- Sela amanzi amaninzi imini yonke. Kuphephe ukutya nokusela i-grapefruit ngokupheleleyo.
- Nokuba awuziva mahluko, kuphephe ukuyeka eli yeza okanye naliphi na elinye iyeza ngaphandle kwengcebiso kagqirha wakho.
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