Ngaba uziva udiniwe imini yonke kwaye ungenawo amandla okwenza nantoni na? Sihlala sicinga ukuba kungenxa yokuba sisebenza nzima kakhulu, asityanga kakuhle, okanye asilalanga ngokwaneleyo. Kodwa, ubusazi ukuba kunokubakho isizathu esinzulu salo lonke eli gama ngaphakathi emizimbeni yethu? Ngaba ukhe weva ngeefektri ezincinci zamandla emizimbeni yethu? Ezi zizinto esizibiza ngokuba yi-mitochondria. Ukuba ezi azisebenzi kakuhle, kunokuvela iingxaki ezinkulu esingazicingiyo. Ngoko masithethe ngale nto ngokweenkcukacha nangokulula namhlanje.
Zithini ezi mitochondria?
Ngamafutshane,
i-mitochondria ifana neenjini ezincinci okanye izityalo zamandla phantse kuzo zonke iiseli emzimbeni wethu. Khawuthelekelele, ukuba imizimba yethu ibisisixeko esikhulu, ezi mitochondria zizizityalo zamandla ezibonelela ngombane kweso sixeko. Sisebenzisa ukutya esikutyayo kunye neoksijini esiyiphefumlayo, ezi mitochondria zincinci zivelisa i-90% yamandla umzimba wethu owadingayo ukuze ubaleke, utsibe, ucinge, usebenze,
kwaye ngokufutshane, uphile. Ingakumbi kwizitho ezisebenza rhoqo kwaye zifuna amandla angakumbi, njengentliziyo yethu
, ingqondo, kunye nezihlunu, kukho amawaka ezi mitochondria. Ngenxa yokuba ezo zitho zifuna 'umbane' ongaphezulu kunezinye.
Ngoko ke zithini ezi zifo ze-mitochondrial?
Khawucinge nje, bekuya kwenzeka ntoni ukuba ezo zikhululo zamandla endizikhankanyileyo ngequbuliso ziyeke ukusebenza kakuhle kwaye ziyeke ukuvelisa amandla aneleyo? Isixeko sonke siya kuba mnyama, kwaye nemisebenzi yomzimba wethu nayo iya kuphazamiseka. Kulapho kuvela khona iimeko ezibizwa ngokuba yi
-'Mitochondrial Diseases' . Ezi zihlala
zingapheliyo , oko kuthetha ukuba zinokuhlala ubomi bonke. Uninzi lwexesha, ziyimfuza, oko kuthetha ukuba
zizuzwe ngabazali ebantwaneni. Ngamanye amaxesha ezi mpawu zinokubakho ekuzalweni, kwaye ngamanye amaxesha zinokuvela kamva ebomini.
Zithini izizathu zezi zifo?
Ixesha elininzi, esona sizathu siphambili soku yimfuza. Oko kukuthi, ezinye iziphene kwimfuza esizizuza njengelifa kubazali bethu. Oku kunokwenzeka ngeendlela ezininzi eziphambili.
| Uhlobo lwelifa | Kalula nje... |
|---|
| Ilifa le-Autosomal Recessive | Kwimeko enjalo, umntwana ufumana ilifa le-gene enesiphene (i-gene eguquliweyo) kumama nakutata. Emva koko, umntwana ngamnye kusapho unethuba elingama-25% lokufumana esi sifo. |
| Ilifa Elilawulayo Le-Autosomal | Okwenzekayo apha kukuba umntwana ufumana i-gene enesiphene kumzali omnye kuphela, nokuba ngumama okanye ngutata. Emva koko, umntwana ngamnye kusapho unethuba elingama-50% lokufumana esi sifo. |
| Ilifa leMitochondrial | Le ikhethekile kancinci. I-Mitochondria ine-DNA yayo. Kule lifa, umama one-mitochondria enesiphene unethuba eliyi-100% lokuba bonke abantwana bakhe bafumane esi sifo. |
| Utshintsho Olungacwangciswanga | Kunqabile kakhulu ukuba utshintsho lwezakhi zofuzo zomntwana luvele xa iijini zomntwana zisandul’ ukwakheka, ngaphandle kwempazamo evela kubazali. |
Ukongeza, ukungasebenzi kakuhle kwe-mitochondrial kunokunxulunyaniswa neemeko ezithile zempilo, ezifana nesifo sika-Alzheimer, i-muscular dystrophy, isifo seswekile, kunye nezinye iintlobo zomhlaza.
Zithini iimpawu zezi zifo?
Kulapho abantu abaninzi badideka khona. Iimpawu zezi zifo zinokwahluka kakhulu ukusuka komnye umntu ukuya komnye. Isizathu kukuba iimpawu ziyahluka ngokuxhomekeke kwilungu lomzimba elichaphazelekileyo. Nangona abanye abantu beneempawu ezincinci
kakhulu , abanye banokuba nazo ezinzima.
Ezi mpawu zinokuvela nakweyiphi na iminyaka. Kwakhona, kuba ezi mpawu zifana nezezinye izifo eziqhelekileyo, ngamanye amaxesha kunokuba nzima ukufumanisa esi sifo.
Itheyibhile engezantsi ibonisa ezinye zeempawu ezinokubakho.
| Inkqubo/ilungu elichaphazelekayo | Iimpawu ezinokwenzeka |
|---|
| Ukukhula kunye nezihlunu | Ukukhula okulibazisekayo, ubuthathaka bemisipha, kunye nokudinwa ngexesha lokuzilolonga. |
| Ingqondo kunye nemithambo-luvo | Ukukhubazeka kokufunda, ukulibaziseka kokukhula, ukuphazamiseka kwe-autism spectrum, iintloko ezibuhlungu, ukuxhuzula, istroke, kunye ne-dementia. |
| Izitho zeemvakalelo | Ukuphazamiseka kokubona nokuva. |
| Izitho zangaphakathi | Isifo sentliziyo, sezintso okanye sesibindi, isifo seswekile, iingxaki ze-thyroid. |
| Inkqubo yokugaya ukutya | Ubunzima bokuginya, isisu esibuhlungu, urhudo okanye ukuqhinwa, ukuhlanza. |
Indlela yokuxilonga esi sifo?
Njengoko benditshilo ngaphambili, iimpawu zezi zifo zinokwahluka kakhulu, ngoko ke kunokuba nzima kancinci ukufumanisa ukuba siyintoni kanye kanye esi sifo.
Asinakubonwa ngovavanyo olunye. Yiyo loo nto ugqirha ehlola isigulana aze asithumele kuthotho lweemvavanyo ezahlukeneyo.
Uvavanyo oluqhelekileyo
- Uphononongo olucokisekileyo lwembali yezonyango yosapho .
- Ukwenza uvavanyo olupheleleyo lomzimba nolwemithambo -luvo .
- Ukuchonga utshintsho lweekhemikhali emzimbeni ngovavanyo lwegazi nomchamo (uvavanyo lweMetabolic).
- I-MRI scan (ingakumbi kwiingxaki zobuchopho).
- Uvavanyo lwe-ECG (i-Electrocardiogram) okanye i-Echocardiogram ukujonga ukusebenza kwentliziyo.
- Uvavanyo lwe-DNA olukhethekileyo ukuze kuchongwe iziphene zemfuza .
- Kwezinye iimeko, kusenokufuneka ukuba kuthathwe iqhekeza elincinci lemisipha okanye ulusu ukuze kuvavanywe (i-biopsy) .
Zithini iindlela zonyango zoku?
Umbuzo abantu abaninzi abawubuzayo kukuba ingaba ikho na indlela yokunyanga le nto. Ukuba ndithetha inyani,
akukho ndlela ithile yokunyanga izifo ze-mitochondrial okwangoku. Kodwa, musa ukoyika loo nto. Kukho iindlela ezininzi zonyango ezikhoyo zokulawula iimpawu kunye nokucothisa ukuqhubela phambili kwesi sifo. Unyango luxhomekeke kwisifo somguli, amalungu achaphazelekayo, kunye nobunzima besifo. Nokuba abantu ababini banesifo esifanayo, unyango olufanayo lusenokungasebenzi ngendlela efanayo.
Ezinye iindlela eziphambili zonyango:
- Iivithamini kunye nezongezo: Ezinye iivithamini zinceda ekusebenzeni kwe-mitochondrial.
- Ukuzilolonga: Ingakumbi ukuzilolonga okuqinisa izihlunu. Oku kufuneka kwenziwe phantsi kwesikhokelo sikagqirha wakho okanye ingcali yezonyango.
- Unyango lomzimba , unyango lomsebenzi, kunye nonyango lokuthetha : Oku kunceda isigulana ukuba senze imisebenzi yemihla ngemihla ngokulula.
Kwakhona, izigulana ziyacetyiswa ukuba zingabandakanyeki kwizinto ezithile. Umzekelo, kubaluleke kakhulu ukuphepha izinto ezifana nokuchanabeka kwingqele egqithisileyo okanye ubushushu, ukulamba, ukungalali ngokwaneleyo, uxinzelelo,
ukutshaya, kunye nokusela utywala .
Umyalezo Wokuya Ekhaya
- IiMitochondria zifana nezityalo ezincinci zamandla ezinika amandla kwiiseli zomzimba wethu.
- Izifo ezibangelwa kukungasebenzi kakuhle kwezi zifo zihlala zithatha ixesha elide kwaye zihlala zizuzwa njengelifa ngokwemfuza.
- Iimpawu zahlukile kakhulu kwaye zingabandakanya ubuthathaka bemisipha, ukukhula okungalindelekanga, ukuphazamiseka kokubona nokuva, kunye nesifo sentliziyo.
- Nangona kungekho ndlela ithile yonyango lwezi zifo, ungaphila ubomi obuhle ngokulawula iimpawu kunye nokulungisa indlela ophila ngayo.
- Ukuba wena okanye umntu osapho lwakho unale meko, kubaluleke kakhulu ukuthetha nogqirha wakho malunga nonyango lwemfuza ngaphambi kokuba ube nabantwana. Eyona nto ingcono onokuyenza kukungabi naxhala, kodwa kukufumana ingcebiso efanelekileyo yezonyango.
I-Mitochondria, iMitochondria, Isifo seMitochondrial, Isifo seMfuzo, Amandla, Iiseli, Iimpawu, Unyango
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