Ithemba elitsha kwabo baneFriedreich Ataxia: Masifunde ngeyeza leSkyclarys!

I-Friedreich Ataxia yimeko engaqhelekanga, efuziselwa njengelifa echaphazela kakhulu inkqubo yethu yemithambo-luvo. Nangona iimpawu zinokubonakala zisencinci, siyazi ukuba kunzima kangakanani ukuphila nazo. Kunzima ukuchaza intlungu kunye noxinzelelo oluza nokuphulukana kancinci nolawulo lwemizimba yethu. Nangona kunjalo, ngokuhambela phambili kwesayensi, sifumana ithemba elitsha lokujongana nezifo ezinjalo. Lelo luhlobo lwethemba elitsha esithetha ngalo namhlanje.

Okokuqala, masibone ukuba yintoni iFriedreich Ataxia.

Ngamafutshane, i-Friedreich's ataxia (FA) sisifo semfuza esonakalisa inkqubo yethu yemithambo-luvo. Oku kunciphisa kancinci amandla okulawula izihlunu zethu. Njengoko isifo siqhubeka, iimpawu zinokuba mandundu.

Makhe sijonge ukuba zeziphi iimpawu eziqhele ukubonwa.

Yintoni le iyeza litsha elibizwa ngokuba yiSkyclarys?

USkyclarys nguFriedrich ngo-2023Unyango lokuqala oluvunyiweyo lwe -ataxia (FA). Luqulathe isithako esisebenzayo esithi `omaveloxolone`.

Izifundo zibonise ukuba iSkyclarys inokuphucula ukusebenza kwemithambo-luvo kwaye icothise ukuqhubela phambili kwesi sifo.

Eli yeza lichaphazela njani umzimba?

Nangona oku kuyinto yesayensi, masiyiqonde ngokulula. Kukho iproteni ebizwa ngokuba yi-'Nrf2' ekhusela iiseli emzimbeni wethu. Yicinge njengenkqubo yokuzikhusela emzimbeni wethu. Kumntu one-FA, le nkqubo yokuzikhusela ye-'Nrf2' ayisebenzi kakuhle. Ke ngoko, uxinzelelo olungeyomfuneko kunye nokuvuvukala kwenzeka ngaphakathi kweeseli, nto leyo eyonakalisa iiseli.

I-Skyclarys isebenza ngokuvuselela inkqubo yokuzikhusela ye-`Nrf2` ebuthathaka. Oko kukuthi, "iyayinika amandla". Ngenxa yoko, i-mitochondria, efana nezityalo zamandla ezinika amandla kwiiseli, iqala ukusebenza ngokuqhelekileyo. Oku kunciphisa umonakalo kwiiseli.

Ndingayisebenzisa njani le mithi?

I-Skyclarys yi-capsule ethathwa ngomlomo. Kufuneka uziqaphele ezi zinto xa uyisebenzisa.

• Kuya kufuneka uthathe ii-capsules ezintathu ze-50-milligram ngosuku ngexesha elinye.
• Oku kufuneka kuthathwe kwisisu esingenanto , oko kukuthi, ubuncinane iyure ngaphambi kokutya.
• Ikhaphu mayiginywe yonke . Akufanele ityunyuzwe okanye ihlafunwe.
• Ukuba ngequbuliso ufumana ubunzima bokuginya ikhapsuli, ungayivula ngononophelo ikhapsuli, wongeze iyeza eliyimpuphu ngaphakathi kwiipuni ezimbini ze-applesauce, udibanise kakuhle, uze uyiginye yonke ngaxeshanye.
• Ungaze udibanise eli yeza nobisi okanye ijusi yeorenji .
• Kwakhona, awunakuyivula ikhapsuli uze unike iyeza umntu ofumana ukutya ngetyhubhu yokondla yamathumbu.
• Ukuba uphoswe yidosi, yitsibe loo dosi uze uthathe idosi yakho elandelayo ngexesha elicwangcisiweyo. Musa ukuthatha idosi ephindwe kabini ukuze ubuyisele idosi oyiphosileyo.

Iziphumo ebezingalindelekanga kunye nendlela yokuzilawula?

Njengayo nayiphi na imithi, iSkyclarysIziphumo ebezingalindelekanga zinokwenzeka. Ezona ziphumo bezingalindelekanga zixhaphakileyo zezi:

• Iienzymes zesibindi ezandisiweyo
• Intloko ebuhlungu
• Isicaphucaphu
• Intlungu yesisu
• Ukudinwa
• Urhudo

Kwezi, kufuneka ukhathazeke ngakumbi ngee -enzymes zesibindi eziphezulu . Oku kuthetha ukuba isibindi sakho sinokuba phantsi koxinzelelo okanye umonakalo othile. Ngenxa yesi sizathu, ugqirha wakho uhlala ekujonga oku ngokwenza uvavanyo lwegazi. Ukuba ufumana naziphi na iimpawu ezingezantsi, xelela ugqirha wakho ngoko nangoko.

• Isicaphucaphu okanye ukuhlanza
• Ukutyheli kolusu okanye amehlo
• Intlungu kwicala eliphezulu lasekunene lesisu

Izinto ezifana nezi zinokunceda ukulawula ezinye iziphumo ebezingalindelekanga:

• Ngentloko ebuhlungu: Sela amanzi amaninzi, utye ukutya okunesondlo, kwaye ulale ngokwaneleyo. Xa intloko ibuhlungu, phumla kwigumbi elipholileyo nelimnyama.
• Isicaphucaphu, iintlungu zesisu, kunye norhudo: Yitya ukutya okuncinci kunokutya ukutya okukhulu. Yitya kancinci kwaye uhlafune ukutya kwakho kakuhle. Ziphephe i-caffeine, utywala, kunye neziselo ezine-carbonated. Ukuba urhudo, kufuneka uhlale unamanzi. Sela amanzi, isuphu, kunye nejusi yeorenji zilungile. Yitya ukutya okungeyondlwantyala njengerayisi, iitapile, isonka, kunye neebhanana. Ukuba urhudo lwakho lunzima, thetha nogqirha wakho malunga nonyango olufanelekileyo.
• Ukudinwa: Kuphephe ukuqhuba okanye ukwenza nantoni na efuna ukuphaphama ude wazi kakuhle ukuba eli yeza likuchaphazela njani.

Ngaba kukho iingxaki ngamanye amayeza?

Ewe, eli linqaku elibaluleke kakhulu. I-Skyclarys inokusebenzisana namanye amayeza.

• Amanye amayeza: Amanye amayeza asebenzisana ne-enzyme emzimbeni wethu ebizwa ngokuba yi-'CYP3A4'. Ukuba usela amayeza anjalo, ugqirha wakho unokufuna ukutshintsha idosi yeSkyclarys okanye akutshintshele kwenye iyeza. Ngoko ke, xelela ugqirha wakho ngawo onke amayeza owasebenzisayo (kuquka iivithamini kunye neemveliso zezityalo).
• Iipilisi zokulawula ukuzala: Oku kubaluleke kakhulu. Iipilisi zokulawula ukuzala zehomoni zisenokungasebenzi kakuhle xa zithathwa ngeSkyclarys. Oku kuthetha ukuba kukho umngcipheko wokukhulelwa. Ke ngoko, kufuneka usebenzise uhlobo lokulawula ukuzala olungelulo olwehomoni, olufana neekhondom, ngelixa uthatha iSkyclarys kwaye kangangeentsuku ezingama-28 emva kokuyeka ukusebenzisa ipilisi.
• Ijusi yeGrapefruit kunye neGrapefruit: Musa ukusela ijusi yegrapefruit okanye yegrapefruit ngelixa uthatha iSkyclarys. Ezi zinokunyusa imiphumo yeyeza kwaye zonyuse iziphumo ebezingalindelekanga.

Ekugqibeleni, wena kunye nogqirha wakho wezifo zengqondo nifanele nigqibe kunye ukuba eli yeza likulungele na. Eli liyeza elinikwa ngugqirha kuphela, lifumaneka kuphela kwiikhemesti ezikhethekileyo. Ugqirha wakho uza kwenza amalungiselelo afunekayo.