Unemibuzo mayelana nokuhlolwa kwegazi kwe-ENA Panel (Extractable Nuclear Antigen Panel)? Ake sixoxe kalula!

Wake wezwa ukuthi uhlelo lwethu lokuzivikela lomzimba, amasosha okufanele asivikele ezifweni, enza iphutha bese eqala ukuhlasela izingxenye zethu ezinempilo? Yilokhu esikubiza ngokuthi izifo zokuzivikela komzimba . Ezimweni ezinjalo, ukuhlolwa kwegazi okukhethekile okubizwa ngokuthi i-ENA panel kungakusiza ukuthola ukuthi inkinga iyini nokuthi kungani lokhu kwenzeka. Ngakho-ke namuhla, ake sixoxe nge- ENA Panel , emele i- Extractable Nuclear Antigen Panel , ngendlela elula ongayiqonda, kulungile?

Kuyini ngempela ukuhlolwa kwe-ENA?

Kalula nje, iphaneli ye-ENA iyisivivinyo segazi. Ihlola ukuthi amasosha ethu omzimba azama yini ukuhlasela izingxenye zomzimba wethu ezinempilo. Manje ake sichaze lokhu kakhudlwana. Amasosha ethu omzimba afana nebutho elivikela izwe. Kuleli butho, kunamasosha akhethekile, esiwabiza ngokuthi ama-antibodies . Umsebenzi wala ma-antibodies ukubona nokulwa namagciwane , njengebhaktheriya namagciwane, angena emzimbeni. Isitha ngasinye sinophawu olukhethekile emzimbeni waso olungalubona, esilubiza ngokuthi i-antigen kwezokwelapha. Ngakho ama-antibodies ayayibona le-antigen futhi ahlasele isitha. Kuyisistimu ehlakaniphile kakhulu, akunjalo? Kodwa-ke, ngezinye izikhathi lolu hlelo oluhlakaniphile lwenza iphutha elincane. Yilokho okwenzekayo ezimweni ezibizwa ngokuthi izifo zokuzivikela komzimba . Okwenzekayo-ke ukuthi ama-antibodies ethu aqala ukwakheka ngokumelene nezingcezu ezithile zamaprotheni (ezibizwa ngokuthi ama-antigen enuzi angakhishwa , okusho ukuthi "ama-antigen angahlukaniswa ne-nucleus") atholakala kuyi-nucleus (isikhungo seseli) yamaseli anempilo emzimbeni wethu. Kufana nebutho lethu elihlasela izakhamuzi zethu ezinempilo. Ngaleso sikhathi, ukuhlolwa kwe-ENA kusiza ukuthola ukuthi yimaphi ama-antigen ethu la ma-antibodies ahlaselayo. Lokhu kungasiza odokotela ukuqagela ukuthi hlobo luni lwesifo sokuzivikela komzimba onaso noma baqinisekise ukuthi awunaso isifo esinjalo.

Kufanele ngithathe nini ukuhlolwa kwe-ENA?

Akuwona wonke umuntu okuzodingeka enze lokhu kuhlolwa kwe-ENA. Kunezimo eziningana lapho udokotela angayala khona lokhu kuhlolwa:

• Uma unezimpawu zesifo sokuzivikela komzimba (isib. ubuhlungu bamalunga , ukukhathala okukhulu, izinkinga zesikhumba) futhi uke waba nokuhlolwa kwe-Antinuclear Antibody (ANA) okuhle , ukuhlolwa kwe-ANA kuwukuhlolwa kwezifo zokuzivikela komzimba .Ukuhlolwa okuyisisekelo okuhlonza. Uma kutholakala ukuthi kunesifo, ukuhlolwa kwe-ENA kuzosiza ekuphenyeni okwengeziwe ukuthi kuzokwenzekani ngokulandelayo.
• Uma ukhulelwe futhi uke watholakala une -lupus ngaphambilini. Ngalesi sikhathi, ama-antibodies akho angawela i-placenta aye enganeni yakho futhi abangele isimo esibizwa ngokuthi i-neonatal lupus . Lokhu kungabangela izinkinga enganeni, njengokuvinjelwa kwenhliziyo , ngakho udokotela wakho angancoma ukuhlolwa kwe-ENA ukuze kuqashwe lokhu.

Yiziphi izinhlobo zezifo ezihlolwa ukuhlolwa kwe-ENA?

Kunezinhlobo eziningana zama-antibodies ezifunwa ukuhlolwa kwe-ENA. Lawa ma-antibodies ahlotshaniswa ngqo nesifo ngasinye sokuzivikela komzimba. Izifo ezivame kakhulu ezifunwa ukuhlolwa yilezi:

• I-Lupus (i-Systemic Lupus Erythematosus /SLE)
• Isifo sikaSjögren
• Isifo sezicubu ezixhumeneyo (MCTD)
• I-Scleroderma/i-systemic sclerosis
• I-Polymyositis
• I-Dermatyositis

Ngayinye yalezi zifo inezimpawu ezihlukile, ngakho udokotela uzoqhathanisa izimpawu zakho nemiphumela yokuhlolwa kwe-ENA ukuze afinyelele esiphethweni.

Kwenziwa kanjani ukuhlolwa kwe-ENA? Kusebenza kanjani?

Kulula kakhulu. Uchwepheshe welabhorethri uthatha isampula encane yegazi emthanjeni osesandleni sakho. Bese besebenzisa leli sampula legazi ukwenza isivivinyo se-ENA. Elabhorethri, basebenzisa izimpawu ezikhethekile. Lezi zimpawu zinamathela kuma-antibodies abawafunayo uma ekhona. Bese lezi zimpawu " ziyakhanya" noma zishintshe umbala. Yileyo ndlela osokhemisi abangabona ngayo ukuthi la ma-antibodies akhona noma cha. Ubuchwepheshe obuthuthukisiwe impela, akunjalo?

Yiziphi izinhlobo zama-antibodies ezifunwa ukuhlolwa kwe-ENA?

Ngokuvamile, ukuhlolwa kwe-ENA kubheka ama-antibodies aphendula kuma -antigen amane kuya kwayisithupha atholakala ngaphakathi kwamaseli ethu. Ngayinye yala ma-antibodies ihlotshaniswa nezifo ezithile zokuzivikela komzimba kanye nezinye izimo. Isibonelo, amanye ama-antibodies ahlotshaniswa ne -lupus.Ezinye ziqondene ngqo nalesi sifo, kanti ezinye zihlobene kakhulu ne -Sjögren's syndrome . Yingakho lolu vivinyo lubalulekile ekuxilongweni. Udokotela wakho uzonquma ukuthi yimaphi ama-antibodies okufanele agxile kuwo ngokusekelwe ezimpawini zakho.

Ingabe ngidinga ukulungiselela kusenesikhathi ukuhlolwa kwe-ENA?

Lezi yizindaba ezinhle kakhulu! Akudingeki wenze amalungiselelo akhethekile ngaphambi kokuya ekuhlolweni kwe-ENA. Ungadla futhi uphuze ngendlela evamile futhi uphuze imithi yakho. Kungcono ukukhuluma nodokotela wakho ngakho ukuze uqiniseke.

Yini ongayilindela lapho ubhala isivivinyo se-ENA?

Njengoba kushiwo ngaphambili, udokotela, umhlengikazi, noma uchwepheshe webhubhu uzosebenzisa inalithi encane ukuthatha igazi elincane emthanjeni osengalweni yakho. Ungase uzizwe ubuhlungu noma ukungakhululeki lapho inalithi ifakwa futhi ikhishwa. Lokhu kuzothatha imizuzwana embalwa kuphela. Uma wesaba izinaliti, kungasiza ukubheka eceleni phakathi nalesi sikhathi. Isampula yegazi izothunyelwa ebhubhu ukuze ihlolwe.

Yiziphi izingozi zokuhlolwa kwe-ENA?

Izingozi zokuhlolwa kwe-ENA ziphansi kakhulu , kodwa izinto ezincane zingenzeka uma kudonswa igazi.

• Ngezinye izikhathi, uma kunzima ukuthola umthambo, kungase kudingeke ubhoboze inaliti izikhathi eziningana. Lokho kuyaphazamisa kancane.
• Ungase uzizwe unesiyezi noma uqulekile lapho ukhishwa igazi lakho.
• Kungase kube nokulimala okukhulu noma ukuqoqwa kwegazi ngaphansi kwesikhumba lapho inaliti ifakwe khona (lokhu kubizwa ngokuthi i-hematoma ).
• Akuvamile kakhulu ukuthi kube nokutheleleka endaweni okuthonywe kuyo.
• Abanye abantu bangase baphuze igazi ngokweqile isikhashana ngemva kokukhipha igazi.

Uma kwenzeka into efana nale, ungesabi, vele wazise abasebenzi bezokwelapha.

Uthola kanjani imiphumela yokuhlolwa kwe-ENA? Isho ukuthini?

Imiphumela yokuhlolwa ivame ukuba negative , positive , noma borderline (ebizwa nangokuthi i-equivocal) . Amabanga ajwayelekile angahluka kancane kuye ngelebhu eqhuba ukuhlolwa. Ngakho-ke, umbiko wakho wokuhlolwa kufanele ufake imiphumela yakho kanye nobubanzi bereferensi yelebhu.

• Umphumela omuhle usho ukuthi i-antibody efanele itholakale kusampula yegazi lakho.
• Umphumela ongemuhle usho ukuthi bekungekho ma-antibodies amelene ne -antigen efanele kusampula yakho yegazi, noma bembalwa kakhulu.

Uma ukuhlolwa kwe-ENA kutholakala ukuthi kuyiqiniso, ingabe lokho kusho ukuthi ngine-lupus?

Cha, awukwazi ukusho ukuthi unesifo esithile njenge -lupus ngenxa nje yemiphumela yokuhlolwa okukodwa.

Lokhu kubaluleke kakhulu. Ukuhlolwa kwe-ENA okuhle akusho ukuthi une -lupus . Isibonelo, abantu abaningi abane -Sjögren's syndrome bahlolwa benama-antibodies abizwa ngokuthi i-anti-SSA kanye ne-anti-SSB . Kodwa-ke, la ma-antibodies afanayo angaba nama-positive nakumuntu one-lupus noma esinye isimo. Ngakho-ke, udokotela wakho uzothatha imiphumela yokuhlolwa kwe-ENA, izimpawu zakho, kanye neminye imiphumela yokuhlolwa (njengokuhlolwa kwe-ANA, i-CRP, i-ESR) ndawonye ukuze enze ukuxilongwa .

Kufanele ngiphinde ngimbone nini udokotela wami?

Uma unemibuzo noma ukukhathazeka ngemiphumela yokuhlolwa kwakho, qiniseka ukuthi ukhuluma nodokotela wakho. Futhi, uma unobuhlungu, ukuvuvukala, ubomvu endaweni lapho igazi lidonswa khona, noma izimpawu zokutheleleka njengomkhuhlane, iya ekamelweni eliphuthumayo (ETU) ngokushesha.

Uyini umehluko phakathi kokuhlolwa kwe-ANA nokuhlolwa kwe-ENA?

Lokhu kuyinkinga nakubantu abaningi. Ake sibone ukuthi umehluko uyini phakathi kwalokhu okubili. Cabanga ngokuhlolwa kwe-ANA njengokuhlolwa kokuqala, okuvame kakhulu okwenziwa ngamaphoyisa. "Ingabe kukhona okungahambi kahle lapha, ingabe kukhona inkinga yokuzivikela komzimba?" Ngokuvamile kuyahlolwa. Lokhu kulinganisa ukuthi mangaki ama-anti-nuclear antibodies (ama-antibodies amelene ne-nucleus yeseli) akhona egazini lakho futhi mangaki ama-anti-nuclear antibodies (ama-antibodies amelene ne-nucleus yeseli) akhona egazini lakho. Ukuhlolwa kwe-ENA kufana nokuhlolwa okukhethekile okwenziwa ngemva kwalokho. Uma i-ANA ine-positive, ibheka ngokujulile bese ibuza, "Kulungile, uma kukhona okungahambi kahle, yini ngempela? Yiliphi iphrotheni (i-antigen) ethile emzimbeni wethu la ma-antibodies enziwa ngokumelene nayo?" Okusho ukuthi, ukuhlolwa kwe-ENA kuqondile kakhulu kunokuhlolwa kwe-ANA. Abantu abaningi abanezifo zokuzivikela komzimba banokuhlolwa kwe-ANA okuhle. Kodwa-ke, abantu abaphilile abangenazo izifo zokuzivikela komzimba ngezinye izikhathi bangaba nokuhlolwa kwe-ANA okuhle (ukuhlolwa kwe-ENA kuvame ukuba ne-negative kuma-antibodies kubantu abanjalo). Yingakho odokotela beyala ukuhlolwa kwe-ENA ukuze bathole ulwazi olwengeziwe mayelana nesifo sokuzivikela komzimba kumuntu one-ANA enhle.

Okokugcina, izinto okufanele uzikhumbule

Iphaneli ye-ENA (iphaneli ye-Extractable Nuclear Antigen) iyisivivinyo esibalulekile esinikeza udokotela wakho ulwazi olwengeziwe mayelana nama-antibodies alimaza amaseli akho futhi angase abangele izimpawu zakho.

Akukho ukuhlolwa okukodwa okungahlonza isifo sokuzivikela komzimba.

Udokotela wakho uzohlanganisa imiphumela ye-ENA, izimpawu zakho, kanye nezinye izivivinyo ukuze athole ukuxilongwa okunembile. Ngakho-ke, uma unemibuzo mayelana nemiphumela yakho yokuhlolwa noma ukuthi ingathinta kanjani izinqumo zakho zezempilo, ungesabi ukubuza udokotela wakho. Khona-ke nawe ungathola ukuqonda okucacile. Ukuhlolwa kwe-ENA, izifo ezizimele, ama-antibodies, ama-antigen, i-lupus, ukuhlolwa kwegazi, ukuhlolwa kwe-ANA