Ingabe unesifo sesibindi esibizwa ngokuthi i-Primary Biliary Cholangitis ( PBC )? Noma ingabe othile omaziyo unalesi simo? Kalula nje, lokhu kwenzeka lapho imisele yenyongo esibindini sethu yonakele futhi inyongo iqoqana emzimbeni. Lokhu kungaba ngezinye izikhathi okungenazimpawu, noma kungase kube nezimpawu ezifana nokukhathala okukhulu nokulunywa . Ngokuhamba kwesikhathi, lesi simo singaba sibi kakhulu. Ngakho-ke namuhla sikhuluma ngomuthi osanda kwethulwa obizwa ngokuthi i-Iqirvo (elafibranor) wokwelapha lesi sifo.
Iyini i-Iqirvo? Isebenza kanjani?
I-Iqirvo umuthi osiza ekwelapheni i-primary biliary cholangitis (PBC). Usebenza ngokunciphisa inani le-bile eliqongeleleka emzimbeni wakho. Uyazi ukuthi ukwenza kanjani lokho? Lo muthi ubonisa umzimba wakho ukuthi uyeke ukukhiqiza i-bile. Okusho ukuthi, ulawula ukukhiqizwa kwama -bile acid .
I-Iqirvo ivame ukunikezwa kanye nomunye umuthi. Lowo muthi yi-ursodeoxycholic acid. Kungenzeka ukuthi udokotela wakho ukunike lo muthi.
Lo muthi ucwaningwe kanjani?
Njenganoma yimuphi umuthi omusha, i-Iqirvo ihlolwe kabanzi ngaphambi kokuba inikezwe abantu. Lolu cwaningo luhilele abantu abangu-161 abane-PBC.
- Amaqembu amabili: Laba bantu bahlukaniswe ngamaqembu amabili. Iqembu elilodwa lanikezwa umthamo wansuku zonke we-Iqirvo 80 mg. Elinye iqembu lanikwa iphilisi le-placebo .
- Iyini i-placebo?: Liyiphilisi elingenalutho elingenawo umuthi osebenzayo futhi elibukeka njengomuthi. Linikezwa ukukala umphumela wangempela womuthi.
- Isikhathi: Ukwelashwa kwanikezwa ngale ndlela okungenani unyaka. Ngemuva kwalokho, labo ababefuna banikezwa ithuba lokuhlala ocwaningweni unyaka owodwa.
Abacwaningi babheke kakhulu amanani elabhorethri yesibindi egazini ukuze babone ukuthi umuthi uyasebenza yini. Isibonelo, babheke ukuthi amazinga e -alkaline phosphatase kanye ne-bilirubin athuthukile yini. Baphinde balinganisa ukuthi iziguli zaziluma kanjani besebenzisa isikali esibizwa ngokuthi i-Worst Itch Numeric Rating Scale (WI-NRS) emavikini angama-24 nama-52.
Yaba yini imiphumela yocwaningo?
Ekupheleni kocwaningo, ngithole izinto ezibaluleke kakhulu.
Kulabo abathathe i-Iqirvo, ama-51% (okungaphezu kwengxenye) abonise ukuthuthuka okukhulu emiphumeleni yokuhlolwa kwegazi okuhlobene nesibindi.
Kodwa-ke, yi-4% kuphela yalabo abathathe i-placebo ababonise lolu hlobo lokuthuthuka. Lokhu kukhombisa ngokusobala ukuthi i-Iqirvo inomphumela osebenzayo.
Ngokuphathelene nokulunywa, yize labo abathatha i-Iqirvo bathole impumuzo ethile, yayifana kakhulu nokukhululeka okwatholwa yilabo abathatha i-placebo. Ngakho-ke, kusenzima ukusho ukuthi uyini ngempela umphumela wokulunywa.
Okubaluleke kakhulu: Khumbula, lokhu kuyimiphumela yocwaningo. Imiphumela yakho ingase ihluke. Yingakho konke kufanele kuxoxwe ngakho nodokotela wakho.
Ubani okungafanele athathe i-Iqirvo?
Lo muthi awufanele wonke umuntu. Uma unezinye zezimo ezilandelayo, akufanele uthathe i-Iqirvo. Qiniseka ukuthi ukhuluma nodokotela wakho ngalokhu.
| Isimo | Incazelo |
|---|---|
| Isifo sesibindi esibi kakhulu | Uma unesifo sesibindi esibi kakhulu, ikakhulukazi isifo sokuqina kwesibindi esingasebenzi kahle. |
| Ukuvaleka kwenyongo | Uma une-bile duct evalekile esibindini sakho. |
| Ukukhulelwa | Uma ukhulelwe noma unethemba lokukhulelwa. |
| Ukuncelisa | Uma ungumama oncelisa ingane yakho. |
Imiphumela emibi nokuthi ungayiphatha kanjani?
Njenganoma yimuphi umuthi, i-Iqirvo ingabangela imiphumela emibi kwabanye abantu.Imiphumela emibi ingase ivele.
Ukuphuka Kwamathambo
Nakuba lokhu kungavamile, ocwaningweni, abanye abantu abathathe i-Iqirvo bake baphuka amathambo. Tshela udokotela wakho uma uke waphuka amathambo ngaphambili noma uma usengozini yokuphuka amathambo (njenge- osteoporosis ). Lezi zinto zingasiza ekugcineni amathambo akho eqinile:
- Yidla ukudla okucebile nge-calcium: izinto ezifana ne-yogurt, i-tofu, i-salmon. Uma kudingeka, thatha amaphilisi e-calcium njengoba kuqondiswe udokotela wakho.
- Thola iVithamini D : IVithamini D itholakala ekudleni okufana nenhlanzi enamafutha, amaqanda , kanye nokukhanya kwelanga.
- Vivinya umzimba njalo: Lokhu kuqinisa imisipha futhi kunciphisa ingozi yokuwa.
- Gwema ukubhema.
- Lawula ushukela notshwala.
Eminye imiphumela emibi evamile
Ngezansi kuneminye yemiphumela emibi abantu abaningi ababhekana nayo kanye nezinto ezilula ongazenza ngayo. Kodwa uma lokhu kuqhubeka , qiniseka ukuthi ubona udokotela wakho .
| Umphumela ongemuhle | Izinto ongazenza |
|---|---|
| Isicanucanu nokuhlanza | Phuza uketshezi olufana ne-ginger ale noma amanzi. Ukudla okuthambile okufana nama-crackers ne-toast kungasiza. |
| Ukuqunjelwa | Phuza amanzi amaningi. Yidla izithelo, imifino kanye ne-fiber eningi. Ama-probiotics afana ne-yogurt kanye ne-kefir alungile. |
| Isilungulela | Gwema izinto ezandisa ukuvuvukala, njengoshokoledi, ukudla okunamafutha, ikhofi, notshwala. Yidla ukudla okuncane kunokudla okuningi ngesikhathi esisodwa. Ungabuza udokotela wakho mayelana nokuthatha imithi yokunciphisa i-asidi. |
| Umlomo owomile | Hlafuna ushungamu noma amaswidi angenashukela. Phuza amanzi amaningi. Zama ukuphefumula ngamakhala akho esikhundleni sokuphefumula ngomlomo wakho. |
Ingabe i-Iqirvo ingasebenzisana neminye imithi? (Ukusebenzisana kwezidakamizwa)
Yebo, leli iphuzu elibaluleke kakhulu. I-Iqirvo ingasebenzisana neminye imithi oyithathayo. Lokhu kunganciphisa ukusebenza kahle komuthi noma kwandise imiphumela emibi.
| Uhlobo lomuthi | Imiphumela engaba khona kanye nezeluleko |
|---|---|
| Amaphilisi/izindlela zokuvimbela inzalo | Ukuthatha i-Iqirvo kunganciphisa ukusebenza kahle kwezindlela zokulawula ukuzalwa ngamahomoni (amaphilisi, ama-patches). Ngakho-ke, kubalulekile ukusebenzisa olunye uhlobo lokulawula ukuzalwa, njengamakhondomu, ngaphezu kwalokho. |
| Ama-statin, uhlobo lomuthi okwehlisa i-cholesterol | Ukuthatha le mithi emibili ndawonye kungandisa ingozi yobuhlungu noma ukulimala kwemisipha. Uma uzwa ubuhlungu obunjalo, tshela udokotela wakho ngokushesha. |
| Ama-sequestrant e-bile acid | Lena futhi imithi yokwelapha i-cholesterol. Lokhu kungavimba umzimba ekumunceni i-Iqirvo. Ngakho-ke, lo muthi kufanele uthathwe amahora ama-4 ngaphambi noma ngemva kokuthatha i-Iqirvo. |
| I-Rifampin | Lona umuthi olwa namagciwane osetshenziselwa ukwelapha isifo sofuba. Unganciphisa inani le-Iqirvo emzimbeni wakho. Uma uthatha yomibili le mithi, udokotela wakho uzokwenza ukuhlolwa kwegazi. |
Ngakho-ke, kubaluleke kakhulu ukutshela udokotela wakho ngayo yonke imithi oyithathayo, ngisho ne-vitamin noma umuthi we-Ayurvedic.
Umlayezo Wokuya Nawe Ekhaya
- I-Iqirvo umuthi omusha osetshenziselwa ukwelapha i-primary biliary cholangitis (PBC).
- Lokhu kusebenza kakhulu ngokunciphisa ukukhiqizwa kwenyongo emzimbeni nokulawula umonakalo esibindini.
- Ucwaningo lukhombisile ukuthi lokhu kusebenza kahle kakhulu ekuthuthukiseni imiphumela yokuhlolwa kwegazi okuhlobene nesibindi.
- Lokhu akufaneleki kwabesifazane abakhulelwe, abesifazane abancelisayo, kanye nalabo abanesifo sesibindi esibi kakhulu.
- Kubalulekile ukwazisa udokotela wakho ngeminye imithi oyithathayo, njengoba eminye imithi ingase ihlangane ne-Iqirvo.
- Khuluma nodokotela wakho ngokukhululekile nganoma yimiphi imiphumela emibi noma ukukhathazeka.
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