Cishe uyazi ukuthi i-Ankylosing Spondylitis (AS) iyisimo esithinta impilo yonke, esiqeda amandla ngandlela-thile. Uyazi ukuthi kunzima kangakanani ukubhekana nosuku nobuhlungu bomhlane kanye nokuqina kwasekuseni. Kodwa, kunezindaba ezinhle. Nakuba lesi sifo singelapheki ngokuphelele, singalawula izimpawu zaso ngemithi efanele, ukuzivocavoca, kanye nendlela yokuphila enempilo. Le mithi ingasiza ekumiseni noma ekubambezeleni ukuqhubeka kwezinkinga zomhlane.
Isinyathelo Sokuqala: Ama-NSAID - okwelapha ubuhlungu nokuvuvukala
Uma uya kudokotela, lolu uhlobo lokuqala lwemithi abazozama ukukunika yona ngalesi simo. Sibiza le mithi ngokuthi i-Nonsteroidal Anti-inflammatory Drugs, noma (ama-NSAID) ngamafuphi. Nakuba eminye yayo ingathengwa ekhemisi, eminye idinga ukunikezwa udokotela.
Kalula nje, le mithi isebenza ngokumisa ukukhiqizwa kwamakhemikhali abizwa ngokuthi ama-prostaglandin emizimbeni yethu abangela ukuvuvukala. Lokhu kunciphisa ubuhlungu nokuvuvukala kwakho. Ukuthatha le mithi ebusuku, ikakhulukazi, kungakusiza ulale kangcono futhi kunciphise ukuqina komhlane ekuseni.
Into ebaluleke kakhulu ukuthatha lo muthi ngesilinganiso nangesikhathi esibekiwe njengoba kunqunywe udokotela wakho . Ungayeki noma ushintshe umthamo ngokuthanda kwakho.
| Uhlobo lomuthi (i-NSAID) | Imiphumela emibi nokuthi yini okufanele uyazi |
|---|---|
| Lo muthi ungabangela ukucasuka kwesisu uma usetshenziswa isikhathi eside. Isibonelo:
Ngakho-ke, udokotela wakho angase akunikeze eminye imithi (njengemithi yokunciphisa i-asidi) ukuvikela isisu sakho kanye nalo muthi. Uma unomlando wesifo senhliziyo, kufanele utshele udokotela wakho nakanjani . Amanye ama-NSAID angandisa kancane ingozi yokuhlaselwa yinhliziyo noma isifo sohlangothi. |
Isinyathelo sesibili: Ama-DMARD - imithi yokulwa namathambo eguqula izifo
Ngezinye izikhathi ama-NSAID ewodwa angase anganeli ukulawula izimpawu zakho. Uma kunjalo, udokotela wakho angase akunike uhlobo lomuthi olubizwa ngokuthi (i-DMARDs) , olumelela i-Disease-Modifying Antirheumatic Drugs . Nakuba igama lingase lizwakale liyinkimbinkimbi, lokho elikwenzayo kulula. Lisebenza ngokunciphisa umonakalo emalungeni nasezicutshini zakho obangelwa ukuvuvukala. Lokhu kunciphisa ijubane lokuqhubeka kwesifo.
| Uhlobo lwemithi (i-DMARD) | Izinto okufanele uzazi ngokukhethekile |
|---|---|
| I-Sulfasalazine | Lokhu kuthathwa njengephilisi. Abanye abantu bangase babe nekhanda elibuhlungu, ukuqunjelwa, isicanucanu, kanye nezilonda emlonyeni. Akuvamile kakhulu ukuthi umnkantsha ungathinteka, ngakho udokotela wakho uvame ukuhlola igazi lakho lapho ekunika lo muthi. |
| I-Methotrexate | Lokhu kuza njengephilisi noma njengomjovo ongazinika wona. Ngokuqinisekile kuzodingeka uphuze iphilisi le-folic acid ngalokhu. Lokhu kwenzelwa ukugwema imiphumela emibi njengezilonda emlonyeni kanye nesicanucanu. Njengoba lokhu kuyimithi enamandla kancane, udokotela wakho uzohlola ukusebenza kwegazi nesibindi sakho njalo. Lo muthi awufanele abesifazane abakhulelwe noma labo abazama ukukhulelwa. |
Ama-Corticosteroids - impumuzo esheshayo yamalunga abuhlungu
Lezi uhlobo lwe-steroid. Udokotela wakho angakunika umjovo we-steroid, njenge-"Prednisone", ngqo esilungwini sakho esibuhlungu kakhulu nesivuvukele. Lokhu kuzokunikeza impumuzo ngokushesha ebuhlungwini nasekuvuvukeni.
Kodwa khumbula, lokhu akuyona indlela yokwelapha enikezwa wonke umzimba. Futhi, le mijovo ayikwazi ukunikezwa njalo. Ngokuvamile, udokotela unikeza le mijovo izikhathi ezimbalwa ngonyaka, kanye nekhefu lezinyanga ezimbalwa.
I-Biologics - indlela yokwelapha yakamuva nenamandla kakhulu
Uma ezinye izindlela zokwelapha zingasebenzi kuwe, udokotela wakho angakutshela ngalolu hlobo lokwelashwa olusha. Lokhu kubizwa ngokuthi yi-biologics . Kwenziwe ngamaseli aphilayo. Ngokukhethekile, le mithi ivimba amaprotheni abizwa ngokuthi ama-cytokine abangela ukuvuvukala ohlelweni lwethu lokuzivikela komzimba. Lokhu kuyindlela yokwelapha eqondiwe. Lokhu kuza njengemijovo. Ezinye zazo ungazinika wena ekhaya.
Izithibi ze-TNF
Lezi uhlobo lwe-biologic oluvame ukusetshenziswa ku-AS. I-TNF imele iphrotheni ebizwa ngokuthi ``Tumor Necrosis Factor''. Le mithi yelapha ukuvuvukala emgogodleni, emalungeni, emehlweni, nasemathunjini. Inganciphisa futhi ijubane lokuqhubeka kwe-AS.
- I-Adalimumab (i-Humira)
- I-Certolizumab pegol (Cimzia)
- I-Etanercept (Enbrel)
- I-Golimumab (i-Simponi)
- I-Infliximab (i-Remicade)
Izithibi ze-Interleukin (IL-17)
Uma izithibi ze-TNF zingasebenzi, udokotela wakho angase akuqalise kulolu hlobo.
- I-Ixekizumab (Taltz)
- I-Secukinumab (i-Cosentyx)
I-biologics iyimithi enamandla kakhulu. Yingakho inemiphumela emibi okufanele uyiqaphele. Udokotela wakho uzokuchazela konke lokhu ngaphambi kokuba uqale ukwelashwa.
| Izingozi ezinkulu kanye nemiphumela emibi ye-biologics | |
|---|---|
| Ingozi yokutheleleka | Ngenxa yokuthi le mithi icindezela amasosha omzimba ngezinga elithile, yandisa ingozi yokuthola izifo, ikakhulukazi isifo sofuba (TB). Ngakho-ke, kubalulekile ukuhlolwa isifo sofuba ngaphambi kokuqala le mithi. |
| Ezinye izingozi | - Ukwanda okuncane kakhulu kwengozi yomdlavuza wesikhumba. - Ingozi eyengeziwe yomdlavuza we-lymphoma ezinganeni. - Uma usuvele unesifo sokuvuvukala kwamathumbu (i-IBD), izimpawu zakho zingase zibe zimbi kakhulu. |
Uma ungazizwa ungcono ngemva kwezinyanga ezingaba ngu-3 zalokhu kwelashwa, udokotela wakho uzonquma ukuyeka umuthi noma akushintshele komunye umuthi webhayoloji.
Ithemba lokwelashwa kwesikhathi esizayo
Ososayensi okwamanje basebenza ukuthola imithi emisha engaguqula i-AS. Bafunda nokuthi izakhi zethu zofuzo zithinta kanjani lesi sifo. Lolu cwaningo lungaholela ekwelashweni okuphumelelayo kakhulu okuqondene nawe esikhathini esizayo.
Umlayezo Wokuya Nawe Ekhaya
- I-Ankylosing Spondylitis (AS) yisimo esihlala isikhathi eside, kodwa singalawulwa kahle ngokwelashwa okufanele kanye nendlela yokuphila.
- Ukwelashwa kuvame ukuqala ngama-NSAID. Uma lokhu kungalawuli isimo, kusetshenziswa imithi efana ne-DMARD noma i-biologics.
- Themba udokotela wakho. Landela imiyalelo yakhe ngqo. Yiya emitholampilo ngesikhathi bese uyohlolwa.
- Ungalokothi uyeke ukuthatha imithi yakho noma ushintshe umthamo ngokwakho. Uma unenkinga, khuluma nodokotela wakho.
- Kanye nemithi, ukuvivinya umzimba okufanele kanye nokudla okunempilo yizinto ezimbili ezibalulekile ukulawula lesi sifo.
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