Imajin, if yu bin no bifo tɛm se yu go mɔs gɛt Alzaima sik tumara bambay, wetin yu go du? Fɔ tru, wetin wi go du afta wi dɔn no dis kayn tin? Dis na big prɔblɛm we bɔku dɔktɔ dɛn ɛn pipul dɛn we de du risach de gɛt tide. Dis biɛn tɛm, wan grup we de stɔdi bɔt dis dɔn kam fɔ no se lɛk 20% pan di pipul dɛn we gɛt Alzaima sik kin no kwik kwik wan jɔs bay we dɛn luk dɛn jin. Na dat mek i rili impɔtant fɔ tɔk bɔt dis.
Wetin na dis APOE4? Wetin mek i gɛt fɔ du wit Alzaima sik?
Fɔ tɔk am simpul wan, dis `APOE` na jin na wi bɔdi. di men wok we i de du na fכ εp fכ transpכt fεt dεm lεk kכ lestכ l na wi bכdi. difrεn vεryכnt dεm de fכ dis `APOE` jin. Wi kin gɛt dis jin, wan frɔm wi mama ɛn di ɔda wan frɔm wi papa.
Mɔs pipul dɛn gɛt di kayn we we dɛn kɔl `APOE3`, bɔt sɔm pipul dɛn kin gɛt di we we dɛn kɔl `APOE4`.
- pan avrej, lεk 20% pan di pipul dεm gεt wan kכpi fכ di `APOE4` jin.
- כltu, lεk 2% pan di pipul dεm de gεt tu kכpi dεm fכ di `APOE4` jin (frכm di mama εn di papa tu). insay mεdikal tεm, wi kin kכl dεn pipul ya `(APOE4 homozygotes)`.
Fɔ lɔng tɛm naw dɛn dɔn no se pipul dɛn we gɛt ɔl tu di kɔpi dɛn fɔ di APOE4 jin kin rili gɛt bɔku sik we dɛn kɔl Alzaima .
Wetin di las risach we dɛn dɔn du se?
Wan stɔdi we dɛn jɔs du we dɛn pul na wan big big mɛdikal magazin we dɛn kɔl Nature Medicine, bin tɔk mɔ bɔt dis. Dɛn bin analayz di wɛlbɔdi data fɔ 3,300 bren we dɛn gi ɛn 10,000 pipul dɛn.
Na de dɛn fɛn sɔntin we sɔprayz: 95% pan di pipul dɛm we gɛt ɔl tu di kɔpi dɛm fɔ di APOE4 jin bin gɛt chenj (bayɔmakɛr) we gɛt fɔ du wit Alzaima sik na dɛn bren ɔ bɔdi wata.
Dɛn chenj ya kin bigin arawnd di ej 55. Dɛn kin bigin fɔ gɛt dis sik arawnd di ej 65. Fɔ dɔn, dɛn bin no se dɛn gɛt dis maynia sik , we na wae pɔrsin kin mɛmba ɛn tink bad bad wan, arawnd wae i ol 74 ia.
Fɔ tɔk am simpul wan, di wan dɛn we de stɔdi bɔt dis tɔk se fɔ gɛt tu kɔpi fɔ APOE4 na tin we pɔsin kin disayd fɔ du pas fɔ mek i ‘de mek di prɔblɛm bɔku.’ If dis na tru, Alzaima sik kin bi di sik we pɔsin kin gɛt frɔm in mama ɛn papa na di wɔl.
De bɛst tin bɔt dis na dat, tumara bambay, chans kin de fɔ no ɛn trit pipul dɛm wae gɛt bren sik bifo dɛn si di sik.
So, yu tink se ɔlman fɔ tek dis tɛst?
Na dis na di kwɛstyɔn we impɔtant pas ɔl. Di ansa na, nɔ! We wi tink bɔt di tin we de apin naw, di mɛdikal ɔganayzeshɔn dɛn nɔ kin se dɛn fɔ du dis tɛst fɔ ɔlman, ilɛksɛf dɛn gɛt di sik. Bɔku rizin dɛn de fɔ dat.
Ɔndastand di tin dɛn we dis risach nɔ ebul fɔ du
- Etnik: Dɛn bin du dis risach mɔ pan wayt pipul dɛn we kɔmɔt na Yurop. So i nɔ klia yet to aw dɛn rizɔlt ya de apin to pipul dɛn na wi kɔntri, dat na, pipul dɛn na Eshia.
- Nature of the sample: Dɛn bin gɛda di data frɔm pipul dɛm wae tek pat pan Alzheimer’s risach, so dɛn kin gɛt smɔl difrɛn prɛdispɔzishɔn fɔ di sik pas di jenɛral pipul dɛm.
Nɔto ɔlman kin gɛt di sik.
Dis na di tin we impɔtant pas ɔl we de kɔrej wi . Di risach insɛf se nɔto ɔlman we gɛt ɔl tu di kɔpi dɛm fɔ `APOE4` dɔn gɛt di sik . Sɔm pipul dɛn dɔn liv fayn fayn wan te to dɛn 80 ia ɛn nɔr gɛt ɛni sayn fɔ gɛt dis maynia sik. Dɔn bak, di ej we di sik kin bigin kin difrɛn frɔm wan pɔsin to ɔda pɔsin.
| Pros fɔ tek di tɛst | Kɔns & Risk fɔ Tek di Tɛst |
|---|---|
| Yu kin no bifo tɛm bɔt di prɔblɛm. | I kin gɛt siriɔs strɛs ɛn wɔri. |
| Big tɛmt de fɔ chenj layf (it, drink, ɛksesaiz). | Di rizulyt nɔto 100% shɔ. I nɔr pɔsibul fɔ tɔk fɔ tru if di sik go kam ɔr na us ej i go gɛt. |
| Yu kin fit fɔ gɛt nyu tritmɛnt ɔ risach tumara bambay. | Naw, no tritmɛnt nɔ de fɔ ɔltɛm we go mek dɛn nɔ gɛt dis sik. |
| Famili dɛn kin gɛt sɔm aidia bak bɔt di risk we dɛn kin gɛt. | Tin dɛm lɛk inshɔrans ɛn wok kin afɛkt tumara bambay (ethical issues). |
If yu de tink bɔt dis tɛst, wetin yu fɔ du?
Imajin se sɔmbɔdi na yu famili gɛt Alzaima ɛn yu de wɔri bɔt am. If yu de tink bɔt dis `APOE4` tɛst, na sɔm tin dɛn fɔ mɛmba.
1. Nɔ jɔs tek di tɛst: Nɔ tek dis kayn tɛst jɔs bikɔs yu want fɔ no mɔ. Tek tɛm mɔ wit di tɛst dɛn we dɛn kin ɔda na di Intanɛt.
2. Tɔk to yu dɔktɔ: Fɔs, tɔk to yu famili dɔktɔ ɔ wan dɔktɔ we de mɛn yu nyuro bɔt dis. Tɔk bɔt yu famili istri ɛn di tin dɛn we yu de fred.
3. Jɛnɛtik Kɔnsul impɔtant : If yu go gɛt tɛst lɛk dis, i nɔ fɔ jɔs bi fɔ gɛt di ripɔt. I rili impɔtant fɔ tɔk to pɔsin we de advays yu bɔt yu jɛnɛtiks ɔ dɔktɔ we spɛshal pan dis bifo ɛn afta. Yu nid fɔ ɛksplen wetin de rizɔlt min, aw e go afɛkt yu layf, ɛn aw fɔ bia wit di saykilɔjik impak we i go gɛt.
4. Tink bɔt tin dɛn we yu go ebul fɔ kɔntrol: Wi nɔ go ebul fɔ chenj wi jin. Bɔt bɔku tin dɛn de we wi go ebul fɔ kɔntrol. Di bɛst tin we wi kin du na fɔ liv layf we fayn fɔ mek wi bren gɛt wɛlbɔdi .
- It di it we balans.
- Ɛksesaiz ɔltɛm .
- Gɛt gud slip na nɛt.
- Kɔntrol di blɔd prɛshɔn, dayabitis, ɛn kɔlɔstrel lɛvɛl.
- Du tin dɛm we de chalenj di bren (rid buk, sɔlv pazl, lan nyu tin).
- Bi pɔsin we de wit ɔda pipul dɛn.
Wan dɔktɔ we dɔn wok fɔ lɔng tɛm se, "A dɔn ivin chenj di langwej we a de tɔk to di wan dɛn we sik naw. A nɔ de ɛva se pɔsin 'de sɔfa wit sik.' A se dɛn de ‘liv wit nyurokognitiv chenj dɛm.'" Dis de sho aw impɔtant op ɛn fayn abit impɔtant.
Mɛsej we dɛn kin kɛr go na os
- di `APOE4` jin na big risk fכ Alzaima sik, spεshal if yu gεt tu kכpi pan am, we de inkrεs yu risk bכku bכku wan.
- Pan ɔl we di risach we dɛn jɔs du dɔn kɔnfɔm dis kɔnekshɔn mɔ, dɛn nid fɔ stɔdi mɔ fɔ no aw di tin dɛn we i dɔn fɛn gɛt sɔntin fɔ du wit wi pipul dɛn.
- Nɔto ɔlman we gɛt dis jin go gɛt dis sik. Pipul dɛn de wae kin ol ɛn nɔr kin gɛt sɔm kayn sik.
- Naw, i nɔ fayn fɔ tɛst fɔ APOE4 ɔltɛm pan pipul dɛn we nɔ gɛt ɛni simptom.
- If yu gɛt ɛnitin fɔ wɔri ɔr kwɛstyɔn bɔt dis, di bɛst tin fɔ du na fɔ tɔk to yu dɔktɔ bɔt aw fɔ advays yu jɛnɛtiks.
- Bifo yu wɔri bɔt jin, yu kin ridyus di prɔblɛm we yu gɛt bay we yu de liv layf we fayn fɔ yu bren we wi go ebul fɔ kɔntrol.
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