Xa ufumanisa ukuba unomhlaza, uziva uloyiko olukhulu kwaye wothukile. Emva koko, xa oogqirha bethetha ngonyango, uva amayeza amaninzi amatsha kunye namagama amatsha ongawaqondiyo. Ngamanye amaxesha, xa ungaziqondi kakuhle ezi zinto, uloyiko lwakho luyanda nangakumbi. I-Avastin liyeza elahlukileyo kancinci elisetyenziswa kunyango lomhlaza . Ngoko ke namhlanje, masithethe ngeli yeza libizwa ngokuba yi-Avastin (Bevacizumab) ngendlela elula onokuyiqonda.
Okokuqala, masibone ukuba zeziphi izithinteli ze-Angiogenesis ezisetyenziswa leli yeza.
Ukuze siqonde oku, masisebenzise umzekelo olula. Khawucinge ngethumba leseli yomhlaza elifana nokhula olubi olukhula emyezweni wethu. Yintoni efunekayo ukuze olu khula lukhule kwaye lusasazeke kulo lonke igadi? Ngokuqinisekileyo lufuna amanzi. Ngokufanayo, ithumba lomhlaza likwafuna ukunikezelwa kwegazi ukuze likhule kwaye lisasazeke kwamanye amalungu omzimba.
Ngoko ke lo mhlaza unobuqili kakhulu. Uthumela "umqondiso" emzimbeni wethu ukuze ufumane igazi olifunayo kwaye ukhule imithambo yegazi emitsha . Kanye njengokuba eso sityalo sokhula sikhulisa inkqubo entsha yombhobho phantsi komhlaba ukuze sizise amanzi. Amayeza abizwa ngokuba yi -angiogenesis inhibitors ayayimisa ukukhula kwale mithambo yegazi mitsha. Oko kukuthi, avimba "imithambo yegazi" eya kumhlaza. Emva koko, xa igazi lilahlekile, umhlaza awukwazi ukukhula okanye ukusasazeka.
Ngoko ke isebenza njani i-Avastin (iBevacizumab)?
I-Avastin liyeza elikwiklasi ye-Angiogenesis inhibitor esithethe ngayo apha ngasentla. Ngokuchanekileyo, eli liyeza elikwiklasi ekhethekileyo ebizwa ngokuba yi-Monoclonal antibody .
Ngoku usenokuba uyazibuza ukuba yintoni i-monoclonal antibody. Ngamafutshane, yiproteni yokwenziwa eyenziwe ngokukodwa kwilebhu, efana nee-antibodies eziveliswa ngumzimba wethu ukulwa nezifo. Into ekhethekileyo ngale nto kukuba ayichaphazeli zonke iiseli emzimbeni njengeziyobisi ze-chemotherapy eziqhelekileyo, kodwa ichaphazela kuphela iiseli zomhlaza kunyango olujoliswe kulo .
I-Avastin ijolise kwi -VEGF (Vascular Endothelial Growth Factor)Imolekyuli. Besitshilo ngaphambili ukuba umhlaza uthumela "umqondiso" wokwenza imithambo yegazi emitsha, kwaye loo mqondiso yi-VEGF. Into eyenziwa yi-Avastin kukuba incamathisele kule molekyuli ye-VEGF ize iyimise ukusebenza. Kufana "nokucima" uphawu. Xa i-VEGF iyeka ukusebenza, imithambo yegazi emitsha ayibumbi, kwaye umhlaza ulahlekelwa sisondlo sawo.
Ngaba kufuneka ndisebenzise i-chemotherapy xa ndithatha i-Avastin?
Ewe, le yingxaki kubantu abaninzi. Nangona i-Avastin ilunyango olujoliswe kuyo, ayisebenzi yodwa . Ifana nomdlali oxhasayo. Umdlali oyintloko webali, oyi-chemotherapy, usafuneka.
I-Chemotherapy luhlobo olunamandla lweyeza elibulala iiseli ezahlukana ngokukhawuleza (ezifana neeseli zomhlaza). I-Avastin isebenza ngokuncedisa i-chemotherapy.
Kodwa eyona nto ilungileyo kukuba, xa i-Avastin idityaniswe ne-chemotherapy, iziphumo ze-chemotherapy ziphumelela ngakumbi. Oko kukuthi, xa la mayeza mabini edityanisiwe, ukulwa nomhlaza kuba namandla ngakumbi. Ngokunciphisa ukuhanjiswa kwegazi kwi-tumor, amayeza e-chemotherapy abulala iiseli zomhlaza.
Zeziphi iintlobo zomhlaza ezinyangwa nge-Avastin?
I-Avastin ivunyiwe kwiintlobo ezininzi zomhlaza . Nangona kunjalo, ayinikwa zonke iintlobo zomhlaza. Ugqirha wakho uya kugqiba ukuba eli yeza lifanelekile na kuwe ngokusekwe kuhlobo lomhlaza onalo, inqanaba lalo, kunye nempilo yakho iyonke.
Itheyibhile engezantsi ibonisa ezinye zezona ntlobo zixhaphakileyo zomhlaza ezisetyenziselwa i-Avastin.
| Uhlobo lomhlaza | Ulwazi olubalulekileyo |
|---|---|
| Umhlaza weColon okanye weRectal | Isetyenziswa kakhulu kwiimeko apho umhlaza usasazeke kwamanye amalungu omzimba (i-metastatic). Idla ngokusetyenziswa kunye namayeza e-chemotherapy afana ne -5-fluorouracil (5-FU) okanye i-capecitabine (Xeloda) . |
| Umhlaza wemiphunga | Isetyenziselwa ezinye iintlobo zomhlaza wemiphunga ophucukileyo. |
| Umhlaza wezintso | Isetyenziselwa i-metastatic renal cell carcinoma. |
| Umhlaza we-Ovarian | Isetyenziswa njengonyango lwezinye iimeko zomhlaza wesibeleko. |
| Umhlaza woMlomo | Isetyenziselwa umhlaza womlomo wesibeleko obuye wavela okanye wasasazeka. |
| I-Glioblastoma | Olu luhlobo lomhlaza wobuchopho, kwaye olu nyango lunokunikwa xa isifo siphinda sibuye. |
Ngaba i-Avastin ayinikwa umhlaza webele?
Nangona i-Avastin yayisetyenziswa ngaphambili ukunyanga umhlaza webele, izifundo ezalandelayo zaqinisekisa ukuba iingozi zeziphumo ebezingalindelekanga zingaphezulu kuneengenelo zale yeza. Ngenxa yoko, amaziko afana ne-FDA eMelika ayisavumi ukusetyenziswa kwe-Avastin kumhlaza webele.
Ngaba i-Avastin ingawunyanga ngokupheleleyo umhlaza wamathumbu amakhulu?
Hayi. I-Avastin ayisiyo "iyeza lomlingo" eliza kunyanga umhlaza ngokupheleleyo. Nangona kunjalo, uvavanyo lweklinikhi lubonise ukuba eli yeza linokwandisa ubomi bezigulane kakhulu . Umzekelo, ezinye izifundo zifumanise ukuba izigulane ezafumana i-Avastin nge-chemotherapy ziphila ixesha elide kangangeenyanga ezi-5 kunezo zafumana i-chemotherapy yodwa. Siyazi ukuba eli xesha lixabiseke kangakanani kumntu olwa nomhlaza.
Zithini iziphumo ebezingalindelekanga ze-Avastin?
Njengalo naliphi na iyeza elinamandla, i-Avastin inokuba nemiphumo emibi. Nangona kunjalo, ayinguye wonke umntu oyithathayo oza kuba nemiphumo emibi . Nangona kunjalo, kubaluleke kakhulu ukuqaphela oku. Oku kuya kukunceda uqaphele naziphi na iimpawu kwaye wazise ugqirha wakho ngoko nangoko.
Apha ngezantsi kukho ezinye zeziphumo ebezingalindelekanga ezinzulu neziqhelekileyo ezinokubakho.
| Iziphumo ebezingalindelekanga ze-Avastin | |
|---|---|
| Imiphumela | Yintoni ekufuneka uyazi ngale nto |
| Iziphumo ebezingalindelekanga ezinzulu ekufuneka zixelwe kugqirha ngoko nangoko | |
| Ukugqobhoza kwamathumbu | Le yimeko embi kakhulu. Iimpawu zingabandakanya iintlungu eziqatha zesisu, umkhuhlane, kunye nokucaphuka. Kusenokufuneka utyando. |
| Ukopha ngaphakathi | Oku kunokukhokelela kwiimeko ezisongela ubomi ezifana nesifo sohlangothi. |
| Ukuphola kwenxeba okulibazisekileyo | Ugqirha ulumke kakhulu xa enika eli yeza ngaphambi okanye emva kotyando. |
| Ukumelwa yintliziyo | Umngcipheko uphezulu kakhulu xa usetyenziswa kunye nezinye iziyobisi ze-chemo ezichaphazela intliziyo. |
| Umonakalo wezintso | Iimpawu ezinje ngokwanda kweproteni kumchamo zinokubakho. |
| Ezinye iziphumo ebezingalindelekanga eziqhelekileyo (xelela ugqirha) | |
| Igazi elonyukayo | Kubalulekile ukujonga uxinzelelo lwegazi rhoqo ngexesha lonyango. |
| Ukudinwa | Le yimpembelelo eqhelekileyo ye-chemotherapy. |
| Amahlwili egazi emithanjeni | Qaphela iimpawu ezinje ngokudumba kwemilenze kunye nentlungu. |
| Urhudo, intloko ebuhlungu, ukungabi namdla wokutya, izilonda emlonyeni | Ezi zihlala ziziphumo ebezingalindelekanga ezilawulekayo. |
| Igazi kumchamo | Ufanele wazise ugqirha wakho ngoko nangoko ukuba uqaphela oku. |
Eyona nto ibalulekileyo kukuba, ukuba unayo nayiphi na kwezi mpawu, musa ukucinga nje ukuba, "Oku akukho nto." Yazisa ugqirha wakho okanye isebe elifanelekileyo lesibhedlele apho unyangwa khona ngoko nangoko. Okukhona uxela ngokukhawuleza, kokukhona kuya kuba lula ukulawula imeko.
Umyalezo Wokuya Ekhaya
- I-Avastin (iBevacizumab) ayisiyoyeza lekhemotherapi eliqhelekileyo. Lunyango olujoliswe kulo oluthintela ukwakheka kwemithambo yegazi ehambisa igazi kwiiseli zomhlaza.
- Eli yeza alisetyenziswa lodwa. Lisetyenziswa kunye ne-chemotherapy ukuze lisebenze kakuhle.
- Oku kusetyenziswa kuphela kwiintlobo ezithile zomhlaza, ezifana ne-colon, i-lung, i-kidney, kunye ne-ovarian.
- Ngenxa yokuba iziphumo ebezingalindelekanga zinokubakho, kubalulekile ukuba wazise ugqirha wakho ngoko nangoko ngazo naziphi na iimpawu ezingaqhelekanga ngexesha lonyango.
- Ukuba wena okanye umntu omthandayo unikwe i-Avastin njengonyango lomhlaza, qiniseka ukuba uxoxa ngayo nayiphi na imibuzo okanye iinkxalabo onazo nogqirha wakho . Baya kukwazi ukukunika ulwazi oluchanekileyo.
I-Avastin, iBevacizumab, umhlaza, unyango lomhlaza, ichemotherapy, i-angiogenesis inhibitor, amayeza omhlaza, iziphumo ebezingalindelekanga, ipilika prathikara, i-anathuru abada, unyango lomhlaza i-sinhala
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