Ngaba ugqirha wakho ukuxelele ngohlobo lwamayeza abizwa ngokuba yi-SERMs okanye ii-SERDs zokunyanga umhlaza webele? Ungakhathazeki, la magama asenokuvakala entsonkothile. Namhlanje, siza kuthetha ngokulula malunga nokuba ziyintoni, indlela ezisebenza ngayo, kunye noko kufuneka ukwazi ngazo. Ezi ziintlobo ezimbini ezibaluleke kakhulu zamayeza ezinokusinceda silwe nomhlaza webele .
Zithini ii-SERM? Zisebenza njani?
Ngamafutshane, ii-SERM (Selective Estrogen Receptor Modulators) luhlobo lwamayeza oluthintela ukukhula kweeseli zomhlaza webele. Nangona kunjalo, zisebenza kuphela kuhlobo oluthile lomhlaza. Olu hlobo lomhlaza olwaziwa ngokuba yi -Estrogen Receptor-Positive . Yi-75% kuphela yomhlaza webele obonwa kwilizwe lethu ongowolu hlobo.
Khawucinge nje, ezi seli zomhlaza zine "antenna" ezincinci kumphezulu wazo. Kwizonyango, sizibiza ezi receptors . Xa i-hormone estrogen emzimbeni wethu inamathela kwezi antenna, iseli yomhlaza ifumana isibonakaliso "sokwahlukana nokukhula ngakumbi."
Nantsi into eyenziwa yi-SERMs :
Bayahamba baze bavale ezo antenna, oko kukuthi, ii-receptors. Emva koko i-hormone ye-estrogen ayinandawo yokuzincamathela. Ngenxa yokuba ingafumani signal, ukukhula kweeseli zomhlaza kuyayeka okanye kulawulwa kakhulu.
Into ebalulekileyo kukuba, ibizwa ngokuba 'kukukhetha' ngesizathu esithile. Nangona la mayeza ethintela ukusebenza kwe-estrogen emabeleni, avumela i-hormone ukuba isebenze kakuhle kwezinye iindawo zomzimba, njengamathambo kunye nesibeleko. Yiyo loo nto iwenza abe akhethekileyo.
Iintlobo zee-SERM kunye nokusetyenziswa kwazo
Kukho iintlobo ezininzi eziphambili ze-SERMs ezivunyiweyo kumhlaza webele .
| Igama lesiyobisi | Iimeko eziphambili zokusetyenziswa |
|---|---|
| Tamoxifen |
|
| I-Toremifene | |
| I-Raloxifene |
Ngoko ke zithini ii-SERD?
Ii-SERD (i-Selective Estrogen Receptor Downregulators) luhlobo lwamayeza asebenza ngamandla ngakumbi kunee-SERM. Njengee-SERM, zikwavimba ii-estrogen receptors. Kodwa ukongeza, ii-SERD zinciphisa inani lee-receptors (zinciphisa) kwaye zitshintsha nomsebenzi wee-receptors ezisele, nto leyo ezenza zingasebenzi kakuhle.
Okwangoku kukho iintlobo ezimbini ze-SERDs ezivunyiweyo:
- I-Fulvestrant
- I-Elacestrant
Ezi zinikwa ikakhulu umhlaza webele ophucukileyo, one-hormone receptor-positive kunye ne -HER2-negative . I-HER2-negative ithetha ukuba iiseli zomhlaza azinaproteni ebizwa ngokuba yi-HER2 kumphezulu wazo enceda ekukhuleni.
Ungayisebenzisa njani le yeza?
- Ii-SERM: Uninzi lwazo luza ngendlela yeepilisi . Ugqirha wakho uza kukuxelela ukuba uthathe i-20mg ukuya kwi-40mg ngosuku. Ukuba usebenzisa la mayeza ukuthintela umhlaza ukuba ungabuyi, kuya kufuneka uqhubeke uwasebenzisa iminyaka emi-5 ukuya kweli-10.
- Ii-SERD: Umzekelo, iFulvestrant iza njengeenaliti.Eyesibini. Ezi naliti zimbini zifakwa kwisihlunu esisempundu. Zinikwa kathathu ngenyanga yokuqala yonyango, emva koko kube kanye ngenyanga emva koko.
Ziziphi iimeko apho ii-SERM kunye nee-SERD zinikwa khona?
Kukho iimeko ezininzi apho ugqirha wakho anokukunika olu nyango.
| Amathuba | Ingcaciso |
|---|---|
| Ngaphambi kotyando (Unyango lweNeoadjuvant) | Ukuba ithumba lakho likhulu, eli yeza lingasetyenziswa ngaphambi kotyando ukuze linciphe kwaye kube lula ukulisusa. |
| Emva kotyando (Unyango oluNcedisayo) | Olu nyango lunikezelwa ukutshabalalisa naziphi na iiseli zomhlaza ezincinci ezinokuthi zihlale emva kotyando kunye nokuthintela umhlaza ukuba ungabuyi. |
| KwiCancer yeXesha Eliqhelekileyo | Ukuba umhlaza usasazeke kwezinye iindawo zomzimba ezingaphandle kwebele, la mayeza anokunceda ukulawula okanye ukucothisa ukukhula kwawo. |
| Ukuthintela | Nokuba awuzange ube nomhlaza webele, ukuba umngcipheko wakho wokuba nawo uphezulu kunomndilili ngenxa yezinto ezifana nemfuza, ii-SERM zinokumiselwa ukunciphisa loo mngcipheko. |
Zithini iziphumo ebezingalindelekanga kunye neengozi zezi ndlela zonyango?
Njengayo nayiphi na imithi, ezi zinokuba nemiphumo emibi. Kodwa ayinguye wonke umntu ozifumanayo. Kubalulekile ukuqaphela iziphumo ebezingalindelekanga.
Iziphumo ebezingalindelekanga ze-SERMs
Iziphumo ebezingalindelekanga ezidla ngokubonakala zifana nezo zibakho ngexesha lokuya exesheni.
- Ubushushu obugqithisileyo
- Ukoma kwesitho sangasese, ukuphuma kwegazi, okanye ukopha kancinci
- Ukubila ebusuku
- Isicaphucaphu
- Utshintsho lweemvakalelo
Iziphumo ebezingalindelekanga ezingaqhelekanga kodwa ezibi kakhulu:
- Ukwanda okuncinci kakhulu komngcipheko womhlaza wesibeleko
- Amahlwili egazi emilenzeni (iDeep Vein Thrombosis, okanye iDVT) okanye amahlwili egazi emiphungeni (iPulmonary Embolism)
- IiCataracts
- Ukuncitshiswa kwamathambo kubafazi ngaphambi kokuya exesheni
Iziphumo ebezingalindelekanga ze-SERDs
- Intlungu yexeshana kwindawo yokujova
- Isicaphucaphu
- Intlungu yamathambo, yemisipha, okanye yamalungu
- Intloko ebuhlungu
- Ukusebenza nzima
- Ubushushu obugqithisileyo
Kubaluleke kakhulu: Ii-SERD zinokunciphisa inani lee-platelet, ezinceda ukujiya kwegazi. Oku kunokunyusa kancinci umngcipheko wokopha. Kwakhona, omabini la mayeza akakhuthazwa ngexesha lokukhulelwa okanye ukuba uzama ukukhulelwa . Kubalulekile ukusebenzisa uhlobo lokulawula ukuzalwa olungelulo olwehomoni ngelixa usebenzisa la mayeza kwaye ubuncinane unyaka emva kokuyeka unyango.
Ukuba ugqirha wakho ucebisa olu nyango, thetha naye ngalo. Musa ukoyika ukubuza imibuzo efana nale, "Ziziphi izibonelelo eziza kundinika eli yeza?", "Ziziphi iziphumo ebezingalindelekanga endinokuzilindela?", kunye "Ndiza kufuneka ndithathe eli yeza ixesha elingakanani?"
Umyalezo Wokuya Ekhaya
- Ii-SERM kunye nee-SERD ziyindlela yonyango esebenzayo kakhulu yomhlaza webele one-estrogen receptor. Zithintela ukusebenza kwehomoni ye-estrogen, ebalulekileyo ekukhuleni kweeseli zomhlaza.
- Ayizizo zonke ezi mithi ezifanelekileyo kumntu wonke. Ngugqirha wakho kuphela onokukumisela unyango olungcono ngokuxhomekeke kuhlobo lomhlaza, ubudala bakho, kunye nempilo yakho.
- Iziphumo ebezingalindelekanga zinokubakho, kodwa uninzi lwazo ziyalawuleka. Thetha nogqirha wakho ngayo nayiphi na ingxaki oyifumanayo, nokuba incinci kangakanani na.
- Kubaluleke kakhulu ukuphepha ukukhulelwa ngelixa usebenzisa la mayeza. Qiniseka ukuba uqhagamshelana nogqirha wakho malunga neendlela ezifanelekileyo zokulawula ukukhulelwa.
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