Xa wena okanye umntu omaziyo efumana
unyango lomhlaza , oko kukuthi,
i-chemotherapy , njengoko sonke sisazi, oogqirha badla ngokuthi, "Kufuneka ulumke, kuba iiseli ezilwa nesifo zinokuncipha." Isizathu soku kukuba xa iiseli zomhlaza zitshatyalaliswa, iiseli ezisempilweni ezibalulekileyo emizimbeni yethu nazo zinokutshatyalaliswa ngandlela ithile. Ngoko ke, kukho uhlobo oluthile lwamayeza olunceda ukuzikhusela komzimba ngeli xesha. Yiloo nto sithetha ngayo namhlanje.
Ngamafutshane, yintoni i-G-CSF?
I-G-CSF liyeza elinceda imizimba yethu ukuba yenze
ii-neutrophils ezingaphezulu, uhlobo lweeseli ezimhlophe zegazi ezinceda imizimba yethu ukuba ilwe nezifo. Ezi neutrophils zifana namajoni okuzikhusela aphambili emzimbeni wethu. Xa izinto ezifana
neentsholongwane , iintsholongwane kunye neebhaktheriya zingena emzimbeni, ezi seli ziyalwa nazo kwaye zisisindise ekuguleni. Ukuba sijonga intsingiselo yegama elithi G-CSF, singakuqonda ngcono oku:
- I-Granulocyte: Eli ligama elinikwa uhlobo lweseli emhlophe yegazi . Ii-neutrophils nazo luhlobo lwe-granulocyte. I-G-CSF ikakhulu ikhuthaza ukuveliswa kwezi neutrophils.
- I-Colony-Stimulating Factor: Oku kufana neproteni exelela iiseli "into ekufuneka zenze." I-G-CSF inokuxelela iseli ye-stem kwi- bone marrow yethu, "Uza kuba yi-neutrophil ngoku." Ingaxelela ne-neutrophil ekhoyo ukuba "yahlule kwaye iphindaphindeke."
Ngamafutshane, i-G-CSF liyeza eliya kumongo wethu wethambo lize lithumele umyalezo othi, "Ingxamiseko! Sifuna amajoni okhuselo angakumbi (ii-neutrophils), zenze ngokukhawuleza kwaye zikhuphele egazini."
Zeziphi iimeko ezisetyenziselwa i-G-CSF?
I-G-CSF isetyenziswa kakhulu ukunyanga nokuthintela
i-neutropenia . I-Neutropenia kuxa inani lee-neutrophils egazini liphantsi kunesiqhelo. Xa oku kusenzeka, amandla omzimba okulwa nosulelo ayancipha kakhulu. Kukho izizathu ezininzi eziphambili zokuba ugqirha wakho angakunika eli yeza.
Ngexesha lonyango lomhlaza (iKhemotherapy)
Xa amayeza e-chemotherapy ebulala iiseli zomhlaza, anokubulala nee-neutrophils ezisempilweni. Yiyo loo nto i-neutropenia ixhaphake kakhulu emva kwe-chemotherapy. Ngamanye amaxesha oku kunokuba yingozi ebomini. I-G-CSF iyanciphisa le ngozi ngokuvuselela umongo wethambo ukuba uvelise ii-neutrophils ezintsha ngokukhawuleza.
Ngexesha lokufakelwa i-stem cell
Abantu abanomhlaza okanye izifo ezithile zegazi banokufuna ukufakelwa iiseli ze-stem. I-G-CSF inceda kule nkqubo ngaphambi nasemva kwayo.
- Ngaphambi kokufakelwa: Xa kunikwa i-G-CSF, inani elikhulu lee-stem cells ezivela kumongo wethambo zikhutshwa ziye egazini. Oogqirha emva koko baqokelela ezo stem cells ziphilileyo.
- Emva kokufakelwa: Emva kokuba iiseli ezingaqhelekanga emzimbeni wesigulana zitshatyalalisiwe, iiseli zokuqala eziphilileyo ebeziqokelelwe ngaphambili zibuyiselwa emzimbeni. I-G-CSF inceda ezo seli zikhule kakuhle kwaye zibe ziiseli zegazi eziqhelekileyo.
Ezinye iimeko ze-neutropenia
Abanye abantu bazalwa bene-neutropenia enzima. Abanye banokuba nale meko ngaphandle kwesizathu esicacileyo. Kwezi meko, i-G-CSF ikwasetyenziselwa ukwandisa amanqanaba e-neutrophil.
Iintlobo ze-G-CSF kunye nendlela ezinikwa ngayo
Iyeza i-G-CSF liyafumaneka kwimarike ngamagama ahlukeneyo. La mayeza ahluka kancinci ngokwexesha lokusebenza kwawo kunye nenkqubo yokwenziwa kwawo.
| Uhlobo lweziyobisi | Inkcazo kunye nemizekelo |
|---|
| I-G-CSF esebenza ixesha elifutshane | Ezi zihlala zifuna ukuselwa yonke imihla. Iyeza eliphambili yiFilgrastim (igama lophawu: Neupogen®). Kukho amayeza amaninzi afanayo, akhuselekileyo nasebenzayo (ii-biosimilars). |
| I-G-CSF esebenza ixesha elide | Ezi zihlala ixesha elide emzimbeni, ngoko ke akufuneki uhlatywe rhoqo. Iyeza eliphambili yiPegfilgrastim (igama lophawu: Neulasta®). Kunokwanela ukufumana inaliti enye phakathi kwezihlandlo ezibini zechemotherapy. |
Eyona nto ibalulekileyo kukuba ugqirha wakho amisele uhlobo kunye nomlinganiselo wamayeza afanelekileyo kuwe.
I-G-CSF idla ngokunikezelwa njengenaliti engaphantsi kwesikhumba. Ngamanye amaxesha inikwa njengenaliti ye-IV. Ukuba unako ukuzinika inaliti ekhaya, ugqirha wakho okanye umongikazi uya kukuchazela indlela yokwenza loo nto.
Zithini iziphumo ebezingalindelekanga ze-G-CSF?
Njengalo naliphi na iyeza, i-G-CSF ineengenelo kunye nemiphumo emibi. Kodwa khumbula, ugqirha ukubhalela eli yeza kuba iingenelo zingaphezulu kakhulu kuneengozi. Uninzi lwemiphumo emibi iyanyamalala xa unyango luyekiswa.
| Iziphumo ebezingalindelekanga eziqhelekileyo | Iimeko ezingaqhelekanga ezinzulu |
|---|
| - Impendulo enzima ye-allergy (i-Anaphylaxis)
- Ukuqhambuka kwepleen
- I-Acute Respiratory Distress Syndrome (ARDS)
- Ukudumba komzimba
|
Kutheni i-G-CSF ibangela iintlungu zamathambo?
Esi sisiphumo esiqhelekileyo esifunyanwa ngabantu abaninzi. Nangona unobangela ochanekileyo ungaziwa, izazinzulu zicinga ukuba kungenxa yokuba i-G-CSF ibangela ukuba umongo wethambo uqalise ngequbuliso ukwenza iiseli ezintsha ngesantya esiphezulu kakhulu. Uxinzelelo olubangelwa kukukhula okukhawulezayo yile nto siyivayo njengentlungu. Le ntlungu idla ngokunyamezeleka. Ungathetha nogqirha wakho ngayo kwaye ufumane i-painkiller efanelekileyo.
Ufanele uye nini kugqirha?
Kubaluleke kakhulu ukuxelela ugqirha wakho ngazo naziphi na iziphumo ebezingalindelekanga ozifumanayo ngelixa usela i-G-CSF. Ngokukodwa, ukuba ufumana naziphi na kwezi mpawu zilandelayo, kufuneka
ufune iingcebiso zonyango ngokukhawuleza . Ngamanye amaxesha kunokufuneka uye kwiSebe lezeMpilo eziNgxamisekileyo (ETU) lesibhedlele.
- Iimpawu zosulelo: umkhuhlane, ukubanda, umphimbo obuhlungu, ukukhwehlela.
- Iimpawu ze-allergy:Ukurhawuzelela kwesikhumba, ukudumba, ubunzima bokuphefumla .
- Ukuphefumla okukhawulezileyo.
- Ukubetha kwentliziyo ngokukhawuleza.
- Ukudumba ngequbuliso kwezandla okanye iinyawo.
Ungalibali, ukhuseleko lwakho luza kuqala. Ukuba unamathandabuzo, nokuba mancinci, ungoyiki ukufowunela ugqirha wakho ubuze.
Umyalezo Wokuya Ekhaya
- I-G-CSF liyeza elinikwa ukwandisa inani leeseli ezimhlophe zegazi ezilwa nezifo ezibizwa ngokuba zii-neutrophils, ezincitshiswa zizinto ezifana nonyango lomhlaza (i-chemotherapy).
- Oku kuya kunciphisa umngcipheko wakho wokufumana usulelo kwaye kukuncede uqhubeke nonyango lwakho lomhlaza ngexesha elicwangcisiweyo.
- Intlungu yamathambo nemisipha yimiphumo eqhelekileyo yale mithi, kodwa idla ngokunyamezeleka.
- Ukuba ubonakalisa iimpawu ezifana nobunzima bokuphefumla, i-allergies enzima, okanye umkhuhlane , yazisa ugqirha wakho ngoko nangoko.
- Ngugqirha wakho kuphela onokugqiba ukuba uyalidinga eli yeza okanye akunjalo, kwaye loluphi uhlobo olufanelekileyo kuwe. Ngoko thetha naye ngayo yonke into.
💬 Comments (0)
Akukho zimvo zithunyelweyo okwangoku. Faka uluvo lwakho apha okokuqala.
Faka uluvo lwakho