Ingaba imilenze yakho idumbile kwaye ulusu lwakho luvakala lurhabaxa? Masifunde ngale nto (iPretibial Myxedema)!

Ngaba wakha waphawula ukuba ulusu lwemilenze yakho, ingakumbi phantsi kwamadolo, luvuvukala ngequbuliso, lube lukhuni, kwaye ngamanye amaxesha lube nombala omdaka? Okanye lubonakala ngathi lixolo loorenji kwezinye iindawo? Ukuba unale mpawu, usenokuba nesifo esibizwa ngokuba yiPretibial Myxedema, esiza kuthetha ngaso namhlanje.

Yintoni le (iPretibial Myxedema)? Masiyiqonde ngokulula!

Ngamafutshane, iPretibial Myxedema, ngamanye amaxesha ebizwa ngokuba yiGraves' Dermopathy, luhlobo lweSifo seGraves, imeko echaphazela ulusu lwethu. Ibangelwa kukuqokelelwa kweecarbohydrates kunye neeswekile, okanye ngokuthe ngqo, iiglycosaminoglycans okanye iimucopolysaccharides, kwiindawo ezinzulu zolusu lwethu. Ezi ziqokelelwa ikakhulu kwimilenze esezantsi, ngaphantsi kwamadolo. Kulapho imilenze idumba khona, ulusu luba namaqhuqhuva, kwaye ulusu luba namaqhuqhuva (ii-scaling plaques). Athetha ukuthini amagama athi "Pretibial" kunye nelithi "Myxedema"?

• "Pretibial": Oku kubhekisa kwithambo elikhulu elisecaleni lomlenze wethu ngaphantsi kwedolo, umphambili we-`(tibia)`. Ukuba sikutsho ngesiSinhala, kufana nokuthi "phambi kwethambo lesifuba".
• "I-Myxedema": Oku kuthetha ukudumba kwezicubu ezingaphantsi kolusu lwethu.

Ngubani ochaphazeleka kakhulu yile meko?

(Pretibial Myxedema) Nangona nabani na enokuba nayo, abanye abantu banamathuba amaninzi okuba nayo. Nazi:

• Abantu abaneSifo samaThuna: Le yeyona nto ixhalabisayo.
• Abantu abaneengxaki ze-thyroid: Oku kuthetha iimeko ezifana ne-`(Hypothyroidism)` ( i-hormone ye-thyroid ephantsi) okanye `( Hyperthyroidism )` ( i-hormone ye-thyroid ephezulu).
• Abantu abanesifo samehlo esibi: Oku kudla ngokunxulunyaniswa neSifo samaGraves.
• Abantu abaphakathi kweminyaka engama-40 ukuya kwengama-60 ubudala.
• Abafazi: Le meko ixhaphake kakhulu kubafazi kunakumadoda.

Khawucinge nje, ummelwane wakho, uAnti Susila, ebeneengxaki ze-thyroid okwethutyana. Ngequbuliso, waphawula ukuba indawo engaphantsi kwamadolo emilenze yakhe yayidumbile, ulusu lwalubomvu kancinci, kwaye lwaluvakala ngathi ngamaqhuqhuva amancinci xa luchukunyiswa. Ekuqaleni, wayecinga ukuba kungenxa yokuzibhokoxa. Kodwa kwaba kuphela xa wayibonisa ugqirha apho waqonda khona ukuba isenokuba yiPretibial Myxedema.

Ziziphi iintlobo eziphambili zePretibial Myxedema?

Kukho iintlobo ezine eziphambili zale meko. Iimpawu zingahluka kancinci ngokwendlela: 1. Ukusasazwa: Olu lolona hlobo luqhelekileyo. Olu luphawulwa kukudumba okungenamingxunya okungadumbanga xa ulusu lucinezelwe eluswini. 2. Iplaque:Ukongeza ekudumbeni, kukho iiplaque ezijiyileyo, eziphakanyisiweyo, nezinamaqhuqhuva kumphezulu wesikhumba. 3. Amaqhuqhuva: Ukongeza ekudumbeni, kukho amaqhuqhuva aqinileyo phantsi kwesikhumba. 4. I-Elephantiasis: Olu lolona hlobo lunqabileyo. Kolu hlobo, ulwelo lwe-lymphatic luqokelelana phantsi kwesikhumba, nto leyo enika ulusu inkangeleko efana ne-wart, erhabaxa.

Zithini iimpawu ze (Pretibial Myxedema)? Masizazi kakuhle!

Ukuba unale meko, unokufumana enye okanye ngaphezulu kwezi mpawu:

• Ukudumba: Ulusu lomlenze wakho lubonakala lukhulu kwaye lukhukhumele kunosuku olungaphambili.
• Amaqhuma aqinileyo phantsi kolusu: La maqhuma anokuviwa xa uwachukumisa ngesandla sakho.
• Ezinye iindawo zesikhumba ziba nkulu zize zibe njengeeplaque: njengezikali zeentlanzi.
• Ulusu kunye neefollicle zeenwele zitshintsha zibe nombala okhazimlayo nofana ne-wax: Zisenokubonakala njengexolo leorenji .
• Umbala wolusu uyatshintsha: ungahluka ukusuka kotyheli noorenji ukuya komdaka, obomvu, nomfusa.
• Kukho ukubila okwandileyo okanye ukukhula kweenwele ngokugqithisileyo kwiindawo ezichaphazelekayo.
• Ulusu lubuhlungu okanye luyarhawuzelela.

Ekuqaleni, le meko ingaqala njengeqhuma eliqinileyo eluswini. Eli qhuma lisenokukhula libe likhulu ngokuhamba kwexesha, okanye lihlangane namanye amaqhuma.

Ziphi emzimbeni apho ezi mpawu zichaphazela kakhulu khona?

Iimpawu eziqhelekileyo zePretibial Myxedema zezi:

• Kwimilenze engaphantsi kwamadolo.
• Ezinyaweni zeenyawo.
• Imilenze emilenzeni.

Ngamanye amaxesha utshintsho lobuso lunokubangelwa siSifo sikaGraves okanye yingxaki ye-thyroid, kodwa loo nto yingxaki eyahlukileyo.

Kutheni sifumana (iPretibial Myxedema)? Zithini izizathu?

Nangona unobangela woku ungekaqondwa ngokupheleleyo, kukho izinto ezininzi eziye zavela kuphando. Isizathu esiphambili soku kukuqokelelana kweekhompawundi zeswekile `(glycosaminoglycans okanye mucopolysaccharides)` esizikhankanyileyo ngaphambili kwi`(dermis)` kunye`(hypodermis)` zesikhumba. Kodwa kutheni iqokelelana ngolo hlobo? 1. Inkqubo yenkqubo yomzimba `(Autoimmune response)`: Ngamafutshane, inkqubo yomzimba wethu yokuzikhusela iqala ukusebenza nxamnye nathi. Kule nto, inkqubo yethu yokuzikhusela inika iiseli zethu umqondiso wokuvelisa `(antibodies)` ngokuchasene neehomoni ze-thyroid. Ezi `(antibodies)` zibangela ukuba iiseli zivelise into ebizwa ngokuba yi`(glycosaminoglycans)` ngokugqithisileyo. 2. Ukusebenza kweeseli (T lymphocyte): `(T lymphocytes)` luhlobo olukhethekileyo lweseli kwinkqubo yethu yomzimba. Ezi seli zingena kwizicubu zesikhumba kwaye zikhuphe iiproteni zezithunywa ezibizwa ngokuba yi`(cytokines)`. Ezi cytokines zibangela ukuba iiseli zivelise inani elikhulu le-glycosaminoglycans. 3. Impendulo yokwenzakala:Khawuthelekelele ukuba wenzakele emlenzeni wakho ongezantsi, kwindawo engaphambi kokuzalwa. Ukuba une-hypothyroidism, iiseli zomzimba kunye neeproteni zinokuqokelelana kwindawo yokwenzakala. Oku kungenxa yokuba iihomoni ze-thyroid zilawula ukuqokelelwa kwezi zinto kwiithishu. Xa iihomoni zingekho, olo lawulo luyalahleka.

Ugqirha uyixilonga njani iPretibial Myxedema?

Xa ubona ugqirha, uza kuqala akubuze ngeempawu zakho kunye nazo naziphi na ezinye iimeko zempilo onokuba nazo (`(imbali yezonyango)`). Emva koko baza kukuhlola (`(uvavanyo lomzimba)`). Ukuqinisekisa ukuba oku kuyenzeka na (iPretibial Myxedema), ugqirha angenza ezi vavanyo zilandelayo:

• Uvavanyo lwegazi: Jonga amanqanaba ehomoni yakho ye-thyroid .
• I-biopsy yolusu: Oku kungasetyenziselwa ukufumanisa ukuba imeko ikhona na kunye nokulinganisa amanqanaba e-glycosaminoglycans eluswini.

Ngaba ikho indlela yokunyanga oku? Yintoni enokwenziwa?

Uninzi lwexesha, iimpawu zePretibial Myxedema zizinto zobuhle kuphela, ngoko ke unyango alusoloko luyimfuneko. Oko kukuthi, azisoloko zibangela monakalo mkhulu . Nangona kunjalo, ukuba awukhululekanga ngembonakalo okanye unezinye iimpawu (ukurhawuzelelwa, iintlungu), kukho unyango olufumanekayo.

• Ukunxiba iikawusi ezicinezelweyo okanye iikawusi: Oku kunokunciphisa ukudumba.
• Iikhrimu okanye amafutha aqholiweyo: Zithintele ukurhawuzelela nokudumba.
• Amayeza kunye neenaliti zomlomo kunye nezomlomo: Ukunciphisa amaqhuma phantsi kolusu okanye ukunciphisa utshintsho kwinkangeleko.
• Ukunyanga Isifo Se-Graves okanye Imeko Ye-Thyroid: Le yeyona nto ibalulekileyo . Xa unobangela oyintloko unyangwa, iimpawu ze-Pretibial Myxedema zihlala ziphucuka.
• I-Plasmapheresis: Olu lunyango oluyinkimbinkimbi kancinci. Lubandakanya ukususa inxalenye yolwelo egazini (i-plasma), ukutshintsha iiseli zegazi ezibomvu nezimhlophe kunye neeplatelets kwisisombululo esitsha, uze uzibuyisele emzimbeni. Oku akuyonto wonke umntu anokuyenza.

Kubalulekile: Nangona utyando lunokususa amaqhuqhuva angaphantsi kwesikhumba, alukhuthazwa rhoqo. Oku kungenxa yokuba, njengoko ulusu luphola emva kotyando, amaqhuqhuva anokuthi aphinde avele kwindawo yokwenzakala. Oku kungenxa yokuba umzimba uphatha indawo yotyando njengenxeba.

Ngawaphi amayeza anikwa iPretibial Myxedema?

Ugqirha wakho angakunika amayeza anjengala ukunceda ukunciphisa iimpawu zesi sifo:

• (Ii-Corticosteroids):La ngamayeza asetyenziswa ekhaya anceda ekunciphiseni ukudumba, ukudumba, kunye nokurhawuzelela.
• (Pentoxifylline): Eli liyeza eliselwayo eliphucula ukujikeleza kwegazi emilenzeni.
• (Octreotide): Le yinaliti. Inganciphisa ubukhulu bamaqhuqhuva angaphantsi kolusu.
• (Rituximab): Oku kukwayi-intravenous infusion. Kunceda ii-antibodies zomzimba wethu zisebenze kakuhle.
• I-Intravenous immunoglobulin (IVIG): Eli liyeza elifakwa emthanjeni. Liphucula ukusebenza kwee-antibodies kwinkqubo yomzimba yokuzikhusela.

Ngaphambi kokuba uqalise amayeza amatsha, qiniseka ukuba uthetha nogqirha wakho malunga nemiphumo yawo emibi, ixesha omele ulithathe, kunye nokuba ingaba liza kubangela iingxaki na kwamanye amayeza owasebenzisayo okwangoku.

Ndingaphila ngokukhawuleza kangakanani emva konyango?

Ubude bexesha oza kuba neempawu zePretibial Myxedema buya kwahluka ngokuxhomekeke kubukhali bemeko yakho. Ngonyango, iimpawu zinokuphucuka kwiiveki ezimbalwa ukuya kwiinyanga ezimbalwa. Ngaphandle konyango, ngamanye amaxesha kungathatha iminyaka eliqela ukuba imeko iphele ngokwayo. Kodwa khumbula, ukuba wenzakele emilenzeni yakho esezantsi, imeko inokuphinda ivele.

Ngaba kukho iindlela zokuthintela oku (iPretibial Myxedema) ukuba kungenzeki?

Akukho ndlela yokuthintela ngokupheleleyo oku ukuba kwenzeke, kodwa ungenza oku kulandelayo ukunciphisa umngcipheko wakho:

• Musa ukusebenzisa iimveliso zecuba.
• Ukuba uneemeko ezichaphazela ukusebenza kwe-thyroid yakho, zinyange ngokufanelekileyo.
• Nxiba iikawusi zokucinezela okanye iikawusi ezinyaweni zakho.

Kuthekani ukuba nam ndinayo le meko? Ngaba yinto endifanele ndiyoyike?

Isiganeko sokugula kwabantu abanePretibial Myxedema sihlala silungile. Ukuba iimpawu zakho zichaphazela kuphela inkangeleko yakho, usenokungadingi unyango. Ukuba unesifo esincinci, siya kuhlala siphela sodwa. Ukuba isifo sakho sinzima ngakumbi, isiganeko sokugula silungile, kodwa kungathatha iminyaka eliqela ukuba siphinde siphile ngokupheleleyo.

Ngaba kufuneka ndibone ugqirha?

I-Pretibial Myxedema inokuphinda ivele nasemva kokuba ipholile, ingakumbi ukuba unesilonda emlenzeni wakho ongezantsi. Ngoko ke, ukuba iimpawu zakho ziphelile kwaye ziphinde zibuye, thetha nogqirha wakho. Kwakhona, ukuba unentlungu okanye ukurhawuzelelwa kakhulu, qiniseka ukuba ubona ugqirha.

Ndingayibuza yiphi imibuzo ugqirha?

Kungcono ukuba ulungiselele imibuzo efana nale xa usiya kugqirha:

• Ndingasebenzisa iisokisi zokucinezela ukunceda ngePretibial Myxedema?
• Ngaba ndifuna unyango lwePretibial Myxedema?
• Ngaba iimpawu zam zibangelwa yingxaki ye-thyroid engaphantsi?
• Ndingalunyamekela njani ulusu lwam oluchaphazelekileyo yiPretibial Myxedema?

Yintoni umahluko phakathi kwe (Pretibial Myxedema) kunye ne (Erythema Nodosum)?

Zombini ezi meko zichaphazela ulusu lwethu, ingakumbi ulusu olusemilenzeni yethu engaphantsi kwamadolo. Nangona kunjalo, kukho umahluko kwiimpawu:

• (Pretibial Myxedema): Oku kubangela ukudumba kunye nokukhazimla, ukutyeba, iiplaque ezifana neekorale.
• (I-Erythema Nodosum): Oku kubangela ukudumba kunye namaqhuma amancinci, abuhlungu eluswini.

Okokugqibela, izinto ekufuneka uzikhumbule

I-Pretibial Myxedema yimeko edla ngokungadingi nyango. Kwiimeko ezininzi, iyaziphelela. Nangona kunjalo, ukuba utshintsho kwinkangeleko luyakukhathaza, kukho unyango olufumanekayo. Ukunxiba iisokisi zokucinezela kunokunceda ukunciphisa ukudumba kwaye kukwenze uzive ukhululekile. Ukuba unentlungu okanye ukurhawuzelela okukhulu kwimilenze yakho esezantsi, qiniseka ukuba uthetha nogqirha. Kwakhona, le meko idla ngokunxulunyaniswa neSifo seGraves kunye neengxaki ze-thyroid, ngoko ke kubalulekile ukuba uzazi ezo zinto.

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