Mhlawumbi uyazi ukuba i-Ankylosing Spondylitis (AS) yimeko ehlala ubomi bonke, ebangela ubuthathaka. Uyazi ukuba kunzima kangakanani ukudlula usuku ngenxa yentlungu yomqolo kunye nokuqina kwasekuseni. Kodwa, kukho iindaba ezimnandi. Nangona esi sifo singenakunyangwa ngokupheleleyo, singalawula iimpawu zaso ngamayeza afanelekileyo, umthambo, kunye nendlela yokuphila enempilo. La mayeza anokunceda ukuyeka okanye ukulibazisa ukuqhubeka kweengxaki zomqolo.
Inyathelo Lokuqala: Ii-NSAID - zokunceda iintlungu nokudumba
Xa usiya kugqirha, olu lolona hlobo lokuqala lwamayeza abaza kuzama ukukunika wona ngenxa yesi sifo. Siwabiza la mayeza angengo-steroidal Anti-inflammatory, okanye (NSAIDs) ngamafutshane. Nangona amanye ala mayeza angathengwa kwikhawuntara kwikhemesti, amanye afuna uxwebhu oluvela kugqirha.
Ngamafutshane, la mayeza asebenza ngokuthintela ukuveliswa kweekhemikhali ezibizwa ngokuba yi-prostaglandins emizimbeni yethu ezibangela ukudumba. Oku kunciphisa iintlungu nokudumba. Ukusela la mayeza ebusuku, ingakumbi, kunokukunceda ulale ngcono kwaye kunciphise ukuqina komqolo kusasa.
Eyona nto ibalulekileyo kukuthatha eli yeza ngokwedosi nangexesha elimiselweyo njengoko ugqirha wakho elichazile. Musa ukuyeka okanye ukutshintsha idosi ngokuthanda kwakho.
| Uhlobo lwamayeza (i-NSAID) | Iziphumo ebezingalindelekanga kunye noko kufuneka ukwazi |
|---|---|
| Eli yeza linokubangela ukuphazamiseka kwesisu xa lisetyenziswa ixesha elide. Umzekelo:
Ngoko ke, ugqirha wakho unokukunika amanye amayeza (afana ne-antacids) ukukhusela isisu sakho kunye nala mayeza. Ukuba unembali yesifo sentliziyo, kufuneka uxelele ugqirha wakho ngokuqinisekileyo . Amanye ama-NSAID anokunyusa kancinci umngcipheko wokuhlaselwa yintliziyo okanye isifo sohlangothi. |
Inyathelo lesibini: Ii-DMARD - amayeza okulwa namathambo aguqula izifo
Ngamanye amaxesha ii-NSAID zodwa zisenokunganeli ukulawula iimpawu zakho. Ukuba kunjalo, ugqirha wakho unokukunika uhlobo lwamayeza olubizwa ngokuba yi- (DMARDs) , olumele i-Disease-Modifying Antirheumatic Drugs . Nangona igama lisenokuvakala liyinkimbinkimbi, into eliyenzayo ilula. Lisebenza ngokunciphisa umonakalo kumalungu akho nakwizicwili ezibangelwa kukudumba. Ezi zicothisa ukuqhubela phambili kwesi sifo.
| Uhlobo lwamayeza (i-DMARD) | Izinto ekufuneka uzazi ngokukodwa |
|---|---|
| I-Sulfasalazine | Oku kuthathwa njengepilisi. Abanye abantu banokuba neentloko ezibuhlungu, ukudumba, isicaphucaphu, kunye nezilonda emlonyeni. Kunqabile kakhulu ukuba umongo wethambo uchaphazeleke, ngoko ugqirha wakho uhlala ejonga igazi lakho xa ekunika eli yeza. |
| I-Methotrexate | Oku kuza njengepilisi okanye njengenaliti onokuyinika wena. Ngokuqinisekileyo kuya kufuneka uthathe ipilisi ye-folic acid kunye noku. Oku kwenzelwa ukunqanda iziphumo ebezingalindelekanga ezifana nezilonda emlonyeni kunye nesicaphucaphu. Ekubeni eli liyeza elinamandla kancinci, ugqirha wakho uya kujonga ukusebenza kwegazi lakho kunye nesibindi sakho rhoqo. Eli yeza alifanelekanga kubafazi abakhulelweyo okanye abo bazama ukukhulelwa. |
I-Corticosteroids - isiqabu esikhawulezileyo samalungu abuhlungu
Ezi luhlobo lwe-steroid. Ugqirha wakho angakunika inaliti ye-steroid, efana ne-"Prednisone", ngqo kwilungu lakho elibuhlungu kakhulu nelidumbileyo. Oku kuya kunceda ngokukhawuleza kwiintlungu nokudumba.
Kodwa khumbula, olu asilonyango olunikwa umzimba wonke. Kwakhona, ezi naliti azinakwenziwa rhoqo. Ngokwesiqhelo, ugqirha unika ezi naliti izihlandlo ezimbalwa ngonyaka, kunye nesithuba seenyanga ezimbalwa.
I-Biologics - indlela yamva nje neyona inamandla kakhulu yonyango
Ukuba ezinye iindlela zonyango azikusebenzeli, ugqirha wakho unokukuxelela ngolu nyango lutsha. Ezi zibizwa ngokuba yi-biologics . Zenziwe ngeeseli eziphilayo. Ngokukodwa, la mayeza athintela iiproteni ezibizwa ngokuba yi-cytokines ezibangela ukudumba kwinkqubo yethu yokuzikhusela komzimba. Olu lunyango olujoliswe kulo. Ezi ziza njengeenaliti. Ezinye zazo ungazinika wena ekhaya.
Izithinteli ze-TNF
Ezi luhlobo lwe-biologic olusetyenziswa rhoqo kwi-AS. I-TNF imele iproteni ebizwa ngokuba yi-"Tumor Necrosis Factor". La mayeza anyanga ukudumba emgogodleni, emalungwini, emehlweni, nasemathunjini. Anganciphisa nokuqhubela phambili kwe-AS.
- I-Adalimumab (iHumira)
- I-Certolizumab pegol (Cimzia)
- I-Etanercept (Enbrel)
- IGolimumab (iSimponi)
- I-Infliximab (iRemicade)
Izithinteli ze-Interleukin (IL-17)
Ukuba izithinteli ze-TNF azisebenzi, ugqirha wakho unokukuqalisa kolu hlobo.
- Ixekizumab (Taltz)
- ISecukinumab (iCosentyx)
Iibhayoloji ngamayeza anamandla kakhulu. Yiyo loo nto zineziphumo ebezingalindelekanga ekufuneka uzazi. Ugqirha wakho uza kukuchazela konke oku ngaphambi kokuba uqale unyango.
| Iingozi eziphambili kunye nemiphumo emibi yebhayoloji | |
|---|---|
| Ingozi yokosuleleka | Ngenxa yokuba la mayeza acinezela amajoni omzimba ngandlela ithile, andisa umngcipheko wokufumana usulelo, ingakumbi isifo sephepha (TB). Ke ngoko, kubalulekile ukuba uvavanyelwe isifo sephepha ngaphambi kokuba uqalise la mayeza. |
| Ezinye iingozi | - Ukwanda okuncinci kakhulu komngcipheko wokuba nomhlaza wolusu. - Umngcipheko ophezulu womhlaza we-lymphoma ebantwaneni. - Ukuba sele unesifo samathumbu esibangela ukudumba (IBD), iimpawu zakho zinokuba mandundu. |
Ukuba awuziva bhetele emva kweenyanga ezi-3 zolu nyango, ugqirha wakho uya kugqiba ekubeni ayeke amayeza okanye akutshintshele kwenye i-biologic.
Ithemba lonyango lwexesha elizayo
Oososayensi ngoku basebenza nzima ukufumana amayeza amatsha anokuguqula i-AS. Bakwafunda nendlela ii-genes zethu ezisichaphazela ngayo esi sifo. Olu phando lunokukhokelela kunyango olusebenzayo ngakumbi oluya kuwe kwixesha elizayo.
Umyalezo Wokuya Ekhaya
- I-Ankylosing Spondylitis (AS) yimeko ehlala ubomi bonke, kodwa inokulawulwa kakuhle ngonyango olufanelekileyo nendlela yokuphila.
- Unyango ludla ngokuqala ngee-NSAID. Ukuba ezi azilawuli imeko, kusetyenziswa amayeza anjenge-DMARD okanye i-biologics.
- Mthembe ugqirha wakho. Landela imiyalelo yakhe ngokuchanekileyo. Yiya kwiikliniki ngexesha kwaye uvavanywe.
- Ungaze uyeke ukuthatha amayeza akho okanye utshintshe umthamo ngokwakho. Ukuba uneengxaki, thetha nogqirha wakho.
- Kunye namayeza, ukuzilolonga ngokufanelekileyo kunye nokutya okunempilo zizinto ezimbini ezibalulekileyo ukulawula esi sifo.
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