Uke waphawula ngokuzumayo ushintsho ekuboneni kwakho, ubuhlungu bamehlo, noma ukungazweli noma ubuthakathaka ezithweni zakho? Kungaba yinto ehlukile. Namuhla sikhuluma ngesimo esingavamile kakhulu ezweni lakithi, kodwa kubaluleke kakhulu ukuqaphela. Leso yi -Neuromyelitis Optica Spectrum Disorder , noma i-NMOSD ngamafuphi. Lesi yisifo sokuzivikela komzimba esithinta kakhulu amehlo akho kanye nomgogodla.
Iyini i-NMOSD? Isebenza kanjani i-Enspryng?
Kalula nje, i-NMOSD yilapho isimiso somzimba wakho sokuzivikela, uhlelo olusivikela ezifweni, luqala ngephutha ukuhlasela amangqamuzana akho anempilo. Ngokukhethekile, umzimba wakho uqala ukwenza ama-antibodies ngokumelene nephrotheni ethile ohlelweni lwakho lwezinzwa olubizwa ngokuthi i-'aquaporin-4 (AQP4).'
Lokhu kuhlasela kubangela kakhulu ukuvuvukala, noma ukuvuvukala, okuzungeze inzwa yakho yokubona (inzwa ethwala imiyalezo phakathi kweso lakho nobuchopho bakho) kanye nomgogodla. Njengoba lokhu kuqhubeka, kungaholela ekulahlekelweni umbono kanye nobunzima bokuhamba.
Akukho ukwelashwa kwe-NMOSD okwamanje. Ukwelashwa kuhloselwe kakhulu ukunciphisa ukuvuvukala, ukulawula izimpawu , kanye nokuvimbela ukubuyela emuva kwesifo.
Yilapho i-Enspryng ingena khona. I-Enspryng umuthi omusha we-biologic. Lo muthi ungasiza ekuvimbeleni i-NMOSD ukuthi ingabuyi, ikakhulukazi uma une-anti-AQP4 antibodies esikhulume ngayo ngaphambilini egazini lakho.
I-Enspryng isebenza ngokuvimba enye iphrotheni emzimbeni wethu ebizwa ngokuthi ``interleukin-6 (IL-6).`` Ngoba le phrotheni ebizwa ngokuthi i-IL-6 nayo ihilelekile ekuvuvukeni okubangelwa ama-anti-APQ4 antibodies. Ngakho-ke uma i-IL-6 ivinjiwe, ukuvuvukala kuyancishiswa, izimpawu ziyalawulwa, futhi lesi sifo singancishiswa.
| Indawo nesimo esithintekile | Izimpawu ezingase zizwakale |
|---|---|
| I-Optic Neuritis |
|
| I-Transverse Myelitis |
Ngingawusebenzisa kanjani lo muthi?
I-Enspryng iwumjovo ongaphansi kwesikhumba . Ngokuvamile unikezwa esiswini esingezansi noma maphakathi nethanga.
- Imijovo emithathu yokuqala kufanele inikezwe njalo emavikini amabili.
- Ngemva kwalokho, kufanele uyishaye kanye ngenyanga.
Kubaluleke kakhulu ukukhumbula izinsuku eziqondile lapho udinga ukuthola le mijovo. Setha isikhumbuzi ekhalendeni noma ocingweni lwakho. Uma uphuthelwa umjovo, kufanele nakanjani ukhulume nodokotela wakho ngalokho okufanele ukwenze ngokulandelayo.
Ungakhathazeki, udokotela wakho uzokuqeqesha ukuthi ungazifaka kanjani lo mjovo, ukuthi uwufake kuphi, nokuthi ungayishintsha kanjani indawo njalo. Geza izandla zakho kahle njalo ngaphambi kokufaka umjovo.
Ngingawugcina kanjani umuthi?
Lomuthi kufanele ugcinwe esiqandisini . Kodwa ungawugcini esiqandisini. Futhi, ungawushukumisi umuthi. Khipha umuthi imizuzu engama-30 ngaphambi komjovo bese uwuvumela ufike ezingeni lokushisa legumbi. Ungalokothi ufudumale umuthi kuma-microwave noma ngamanzi ashisayo.
Kubalulekile ukukhuluma nodokotela wakho nganoma yimiphi imijovo okufanele uyithole ngenkathi uthatha i-Enspryng. Eminye imijovo ayinconywa ngenkathi uthatha lo muthi.
Lo muthi ucwaningwe kanjani?
Kuye kwenziwa izifundo ezimbili ezinkulu ukuze kubhekwe ukuphepha nokusebenza kahle kwe-Enspryng. Lezi ziqhathanisa i-Enspryng ne-placebo, umuthi ongenaso isithako esisebenzayo. Yilapho-ke esingabona khona ngempela ukuthi umuthi uwusizo noma uyingozi ngempela.
Bonke abahlanganyeli kulolu cwaningo babene-NMOSD, umlando wokubuyela emuva, kanye namaphuzu aphakathi kuka-0 no-6.5 ku-Expanded Disability Status Scale (EDSS), isikali esilinganisa izinga labo lokukhubazeka. (Amaphuzu e-EDSS angu-0 asho ukuthi akukho ukukhubazeka, angu-6.5 asho ukuthi kukhona ukulinganiselwa ekuhambeni.)
Ucwaningo lubheke kakhulu ukuthi kwathatha isikhathi esingakanani ukuthi lesi sifo siphinde sibuye. Ngaphezu kwalokho, kwanakwa izinguquko ku-'Visual Analog Scale (VAS)', elinganisa ubuhlungu, kanye ne-'Functional Assessment of Chronic Illness Therapy (FACIT)', elinganisa ukukhathala.
Iyini imiphumela yocwaningo?
Kuzo zombili izifundo, iziguli ezithatha i-Enspryng zazinokwehla okuncane kakhulu kokwelashwa kunalezo ezithatha i-placebo. Lokhu kusho ukuthi i-Enspryng inganciphisa izimpawu zakho kanye nenani lokwehla kokwelashwa.
Kodwa-ke, iziguli ezingenawo ama-antibody e-anti-AQP4 azizange zizuze kakhulu ku-Enspryng uma kuqhathaniswa ne-placebo.
| Amazinga okubuyela emuva ezigulini ezine-anti-AQP4 antibodies | ||
|---|---|---|
| Ucwaningo | Isigaba se-Enspryng | Iqembu le-Placebo |
| Ucwaningo 1 (i-Enspryng kuphela) | U-20% uphinde wabuyela emuva | Ama-43% aphinde abuyela emuva |
| Isifundo 2 (Ukusebenzisa eminye imithi) | U-30% uphinde wabuyela emuva | U-50% uphinde wabuyela emuva |
Kodwa khumbula, lena imiphumela yocwaningo. Imiphumela yakho ingase ihluke. Wena nodokotela wakho kufanele ninqume ndawonye ukuthi lo muthi ukulungele yini nokuthi izinzuzo zidlula yini izingozi.
Ungayiphatha kanjani imiphumela emibi uma ivela?
Imiphumela emibi evame kakhulu yalo muthi ukutheleleka kwamakhala nomphimbo, ikhanda elibuhlungu, isicanucanu, ukuqubuka kwesikhumba, isifo sofuba esiswini, ukukhathala, kanye nobuhlungu ezithweni noma emalungeni. Tshela udokotela wakho uma unanoma yikuphi kwalokhu.
Izifo
Kukhona ingozi ekhulayo kancane yokuthola izifo ezivamile noma ezingathi sína ngenkathi uthatha i-Enspryng. Tshela udokotela wakho uma welashwa ukutheleleka. Futhi, tshela udokotela wakho ngokushesha uma unezinye zezimpawu ezilandelayo:
- Umkhuhlane, izinhlungu zomzimba, umkhuhlane, umphimbo obuhlungu, ukukhwehlela okuqhubekayo
- Ukubomvu kwesikhumba noma ukuvuvukala
- Ukuphazamiseka kwesisu, isifo sohudo
- Ukusha lapho uchama noma isidingo sokuphuza njalo
Ukuqubuka
Tshela udokotela wakho uma uqubuka esikhumbeni ngenkathi uthatha umuthi. Uma uqubuka lusakazeka ngokuzumayo emzimbeni wakho wonke, hamba uye egumbini lezimo eziphuthumayo esibhedlela (ETU) ngokushesha.
Lezi akuzona zodwa imiphumela emibi engaba khona. Uma unezimpawu ezikukhathazayo, khuluma nodokotela wakho ngazo.
Yiziphi izivivinyo okufanele zenziwe ngaphambi kokuqala ukwelashwa nangesikhathi sokwelashwa?
Ngaphambi kokuthi uqale i-Enspryng, udokotela wakho uzokwenza ukuhlolwa kwegazi okuningana ukuhlola ukusebenza kwesibindi sakho, i-hepatitis B, isifo sofuba, noma ezinye izifo. Lokhu kuhlolwa kungadinga ukuphindaphindiwe ngesikhathi sokwelashwa. Ngakho-ke kubaluleke kakhulu ukuthi ukuhlolwa kwakho kwenziwe ngesikhathi.
Ingabe kungaba nezinkinga ngeminye imithi?
Akukho ukuxhumana okukhulu okubikiwe phakathi kwe-Enspryng nokudla noma eminye imithi. Kodwa-ke, kubalulekile ukutshela udokotela wakho ngayo yonke imithi oyithathayo (kufaka phakathi imithi yezinye izimo, amavithamini, imithi yamakhambi, kanye nezithasiselo). Lokhu kungasiza ekuvimbeleni noma yimiphi imiphumela emibi engafuneki.
Umlayezo Wokuya Nawe Ekhaya
- I-NMOSD yisimo esingavamile kodwa esibucayi lapho amasosha omzimba wakho ehlasela khona amehlo akho kanye nomgogodla.
- I-Enspryng umuthi omusha osiza ekunciphiseni ukubuyela emuva kwesifo, ikakhulukazi ezigulini ezine-anti-AQP4 antibodies.
- Lona umjovo ngaphansi kwesikhumba. Kubalulekile ukuthola ukuqeqeshwa okufanele kudokotela wakho.
- Yazisa udokotela wakho ngokushesha ngayo yonke eminye imithi oyithathayo kanye nanoma yimiphi imiphumela emibi eyenzeka ngesikhathi sokwelashwa.
- Ungalokothi uyeke ukwelashwa noma ushintshe umthamo ngaphandle kweseluleko sikadokotela wakho.
💬 Comments (0)
Awekho amazwana athunyelwe okwamanje. Faka amazwana akho lapha okokuqala ngqa.
Engeza amazwana akho