Cabanga nje ukuthi ingxenye eyodwa kuphela yomzimba wakho, isibonelo ingalo, umlenze, noma indawo ethile yesikhumba, ikhula ngokushesha ngendlela engavamile kunezinye. Lesi yisimo esingavamile kakhulu abanye abantu abazalwa naso. Ngokwezokwelapha, sibiza leli qembu lezimo ngokuthi i-PIK3CA-Related Overgrowth Spectrum, noma i-PROS ngamafuphi. Lokhu kuyinto ebangela izinkinga eziningi kumuntu oyibonayo, kanye nomuntu obhekana nayo. Namuhla, kulesi sihloko, sizokhuluma ngokuthi iyini le PROS kanye ne-Vijoice, umuthi wokuqala ovunyelwe ngqo lesi simo.
Kuyini ngempela i-PROS?
Kalula nje, i-PROS yisimo esibangelwa izici zofuzo. Sonke sinezakhi zofuzo emizimbeni yethu ezilawula ukukhula, ukuhlukana, nokufa kwamaseli. I-'PIK3CA' ingenye yezakhi zofuzo ezibaluleke kangaka. Cabanga ngaleli zakhi zofuzo njenge-'switch' elawula ukukhula kwamaseli ethu.
Kodwa-ke, kumuntu one-PROS, kukhona iphutha, noma ukuguquka kwezakhi zofuzo ze-`PIK3CA`. Lokhu kubangela ukuthi i-`switch` ibambeke endaweni ethi 'on'. Ngemuva kwalokho iphrotheni okukhulunywa ngayo iqala ukusebenza ngokushesha kakhulu futhi kakhulu. Ngenxa yalokho, ezinye izingxenye zomzimba, isibonelo, isikhumba, imithambo yegazi , amathambo , kanye nobuchopho, ziqala ukukhula ngokungalawuleki.
Into ebalulekile ukuthi i-PROS ayithinti zonke izingxenye zomzimba. Ingahluka kusuka kwesinye isici somzimba kuya kwesinye, nakumuntu nomuntu. Ngakho-ke, izimpawu nazo ziyahlukahluka kakhulu.
Kuze kube manje, bekungekho ikhambi eliphelele le-PROS. Ukwelashwa kugxile ekuphatheni izimpawu. Isibonelo, imithi yobuhlungu, ukulunywa, kanye nokuxhuzula, kanye nokuhlinzwa ukususa ukukhula okungavamile. Kodwa-ke, kwakukhona ingozi yokuthi lokho kukhula kuphinde kukhule ngemva kokuhlinzwa.
Isebenza kanjani isidakamizwa i-Vijoice (alpelisib)?
Yilapho umuthi i-Vijoice ungena khona. I-Vijoice umuthi wokuqala ukuqondisa imbangela eyisisekelo ye-PROS, ukusebenza ngokweqile okubangelwa ukuguquka kwezakhi zofuzo.
Isithako esisebenzayo kulokhu yi -alpelisib . Lo muthi empeleni usetshenziselwa ezinye izinhlobo zomdlavuza webele . Isizathu salokho ukuthi,Amaseli omdlavuza akhula ngenxa yokusebenza ngokweqile kwendlela ye-PIK3, njengaku-PROS.
Ngakho-ke lokho okwenziwa yiVijoice ukuvimba indlela ye-PIK3, esebenza njenge-'switch' ebambeke endaweni 'yoku-on'. Lokhu kunciphisa ukukhula okungavamile kwamaseli, kunciphisa usayizi wezicubu ezikhula kakade, futhi kulawula izimpawu.
Ziyini izinzuzo zalo muthi?
Izifundo ezenziwe ngalo muthi (i-EPIK-P1 kanye ne-EPIK-P3) zibonise izinzuzo ezibalulekile ezigulini.
| Inzuzo | Incazelo elula |
|---|---|
| Ukukhula okuncane (izilonda) | Kuye kwaphawulwa ukuthi abantu abaningi abathathe lesi sidakamizwa baye baba nezimila ezinamafutha ezikhule ngendlela engavamile (ama-lipomas) kanye nokukhubazeka kwemithambo yegazi okuncishisiwe ngo-20% noma ngaphezulu. |
| Isidingo esinciphile sokuhlinzwa | Cishe ama-70% ezingane kanye nama-90% abantu abadala abasebenzisa i-Vijoice abazange badinge ukuhlinzwa. |
| Ukuqeda izimpawu | Iziguli zibike ukwehla okukhulu kwezimpawu ezifana nobuhlungu, ukulunywa, kanye nokukhathala. |
| Ukwenza imisebenzi yansuku zonke ibe lula | Cishe ama-81% eziguli ezihlanganyele ocwaningweni abike ukuthi ikhono lazo lokwenza imisebenzi yansuku zonke kanye nekhwalithi yokuphila lithuthukile uma kuqhathaniswa nangaphambi kokusetshenziswa komuthi. |
Okubalulekile: Le miphumela ingase ingafani kuwo wonke umuntu. Khuluma nodokotela wakho mayelana nokuthi lo muthi ukulungele yini wena nokuthi yiziphi izinzuzo nezingozi.Kungcono ukukhuluma nabo bese unquma.
Yimiphi imiphumela emibi evame kakhulu nokuthi ungayiphatha kanjani?
Njenganoma yimuphi umuthi, i-Vijoice ingabangela imiphumela emibi . Kodwa-ke, eminingi yale miphumela incane noma iphakathi nendawo futhi ingalawulwa.
| Umphumela ongemuhle | Indlela yokuphatha nokuthi yini okufanele uyinake |
|---|---|
| Uhudo | Phuza uketshezi oluningi olufana namanzi nojusi. Uma uzwa izimpawu ezifana nohudo olunzima, izinhlungu zesisu, noma igazi noma i-mucus esitulweni sakho, tshela udokotela wakho ngokushesha . |
| Ukuphelelwa amanzi emzimbeni | Uhudo lungabangela ukuphelelwa amanzi emzimbeni. Qaphela izimpawu ezifana nesiyezi esikhulu, ukukhathala, kanye nokuncipha kokuchama. Lokhu kungathinta izinso zakho, ngakho-ke tshela udokotela wakho ngokushesha. |
| Izilonda zomlomo (i-Stomatitis) | Kungase kube nezilonda emlonyeni kanye nobuhlungu. Gwema ukugeza umlomo okuqukethe utshwala. Hlanza umlomo wakho ngamanzi anosawoti afudumele. Gwema ukudla okubabayo nokune-asidi. |
| Ukwanda koshukela egazini (i-Hyperglycemia) | Udokotela wakho uzohlola amazinga kashukela egazini lakho ngaphambi kokuthi uqale ukuthatha lo muthi nangesikhathi sokwelashwa kwakho. Tshela udokotela wakho uma unezimpawu ezifana nokoma ngokweqile, ukuchama njalo, noma ukukhathala. Abantu abanesifo sikashukela kufanele baqaphele kakhulu ngalokhu. |
| Ukuncipha kwezinwele (i-Alopecia) | Ukulahlekelwa izinwele noma ukuncipha kungase kwenzeke ngesikhathi sokwelashwa. Sebenzisa ama-shampoo athambile. Khuluma nodokotela wakho ngalokhu. |
Ingabe kungaba nezinkinga ngeminye imithi?
Yebo. I-Vijoice ingasebenzisana neminye imithi. Kalula nje, eminye imithi inganciphisa ukusebenza kwe-Vijoice. I-Vijoice ingashintsha nokusebenza kweminye imithi.
Isibonelo, imithi efana ne-carbamazepine yesifo sokuwa, i-rifampin yesifo sofuba, kanye nemikhiqizo yamakhambi efana ne-St. John's wort ingathinta lokhu.
Ngakho-ke, ngaphambi kokuba uqale lo muthi, kubalulekile ukutshela udokotela wakho ngayo yonke imithi oyithathayo njengamanje (kufaka phakathi amavithamini, imikhiqizo yamakhambi, kanye nemithi yokubulala izinhlungu) ukuze akwazi ukwenza noma yiziphi izinguquko ezidingekayo.
Umlayezo Wokuya Nawe Ekhaya
- I-PROS yisimo esingavamile lapho izingxenye zomzimba zikhula ngendlela engavamile ngenxa yokuguquka kwezakhi zofuzo okubizwa ngokuthi `PIK3CA`.
- I-Vijoice (i-alpelisib) umuthi wokuqala ovunyelwe ukuqondisa inqubo eyisisekelo ebangela lesi sifo.
- Lokhu kungasiza ekunciphiseni ukukhula okungavamile, ukunciphisa isidingo sokuhlinzwa, nokuthuthukisa ikhwalithi yokuphila.
- Imiphumela emibi efana nesifo sohudo, ushukela wegazi ophakeme, kanye nezilonda emlonyeni zingase zibe khona, futhi kubaluleke kakhulu ukuzilawula nokwazisa udokotela.
- Kubalulekile ukwazisa udokotela wakho ngayo yonke eminye imithi oyithathayo. Ungalokothi uqale noma uyeke ukuthatha noma yimuphi umuthi ngaphandle kweseluleko sikadokotela.
💬 Comments (0)
Awekho amazwana athunyelwe okwamanje. Faka amazwana akho lapha okokuqala ngqa.
Engeza amazwana akho