Alzheimer’s Disease leh Genes (Alzheimer’s & APOE4 Gene) Inzawmna - Nang pawhin i hlauhawm em?

Kan upat deuh deuh hian hriatrengna hloh hlauhna tlem kan nei vek a ni lawm ni? A bik takin i chhungkuaa mi tu emaw chuan Alzheimer 's ang natna a vei tawh a nih chuan 'Kei pawhin ka vei ang em?' i rilru hnung lamah a awm mai thei. Engtin nge kan genes hian hei hi a nghawng tak tak? Tun hnaia zirchianna hrang hrangah chuan gene bik pakhat APOE4 an tih leh Alzheimer natna inkarah hian a hmaa ngaihtuah aiin inzawmna nghet zawk a awm tih a tarlang. Chuvangin vawiinah hian he thil hi i sawi dawn a, nangmah a nghawng em tih te, eng nge kan tih theih tih te i sawi dawn nia.

He gene hi eng chiah nge APOE4 an tih?

A awlsam zawngin APOE hi kan taksaa gene pakhat a ni. A hna ber chu kan cell inkara thau , cholesterol ang chi (lipid transport) phurh hi a ni. Kan taksa chhunga cell awmte hi in te tak te angin ngaihtuah rawh. Heng in te hian an hnathawh theih nan te, an sak theih nan te, leh chakna siam chhuah nan te thau an mamawh a ni. APOE gene hi ‘delivery service’ ang mai a ni a, heng thau te hi cell chhungah a luhtir a, a chhuah tir bawk. He hna hian a thawk tha lo a nih chuan harsatna a awm thei a, a bik takin thluak cell-ah hian harsatna a awm thei a ni.

Mi zawng zawng hian he APOE gene hi kan nei vek em?

Ni e, kan taksaah hian he APOE gene hi kan nei vek a. Mahse, a inang lo. Engtin nge, ‘delivery service’ khatah pawh hnathawk thenkhat chu an fing hle a, thenkhat chu an average a, thenkhat chu an lazy deuh bawk. A chi thum a awm a. A danglamna chu eng nge ni tih i lo en ang u.

Zirna thar hian eng nge a sawi?

APOE4 hi Alzheimer’s natna ‘risk factor’ mai mai niin kan ngai thin. Chu chu i neih chuan natna i vei dawn tihna a ni lo va, chance a sang zawk tihna a ni.

Mahse he zirchianna thar hian APOE4 gene copy pahnih neih hi risk factor mai ni lovin, Alzheimer natna ngei pawh hi genetic form a ni thei tih a tilang. Chumi awmzia chu gene pahnih nei te hi natna kai theihna chance a sang zawk tihna a ni. Tin, symptoms hi kum naupang deuh atang pawhin a intan thei bawk.

Alzheimer natna thlentu genes te chu `(APP)`, `(PSEN1)` leh `(PSEN2)` te an ni tih kan hre tlangpui. An tlem hle. Mahse he zirchianna hian APOE4 gene chu an hnaih tir ta a ni. An hmuhchhuah dan chuan APOE4 copy hnih nei zinga 95% chuan kum 65 an tlin chuan thluaka Alzheimer natna nena inzawm protein hlauhawm tak `(beta amyloid)` chu a tlangpuiin a sang hle tih an hmuchhuak.

APOE4 gene neih hian Alzheimer’s i vei ngei ang tihna em ni?

No. 100% guarantee a ni lo. Mahse a risk a sang hle. Car khalh chak lutuk a, accident i neih chuan accident i neih theihna a tipung ang mai a ni. A thleng lovang, mahse i chance a tipung. Mipui 2% vel chuan APOE4 gene copy pahnih hi an nei vek a ni. 15% leh 25% inkar hian copy pakhat an nei.

He gene hi ka nei em tih ka test thei ang em?

Ni e, hei hi genetic test a awm. Mahse hei hi i doctor-in a tih tlangpui a ni lo va, damdawi inah awlsam taka tih theih a ni. Hei hi Sri Lanka-ah chuan a awm vak lo. Ram dangah phei chuan insurance-in a huam tam lo hle.

Heng test te hi private institution kaltlangin pawisa pek theih a ni. Hei hi tihsak i duh leh duh loh chu i mimal thutlukna a ni vek. I chhungte zinga mi engemaw zatin Alzheimer natna an vei a nih chuan doctor nen inbiakna neihpui la, hemi chungchangah hian thutlukna siam i duh mai thei.

A hlauhawm hle chung pawhin he natna laka inven nan eng nge kan tih theih ang?

Hetah hian a pawimawh ber chu a awm. Kan genes hi kan thlak danglam thei lo. Mahse, anmahni nena lo awm risk chu kan do thei a ni. Natna hi a lo thang kim tawh chuan kan reverse thei lo nain, kan nunphung hian a tikhawtlai thei a, a lo veng thei lo bawk .

1. Nutrition atanga tan ila.

Zirna hrang hrangah chuan thing leh mau tamna ei hian Alzheimer’s vei theihna chu 50% velin a tihniam thei tih hmuhchhuah a ni. Chu chu thlai, thei, legumes, nut, leh whole grains tamna ei tur tihna a ni . Mediterranean diet pawh hi a hlawkthlak hle.

2. Exercise hi kea kal mai mai a ni lo.

Exercise hi risk tihtlem nan hmanraw chak tak dang a ni bawk. Mahse huana kal mai mai chu a tawk lo. Exercise chi khat, i thawmhnaw ti hahdamtu leh taksa hahthlak tak tak , i thluak a thawk tak zet a ni. Strength training, weightlifting ang chi hi a pawimawh zual hle. Zirchianna pakhatah chuan pre-dementia vei, ke tihchakna exercise ti thinte chuan he natna vei theihna hi 40% in an tihhniam thu a tarlang.

3. I thluak pawh exercise la

Rilru exercise hi taksa exercise ang bawkin a pawimawh hle. Hei hian thluaka neuron an tih cell inzawmna a tichak a ni.

• Thil thar (Ṭawng, musical instrument) zir rawh.
• Puzzle, Sudoku, etc. te chinfel dan.
• I hobby duh ber pakhatah thuk takin lut rawh.
• Harsatna thar hmachhawn rawh.

Genes chungchanga mi zawng zawngin kan hriat tur, an hriat loh pawhin

Chumi awmzia chu kum 30, 40, 50 vel kan nih zawng zawng hian tunah hian kan thluak hriselna hi kan ngaihtuah a ngai tihna a ni.

I doctor nen inbia la, i cholesterol level, thisen sang leh HbA1c test value te zir la, hei hian i zunthlum dinhmun a tarlang a ni. Hengte hi control hi i thluak venhimna atana investment lian ber pakhat a ni.