Me ako noa tātou mō ngā DMARD, arā, ngā rongoā e whakamahia ana hei rongoā i te Ankylosing Spondylitis.

Ka ara ake koe i te ata me te mārō, te pūmau rānei? He uaua ki te piko mō tētahi wā? Tērā pea nā te Ankylosing Spondylitis tēnei, he mate e pā ana ki ngā hononga o te tuaiwi. Mena kua whakamātau koe i ngā rongoā mamae kore-tohu ( NSAID ) ā, kāore anō kia memeha te mamae me te pupuhi, ka tūtohu pea tō tākuta i tētahi DMARD. Nō reira, me rapu tātou i te pūtake o tēnei.

He aha ngā DMARD, ā, me pēhea tā rātou mahi?

I roto i te Ankylosing Spondylitis, ka kaha rawa te pūnaha parepare o te tinana, arā, te pūnaha ārai mate, ka tīmata ki te whakaeke i ō tātou hononga tuaiwi. Ka puta te mumura , te mamae, me te pakari, ā, ka uaua ai te neke tika i te tuaiwi.

Ko te DMARD he whakarāpopototanga mō te 'Disease-Modifying Antirheumatic Drug' . Ki te whakarāpopototanga, ko tōna tikanga he 'rongoā mate rumatiki e whakarerekē ana i te mate'. Ka mahi ēnei rongoā mā te whakamarie i te pūnaha ārai mate e kaha rawa ana te mahi. He rerekē ki ngā rongoā whakamamae mamae noa (NSAID), ehara i te mea ka whakaiti noa i te mamae, engari ka āwhina hoki ki te whakahaere i te haere whakamua o te mate me te ārai i ngā kino atu ki ngā hononga. Koia te take i huaina ai rātou he "rongoā whakarerekē mate".

He aha ngā momo DMARD e hoatu ana mō te Ankylosing Spondylitis?

Ka taea te wehewehe i ngā DMARD e hoatu ana mō tēnei mate ki ētahi wāhanga matua. Ka kiia ēnei he DMARD koiora me ngā DMARD tuku iho. Me titiro tātou ki ia momo.

Ngā rongoā koiora: Ngā rongoā e mahi ana i te whāinga kotahi

He rite ngā matū koiora ki ngā kaipupuhi. Ka whaia , ka whakaekea hoki e rātou ngā pūmua e tino puta ai te raruraru.

• Ngā aukati TNF: Koinei te momo rongoā koiora tuatahi kua whakaaetia mō te ankylosing spondylitis. Ka mahi rātou mā te aukati i tētahi pūmua e kiia nei ko te Tumor Necrosis Factor (TNF), e puta ai te mumura. Ka taea e rātou te āwhina i te mate rumatiki o te tuaiwi me ētahi atu hononga, tae atu ki ngā āhuatanga ka puta mai i te mate, pērā i te uveitis , te mumura o te kanohi, me te Inflammatory Bowel Disease (IBD) ( te mate a Crohn me te ulcerative colitis). Ka tohua ēnei e tō tākuta mēnā kua whakamātau koe i te iti rawa i te rua ngā momo rongoā mamae (NSAID) ā, kāore anō kia puta he hua.
• Adalimumab (Hūmira)
• Certolizumab (Cimzia)
• Etanercept (Enbrel)
• Infliximab (Remicade)
• Golimumab (Simponi)

• Ngā aukati IL-17: Ka mahi ēnei mā te aukati i tētahi atu pūmua mumura e kiia nei ko te Interleukin-17 (IL-17). He kōwhiringa pai ēnei mō te hunga kāore anō kia aro ki ngā aukati TNF, kāore rānei e taea te tango i ngā aukati TNF nā ngā āhuatanga pēnei i te mate manawa, te sclerosis maha rānei (MS).
• Ixekizumab (Taltz)
• Secukinumab (Cosentyx)

Ngā aukati JAK: Ngā rongoā hou ka taea te tango hei pire

He rerekē ēnei i ngā rongoā koiora. He otinga pai ēnei mō te tangata kāore e pai ki ngā werohanga, nā te mea he pire kei roto. Ka mahi rātou mā te aro ki tētahi pūnaha whākōkī e kiia nei ko Janus Kinase (JAK), e puta ai te mumura.

• Tofacitinib (Xeljanz)
• Upadacitinib (Rinvoq)

Ngā DMARD Tuku Iho: Ngā rongoā e whakamahia whānuitia ana mō ngā hononga ā-taha

Ko te nuinga o ēnei ka hoatu hei rongoā mō te mamae me te pupuhi o ngā hononga pēnei i te ringa, te waewae, te hope, me te turi, kaua mō te mamae o te tuaiwi.

• Methotrexate: Ka puta mai tēnei hei pire, hei werohanga rānei. Ka āwhina ki te ārai i te kino o ngā hononga.
• Sulfasalazine (Azulfidine): He rongoā anō hoki tēnei mō ngā hononga taha me te IBD. Ka tangohia hei pire.

Me pēhea te whiriwhiri a te tākuta i te DMARD tika māu?

He maha ngā āhuatanga ka whakaarohia e tō tākuta i te wā e whiriwhiri ana i tētahi rongoā.

• Te kaha o ō tohumate.
• Ngā rongoā i whakamahia e koe i mua me ngā hua i puta mai i aua rongoā.
• Ngā pānga taha o te rongoā e pā ana ki a koe me tōna pānga ki tō hauora.

He aha ngā pānga taha o tēnei rongoā?

Pērā i ngā rongoā katoa, ka pāngia pea koe e ngā DMARD. Ko ētahi he iti noa iho, ko ētahi he kino rawa atu. Nō reira, kōrero ki tō tākuta mō ēnei i mua i te tīmatanga o te rongoā.

• Ngā rongoā koiora me ngā aukati JAK: Ka whakaroa ēnei i te pūnaha ārai mate, ka kore e kaha ki te whawhai ki ngā mate. Nō reira, he mea nui kia mōhio koe kei a koe ō werohanga katoa i mua i te tīmatanga o ēnei rongoā.
• Whakamātautau Mate Kohi (TB): He mea nui kia whakamātauria koe mō te mate kohi (TB) i mua i te tīmatanga o te tango i ngā aukati TNF, nā te mea ka taea e ēnei rongoā te whakahohe anō i ngā iroriki mate kohi e moe ana i roto i tō tinana.
• Ētahi atu pānga taha: Tērā pea ka whero te wāhi i werohia ai, ka pāngia te upoko, ka puta hoki te kiri mākūkū. I ētahi wā, ka kino ake pea te IBD i ngā aukati IL-17.

Ngā pānga taha o ngā DMARD tuku iho

• Methotrexate: Ka pā mai pea ngā mate pāwera, te kirika, me te marō i te puku, ngā mate waha, me te iti o ngā toto toto. Hei whakaiti i ēnei, ka hoatu e tō tākuta he papa waikawa folic ki a koe. I a koe e tango ana i tēnei rongoā , me whakamātau toto koe i ia 1-3 marama hei tirotiro i te mahi a tō whatukuhu me tō ate. Kāore i te tūtohutia tēnei rongoā i te wā e hapu ana.
• Sulfasalazine: Tērā pea ka pā te whakapairuaki, te ruaki, te aro ki te rā, te kiri mākūkū, me te ānini. Tērā pea ka huri tēnei rongoā i tō mimi, tō werawera, me ō roimata ki te tae kōwhai-karaka. Ehara i te mea morearea, engari ka taea e ia te whakapoke i ngā kākahu.

He aha ngā mea hei tumanako atu ina tīmata te maimoatanga?

Kāore ēnei rongoā e mahi ōrite mō te katoa. Tirohia ngā huaKa roa pea mō ētahi wiki, mō tētahi marama, mō ētahi rānei. Nō reira, he mea nui kia manawanui. Kaua e mutu ohorere te tango i te rongoā nā te mea e whakaaro ana koe kāore e pai ake.

Ahakoa kua memeha katoa ō tohumate, he mea nui tonu kia haere tonu te tango i tō rongoā mō te roa e tohutohu ana tō tākuta. Ki te mutu, tera pea ka hoki anō te mate.