Kunzima kangakanani ukuziva ngathi awukwazi ukulawula umzimba wakho? Khawuthelekelele, xa uthetha, usitya, okanye uzama ukusayina uxwebhu, ubuso bakho, amalungu, okanye ezinye iindawo zomzimba wakho ziqala ukuxhuzula nokuxhuzula ngokungalawulekiyo... Oku kukuphazamiseka okukhulu kubomi bakho bemihla ngemihla kwaye kunokukwenza woyike ukujongana noluntu. Kweli nqaku, siza kuthetha ngeyeza elinokunceda abo banengxaki yokushukuma okungalawulekiyo .
Iimeko ezimbini eziphambili zempilo ezibangela ezi ntshukumo zingalawulekiyo zezi:
Iyeza i-Austedo lisetyenziswa kakhulu ukunyanga izifo ezimbini. Makhe sijonge ukuba zeziphi.
1. I-Chorea ngenxa yesifo sikaHuntington: Nangona oku kusenokuvakala njengegama elintsonkothileyo, ngamafutshane, yimeko yelifa. Kule meko, iiseli zemithambo-luvo ebuchotsheni ziyatshatyalaliswa kancinci kancinci. Oku kubangela iingxaki zokucinga, ukulawula iimvakalelo, kunye neentshukumo zomzimba. Oku sikubiza ngokuba ziintshukumo ezingalawulekiyo, ezikhawulezileyo, ezishukumayo, nezishukumisayo.
2. I-Tardive Dyskinesia (TD): Le yimeko ebangela iintshukumo ezingalawulekiyo eziphindaphindayo (umz., ukuxhuzula, ukungcangcazela) kobuso (amehlo, umlomo), izandla, iinyawo, kunye nezinye iindawo zomzimba. Eyona nto ibangela oku kukuchaphazela kakubi amayeza asetyenziswa kwezinye iimeko, ingakumbi amayeza okulwa neengqondo.
I-Austedo isebenza njani emzimbeni?
Ingqondo yethu ifana neziko elikhulu lemiyalezo. Ithumela imiyalezo kwimisipha emzimbeni, efana "nokushukuma" kunye "nokuma," ngeeseli zemithambo-luvo. Izithunywa zeekhemikhali ezithwala le miyalezo zibizwa ngokuba zii-neurotransmitters .
Cinga ngala ma-neurotransmitters njengabantu abathumela imiyalezo. Athwala iileta (imiyalezo) ezivela engqondweni ukuya kwizihlunu.
I-Dopamine yenye yezona zinto zibalulekileyo. Kuzo zombini ezi meko i-Chorea kunye ne-Tardive Dyskinesia (TD) zikhankanyiweyo apha ngasentla, ezi zithunywa ezifana ne-dopamine zithumela imiyalezo ngokugqithisileyo okanye ngendlela engafanelekanga. Oku kuthetha ukuba izihlunu zifumana imiqondiso emininzi engafunekiyo ukuba "zishukume, zishukume." Yiyo loo nto umzimba uqala ukushukuma nokushukuma ngokungalawulekiyo.
Oko kwenziwa yi-Austedo kukulawula inani lemiyalezo engeyomfuneko ethunyelwayo. Oko kukuthi, kunceda ekunciphiseni loo 'trafikhi' kancinci kwaye kunciphise ukuhambahamba okungeyomfuneko.
Lifanele lisetyenziswe njani eli yeza?
Iipilisi ze-Austedo ziza kwiindidi ezimbini.
- Ipilisi eqhelekileyo: Ugqirha wakho unokucebisa ukuba uyithathe kanye okanye kabini ngemini.
- I-Austedo XR: Le yipilisi ethi 'Extended-Release' . Oku kuthetha ukuba iyeza likhutshwa emzimbeni kangangeeyure ezithile. Ngoko ke, lidla ngokuthathwa kube kanye ngemini.
Ugqirha wakho uza kukuqalisa ngedosi ephantsi kakhulu (idosi yokuqala) . Emva koko, iveki neveki, baya kunyusa idosi kancinci kancinci ude ufumane idosi yokugcina elawula ngcono iimpawu zakho. Ke ngoko, kubaluleke kakhulu ukulungisa idosi yakho njengoko ugqirha wakho ekuxelela.
Khumbula ezi zinto xa usebenzisa amayeza:
- Iipilisi ze-Austedo eziqhelekileyo mazithathwe kunye nokutya. Iipilisi ze-Austedo XR zingathathwa kunye nokutya okanye ngaphandle kokutya.
- Musa ukuphula, ukutyumza, okanye ukuhlafuna ipilisi. Yiginye yonke ngeglasi yamanzi.
- Ukuba uthatha i-Austedo XR, ungaqaphela ukuba ezinye zeepilisi, njengengubo eseleyo, ziphuma kwindle yakho emva kokuba iyeza lifunxwe ngokupheleleyo. Oku kuqhelekile kwaye akufanele kube sisizathu sokukhathazeka.
- Ukuba uphoswe yidosi, yithathe ngokukhawuleza xa ukhumbula. Nangona kunjalo, ukuba sele kuza kufuneka uyithathe idosi elandelayo, yitsibe idosi oyiphosileyo uze uthathe idosi elandelayo ngexesha eliqhelekileyo. Ungaze uthathe iidosi ezimbini ngaxeshanye ukuze ubuyisele idosi oyiphosileyo. Ukuba awuqinisekanga, buza ugqirha wakho.
Uyazi njani ukuba iyeza liyasebenza?
Kunzima ukulindela iziphumo ngoko nangoko. Kungathatha iiveki ukuya kwiinyanga ukuba iintshukumo zakho ezingalawulekiyo ziphele. Kubalulekile ukuba nomonde njengoko ugqirha wakho eza kuthatha ixesha ukufumana idosi efanelekileyo kuwe.
Ukuba uziva ngathi iimpawu zakho aziphucuki okanye zibonakala zisiba mandundu, qiniseka ukuba uthetha nogqirha wakho. Usenokukwazi ukutshintsha umthamo wakho okanye acinge ngonyango olwahlukileyo.
Iziphumo ebezingalindelekanga ezinokubakho kunye nendlela yokujongana nazo?
Njengayo nayiphi na iyeza, i-Austedo inokubangela iziphumo ebezingalindelekanga kwabanye abantu. Nangona kunjalo, ayinguye wonke umntu ozifumanayo. Itheyibhile engezantsi idwelisa ezinye zeziphumo ebezingalindelekanga eziqhelekileyo kunye neendlela ezilula zokuzilawula.
| Imiphumela | Ungayilawula njani? |
|---|---|
| Ukozela, ukudinwa | Ziphephe izinto ezifuna ukuphaphama, njengokuqhuba okanye ukusebenzisa oomatshini, ude wazi kakuhle indlela amayeza akuchaphazela ngayo. |
| Urhudo | Ukuthintela ukuphelelwa ngamanzi emzimbeni, sela iziselo ezininzi ezifana namanzi kunye nejusi. Yitya ukutya okufana neebhanana, irayisi kunye nesonka. Ukuba kukhulu, xelela ugqirha wakho. |
| Umlomo Owomileyo | Sela amanzi amaninzi rhoqo. Zama ukuphefumla ngeempumlo zakho endaweni yokuphefumla ngomlomo. Ukuhlafuna itshungama engenaswekile nako kunokunceda. |
| Ingxaki Yokulala | Kuphephe ukusela iziselo ezine-caffeine ezifana nekofu neti ngokuhlwa. Zibekele ixesha elithile lokulala. Nciphisa ukusebenzisa ifowuni kunye nethebhulethi yakho ngaphambi kokulala. |
| Izifo zempumlo okanye zomqala (ezifana nomkhuhlane) | Ezi zinto zihlala ziphela kwiintsuku ezimbalwa. Ukusela ulwelo olufudumeleyo nokuphumla kunokunceda. Ukuba iimpawu zinzima okanye ziyaqhubeka, xelela ugqirha wakho. |
Amanye amayeza angahambelaniyo nalo mayeza (Ukusebenzisana kwamayeza)
Le yinxalenye ebaluleke kakhulu . Xa usebenzisa i-Austedo, kukho amayeza ekungafanele athathwe nayo kwaye afanele athathwe ngononophelo olukhulu.
Amayeza angafanele asetyenziswe:
- Ii-MAOI (iiMonoamine Oxidase Inhibitors): Ezi luhlobo lwamayeza anikwayo ngenxa yokudakumba okanye isifo sikaParkinson.
- I-Reserpine: Iyeza elidala elisetyenziselwa uxinzelelo lwegazi oluphezulu.
- I-Tetrabenazine kunye neValbenazine: La ngamanye amayeza asetyenziselwa ukunyanga iingxaki zokunyakaza, njenge-Austedo. Ukuwasebenzisa kunye kunokunyusa umngcipheko wemiphumo emibi kakhulu.
Amayeza ekufuneka athathwe ngononophelo:
- Izithinteli ze-CYP2D6: Le iyinkimbinkimbi ngakumbi. Ngamafutshane, ukuthatha i-Austedo kunye namayeza okudakumba afana ne-bupropion kunye ne-fluoxetine, okanye amayeza e-heart rhythm afana ne-quinidine kunokunyusa amanqanaba e-Austedo egazini lakho kwaye kwandise umngcipheko weziphumo ebezingalindelekanga. Ukuba uthatha elinye lala mayeza, ugqirha wakho unokunciphisa umthamo wakho we-Austedo.
- Amayeza okulwa nesifo sengqondo (amayeza okugula ngengqondo): Xa esetyenziswa ne-Austedo, la mayeza anokunyusa umngcipheko wezifo ezifana ne-Parkinsonism, ukuqina kwemisipha (i-neuroleptic malignant syndrome), kunye nokungaphumli (akathisia).
- Amanye amayeza abangela ukozela notywala: I-Austedo inokubangela ukozela. Ngoko ke, ukuyithatha kunye namayeza okubangela ukozela afana neBenadryl okanye amanye amayeza abangela ukozela kunokunyusa ukozela. Kuphephe ukusela utywala ngokupheleleyo ngelixa usebenzisa i-Austedo.
Ngoko ke, kubalulekile ukwazisa ugqirha wakho malunga nawo onke amayeza owasebenzisayo (kuquka amayeza ezinye izifo, iivithamini, kwanamayeza emveli).
Umyalezo Wokuya Ekhaya
- I-Austedo liyeza elithile elisetyenziselwa ukunyanga iintshukumo ezingalawulekiyo ezibangelwa sisifo sikaHuntington kunye neTardive Dyskinesia (TD).
- Eli yeza lifanele lithathwe kuphela ngokwengcebiso kagqirha. Landela idosi ngqo njengoko ugqirha wakho ekuyalele. Kuphephe ukutshintsha okanye ukuyeka idosi ngokwakho.
- Nceda ube nomonde ngonyango kuba kungathatha iiveki okanye iinyanga ezininzi ukubona iziphumo.
- Kubaluleke kakhulu ukwazisa ugqirha wakho malunga nawo onke amanye amayeza, iivithamini, kunye nezongezo ozithathayo.
- Ukuba kuvela iziphumo ebezingalindelekanga ezibi kakhulu, iimpawu ziya zisiba mandundu, okanye uneengxaki ngale yeza, thetha nogqirha wakho ngoko nangoko.
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