Ukushukuma kwamalungu omzimba okanye ukutshintsha kwembonakalo yobuso ngaphandle kolawulo lwakho kunokuba yinto engathandekiyo. Kunokwenza kube nzima ukwenza imisebenzi yemihla ngemihla okanye nokuba nabantu abane. Abantu abaninzi badandathekile ngenxa yezi meko. Ukuba wena okanye umntu osondeleyo kuwe ukhe wahlangabezana noku, eli nqaku liza kuba luncedo kakhulu kuwe.
Yintoni iTardive Dyskinesia kunye neChorea?
Ngamafutshane, ezi ziimeko ezimbini zempilo ezenzekayo ezinxulumene nokuhamba kwemizimba yethu.
I-Tardive Dyskinesia (TD): Le yimeko apho sifumana khona iintshukumo zomzimba ezizenzekelayo nezishukumisayo, ingakumbi ubuso kunye namalungu. Oku kungabandakanya ukuvela kolwimi ngaphandle kokuzithandela, ukubetha imilebe, ukuqhwanyaza amehlo, okanye ukuxhuzula amalungu. Le meko inokubakho njengesiphumo esibi sokusetyenziswa ixesha elide kweminye imithi yokuthintela ukugula kwengqondo okanye amanye amayeza esisu.
I-Chorea: Esi sisifo sokushukuma esibangelwa yimeko yemfuza ebizwa ngokuba yi-Huntington 's Disease . Kwisifo sikaHuntington, iiseli zemithambo-luvo ebuchotsheni ziyatshatyalaliswa kancinci kancinci. Oku kubangela iingxaki zokucinga, ukulawula iimvakalelo, kunye nokuhamba komzimba. I-Chorea ibangela ukushukuma okungalawulekiyo kwezandla, iinyawo, kunye nobuso.
Iyeza elithi Ingrezza linceda ekulawuleni iintshukumo ezingalawulekiyo ezenzeka kuzo zombini ezi meko. Kodwa khumbula, i-Ingrezza ayinyangi ezinye iimpawu zesifo sikaHuntington (ezifana neengxaki zokucinga).
Isebenza njani iyeza i-Ingrezza?
Ukuze siqonde oku, kufuneka siqale sazi ngesithunywa esincinci sekhemikhali engqondweni yethu. Igama laso yiDopamine . Ngokuchanekileyo, iDopamine yi-neurotransmitter. Le Dopamine ibaluleke kakhulu ekulawuleni iintshukumo zomzimba wethu.
Khawucinge ukuba kwenzeka ntoni xa ubuchopho bethu buthumela i-dopamine eninzi kakhulu? Njengempompo yamanzi evula ngokukhawuleza, kukholelwa ukuba xa imiqondiso ye-dopamine isanda, imizimba yethu ayizikhetheli .
Nantsi into eyenziwa ngu-Ingrezza. Ijolise kwiproteni esebuchotsheni bethu ebizwa ngokuba yi-VMAT2 (vesicular monoamine transporter 2) . Le proteni yiyo enceda ukukhupha i-dopamine. Ngokulawula umsebenzi we-VMAT2, i-Ingrezza iyanciphisa i-dopamine signaling egqithisileyo. Kufana nokuvula i-faucet kancinci. Ngenxa yoko, iintshukumo ezingalawulekiyo ziyancipha kancinci kancinci.
Ndingayisebenzisa njani le yeza?
I-Ingrezza liyeza eliza ngendlela ye-capsule. Lingathathwa nokutya okanye ngaphandle kokutya. Ugqirha wakho uza kukunika eli yeza. Ungaze uthathe ngaphezulu okanye ngaphantsi komthamo ochazwe ngugqirha wakho.
Idosi eqhelekileyo idweliswe kwitheyibhile engasezantsi, kodwa ugqirha wakho angakutshintsha oku kuxhomekeke kwimeko yakho.
| Imeko yezonyango | Idosi yokuqala | Idosi ecetyiswayo | Indlela yokunyusa umthamo |
|---|---|---|---|
| I-Tardive dyskinesia (TD) | 40mg kanye ngemini | 80mg kanye ngemini | Emva kweveki, inyuswa iye kwi-80mg. |
| I-Chorea | 40mg kanye ngemini | 80mg kanye ngemini | Emva kweeveki ezi-2, inyuswa iye kwi-60mg, kwaye emva kweeveki ezi-2, iye kwi-80mg. |
Indlela yokuthatha i-Ingrezza Sprinkle capsule
Abanye abantu banengxaki yokuginya iikhaphu. Kwabo bantu, kukho uhlobo olukhethekileyo olubizwa ngokuba yi-"Ingrezza Sprinkle." Nantsi indlela yokuyisebenzisa:
1. Vula i-capsule ngononophelo uze wongeze iinkozo ezincinci zamayeza (iifafaza) ngaphakathi kwithisipuni yokutya okuthambileyo okufana ne-applesauce, iyogathi, okanye i-pudding.
2. Musa ukuhlafuna okanye ukutyumza eli yeza .
3. Yitya yonke icephe lokutya elixutywe neyeza ngoko nangoko .
4. Emva koko sela iglasi yamanzi (malunga ne-240 ml).
5. Ungaze udibanise eli yeza nobisi okanye amanzi.
Eyona nto ibalulekileyo kukulandela imiyalelo kagqirha wakho ngokuchanekileyo. Ukuba uneengxaki, thetha nogqirha wakho ngazo.
Uyazi njani ukuba iyeza liyasebenza?
Ngokwezifundo zeklinikhi, ungabona ukuphucuka kweempawu kwiiveki nje ezimbini emva kokuqala i-Ingrezza. Uza kubona ukuba ezo ntshukumo zomzimba ezingalawulekiyo ziya zincipha kancinci kancinci.
Ugqirha wakho uza kukuqalisa ngedosi ephantsi aze alungise idosi njengoko kufuneka ukuze abone ukuba umzimba wakho usabela njani. Ngoko ke kungathatha ixesha ukubona iziphumo ezilungileyo. Ukuba uvakalelwa kukuba iimpawu zakho aziphucuki okanye ziya zisiba mandundu, xelela ugqirha wakho ngoko nangoko. Angalungisa idosi, ongeze elinye iyeza, okanye akutshintshele kwelinye iyeza ukuba kuyimfuneko.
Iziphumo ebezingalindelekanga ezinokubakho kunye nendlela yokuzilawula?
Njengayo nayiphi na iyeza, i-Ingrezza inokubangela ezinye iziphumo ebezingalindelekanga, nangona ingenguye wonke umntu ozifumanayo.
- Iziphumo ebezingalindelekanga eziqhelekileyo phakathi kwezigulane ezine-tardive dyskinesia (TD) zezi:
- Ukozela
- Iziphumo ebezingalindelekanga eziqhelekileyo phakathi kwabantu abanesifo seChorea:
- Ukozela
- Iimpundu zesikhumba (iiHives)
- Ukuqhambuka kwesikhumba
- Ingxaki yokulala
Ujongana njani nezi zinto?
- Ukozela: Ziphephe izinto ezifuna ukuphaphama, njengokuqhuba okanye ukusebenzisa oomatshini, ude wazi kakuhle indlela eli yeza elikuchaphazela ngayo.
- Ukuqhambuka kwesikhumba okanye amaqhuqhuva: Ezi zinokuba ziimpawu zokuba umntu une-allergy. Ukuba oku kuyenzeka, tsalela umnxeba ugqirha wakho ngoko nangoko, okanye uye kwigumbi elikufutshane lesibhedlele esingxamisekileyo (ETU).
- Ukungalali: Zikhona izinto onokuzenzela zona. Ukunciphisa ukutya kwakho iziselo ezine-caffeine ezifana nekofu, iti, kunye ne-cola, ukuziqhelisa ukuya kulala nokuvuka ngexesha elinye yonke imihla, ukugcina igumbi lakho lokulala limnyama, kunye nokunciphisa ukusebenzisa iifowuni kunye neetablethi ngaphambi kokuba ulale kunokunceda.
Ukusebenzisana neziyobisi
Ukuba usebenzisa i-Ingrezza, kubaluleke kakhulu ukuxelela ugqirha wakho ngazo zonke ezinye iziyobisi ozisebenzisayo, kuquka neevithamini, kuba ezinye iziyobisi zinokusebenzisana ne-Ingrezza.
- Izithinteli ze-Monoamine oxidase (ii-MAOI):La ngamayeza asetyenziselwa ukunyanga uxinzelelo okanye isifo sikaParkinson. La mayeza e-MAOI awavumelekanga ngokupheleleyo ukuba asetyenziswe kunye ne-Ingrezza.
- I-Digoxin: Eli liyeza elisetyenziselwa ukunyanga ukungasebenzi kakuhle kwentliziyo kunye nokubetha kwentliziyo okungahambelaniyo. Ukusela i-Ingrezza kunye ne-Digoxin kunokunyusa amanqanaba e-Digoxin egazini lakho, okubangela iziphumo ebezingalindelekanga. Ugqirha wakho uza kuvavanya igazi lakho aze anciphise umthamo wakho we-Digoxin ukuba kuyimfuneko.
- Ii-CYP3A4 kunye nee-CYP2D6 inhibitors/inducers: La ngamagama anzima kakhulu kwezonyango. Asebenza kwiintlobo ezahlukeneyo zamayeza. Eyona nto ilula nekhuselekileyo onokuyenza kukuxelela ugqirha wakho ngawo onke amayeza owasebenzisayo. Uya kwenza naluphi na utshintsho olufunekayo.
Umyalezo Wokuya Ekhaya
- I-Ingrezza liyeza elinceda ukulawula iintshukumo zomzimba ezingalawulekiyo ezenzeka kwiimeko ezibizwa ngokuba yi-tardive dyskinesia (TD) kunye ne-chorea ebangelwa sisifo sikaHuntington.
- Oku kulawula imiqondiso ye-dopamine engqondweni.
- Soloko ulandela idosi kunye nemiyalelo echazwe ngugqirha wakho ngokuchanekileyo. Ungaze utshintshe idosi ngokwakho.
- Lumka ngeziphumo ebezingalindelekanga ezifana nokozela kunye nokunganyamezelani nolusu. Ukuba kuvela iimpawu zokunganyamezelani, funa ingcebiso kagqirha ngoko nangoko.
- Kubalulekile ukwazisa ugqirha wakho malunga nazo zonke ezinye iziyobisi, iivithamini, kunye nezongezo ozithathayo.
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