Igama elithi "umhlaza" lisoyikisa kancinci sonke, akunjalo? Kodwa ngokuhambela phambili kwesayensi yezonyango, kuye kwavela iindlela ezininzi ezintsha neziphumelelayo zokulwa nomhlaza. Namhlanje, siza kuthetha ngendlela yonyango ephumelelayo ekuthethwa ngayo kakhulu, ingakumbi kumhlaza webele. Oku kubizwa ngokuba yi-Targeted Therapy . Makhe sijonge ukuba yintoni, isebenza njani, kwaye yintoni ekufuneka uyazi ngayo.
Ngamafutshane, yintoni iTargeted Therapy?
Cinga ngako oku, i-chemotherapy, njengoko sisazi, itshabalalisa iiseli ezahlulahlula ngokukhawuleza. Oku kungonakalisa kungekuphela nje iiseli zomhlaza kodwa neeseli ezisempilweni emzimbeni wethu. Yiyo loo nto i-chemotherapy idla ngokuba neziphumo ebezingalindelekanga ezifana nokulahlekelwa ziinwele kunye nokucaphuka.
Kodwa le ndlela yonyango ebizwa ngokuba yiTargeted Therapy yahlukile kakhulu kuloo nto. Ukuchaneka, olu lunyango 'olukrelekrele' kakhulu. Lujolise kwaye luhlasele iiseli zomhlaza kuphela . Le ndlela yonyango isebenzisa amasosha omzimba wethu ukutshabalalisa iiseli zomhlaza, okanye ukuthintela imiqondiso yokuba iiseli zomhlaza kufuneka zikhule. Oku kubangela umonakalo omncinci kwiiseli eziphilileyo. Inzuzo yoku kukuba iziphumo ebezingalindelekanga zihlala zincinci kuneze-chemotherapy.
Olu nyango lusebenza ngeendlela ezimbini eziphambili:
1. Ukusetyenziswa kwee-Antibodies: Ezi antibodies ziveliswa ziiseli ezikhethekileyo kwinkqubo yomzimba yethu yokuzikhusela. Ezi antibodies zenziwa ngokwenziwa kwilebhu kwaye zinikwe umzimba njengeyeza. Ezi zinamathela kwiiseli zomhlaza kwaye ziyazithintela ekukhuleni okanye ekuzitshabalaliseni.
2. Amayeza eemolekyuli ezincinci: La ngamayeza anokusetyenziswa njengeepilisi. Asebenza ngokuvala iindlela zokuhambisa imiyalezo ngaphakathi kwiiseli zomhlaza ezizinceda zahlukane kwaye zikhule.
Ugqirha wakho uya kugqiba ukuba loluphi uhlobo lonyango olujoliswe kuwe ngokusekelwe kuhlobo oluchanekileyo lomhlaza webele onalo.
Umhlaza Webele Olungileyo we-HER2 kunye noNyango Lwawo
Malunga nama-20% abantu abanomhlaza webele, okanye malunga nomnye kwabahlanu, banesiphako kwijini ebizwa ngokuba yi-'HER2'. Esi siphene sibangela ukuba ijini yenze iikopi ezininzi kakhulu. Ukuba kukho iproteni ye-'HER2' eninzi kwiiseli zomhlaza, loo mhlaza siwubiza ngokuba yi-'HER2-positive'.
Ukuba umhlaza wakho 'une-HER2-positive', kukho unyango oluthile nolusebenzayo kakhulu olujoliswe kuwo.
- I-Trastuzumab :Olu lolona nyango luphambili olujoliswe kulo lomhlaza we-'HER2-positive'. Eli yeza lifumaneka phantsi kwamagama eempawu ezahlukeneyo ezifana ne-'Herceptin', 'Kanjinti', 'Ogivri'. Liyinaliti efakwa emthanjeni. Kukholelwa ukuba ilawula umhlaza ngeendlela ezintathu eziphambili:
- Iiseli zomhlaza zinamathela kumphezulu kwaye ziyazithintela ekukhuleni.
- Inceda ekutshabalaliseni iiseli zomhlaza ngokwazisa inkqubo yethu yomzimba yokuzikhusela.
- Xa inikwa kunye ne-chemotherapy, iyandisa impumelelo yezo zonyango.
- IPertuzumab: Eli yeza, eliphantsi kwegama lophawu elithi `Perjeta`, lelinye i-antibody elinikwa umhlaza we-`HER2-positive`. Lidla ngokunikezelwa kunye ne-`Trastuzumab` kunye neyeza le-chemotherapy `docetaxel`. Nangona kunjalo, alifanelekanga kubafazi abakhulelweyo, kuba linokulimaza usana olungekazalwa.
- Amanye amayeza: `Ado-trastuzumab emtansine (Kadcyla), `Margetuximab (Margenza), kunye `Fam-trastuzumab deruxtecan-nxki (Enhertu)` nazo ngamayeza anamhlanje anikezelwayo kolu hlobo lomhlaza, ingakumbi kwiimeko apho umhlaza usasazeke khona (uqhubele phambili) okanye xa ezinye iindlela zonyango zingaphumelelanga.
- Iipilisi: I-Lapatinib (Tykerb) kunye ne-Neratinib (Nerlynx) ngamayeza ajoliswe kumhlaza we-HER2-positive anokuthatyathwa njengeepilisi. La mayeza anikwa emva kwezinye iindlela zonyango.
Unyango lwe-HER2-Negative Breast Cancer
Ukuba iiseli zakho zomhlaza azinaso esi siphene se-'HER2' esikhankanyiweyo apha ngasentla, oko kuthetha ukuba akukho protein ininzi ye-'HER2', loo mhlaza ubizwa ngokuba "ngumhlaza webele ongengowakhe uHER2." Emva koko uza kunikwa uhlobo olwahlukileyo lonyango.
Kukho amayeza athile onyango olujoliswe kuwo olu hlobo lomhlaza.
- Amayeza afana ne-'Everolimus (Afinitor), 'Palbociclib (Ibrance),' kunye ne-'Ribociclib (Kisqali)' anikwa kunye nonyango lweehomoni. La ngamayeza anikwa abafazi, ingakumbi emva kokuya exesheni, abanomhlaza osasazekileyo.
- Ii-PARP Inhibitors: Ukuba umhlaza wakho awunayo i-HER2 kwaye une-BRCA gene mutation, unganikwa udidi olukhethekileyo lwamayeza abizwa ngokuba yi-PARP inhibitors, njenge-Olaparib (Lynparza) kunye ne-Talazoparib (Talzenna). Ezi zikwayindlela yonyango ejoliswe ngqo kwiiseli zomhlaza.
Into ebalulekileyo kukuba zonke ezi ndlela zonyango zixhomekeke kwinqanaba lemfuza kunye neleeseli zomhlaza wakho. Ngoko ke kubalulekile ukuxoxa ngale nto ngononophelo nogqirha wakho uze ukhethe unyango olulungele wena.
Zithini iziphumo ebezingalindelekanga eziqhelekileyo?
Njengoko bekutshiwo ngaphambili, nangona zimbalwa iziphumo ebezingalindelekanga kune-chemotherapy, unyango olujoliswe kulo lunokubangela ezinye iziphumo ebezingalindelekanga. Ezi ziyahluka ngokweziyobisi. Ukuba ufumana naziphi na iziphumo ebezingalindelekanga , xelela ugqirha wakho ngoko nangoko . Uninzi lwexesha, zinokulawulwa.
| Iziphumo Eziqhelekileyo Ezingalindelekanga |
|---|
| Iimpendulo ze-allergy - ukurhawuzelela kwesikhumba, ukurhawuzelela. |
| Isicaphucaphu kunye norhudo. |
| Umkhuhlane kunye nokubanda. |
| Intlungu yomzimba, ukudinwa, kunye nobuthathaka. |
| Ingxaki yokuphefumla kunye nokudumba. |
| Isiyezi . |
Ungayiqaphela njani imeko engxamisekileyo?
Ukuba ufumana enye okanye ngaphezulu kwezi mpawu zilandelayo, isenokuba yimeko engxamisekileyo. Ungaze uyityeshele. Tsalela umnxeba ugqirha wakho ngoko nangoko. Ukuba awukwazi ukufikelela kuye, yiya kwiSebe leNgxamiseko (ETU) lesibhedlele esikufutshane.
| Nika ingqalelo kwezi mpawu! | |
|---|---|
| Umkhuhlane: Umkhuhlane ongaphezulu kwe-100.4 Fahrenheit (38 Celsius). Ukuba uba nomkhuhlane emva kokubanda, xelela ugqirha wakho ngoko nangoko. | Iingxaki zomlomo: Izilonda ezintsha emlonyeni, amabala amhlophe, ulwimi oluvuvukileyo, okanye iintsini eziphuma igazi. |
| Umphimbo obuhlungu: Ukuziva womile, ubuhlungu, ukrweleka, okanye "udumbile" emqaleni. | Ukukhwehlela: Ukukhwehlela okutsha okanye okungapheliyo. |
| Iingxaki zomchamo: Ukuchama rhoqo, usulelo lomchamo, okanye igazi kumchamo. | Iingxaki zesisu: Isitshiso esibuhlungu, isicaphucaphu, ukuhlanza, ukuqhina, okanye urhudo oluhlala iintsuku ezingaphezu kwezi-2-3. |
| Ubunzima bokuphefumla: Ukuphefumla nzima nokuba ungazibhokoxa kancinci. | Ukopha okungaqhelekanga: Igazi elikwisitulo. |
| Ukudumba: Ukudumba emilenzeni okanye eqatheni. | Ukudinwa kakhulu: Ukuziva udiniwe kangangokuba awukwazi kwenza nto. |
Umyalezo Wokuya Ekhaya
- I-Targeted Therapy yindlela yonyango yanamhlanje ejolise kwaye ihlasele iiseli zomhlaza webele, eyahlukileyo kwi-chemotherapy eqhelekileyo.
- Uhlobo lonyango olufumanayo luya kuxhomekeka kuhlobo lomhlaza onalo (umz., nokuba `une-HER2` okanye `une-HER2`). Uvavanyo olukhethekileyo lwenziwa ukuze kuqinisekiswe oku.
- Olu nyango lunokuba nemiphumo emibi, ngoko ke thetha nogqirha wakho ngalo naluphi na utshintsho okanye ukungakhululeki okuzivayo.
- Soloko ujonge iimpawu ezingxamisekileyo ezifana nomkhuhlane ophezulu, ubunzima bokuphefumla, kunye nokudumba okungaqhelekanga. Ukuba ubona nayiphi na kwezi, funa ingcebiso kagqirha ngokukhawuleza.
- Unyango lomhlaza luhambo olunzima. Ugqirha wakho kunye neqela lezempilo ngabahlobo bakho ababalaseleyo kolu hambo. Ngoko ke bathembe kwaye usebenzisane nabo.
💬 Comments (0)
Akukho zimvo zithunyelweyo okwangoku. Faka uluvo lwakho apha okokuqala.
Faka uluvo lwakho