Ingaba uneqhuma emzimbeni wakho? Ngaba le yi-Epithelioid Sarcoma? Masifumanise ngokuqinisekileyo!

Kuqhelekile ukuba nexhala xa ubona iqhuma elincinci okanye ithumba emzimbeni wakho, akunjalo? Ngamaxesha anjalo, ucinga ngezinto ezininzi. "Yintoni le? Ingaba iyingozi?" Imibuzo efana nale ifika engqondweni. Namhlanje siza kuthetha ngohlobo lomhlaza olungaqhelekanga olunokuvela njengeziqhuma ezinjalo. Loo nto ibizwa ngokuba yi-Epithelioid Sarcoma . Nangona eli gama lisenokuvakala lingaqhelekanga, kubalulekile ukulazi.

Yintoni i-Epithelioid Sarcoma? Ngokuchanekileyo...

Ngamafutshane, i-Epithelioid Sarcoma (ES) luhlobo lomhlaza olungaqhelekanga kakhulu olukwiqela lee-cancer ezibizwa ngokuba zii- soft tissue sarcomas . Igama elithi “soft tissue” libhekisa kwizinto ezisemizimbeni yethu ezifana nezihlunu, izicubu ezinamafutha, imithambo yegazi, kunye nemithambo-luvo. Ngoko ke lo mhlaza ukhula kwiindawo ezinjalo.

Idla ngokuqala njengeqhubu elisezingalo zakho , ezandleni, kwiminwe, emilenzeni esezantsi, okanye ezinyaweni zeenyawo zakho . Nangona kunjalo, linokukhula naphi na emzimbeni wakho. Ngamanye amaxesha, linokuvela iqhubu elingaphezulu kwelinye. Abanye abantu bakhula nezilonda eluswini apho kukho iqhubu khona.

Eyona nto ilungileyo kukuba, i-epithelioid sarcoma ngumhlaza okhula kancinci . Khawucinge nje, abanye abantu banokuba nolu hlobo lomhlaza kangangeenyanga, kwaneminyaka, bengabonakalisi zimpawu. Oko kuthetha ukuba inokukhula emzimbeni wakho ngaphandle kokuba wena ungazi.

Oku kukwabizwa ngokuba yi-epithelial sarcoma. Kukho iintlobo ezimbini eziphambili zale nto: i-distal kunye ne-proximal. Masijonge naleyo.

Ngaba zikho iintlobo zezi zinto? Zithini?

Ewe, njengoko besitshilo ngaphambili, kukho iintlobo ezimbini eziphambili ze-epithelioid sarcoma.

• Uhlobo olukude: Olu lolona hlobo luqhelekileyo . Igama elithi “Distal” lithetha ukuba kude nombindi womzimba. Oku kuthetha ukuba olu hlobo luqheleke kakhulu kwiindawo ezifana nezandla zakho, iinyawo, umphambili weengalo zakho, kunye nenxalenye esezantsi yemilenze yakho .

• Uhlobo olukufutshane: Olu lolona hlobo lunqabileyo . Igama elithi “Proximal” lithetha ukusondela embindini womzimba. Ngoko ke, le Proximal Epithelioid Sarcoma (PES) inokukhula kwiindawo ezifana nesifuba sakho, isisu, amakhwapha, amalungu esini (umz. ipenis okanye i-vulva), okanye intloko nentamo .

Ngokwesiqhelo, olu hlobo lweproximal lukhulu kancinci kunolo hlobo lwedistal.Inomsindo. Oko kuthetha ukuba inokusasazeka ngokukhawuleza kwaye ibe mandundu. Ngenxa yoko, kunokuba nzima ngakumbi ukunyanga.

Ixhaphake kangakanani i-epithelioid sarcoma? Ngubani onokuba nayo kakhulu?

Lo ngumhlaza ongaqhelekanga ngokwenene. Khawucinge nje, kukho iintlobo ezingaphezu kwama-50 ze-soft tissue sarcoma. Zonke xa zidibene, zimalunga ne-1% yazo zonke iintlobo zomhlaza kubantu abadala. Kwaye ke, le epithelioid sarcoma, kwakhona, linani elincinci kakhulu, malunga ne-1% yezo soft tissue sarcomas. Oko kuthetha ukuba, ngokwenene, kunqabile kakhulu.

Ngokutsho kweengcali, nokuba kwilizwe elifana neMelika, okwangoku kukho abantu abangaphantsi kwe-1,000 abanale epithelioid sarcoma. Ngoko ke ungacinga ukuba oku kunqabile kangakanani.

Ngokwesiqhelo,

• Uhlobo olukude lwe-ES – uhlobo oluqhelekileyo – luchaphazela kakhulu ulutsha kunye nabantu abadala abaselula .
• Uhlobo olusondeleyo lwe-ES – uhlobo olungaqhelekanga, olunzima kancinci – lubonakala kakhulu kubantu abadala .

Zithini iimpawu? Uzibona njani?

Kwinqanaba lokuqala, i-epithelioid sarcoma isenokungabangeli zimpawu. Oku kuthetha ukuba usenokungayiboni into engalunganga ngayo. Nangona kunjalo, njengoko ithumba likhula, unokubona iimpawu ezifana nezi:

• Kuvela iqhuma elitsha okanye ukudumba . Oku kungaba kuncinci okanye kukhulu.
• Izilonda zenzeka kumphezulu wesikhumba apho kukho khona iqhuma, njengenxeba elincinci okanye isilonda.
• Intlungu iyavakala. Kodwa oku kwenzeka kuphela ukuba ithumba likhulu kancinci kwaye licinezela izihlunu okanye imithambo-luvo ejikelezileyo. Asinguye wonke umntu ova iintlungu.
• Kuvakala ngathi iqhuma ebelikho ixesha elide liya likhula .

Kubalulekile: Ukuba ubona iqhuma elitsha okanye ukudumba okunje naphi na emzimbeni wakho, okanye ukuba uziva ngathi elikhoyo liya likhula, qiniseka ukuba ubonana nogqirha . Kungaba yinto elula, kodwa kungcono ukuba ulihlole.

Kutheni oku kusenzeka? Zithini izizathu?

Inyaniso kukuba, oogqirha abakakwazi ukutsho ngokuqinisekileyo ukuba yintoni kanye kanye ebangela i-epithelioid sarcoma. Nangona kunjalo, uphando lufumanise ukuba inxulunyaniswa nokungaqheleki kwi-gene ebizwa ngokuba yi-SMARCB1 . Le gene yiyo exelela umzimba wethu ukuba wenze iiproteni. Olu tshintsho lwe-gene ludla ngokwenzeka ebomini. Oko kuthetha ukuba asinto ozalwa nayo, kwiimeko ezininzi.

Njengezinye ii-sarcomas zezicubu ezithambileyo, ii-epithelioid sarcomas zihlala zikhula ngaphandle kwesizathu esicacileyo . Nangona kunjalo, zihlala zifunyaniswa emva komhlaza wangaphambili.Umngcipheko wokufumana oku uphezulu kancinci kubantu abaye bafumana unyango lwemitha.

Ukongeza, iingcali zifumanise ukuba abantu abaneempawu ezithile zomhlaza wosapho banokuba sengozini enkulu yokuba ne-epithelioid sarcoma. Ezinye zezi meko ziquka:

• Isifo sikaGardner
• Uhlobo lwe -Neurofibromatosis 1 kunye nohlobo lwe-2
• I-Retinoblastoma
• Isifo seLi-Fraumeni
• I-Tuberous sclerosis complex
• isifo sikaWerner
• Isifo sikaGorlin

Oku kunzima kancinci, kodwa kulungile ukwazi. Ukuba unale meko, thetha nogqirha wakho ukuze ufumane ingcebiso engaphezulu.

Ingaba esi sifo sisasazeka emzimbeni wonke?

Kwiimeko ezininzi, i-epithelioid sarcoma ayisasazeki kwezinye iindawo. Oko kukuthi, ihlala apho yaqala khona. Nangona kunjalo, ngamanye amaxesha, ingakumbi iintlobo ezinobundlongondlongo ezifana nohlobo olukufutshane, inokusasazeka. Ukuba iyenzeka, kusenokwenzeka ukuba iye kwiindawo zakho ze-lymph, imiphunga kunye namathambo .

Uyibona njani le nto? (Ukuxilongwa)

Ugqirha uza kwenza uvavanyo oluninzi ukuze axilonge i-epithelioid sarcoma. Ezona ziphambili zezi:

• Uvavanyo lomzimba : Ugqirha uza kukuhlola, ejonga izinto ezifana nendawo elikuyo iqhuma kunye nobukhulu balo.
• I-Biopsy: Olu lolona vavanyo lubalulekileyo . Iqhekeza elincinci kakhulu leqhubu liyathathwa lize lihlolwe phantsi kwemakroskopu. Kulapho kuphela apho sinokuqiniseka khona ukuba ngumhlaza, kwaye ukuba kunjalo, loluphi uhlobo.
• Uvavanyo lwegazi lomhlaza: Ezinye iimpawu zomhlaza zinokufunyanwa egazini.
• Iskeni se-MRI (Magnetic Resonance Imaging – MRI): Oku kunokubona ngokucacileyo indawo yethumba, ubungakanani balo, nokuba lisasazeke na kwizicwili ezingqongileyo.
• I-CT scan (i-Computed Tomography – ii-CT scans): Oku kunokujonga nethumba kwaye kubone ukuba umhlaza usasazeke na kwezinye iindawo, njengemiphunga.
• I-PET scan (i-Positron Emission Tomography – ii-PET scans): Oku kunceda ekufumaneni iindawo emzimbeni apho iiseli zomhlaza zisebenza khona.

Usenokunganyanzelekanga ukuba wenze zonke ezi vavanyo. Ugqirha wakho uya kugqiba ukuba zeziphi iimvavanyo ezifunekayo ngokusekelwe kwimeko yakho.

Luthini unyango?

Ugqirha wakho uza kukhetha isicwangciso sonyango esisekelwe kwizinto ezahlukeneyo, kuquka ubungakanani bethumba, indawo elikuyo, nokuba umhlaza usasazeke na kwezinye iindawo, amandla omzimba wakho okuphilisa, kunye nezinto ozikhethayo.

Utyando

Unyango oluphambili noluqhelekileyo lwe-epithelioid sarcoma kukususa ithumba ngotyando . Ukuba umhlaza usasazeke kwiindawo ze-lymph ezikufutshane, ugqirha angawasusa nawo.

Unyango lweMisebe

Olu lolunye unyango oluqhelekileyo lomhlaza. Lusebenzisa ii-X-reyi ezinamandla aphezulu ukutshabalalisa iiseli zomhlaza. Oogqirha banokunika olu nyango ukunciphisa ithumba ngaphambi kotyando. Okanye, lungasetyenziswa ukubulala naziphi na iiseli zomhlaza eziseleyo emva kotyando.

Unyango ngamakhemikhali

Ukuba umhlaza usasazeke kwamanye amalungu omzimba wakho, ugqirha wakho unokucebisa i-chemotherapy . Oku kuquka ukukunika amayeza akhethekileyo okubulala iiseli zomhlaza. La mayeza adla ngokunikezelwa ngemithambo yegazi. Kodwa anokunikwa njengeepilisi, ulwelo, ikhrimu efakwe eluswini, okanye inaliti.

Unyango olujoliswe kumayeza

Olu lunyango olutsha. Lubandakanya ukunika amayeza ajolise kuphela kwiijini kunye neeproteni ezilawula indlela iiseli zomhlaza ezikhula kwaye zahlukane ngayo. Oku kuthetha ukuba iiseli eziphilileyo azinakwenzeka ukuba zonakaliswe. Kukho iintlobo ezahlukeneyo zamayeza asetyenziselwa oku. Ugqirha wakho uza kukwenzela isicwangciso esithile sonyango ngokusekelwe kwimeko yakho. I-Tazemetostat luhlobo lweyeza elisetyenziselwa i-epithelioid sarcoma. Inceda ukunyanga iiseli zomhlaza ezingenakususwa ngokupheleleyo ngotyando.

Ngaba oku kungathintelwa ukuba kwenzeke?

Into ebuhlungu kukuba, kuba i-epithelioid sarcoma idla ngokuvela ngaphandle kwesizathu esicacileyo, asinandlela yokuyithintela ukuba ingaphumi . Oko kuthetha ukuba kunzima ukuthi, "Ukuba wenza oku, akuyi kwenzeka."

Kwenzeka ntoni ukuba unesifo se-epithelioid sarcoma? Ngaba sinokunyangeka?

Kuqhelekile ukuba uzive usoyika xa usiva oku. Nangona kunjalo, i-epithelioid sarcoma sisifo esinokunyangwa , ingakumbi ukuba sifunyenwe kwangethuba . Ugqirha wakho uza kwenza uvavanyo oluthile ukuze abone ukuba ithumba likhulu kangakanani na kwaye nokuba lisasazeke na kwezinye iindawo. Emva koko, baza kwenza isicwangciso sonyango esifanelekileyo kuwe.

Kusenokuba kukho iqela loogqirha abakunyangayo. Phakathi kwabo kukho:

• Ugqirha wakho oyintloko ( ugqirha ohlala ekubona).
• Iingcali zomhlaza: Aba baquka iingcali zomhlaza wamathambo, oogqirha botyando lwe-oncology, kunye noogqirha abanika unyango lwe-chemotherapy kunye ne-radiation.
• Iingcali zesikhumba: Ngeengxaki zolusu.
• Iingcali zezifo: Abo bajonga iingxelo zovavanyo lwegazi lakho kunye ne-biopsy baze bakunike iinkcukacha.
• Iingcali zonyango: Abantu abakuncedayo ukujongana noxinzelelo kunye noloyiko oluza nesifo esifana nesi.

Eyona ndlela ikuphela kwayo yokunyanga ngokupheleleyo i-epithelioid sarcoma kukususa ngokupheleleyo ithumba ngotyando . Nangona kunjalo, kusenokwenzeka ukuba akunakwenzeka rhoqo ukulisusa ngokupheleleyo.

Ukuba ugqirha akanakukwazi ukususa ngokupheleleyo ithumba, ugqirha wakho uya kucebisa ngokudibeneyo unyango lokulawula imeko yakho. Ngenxa yokuba i-epithelioid sarcoma ngumhlaza okhula kancinci, abantu abaninzi abanale sifo banokuphila ubomi obude nobonwabisayo .

Kukho iingxelo ezininzi zophando malunga nezinga lokusinda kwesi sifo. Nangona kunjalo, kuba sisifo esingaqhelekanga, izibalo zahlukile kakhulu. Ngokwezinye iingxelo, izinga lokusinda kweminyaka emihlanu liqala kwi-25% ukuya kwi-92%. Kuxhomekeke kwizinto ezininzi, ezifana nohlobo lwesifo kunye nempendulo kunyango.

Ndifanele ndimbone nini ugqirha?

Ukuba ubona iqhuma elingaqhelekanga okanye ukudumba naphi na emzimbeni wakho, musa ukulityeshela. Qiniseka ukuba ubona ugqirha. Abantu abane-epithelioid sarcoma badla ngokuba namaqhuma kwiingalo, ezandleni, kwiminwe, emilenzeni esezantsi, okanye ezinyaweni. Kodwa khumbula, la maqhuma anokuvela naphi na emzimbeni.

Yeyiphi imibuzo omele uyibuze ugqirha?

Ukuba wena okanye umntu omthandayo nifunyaniswa ukuba ninesifo se-epithelioid sarcoma, nantsi eminye imibuzo eninokuyibuza ugqirha wenu:

• Iphi ithumba?
• Ngaba ndinethumba elinye kuphela? Okanye kukho amanye?
• Ingaba umhlaza usasazeke nakwamanye amalungu omzimba?
• Ucebisa luphi unyango?
• Unyango lwam luza kuthatha ixesha elingakanani?
• Ndiza kuziva njani ngexesha lonyango? (Izinto ezifana neziphumo ebezingalindelekanga)
• Ngaba kukho iindawo apho ndingafunda khona ngakumbi ngale nto? (njengeewebhusayithi ezithembekileyo, iincwadi)

Kuqhelekile ukuziva usoyika, unomsindo, kwaye udanile xa ufumana isifo esifana nesi. Thetha nogqirha wakho malunga nento omawuyilindele ngaphambi, ngexesha, nasemva konyango. Kunganceda nokuthetha nomcebisi okanye ingcali yezonyango. Banokukunceda ujongane neemvakalelo ezinzima odlula kuzo ngexesha elifana neli. Ukuba kunokwenzeka, joyina iqela lenkxaso nabantu abadlula kwinto efanayo nawe. Oku kunokukunceda uzive ungedwa.

Umyalezo Wokuya Ekhaya

• I-Epithelioid sarcoma ngumhlaza ongaqhelekanga nonamandla kakhulu wezicubu ezithambileyo .
• Idla ngokuba namaqhuma emalungeniIngabonakala njengerhashalala, ngamanye amaxesha inezilonda zesikhumba.
• Iimpawu zisenokungabonakali kwizigaba zokuqala.
• Inxulunyaniswa nesiphene kwi-gene ebizwa ngokuba yi-SMARCB1 , kodwa isizathu esichanekileyo asikaziwa okwangoku.
• Utyando lolona nyango luphambili . Unyango lwemitha, i-chemotherapy, kunye namayeza ajoliswe kuwo nawo ayasetyenziswa.
• Kunzima ukuyithintela , kodwa ukuba ichongiwe kwangethuba, inganyangwa .
• Ukuba ubona iqhuma elitsha emzimbeni wakho, bonana nogqirha ngokukhawuleza.
• Musa ukoyika, ungoyiki, kwaye landela iingcebiso zonyango ezifanelekileyo . Awuwedwa, kukho oogqirha nabantu obathandayo abanokukunceda.

Khumbula, eli nqaku lenzelwe ulwazi ngokubanzi kuphela. Ukuba uneengxaki, kungcono ukubonana nogqirha.