Xa ugqirha ekuxelela ukuba unomhlaza webele , umele ukuba uzive uloyiko olukhulu kwaye wothukile. 'Ndenze ntoni ngoku?', 'Ndiza kunikwa luphi uhlobo lonyango?', 'Ndiza kunyangwa nge-chemotherapy ?' Imibuzo emininzi imele ukuba yafika engqondweni. Siyazi ukuba ukulwa nomhlaza akuyonto ilula. Kodwa isayensi yezonyango yanamhlanje ihambele phambili kakhulu. Ngexesha elinje, namhlanje sithetha ngovavanyo olukhethekileyo olunceda oogqirha bagqibe ukuba loluphi unyango abafanele bakunike lona.
Yintoni i-Oncotype DX?
Ngamafutshane, i-Oncotype DX luvavanyo olukhethekileyo olujonga nzulu iiseli zomhlaza webele lakho. Ayilovavanyo lwegazi oluqhelekileyo. Isebenzisa isiqwenga sethishu yomhlaza esithathwe kwi -biopsy ukuqinisekisa umhlaza wakho okanye kutyando lokususa ithumba.
Olu vavanyo lujonga ukusebenza kweejini ezithile ngaphakathi kweeseli zomhlaza. Njengazo zonke iiseli zethu, iiseli zomhlaza nazo zinejini. Ezi jini zimisela indlela umhlaza oziphatha ngayo, oko kukuthi, ukuba unzima kangakanani, ukuba ungasasazeka ngokukhawuleza kangakanani, kunye nokuba kunokwenzeka kangakanani ukuba ubuye emva konyango.
Uvavanyo lwe-Oncotype DX lugxile kwiijini ezingama-21, yiyo loo nto unokuluva lubizwa ngokuba luvavanyo "lwesiginitsha sejini ezingama-21". Ngokuhlalutya ezi patheni zejini, oogqirha banokufunda ulwazi oluninzi olubalulekileyo malunga nomhlaza wakho.
Ngubani ocetyiswayo ukuba athathe olu vavanyo?
Olu vavanyo alufuneki kubo bonke abaguli abanomhlaza webele. Ugqirha wakho unokuba nethuba elikhulu lokucebisa olu vavanyo ukuba unenye yezi meko zilandelayo:
- Ukuba unomhlaza wesigaba sokuqala (Isigaba I okanye II): Oku kuthetha ukuba umhlaza awukasasazeki kwiindawo ezikude zomzimba.
- Ukuba umhlaza une-estrogen-receptor positive (ER+): Oku kuthetha ukuba iiseli zomhlaza ziyakhula ngenxa ye-hormone ye-estrogen eveliswa ngumzimba wakho. Olu hlobo lomhlaza ludla ngonyango ngonyango lweehomoni .
- Ukuba umhlaza awukasasazekanga kwiindawo ze-lymph emlenzeni.
Ukongeza, olu vavanyo ngamanye amaxesha lunokwenziwa kubantu abanezigaba zokuqala zomhlaza ezibizwa ngokuba yi -DCIS (Ductal Carcinoma in Situ) , ukunceda ekugqibeni ukuba ngaba unyango lwemitha luyafuneka na.
Eyona nto ibalulekileyo kukuba uncedo olukhulu kolu vavanyo lukhokelo olufumanayo ekugqibeni ukuba uyalufuna na unyango lwe-chemotherapy ukongeza kunyango lwe-hormone.
Ufunda njani amanqaku ovavanyo?
Uvavanyo lwe-Oncotype DX lukunika "i-Recurrence Score" phakathi kwe-0 ne-100. Okukhona eli nqaku liphezulu, kokukhona umngcipheko wokuba umhlaza ubuye emva konyango uphezulu. Nangona kunjalo, indlela efundwa ngayo le nqaku iya kwahluka kancinci ngokuxhomekeke kwiminyaka yakho.
| Uluhlu lwamanqaku | Umngcipheko | Ingcebiso enokwenzeka |
|---|---|---|
| 0 – 25 | Umngcipheko ophantsi | Unyango lweehomoni kuphela lunokwanela. Amathuba amancinci kakhulu okufumana iingenelo ezongezelelweyo kwi-chemotherapy. |
| 26 - 100 | Umngcipheko ophezulu | Umngcipheko wokuba umhlaza uphinde ubuye uphezulu. Kunokucetyiswa unyango lwe-chemotherapy kunye nonyango lwe-hormone. |
| Uluhlu lwamanqaku | Umngcipheko | Ingcebiso enokwenzeka |
|---|---|---|
| 0 – 15 | Umngcipheko ophantsi | Unyango lweehomoni kuphela lunokwanela. Akukho thuba lincinci lenzuzo eyongezelelweyo evela kwi-chemotherapy. |
| 16 – 20 | Umngcipheko ophantsi ophakathi | I-chemotherapy isenokunika inzuzo encinci, kodwa kufuneka uxoxe nogqirha wakho malunga nokuba inzuzo ifanelekile na xa ithelekiswa nemiphumo emibi. |
| 21 – 25 | Umngcipheko ophakathi | Iingenelo ze-chemotherapy zinokuba ngaphezulu kweengozi zemiphumo emibi. Kufuneka uxoxe ngale nto nogqirha wakho uze wenze isigqibo. |
| 26 - 100 | Umngcipheko ophezulu | Umngcipheko wokubuya komhlaza uphezulu. Kunokwenzeka ukuba unyango lwe-chemotherapy lucetyiswe kunye nonyango lwe-hormone. |
Ngaba olu phawu lodwa lufanele lumisele unyango?
Akunjalo konke konke. Oku kubaluleke kakhulu. Inqaku le-Oncotype DX yinto enye enamandla yokukunceda wenze isigqibo. Ugqirha wakho uza kuthathela ingqalelo ezinye izinto ezininzi ngaphambi kokuba enze isicwangciso sonyango esifanelekileyo kuwe.
Umzekelo:
- Ubungakanani bethumba
- Inqanaba lethumba
- Inani lee-receptors zehomoni kwiiseli zomhlaza
- Ubudala bakho kunye nempilo yakho iyonke
Zonke ezi zinto ziyadibana ukuze kwenziwe isigqibo sokugqibela. Ke ngoko, le ngxelo yovavanyo sisixhobo esinye esinokunceda ugqirha wakho ukuba enze isicwangciso sonyango esifanelekileyo kuwe.
Ngaba kukho ezinye iimvavanyo zemfuza ezifana nale?
Ewe, kukho ezinye iimvavanyo ezininzi zemfuza ezisetyenziselwa umhlaza wamabele. Kodwa elona lisetyenziswa kakhulu yi-Oncotype DX. Makhe sifunde ngokufutshane ngezinye.
- I-MammaPrint: Le vavanyo yezakhi zofuzo ezingama-70. Inceda ekuqikeleleni umngcipheko wokusasazeka komhlaza ngaphandle kwebele. Ingasetyenziselwa zombini iintlobo ze-ER+ kunye ne-ER.
- I-Mammostrat: Le ivavanya ii-genes ezi-5 kwaye ilinganisa umngcipheko wokubuya komhlaza webele one-hormone-receptor kwisigaba sokuqala.
- IProsigna: Le isetyenziselwa umhlaza webele one-hormone-receptor-positive kubasetyhini abasele beyekile ukuya exesheni. Ihlalutya ii-genes ezingama-58 kwaye iqikelela umngcipheko wokubuyela komhlaza kwenye indawo emzimbeni kwiminyaka eli-10.
Zonke ezi zizilingo eziphambili. Ugqirha wakho uya kugqiba ukuba ufuna olunye lwazo na kwaye loluphi olufanelekileyo.
Umyalezo Wokuya Ekhaya
- I-Oncotype DX luvavanyo olukhethekileyo oluhlola iijini zeeseli zomhlaza wamabele ukunceda ekufumaneni umngcipheko wokuphinda umhlaza ubuye kunye nokuba ngaba i-chemotherapy iyafuneka na.
- Oku kwenziwa ngesiqwenga sethishu yomhlaza esithathwe kwi-biopsy okanye kutyando, kungekhona egazini.
- Olu vavanyo alufuneki kuwo wonke umntu. Lusetyenziswa kakhulu kumhlaza okwiSigaba I/II, ER+, kwaye awukasasazeki kwiindawo ze-lymph nodes.
- Amanqaku ovavanyo yinxalenye enye yesicwangciso sonyango. Ugqirha wakho uza kuqwalasela ezinye izinto ezininzi, njengobungakanani bomhlaza, ubukhali bawo, kunye nobudala bakho.
- Ukuba unemibuzo okanye iinkxalabo malunga noku, qiniseka ukuba uthetha ngokukhululekileyo nogqirha wakho . Ngokuqinisekileyo uya kukunceda ukhethe eyona ikulungeleyo.
I-Oncotype DX Sinhala, Umhlaza Webele, Unyango lweKhemotherapy, Uvavanyo lweGenetic lomhlaza, Ukuphinda Ubuye Umhlaza, Umhlaza Olungileyo we-ER , Unyango lomhlaza
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