Usenokungazi nokuba ngamanye amaxesha kukho iimfazwe eziqhubekayo ngaphakathi emizimbeni yethu. Umzekelo, iMantle Cell Lymphoma (MCL) ngumhlaza ongaqhelekanga oqala kwiiseli zethu ezimhlophe zegazi ezibizwa ngokuba yi-lymphocytes. Ngokwenene luhlobo lwe-lymphoma olubizwa ngokuba yi-non-Hodgkin lymphoma. Makhe sithethe ngale nto ngokulula, ngendlela onokuyiqonda.

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Ikhula njani i-mantle cell lymphoma (MCL)? Kwenzeka ntoni emzimbeni?

Khawucinge nje, lo mhlaza obizwa ngokuba yi-MCL uqala ukusasazeka kancinci kwaye ngokufihlakeleyo emzimbeni ekuqaleni. Kodwa emva kwexesha elithile, unokukhula ngokukhawuleza ngequbuliso. Oku kusasazeka kakhulu kuyo yonke inkqubo yethu ye-lymphatic. Inkqubo ye-lymphatic luhlobo lolwelo emzimbeni wethu kunye nenethiwekhi yemithambo ethwala olo lwelo. Kufana nenkqubo esusa inkunkuma emzimbeni wethu. Xa isifo siba sibi kancinci , ezi seli zomhlaza zinokuphuma kwi-lymph nodes zisasazeke ziye egazini lethu, kumongo wethambo, kwaye ngamanye amaxesha nakwiindawo ezifana nenkqubo yokugaya ukutya.

Okubalulekileyo kukuba, umntu one-MCL unokuba nexesha lokuphumla, kwaye angakwazi nokubuyela umva kwakhona. Oku kunokwenzeka amaxesha amaninzi. Nangona unyango lungenakuyinyanga ngokupheleleyo i-MCL, lunokunceda ukwandisa ixesha lokuphumla.

I-Mantle cell lymphoma ngumhlaza ongaqhelekanga kakhulu . Ichaphazela malunga nomntu omnye kwabangama-200,000. Nangona nabani na enokuba nalo mhlaza, abantu abaphakathi kweminyaka engama-60 ukuya kwengama-70 basengozini enkulu kancinci.

Ziziphi iintlobo ze-mantle cell lymphoma (MCL)?

Kukho iintlobo ezimbini eziphambili ze-MCL: 1. I-MCL yakudala: Olu lolona hlobo luqhelekileyo. Luqala kwi-lymph nodes luze lusasazeke kwezinye iindawo zomzimba. Luhlala luluhlobo olunobundlongondlongo ngakumbi. 2. I-MCL engeyiyo i-leukaemic: Olu hlobo ludla ngokubandakanya iiseli ze-spleen kunye ne-lymphoma ezandisiweyo egazini nasemongweni wethambo. Lukhula kancinci kunohlobo lwakudala.

Zithini iimpawu zesi sifo? Uzibona njani?

Iimpawu ze-MCL zingahluka kumntu nomntu. Ngamanye amaxesha zinokubonakala ngathi ziimpawu zesifo esiqhelekileyo, ngoko usenokungacingi nokuba ngumhlaza. Yiyo loo nto i-MCL idla ngokufunyaniswa kade, xa isifo sele sisasazekile. Usenokungabi nazo kwaphela iimpawu. Nangona kunjalo, ukuba unazo iimpawu, zingabandakanya:

Ukugruzuka
Intloko ebuhlungu
Ndiziva ndidiniwe ngalo lonke ixesha ( Ukudinwa )
Ifiva
Ukuphazamiseka kwesisu
Umnqweno wokutya
NgobusukuUkubila
Ii-lymph nodes ezidumbileyo (ezifana nentamo, emakhwapheni, emqolo)
Ukuziva ubuthathaka
Ukunciphisa umzimba ngaphandle kwesizathu

Musa ukoyika i-MCL kuba nje unale mpawu. Kodwa ukuba ezi mpawu ziyaqhubeka, kungcono ukubona ugqirha .

Yintoni ebangela i-mantle cell lymphoma (MCL)?

Ixesha elininzi, i-MCL ibangelwa kukuguquka kwezinye zezakhi zofuzo zethu. Olu tshintsho lutshintsha indlela iiseli zethu ze-B, uhlobo lwe-lymphocyte, ezisebenza ngayo. Abaphandi abazi kakuhle ukuba kutheni olu tshintsho lwenzeka. Kodwa nantsi into eyenzekayo: 1. Iiseli ze-B eziguqukileyo ngokungaqhelekanga zivelisa iproteni eninzi ebizwa ngokuba yi-cyclin D1. Le proteni inceda iiseli ze-B zikhule. 2. Ukuveliswa okugqithisileyo kwale protein ye-cyclin D1 kubangela ukuba iiseli ze-B zahlukane kwaye zande ngokungalawulekiyo. 3. Iiseli ezahlulahlula ngokungalawulekiyo zihlangana ndawonye ukuze zenze iithumba.

Zithini iingxaki zale meko?

Njengoko i-mantle cell lymphoma iqhubeka, iingxaki ezifana nezi:

Ukopha kwamathumbu
I-spleen eqhekekileyo
Isifo se-tumor lysis (ingxaki ebangelwa kukuqhekeka ngokukhawuleza kweeseli zomhlaza)

Ifunyanwa njani i-mantle cell lymphoma (MCL)?

Ukuba ugqirha wakho ukrokrela ukuba une-MCL, kusenokwenzeka ukuba enze uvavanyo oluninzi.

Uvavanyo lwelebhu: Olu vavanyo lunokubandakanya ukubalwa kwegazi okupheleleyo (CBC), iphaneli epheleleyo ye-metabolic (CMP), uvavanyo lwe-LDH, okanye uvavanyo lwenqanaba le-uric acid. Oogqirha badla ngokurhanela ukuba babona ukwanda kwenani lee-lymphocytes kuvavanyo lwegazi.
IiBiopsies: Ugqirha wakho unokucebisa ukuba kwenziwe i-lymph node biopsy okanye i-bone marrow biopsy ukuqinisekisa ukuba kukho iiseli zomhlaza. Isampuli yezicubu ihlolwa yingcali yezifo.
Uvavanyo lokufota: Olu vavanyo lunceda ekuboneni ukuba umhlaza usasazeke kangakanani. Ngokuxhomekeke ekubeni umhlaza ukuphi, kunokufuneka wenze i-colonoscopy, i-CT scan, i-EGD (esophagogastroduodenoscopy), okanye i-PET scan.

Ukuba iziphumo zovavanyo lwegazi aziqhelekanga, ugqirha wakho uza kukuxilonga aze akubuze ngeempawu zakho. Basenokuziva neendawo ezifana nentamo yakho kunye namakhwapha ukuze babone ukuba ii-lymph nodes zakho zidumbile na.

Zithini izigaba ze-mantle cell lymphoma (MCL)?

Oogqirha bahlulahlula esi sifo ngokwamanqanaba ngokusekelwe ekubeni sisasazeke kangakanani. Basebenzisa inkqubo ekhethekileyo ebizwa ngokuba yiMantle Cell Lymphoma International Prognostic Index (MIPI). Oku kunika umbono ocacileyo wokuba isigulana sinokulindela ixesha elingakanani siphile. Ngokubanzi, esi sifo sinokuthi siphinde sibuye kumanqanaba amva kunakwinqanaba lokuqala. Eli nqanaba limiselwa kukuba umhlaza usasazeke kangakanani:

Isigaba I: Sinqunyelwe kwi-lymph nodes enye okanye ezimbalwa kwindawo enye.
Inqanaba lesiBini: Isasazeke ukuya kuma-lymph nodes amabini okanye ngaphezulu kwicala elinye le-diaphragm yakho.
Inqanaba lesi-3: Isasazeke kumacala omabini e-diaphragm, okanye kwi-spleen nakwii-lymph nodes ezingaphezulu kwe-diaphragm.
Isigaba sesi-4: I-Mantle cell lymphoma isasazeke kwiindawo ezikude emzimbeni, okanye kwezinye iindawo ezingezizo ii-lymph nodes.

Iphathwa njani i-mantle cell lymphoma (MCL)?

Unyango lwe-MCL alufani kuwo wonke umntu. Unyango olufanelekileyo kuwe luxhomekeke kwizinto ezifana nokuba umhlaza ukuphi kwaye ukhula ngokukhawuleza kangakanani. Nazi ezinye zeendlela zonyango ezikhoyo ze-MCL:

I-Chemotherapy: Amayeza anikwa ukutshabalalisa iiseli zomhlaza.
Unyango lwe-Immunotherapy: Unyango oluvuselela amajoni omzimba wakho ukuba alwe nomhlaza.
Unyango lwemitha: Ukutshabalalisa iiseli zomhlaza kusetyenziswa imitha enamandla aphezulu.
Unyango olujoliswe kulo: Amayeza ajolise kwiimolekyuli ezithile ezinceda iiseli zomhlaza zikhule kwaye zisasazeke.
Ukufakelwa kweeseli zesiqu: Ukufakelwa kweeseli zesiqu eziphilileyo ukuze kuthathelwe indawo umongo wethambo onesifo.

Usenokufanelekela ezinye zezi ndlela zonyango, kwaye usenokungafaneleki kwezinye.

Ukuba une-MCL, kukwangcono ukuqwalasela iimvavanyo zeklinikhi ezivavanya unyango olutsha. Olu nyango lutsha lusenokungayinyangi ngokupheleleyo i-MCL, kodwa lunokukunika ixesha elingakumbi lokuphila ubomi obonwabisayo nobungenazo iimpawu. Buza ugqirha wakho ngale nto.

Ngaba i-mantle cell lymphoma (MCL) ingathintelwa?

Ngelishwa, i-MCL ayinakuthintelwa. Ukuba nje unesi sifo akuthethi ukuba wenze into engalunganga. Abaphandi basazama ukufumanisa ukuba kutheni ii-genes emizimbeni yethu zitshintsha ) ngeendlela ezibangela umhlaza njenge-MCL.

Bunjani ubomi nge-mantle cell lymphoma (MCL)?

I-Mantle cell lymphoma ayilohlobo lwe-lymphoma olunganyangekiyo ngokupheleleyo. Nangona kunjalo, kukho unyango olunokukunceda ungene ekuxolelweni ngokupheleleyo. Ukuba se-relapse akuthethi ukuba umhlaza unyangekile ngokupheleleyo. I-MCL inokuphinda ibuyele emva kweenyanga okanye iminyaka. Ixesha ohlala ngalo ekuxolelweni nge-MCL lisenokuba lifutshane. Nangona kunjalo, unyango olutsha olujoliswe kulo lubonakalisiwe ukuba luyanda ngeli xesha. Thetha nogqirha wakho ukuze ufunde okungakumbi malunga noqikelelo lwakho.

Izinga lokusinda

Izinga lokusinda iminyaka emihlanu kwi-mantle cell lymphoma limalunga nama-50%. Oku kuthetha ukuba malunga nesiqingatha sabantu abafunyenwe benale sifo basaphila emva kweminyaka emihlanu bexilongiwe.

Kodwa khumbula, la mazinga okusinda aqikelelwa nje. Awakuxeleli ngokuthe ngqo ukuba uza kuphila ixesha elingakanani okanye uza kusabela njani kunyango. Kungcono ukuthetha nogqirha wakho ukuze ufumane indlela la mazinga asebenza ngayo kuwe.

Uzinyamekela njani?

Kubaluleke kakhulu ukuzinyamekela ngokwasemzimbeni, engqondweni, nangokweemvakalelo xa uphila ne-mantle cell lymphoma. Nazi ezinye iingcebiso ezinokukunceda:

Yamkela iimvakalelo zakho: Ukuthintela iimvakalelo ezifana nosizi noloyiko akuyi kuzisusa. Ukuqonda nokuvumela iimvakalelo zakho zibonakale linyathelo lokuqala lokufumana inkxaso oyifunayo.
Fumana inkxaso: Kuluncedo ukujoyina iqela lenkxaso elinabantu abanamava afanayo. Buza ugqirha wakho ngamaqela akwindawo okuyo okanye kwi-intanethi.
Lawula uxinzelelo: Fumana iindlela zokuphumla. Zama ukwenza umthambo wokuzilolonga, njengokucamngca.
Yenza ucwangciso: Umjikelo wokuphumla nokubuyela esiqhelweni kwesi sifo unokwenza yonke into ibonakale ingalungelelananga. Ukumisela ucwangciso lwemisebenzi yakho yemihla ngemihla kunye nokunamathela kulo kunokukunceda ufumane ulawulo oluthile.
Thetha nomcebisi: Kubalulekile ukunyamekela impilo yakho yengqondo. Umcebisi okanye ingcali yezonyango ingakunceda ujongane neemvakalelo ezinzima.

Ufanele uye nini kugqirha?

Ukuba unyangwa i-mantle cell lymphoma, kuya kufuneka ubone ugqirha wakho rhoqo. Baza kujonga imeko yakho kwaye bakuncede ulawule iziphumo ebezingalindelekanga zonyango lwakho. Ukuba isifo sakho siphelile, kuya kufuneka ubone ugqirha wakho ngamanye amaxesha (ulandelelwano). Buza ugqirha wakho ukuba kufuneka ube nala madinga kangaphi. Ukuba une-mantle cell lymphoma (MCL), uphila nokungaqiniseki kwesifo esingapheliyo ngokwenene. Usenokuhlala uxhalabile malunga nokuba isifo siza kuphinda sibuye na. Okanye unokuzibuza ukuba unyango lukulungele na. Kuqhelekile ukuba uzive ezi mvakalelo. Kodwa ukuba olu xhala lukuthintela ekubeni ukonwabele ubomi, qiniseka ukuba uthetha nogqirha wakho . Banokukuthumela kwizibonelelo ezinokukunceda kuhambo lwakho.

Okokugqibela, umyalezo oya ekhaya:

I-Mantle cell lymphoma (MCL) inokuba ligama eloyikisayo. Nangona kunjalo, kubalulekile ukuyiqonda, uqaphele iimpawu, kwaye ufune iingcebiso zonyango ngexesha elifanelekileyo. Khumbula, awuwedwa. Ngonyango olufanelekileyo kunye nenkxaso, uya kufumana amandla okumelana nale meko. Ungathandabuzi ukwabelana ngayo nayiphi na imibuzo okanye iinkxalabo onazo nogqirha wakho. I -Mantle Cell Lymphoma, Umhlaza, Umhlaza Wegazi, Inkqubo Ye-Lymphatic, Iimpawu, Unyango