Khawuthelekelele ukuba lilungu elinye lomzimba wakho, umzekelo ingalo, umlenze, okanye indawo ethile yolusu, likhula ngokukhawuleza ngendlela engaqhelekanga kunezinye. Le yimeko engaqhelekanga kakhulu abanye abantu abazalwa nayo. Ngokwezonyango, eli qela leemeko silibiza ngokuba yi-PIK3CA-Related Overgrowth Spectrum, okanye i-PROS ngamafutshane. Le yinto ebangela iingxaki ezininzi kumntu oyibonayo, kunye nomntu ohlangabezana nayo. Namhlanje, kweli nqaku, siza kuthetha ngayo le PROS kwaye malunga neVijoice, iyeza lokuqala elivunyiweyo ngokukodwa kule meko.
Yintoni kanye kanye i-PROS?
Ngamafutshane, i-PROS yimeko yemfuza. Sonke sinemfuza emizimbeni yethu elawula ukukhula, ukwahlukana, kunye nokufa kweeseli. I-'PIK3CA' yenye yemfuza ebaluleke kakhulu. Cinga ngale mfuza njenge-'switch' elawula ukukhula kweeseli zethu.
Nangona kunjalo, kumntu one-PROS, kukho isiphene, okanye utshintsho, kwi-gene ye-'PIK3CA'. Oku kubangela ukuba i-'switch' ibambeke kwindawo 'yoku-on'. Emva koko iproteni ekuthethwa ngayo iqala ukusebenza ngokukhawuleza kakhulu. Ngenxa yoko, amanye amalungu omzimba, umzekelo, ulusu, imithambo yegazi , amathambo kunye nengqondo, aqala ukukhula ngokungalawulekiyo.
Into ebalulekileyo kukuba i-PROS ayichaphazeli onke amalungu omzimba. Ingahluka ukusuka kwelinye icala ukuya kwelinye, nakumntu ngamnye. Ngenxa yoko, iimpawu nazo zahlukile kakhulu.
Ukuza kuthi ga ngoku, bekungekho nyango lupheleleyo lwe-PROS. Unyango belugxile ekulawuleni iimpawu. Umzekelo, amayeza eentlungu, ukurhawuzelelwa, kunye nokuxhuzula, kunye notyando lokususa ukukhula okungaqhelekanga. Nangona kunjalo, bekukho umngcipheko wokuba loo kukhula kuphinde kukhule emva kotyando.
Isebenza njani iyeza iVijoice (alpelisib)?
Kulapho ke iyeza iVijoice lingena khona. IVijoice liyeza lokuqala elijolise kwisizathu esiyintloko sePROS, ukusebenza kakhulu okubangelwa kukuguquka kwezakhi zofuzo.
Isithako esisebenzayo kwesi sithako yi- alpelisib . Eli yeza lisetyenziselwa ezinye iintlobo zomhlaza webele . Isizathu saloo nto kukuba, yiyoIiseli zomhlaza ziyakhula ngenxa yokusebenza kakhulu kwendlela ye-PIK3, njengakwi-PROS.
Ngoko ke into eyenziwa nguVijoice kukuvala indlela yePIK3, esebenza njenge-'switch' ebambeke kwindawo 'yoku-on'. Oku kucothisa ukukhula okungaqhelekanga kweeseli, kunciphisa ubungakanani bezicubu ezisele zikhula, kwaye kulawula iimpawu.
Zithini iingenelo zale yeza?
Izifundo ezenziweyo kweli yeza (i-EPIK-P1 kunye ne-EPIK-P3) zibonise iingenelo ezibalulekileyo kwizigulana.
| Inzuzo | Ingcaciso elula |
|---|---|
| Ukukhula okuncinci (izilonda) | Kuye kwaphawulwa ukuba abantu abaninzi abathathe eli yeza baye baphuhliswa ngokungaqhelekanga ngamathumba abo anamafutha (ii-lipomas) kunye nokukhubazeka kwemithambo yegazi okuncitshiswe ngomthamo ngama-20% nangaphezulu. |
| Ukunciphisa isidingo sotyando | Malunga nama-70% abantwana kunye nama-90% abantu abadala abasebenzisa iVijoice abazange bafune utyando. |
| Ukunceda kwiimpawu | Izigulana zixele ukwehla okukhulu kweempawu ezifana nentlungu, ukurhawuzelela, kunye nokudinwa. |
| Ukwenza imisebenzi yemihla ngemihla ibe lula | Malunga ne-81% yezigulana ezithathe inxaxheba kolu phando zibike ukuba amandla azo okwenza imisebenzi yemihla ngemihla kunye nomgangatho wobomi uphucukile xa kuthelekiswa nangaphambi kokuba zisetyenziswe. |
Kubalulekile: Ezi ziphumo zisenokungafani kuye wonke umntu. Thetha nogqirha wakho malunga nokuba eli yeza likulungele na kwaye zeziphi izibonelelo kunye neengozi.Kungcono ukuthetha nabo uze wenze isigqibo.
Zeziphi iziphumo ebezingalindelekanga eziqhelekileyo kwaye ungaziphatha njani?
Njengayo nayiphi na imithi, iVijoice inokubangela iziphumo ebezingalindelekanga . Nangona kunjalo, uninzi lwazo zincinci okanye ziphakathi kwaye zinokulawulwa.
| Imiphumela | Indlela yokuphatha kunye noko kufuneka unikele ingqalelo kuko |
|---|---|
| Urhudo | Sela iziselo ezininzi ezifana namanzi kunye nejusi. Ukuba ufumana iimpawu ezifana norhudo olunzima, isisu esibuhlungu, okanye igazi okanye i-mucus kwi-stool yakho, xelela ugqirha wakho ngoko nangoko . |
| Ukuphelelwa ngamanzi emzimbeni | Urhudo lunokubangela ukuphelelwa ngamanzi emzimbeni. Lumka kwiimpawu ezifana nesiyezi esigqithisileyo, ukudinwa, kunye nokuncipha kokuchama. Ezi zinto zinokuchaphazela izintso zakho, ngoko ke xelela ugqirha wakho ngoko nangoko. |
| Izilonda zomlomo (iStomatitis) | Umlomo unokuba nezilonda kunye nentlungu. Ziphephe izihlambi zomlomo ezine-alcohol. Hlamba umlomo wakho ngamanzi anetyuwa afudumeleyo. Ziphephe ukutya okuneziqholo, okune-asidi. |
| Ukwanda kweswekile egazini (i-Hyperglycemia) | Ugqirha wakho uza kujonga amanqanaba eswekile egazini lakho ngaphambi kokuba uqale ukuthatha eli yeza nangexesha lonyango lwakho. Xelela ugqirha wakho ukuba uneempawu ezifana nokunxanwa kakhulu, ukuchama rhoqo, okanye ukudinwa. Abantu abanesifo seswekile kufuneka balumke kakhulu ngale nto. |
| Ukuncipha kweenwele (i-Alopecia) | Ukulahleka kweenwele okanye ukuncitshiswa kwazo kunokwenzeka ngexesha lonyango. Sebenzisa iishampu ezithambileyo. Thetha nogqirha wakho ngale nto. |
Ngaba kukho iingxaki ngamanye amayeza?
Ewe. IVijoice inokusebenzisana namanye amayeza. Ngamafutshane, amanye amayeza anokunciphisa ukusebenza kweVijoice. IVijoice inokutshintsha nokusebenza kwamanye amayeza.
Umzekelo, amayeza afana ne-carbamazepine yesifo sokuwa, i-rifampin yesifo sephepha, kunye neemveliso zemifuno ezifana ne-St. John's wort zinokuchaphazela oku.
Ngoko ke, ngaphambi kokuba uqale eli yeza, kubalulekile ukuxelela ugqirha wakho malunga nawo onke amayeza owasebenzisayo ngoku (kuquka iivithamini, iimveliso zamayeza, kunye neentlungu) ukuze akwazi ukwenza naluphi na utshintsho olufunekayo.
Umyalezo Wokuya Ekhaya
- I-PROS yimeko engaqhelekanga apho amalungu omzimba akhula ngendlela engaqhelekanga ngenxa yotshintsho kwi-gene ebizwa ngokuba yi-`PIK3CA`.
- I-Vijoice (alpelisib) liyeza lokuqala elivunyiweyo ukujolisa kwinkqubo ebangela esi sifo.
- Oku kunokunceda ukunciphisa ukukhula okungaqhelekanga, ukunciphisa isidingo sotyando, kunye nokuphucula umgangatho wobomi.
- Iziphumo ezinje ngorhudo, iswekile egazini eyonyukileyo, kunye nezilonda emlonyeni zinokubakho, kwaye kubaluleke kakhulu ukuzilawula nokwazisa ugqirha.
- Kubalulekile ukwazisa ugqirha wakho ngazo zonke ezinye iziyobisi ozisebenzisayo. Ungaze uqale okanye uyeke ukuthatha naluphi na unyango ngaphandle kwengcebiso kagqirha.
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