Umuthi we-Amvuttra wesifo esingavamile esiqeda amandla imizwa (i-haATTR Polyneuropathy)

Ingabe uzizwa nje ungezwani noma uqhaqhazela ezandleni nasezinyaweni? Noma unobuthakathaka bemisipha kanye nobunzima bokuhamba? Ngezinye izikhathi, lezi zimpawu zingabangelwa yisimo esingavamile esingakasizwa. Namuhla, sizokhuluma ngesinye salezi zimo kanye nokwelashwa okusha kwaso.

Kuyini i-haTTR? Isebenza kanjani i-Amvuttra?

Kalula nje, i-hATTR (i-Heroditary Transthyretin-Mediated Amyloidosis) iyisifo esidluliselwa ngofuzo. Ingeqembu lezifo ezibizwa ngokuthi i-amyloidosis. Kulezi zifo, amaprotheni athile emzimbeni wethu ashintsha isimo sawo, aqongelela ngezindlela ezingavamile, futhi ahlala ezithweni ezahlukahlukene zomzimba.

Esifweni se-haTTR, iphrotheni ebizwa ngokuthi i-Transthyretin (TTR) ifakwa ngale ndlela. I-TTR empeleni iyiphrotheni enhle ekhiqizwa esibindini sethu futhi isiza ukuthutha ama-hormone e-thyroid kanye ne-vitamin A emzimbeni wonke. Kodwa-ke, umuntu onesifo se-haTTR uba noshintsho oluncane ku-gene ye-TTR, okungukuthi, ukuguquka kwezakhi zofuzo. Ngenxa yalokho, iphrotheni ye-TTR ekhiqizwayo isesimweni esingalungile. Le phrotheni engaguquki iyaqongelela futhi ifakwa ezindaweni ezifana nemizwa, inhliziyo, kanye nohlelo lokugaya ukudla njengama-deposit abizwa ngokuthi i-amyloid .

Uma lawa ma-deposit eqoqana eduze kwezinzwa, ayalimala. Lokhu sikubiza ngokuthi i -polyneuropathy . Yilapho izimpawu okukhulunywe ngazo ngaphambili, njengokuvuvukala, ukungazweli, ubuhlungu, kanye nobunzima bokuhamba, zivela khona.

Into ebalulekile ukuthi noma ngabe uzuze uhlobo lwezakhi zofuzo oluhambisana nalesi sifo elungwini lomndeni, akusho ukuthi nakanjani uzoba nesifo se-hATTR.

Umuthi i -Amvuttra usebenza ngokunciphisa inani lale phrotheni ye-TTR engajwayelekile ekhiqizwa yisibindi. Lokhu kunciphisa ukuqongelela kwama-amyloid emzimbeni, okusiza ukulawula izimpawu nokuvimbela noma ukulibazisa lesi sifo ukuthi singabi sibi kakhulu.

Udokotela wakho uzophinde ancome izinguquko ekudleni kwakho kanye nokuzivocavoca umzimba, kanye nokwelapha izimpawu zakho. Kuze kube muva nje, izindlela zokwelapha lesi sifo kuphela kwakuwukulawula izimpawu, futhi uma kudingeka, ukufakelwa isibindi noma inhliziyo. Kodwa imithi yesimanje efana ne-Amvuttra manje ikuvumela ukuthi ulawule lesi sifo ngokunciphisa iphrotheni ye-TTR, okuyimbangela eyinhloko yalesi sifo.

Uyisebenzisa kanjani le mithi?

I-Amvuttra iwumjovo onikezwa ngaphansi kwesikhumba . Unikezwa uchwepheshe wezempilo, njengodokotela noma umhlengikazi oqeqeshiwe. Ngokuvamile unikezwa kane ngonyaka (njalo ezinyangeni ezintathu) . Ungahlela ukuthola umjovo ehhovisi likadokotela wakho, emtholampilo, noma ngisho nasekhaya.

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Lo muthi ucwaningwe kanjani?

Njenganoma yimuphi umuthi omusha, i-Amvuttra ihlolwe ezivivinyweni zemitholampilo ukuze kutholakale ukusebenza kwayo kanye nokuphepha kwayo. Kulolu cwaningo, iqembu leziguli ezithole i-Amvuttra laqhathaniswa neqembu leziguli ezithole i-placebo , ukwelashwa okungafanele okwakungenaso isithako esisebenzayo. Lena yindlela esinganquma ngayo ukuthi umuthi usebenza ngempela.

Ucwaningo luhlanganise iziguli ezinesifo se-hATTR kanye ne-polyneuropathy eyabangelwa yiso. Ubuthakathaka bazo bemizwa, amandla emisipha, kanye nekhono lokwenza imisebenzi yansuku zonke kwalinganiswa kusetshenziswa izinhlelo ezikhethekile zokulinganisa.

Ngokusho kwemiphumela yocwaningo, iziguli ezathola i-Amvuttra zithuthukise ukusebenza kwazo kwezinzwa kanye nekhwalithi yokuphila. Ngenkathi amaphuzu azo ezinzwa ehla futhi izimpawu zithuthuka, labo abathole i-placebo babhekane nokwanda kwezimpawu.

Kodwa khumbula, imiphumela yalezi zifundo ingase ingafani kuwo wonke umuntu. Kufanele uxoxe nodokotela wakho ukuthi lo muthi ukulungele yini nokuthi izinzuzo zidlula yini izingozi.

Ngizoqala nini ukuzwa imiphumela yomuthi?

Lokhu akulona ikhambi elisheshayo. Njengoba imithi iqala ukusebenza kancane kancane emzimbeni wakho, ungase uqaphele ukwehla noma ukuthuthuka kwezimpawu zakho zingakapheli izinyanga ezimbalwa . Umgomo wesikhathi eside walokhu kwelashwa ukulawula ukuqhubeka kwesifo. Ngakho-ke, kubaluleke kakhulu ukuqaphela izimpawu zakho.

Tshela udokotela wakho ukuthi aqaphele lezi zinto:

• Ikhono lokuhamba ngaphandle kosizo
• Ukuba ndikindiki nokuthuthumela emilenzeni
• Ukusabela komzimba
• Ukulawula umfutho wegazi ngenkathi umile

Ngisho noma ungaluboni ushintsho olusheshayo, ungaphuthelwa ukuthola imijovo yakho ngesikhathi. Udokotela wakho angase futhi enze ukuhlolwa kwegazi okuhlukahlukene, ukuskena, noma ukuhlolwa ngokomzimba ukuze aqaphe intuthuko yakho.

Imiphumela emibi nokuthi ungayiphatha kanjani?

Imiphumela emibi evame kakhulu ebonwa nge-Amvuttra yile:

• Ubuhlungu ezingalweni noma emilenzeni
• Ubuhlungu bamalunga
• Ubunzima bokuphefumula

Ngaphezu kwalokho, i-Amvuttra inganciphisa amazinga akho e-vitamin A. Ngakho-ke, udokotela wakho uzokwenza ukuhlolwa kwegazi ukuhlola amazinga akho e-vitamin A ngaphambi nangesikhathi sokwelashwa. Uma ubona noma yiziphi izinguquko embonweni wakho, ikakhulukazi izinkinga zokubona ebusuku , yazisa udokotela wakho ngokushesha.

Lena akuyona yodwa imiphumela emibi engaba khona. Uma unezimpawu ezintsha ezikwenza uzizwe ungakhululekile, tshela udokotela wakho ngokushesha.

Ingabe kungaba nezinkinga ngeminye imithi?

I-Amvuttra ayaziwa ukuthi ibangela noma yikuphi ukuhlangana okuphawulekayo nokunye ukudla, iziphuzo, noma imithi. Kodwa-ke, kungcono ukutshela udokotela wakho ngayo yonke imithi, amavithamini, imikhiqizo yamakhambi, kanye nezithasiselo ozithathayo.