Ingabe uhlala uluma umzimba wakho? Ingabe uba bomvu? Ake sifunde ngalesi sifo esingavamile (i-Systemic Mastocytosis)

Ingabe nawe uyalunywa umzimba wonke ngezikhathi ezithile? Ingabe ubuso bakho nentamo yakho kuyaphenduka kube bomvu ngokuzumayo bese uzizwa sengathi uthola ukushisa? Ingabe unesisu esibuhlungu, isiyezi, kanye nenhliziyo egijimayo? Ngisho noma ucabanga ukuthi lezi zinto ziyi-allergies nje, ngezinye izikhathi kungase kube nesimo esihlukile ngemuva kwalokhu, esingakaze sizwe okuningi ngaso. Namuhla sikhuluma ngesifo esisodwa esingavamile, i-Systemic Mastocytosis. Ungakhathazeki, ake sikuqonde kalula lokhu.

Kuyini i-systemic mastocytosis?

Kalula nje, lesi yisifo esibangelwa ukwanda okungavamile kohlobo lweseli olubizwa ngokuthi 'amaseli e-mast' emzimbeni wethu. Amaseli e-mast awuhlobo lweseli elimhlophe legazi. Cabanga ngala maseli e-mast njengamasosha ohlelweni lwethu lokuzivikela komzimba. Umsebenzi wawo oyinhloko ukusivikela ezifweni nokusisiza siphilise lapho silimele . Kodwa kulesi sifo, la maseli e-mast aqoqana ngokweqile nangokungajwayelekile ezithweni ezahlukahlukene njengesikhumba sethu, umongo wamathambo , amathambo, namathumbu. Kwenzekani-ke? Ngenxa yesizathu esithile, la maseli e-mast amaningi aqala ukusebenza ngokuzumayo futhi akhiphe inani elikhulu lamakhemikhali afana ne -'histamine' emzimbeni. Yilapho izimpawu engizikhulumile ekuqaleni, njengokuhlanza, ukulunywa, kanye ne-eczema , zivela khona.

Yini ebangela lesi sifo?

Abantu abaningi bayazibuza ukuthi lesi yisifo esizuzwa njengefa. Kodwa lesi akusona isifo esizuzwa njengefa. Esikhathini esiningi, kwenzeka ku-gene ebizwa ngokuthi i-KIT, etholakala kumaseli ethu e-mast.Kubangelwa ushintsho olungahleliwe (ukuguqulwa). Lesi sakhi sofuzo sisiza ekwakheni iphrotheni elawula ukukhula kwamaseli. Ngakho-ke uma lokhu kushintsha, amaseli e-mast aqala ukukhula ngokungalawuleki. Nakuba lezi zimpawu zingavela kunoma yimuphi ubudala, zivame kakhulu kubantu asebekhulile, ikakhulukazi abaneminyaka ephakathi kuka-40 no-50 .

Izimbangela ezenza izimpawu zibe zimbi kakhulu

Akuwona wonke umuntu onalesi sifo obhekana nezimpawu ezifanayo. Futhi, izimbangela ezibangela izimpawu zingahluka kumuntu nomuntu. Kodwa-ke, ezinye zezimbangela ezivamile zibalwe kuthebula elingezansi. Kubalulekile ukuzazi lezi. Kubalulekile futhi ukukhumbula ukuthi ngezinye izikhathi izimpawu zingavela ngaphandle kwesizathu esithile.

Yiziphi izinhlobo nezimpawu eziyinhloko zalesi sifo?

Kunezinhlobo ezinhlanu eziyinhloko ze-Systemic Mastocytosis. Udokotela wakho uzokuvivinya futhi akutshele ukuthi uluhlobo luni onalo.

• Indolent Systemic Mastocytosis (ISM): Lolu uhlobo oluvame kakhulu futhi olungelubi kakhulu. Lesi sifo siqhubeka kancane futhi asibangeli umonakalo omkhulu ezithweni zomzimba.
• I-Smoldering Systemic Mastocytosis (SSM): Inzima kancane kune-ISM. Izimpawu zinzima kakhulu futhi zingathinta izitho zomzimba ngokuhamba kwesikhathi.
• I-Mastocytosis Yesistimu ene-Associated Hematological Neoplasm (SM-AHN): Kulesi simo, i-mastocytosis ihambisana nesinye isifo esihlobene negazi (isb. i-leukemia ).
• I-Aggressive Systemic Mastocytosis (ASM): Lolu hlobo lukhula ngokushesha futhi lungalimaza izitho ezifana nesibindi, udende, namathambo.
• I-Mast Cell Leukemia (MCL): Lolu uhlobo olungavamile kakhulu nolunzima kakhulu. Kunezinombolo ezinkulu zamaseli e-mast emnkantsheni nasegazini.

Izimpawu ozizwayo zincike ohlotsheni lwesifo onaso nokuthi amaseli e-mast angavamile agxile kuphi emzimbeni wakho. Nazi ezinye zezimpawu ezivamile:

• Ukuluma, ukuqubuka , ukuhlanza
• Ubuhlungu besisu, ukuqunjelwa, isifo sohudo
• Isicanucanu noma ukuhlanza
• Ikhanda elibuhlungu kanye nokukhathala
• Ukushaya kwenhliziyo okusheshayo
• Umfutho wegazi ophansi, isiyezi, ukulahlekelwa ukwazi
• Ukuvuvukala kwesibindi, i-spleen, kanye nama-lymph nodes
• I-anemia kanye nezimo zokopha
• Ubuthakathaka bamathambo (i-Osteoporosis)
• Engqondweni, izimo ezinjengobunzima bokugxilisa ingqondo, ukukhathazeka njalo, noma ukucindezeleka.

Ungasithola kanjani lesi sifo? (Ukuxilongwa)

Udokotela wakho uzoqala ngokukubuza ngezimpawu zakho bese ekwenza ukuhlolwa ngokomzimba. Ngemuva kwalokho, bangase batuse ukuhlolwa okuningana ukuqinisekisa ukuxilongwa:

• I-biopsy yesikhumba: Ingcezu encane yesikhumba ithathwa endaweni ethintekile bese ihlolwa ngaphansi kwe-microscope ukuze kubonakale ukuthi kunamaseli amaningi e-mast.
• I-Bone Marrow Biopsy: Udokotela wegazi usebenzisa inalithi encane ukuthatha isampula encane yomnkantsha wakho bese eyihlola.
• Ukuhlolwa kwegazi nomchamo:Ukubalwa kwegazi okuphelele (i-CBC) kungasetshenziswa futhi ukuhlola ezinye izimo, njenge-anemia.
• Ukuhlolwa Kwezakhi Zofuzo: Kuhlolwa isampula yegazi noma yezicubu ukuze kubonakale ukuthi kukhona yini izinguquko ku-KIT gene okukhulunywe ngayo ekuqaleni.
• Ukuhlolwa kwezithombe: Ama-X-ray, ama-ultrasound, kanye nama-CT scan kungasiza ekutholeni ubuthakathaka bamathambo kanye nokuvuvukala kwezitho ezifana nesibindi kanye ne-spleen.
• I-Endoscopy noma i-Colonoscopy: Ipayipi elincane elinekhamera elinamathiselwe kulo lisetshenziselwa ukuhlola ingaphakathi lesisu noma amathumbu ukuze kuhlolwe noma yikuphi ukukhubazeka, njengezilonda.

Yiziphi izindlela zokwelapha?

Udokotela uzonquma uhlelo lokwelashwa ngokusekelwe ezimpawini zakho, izitho zomzimba ezithintekile, kanye nohlobo lwesifo.

• Ama-Antihistamine: Le mithi isiza ukulawula izinto ezifana nokulunywa kwesikhumba, ukubomvu, kanye nokuphazamiseka kwesisu.
• I-Epinephrine: I-hormone esetshenziswa uma kwenzeka ukusabela okukhulu kokungezwani komzimba (i-anaphylaxis).
• Ama-Proton Pump Inhibitors: Lawula i-asidi yesisu futhi unciphise izinto ezifana nokuvuvukala kwesisu.
• Izinzinzisi Zeseli Le-Mast: Imithi evimba ukukhishwa kwe-histamine kumaseli e-mast.
• Ama-Steroids: Angasiza ngezimpawu zesikhumba kanye nokuphefumula.
• Ukwelashwa Okuqondiwe: Imithi eqondisa isakhi sofuzo noma iphrotheni ethile ehilelekile kulesi sifo. Lokhu kungadingeka kubantu abanezimpawu ezinzima.
• Ukwelashwa ngamakhemikhali: Lokhu kwelashwa kungadingeka ezimweni lapho isifo sisakazeka ngokushesha futhi sibangela umonakalo omkhulu ezithweni zomzimba.
• Ukufakelwa Kwamaseli Esiqu: Inketho yokwelapha ecatshangelwa ezimweni ezingavamile kakhulu.

I-Mastocytosis yesistimu, amaseli e-mast, ukuqubuka kwesikhumba, i-anaphylaxis, i-anaphylaxis, i-KIT gene, i-histamine