Xa wena okanye umntu osondeleyo kuwe efunyaniswa ukuba unomhlaza webele, usenokuba ukhe weva oogqirha besebenzisa amagama anje ' HER2-Positive ' okanye 'HER2-low'. La ngamagama asetyenziselwa ukuchaza iintlobo zeeseli zomhlaza. Ngoku kukho amayeza amatsha, aphucukileyo okunyanga ezi ntlobo zomhlaza. Elinye la mayeza akhethekileyo yi-Enhertu. Namhlanje, siza kuthetha ngale nto ngendlela elula neqondakala lula.
Luhlobo luni lonyango i-Enhertu? Isebenza njani?
Ngamafutshane, i-Enhertu lunyango olujoliswe kulo . Ngokuchanekileyo, luhlobo lwesiyobisi esibizwa ngokuba yi-'Antibody-Drug Conjugate (ADC).' Nangona igama lisenokuvakala liyinkimbinkimbi kancinci, indlela elisebenza ngayo iyamangalisa.
Cinga ngale mithi njengesixhobo esikrelekrele. Yenziwe ngamacandelo amathathu:
1. Inxalenye yokufumana ithagethi (i-Antibody): Le nxalenye ifumana iproteni ekhethekileyo ebizwa ngokuba yi-'HER2' kumphezulu weeseli zomhlaza ize inamathele kuyo. Umsebenzi wale nxalenye kukuchonga nokukhusela iiseli zomhlaza kuphela, ngaphandle kokulimaza iiseli eziphilileyo.
2. Umthwalo: Eli liyeza elibulala iiseli zomhlaza. Ngokuchanekileyo, olu luhlobo olunamandla lwe-chemotherapy.
3. Inxalenye edibanisa ezi zimbini (iLinker): Ezi nxalenye zimbini zikhankanyiweyo apha ngasentla zidibene kunye yile linker.
Ngoko ke, xa unika eli yeza, inxalenye yalo ye-antibody iya ngqo kwiiseli zomhlaza ezineproteni ethi 'HER2'. Emva koko, eli yeza lifunxwa kwiseli. Nje ukuba lingene kwiseli, inxalenye ye-chemo iyakhululwa ize itshabalalise iseli yomhlaza. Njengoko iiseli zomhlaza zisifa, iiseli zomhlaza ziyancipha kwaye ziyeke ukukhula.
Eyona nzuzo inkulu yale ndlela kukuba iyeza lijolise ngqo kwiiseli zomhlaza kuphela, ngoko ke umonakalo kwiiseli ezisempilweni uncitshiswa kakhulu.
Inikwa njani i-Enhertu?
I-Enhertu liyeza elinikwa ngemithambo yegazi. Oku kuthetha ukuba linikwa emzimbeni njengesisombululo setyuwa (i-IV infusion). Olu nyango luza kunikwa ngugqirha wezempilo esibhedlele, eklinikhi, okanye kwiziko lonyango elikhethekileyo.
- Ubude bexesha: Olu nyango ludla ngokwenziwa kube kanye kwiiveki ezi -3 .
- Umlinganiselo: Ubungakanani beyeza olifunayo buxhomekeke kubunzima bomzimba wakho. Ugqirha wakho uza kulibala ngokuchanekileyo aze alinike umyalelo.
- Umda wexesha:Ukuba umhlaza wakho usabela kakuhle kweli yeza, ugqirha wakho uya kukucebisa ukuba uqhubeke nolu nyango ixesha elide kangangoko unako. Nangona kunjalo, ukuba ufumana ezinye iziphumo ebezingalindelekanga, kunokufuneka utshintshe umthamo weyeza, uyeke okwethutyana unyango, okanye uyeke kwaphela. Ugqirha wakho uya kuxoxa nawe ngazo zonke ezi zinto aze enze izigqibo.
Isebenza kangakanani na iyeza le-Enhertu?
Izilingo ezimbini zeklinikhi eziphanda ukusebenza kakuhle kweyeza le-Enhertu zivelise iziphumo ezilungileyo kakhulu.
1. Uthelekiso lwe-Enhertu kunye neKadcyla (uvavanyo lwe-DESTINY-Breast03)
Kolu vavanyo, i-Enhertu ithelekiswe neKadcyla (ado-trastuzumab emtansine), elinye iyeza elijolise kwi-"HER2." Iziphumo ziboniswe kwitheyibhile engasezantsi.
| Indawo yokuthelekisa | Unyango lwe-Enhertu | Unyango lweKadcyla |
|---|---|---|
| Ukusinda Okungenankqubela-phambili (Eli lixesha elithatha isiqingatha sezigulane ukuba ziphinde zifumane umhlaza wazo okanye zingasasazeki) | Iinyanga ezingama-28.8 | Iinyanga ezi-6.8 |
| Ipesenti yezigulana ezingazange zisasaze esi sifo emva kweenyanga ezili-12 | 75.2% | 33.9% |
| Ipesenti yezigulana ezingazange zisasaze esi sifo emva kweenyanga ezingama-24 | 53.7% | 26.4% |
2. Uthelekiso lwe-Enhertu kunye ne-chemotherapy (uvavanyo lwe-DESTINY-Breast04)
Olu vavanyo luthelekise i-Enhertu ne-chemotherapy eqhelekileyo.
| Indawo yokuthelekisa | Unyango lwe-Enhertu | Unyango lwe-chemotherapy |
|---|---|---|
| Ukusinda Okungenankqubela-phambili | Iinyanga ezi-9.9 | Iinyanga ezi-5.1 |
| Ukusinda Ngokupheleleyo (Eli lixesha apho isiqingatha sabaguli abafumene unyango sasinda khona) | Iinyanga ezingama-23.4 | Iinyanga ezili-16.8 |
Olu lwazi lubonisa ukuba i-Enhertu lolona nyango lusebenza ngakumbi kunezinye zonyango ezikhoyo ngoku.
Ndingakujonga njani ukuchacha kwam?
I-Enhertu iqala ukusebenza kwangoko nje ukuba ufumane idosi yakho yokuqala. Ugqirha wakho uza kwenza iimvavanyo ezahlukeneyo ukuze abone ukuba umzimba wakho usabela njani kwiyeza.
- Iiskeni: Iskeni idla ngokwenziwa malunga neeveki ezi-6 emva kokuqala unyango ukujonga inkqubela yomhlaza. Oku kungenziwa kwangethuba okanye kamva.
- Uvavanyo lwegazi: Uvavanyo lwegazi oluqhelekileyo lwenziwa ukujonga inani leeseli zakho ezimhlophe zegazi, i-neutrophil, kunye neeplatelet. Oku kuya kunceda ekuqinisekiseni ukuba ungaqhubeka nokusebenzisa amayeza ngokukhuselekileyo. Ukuba ufumana iziphumo ebezingalindelekanga, ezifana nokukhwehlela, usenokuba nezinye iimvavanyo ezikhethekileyo ukuze uzikhangele.
Iziphumo ebezingalindelekanga kunye nendlela yokuzilawula?
Iziphumo ebezingalindelekanga ziqhelekile kunyango lomhlaza. Oku kuyinyaniso nakwi-Enhertu. Eyona nto ibalulekileyo kukuxelela ugqirha wakho ngazo naziphi na iziphumo ebezingalindelekanga ozifumanayo. Nguye oza kugqiba ukuba zimbi na aze akuxelele into omawuyenze ngazo.
Ukuthintela iziphumo ebezingalindelekanga ezifana nokuhlanza kunye nokucaphuka, ugqirha wakho angakunika amanye amayeza omawuwasebenzise ngaphambi kokuba akunike amayeza. Kubaluleke kakhulu ukulandela loo miyalelo ngokuchanekileyo.
Ukongeza, ungenza nezinto ezilula ezifana nezi ukunceda ukulawula isicaphucaphu, ukuhlanza, kunye norhudo:
- Yitya ukutya okungeyondlwanga okunamafutha amancinci kunye netshili.
- Endaweni yokutya kathathu okukhulu, yitya izidlo ezincinci ezimbalwa ngemini.
Ngokuxhomekeke kubukhali bezinye iziphumo ebezingalindelekanga, ugqirha wakho unokugqiba ekubeni anciphise umthamo wamayeza akho, ayeke okwethutyana unyango, okanye ayeke ngokupheleleyo. Ungakhathazeki ngayo. Konke kungenxa yokhuseleko lwakho.
Ngaba kukho naziphi na izilumkiso ezikhethekileyo ekufuneka uziqaphele?
Ewe. I-Enhertu inesilumkiso esinzulu kakhulu . Esi sesona silumkiso siphezulu esikhutshwe yi-FDA (US Food and Drug Administration).
1. Ukulimala komntwana ongekazalwa: Kufuneka uphephe ngokupheleleyo ukukhulelwa ngelixa usebenzisa eli yeza. Oku kunokulimaza kakhulu usana olungekazalwa. Ukuba wena okanye iqabane lakho niceba ukukhulelwa, qiniseka ukuba nimxelele ugqirha wakho . Ugqirha wakho uza kukunika iingcebiso ngeendlela ezifanelekileyo zokulawula ukukhulelwa onokuzisebenzisa ngexesha lonyango.
2. Ukonakala kwemiphunga: Eli yeza linokubangela imeko embi yemiphunga ebizwa ngokuba yi-'Interstitial Lung Disease (ILD).' Ngoko ke, ugqirha wakho uza kukujonga oku kulo lonke ixesha lonyango. Ukuba ufumana iimpawu ezifana nokukhwehlela kunye nobunzima bokuphefumla, yazisa ugqirha wakho ngoko nangoko.
Ngenxa yezi zinto, kubaluleke kakhulu ukuhlala unxibelelana nogqirha rhoqo kwaye ulandele imiyalelo yakhe ngokuchanekileyo.
Umyalezo Wokuya Ekhaya
- I-Enhertu liyeza eliphambili elijolise kwiproteni ye-HER2 kumhlaza webele kwaye libulala iiseli zomhlaza kuphela.
- Olu lunyango olunikwa ngemithambo yegazi (IV) rhoqo kwiiveki ezi-3.
- Uvavanyo lwezonyango lubonakalise ukuba eli yeza lisebenza ngcono kunezinye iindlela zonyango ezisetyenziswayo ngoku.
- Iziphumo ezingezizo ezifana nokucaphuka nokuhlanza zinokwenzeka ngexesha lonyango, kwaye kukho iindlela zokuzilawula. Yazisa ugqirha wakho ngoko nangoko malunga nokungonwabi.
- Ukusela eli yeza ngexesha lokukhulelwa kunokubangela ingozi enkulu kusana olungekazalwa, kwaye kukho umngcipheko weziphumo ebezingalindelekanga ezichaphazela imiphunga. Thetha nogqirha wakho ngale nto ngokukhululekileyo.
💬 Comments (0)
Akukho zimvo zithunyelweyo okwangoku. Faka uluvo lwakho apha okokuqala.
Faka uluvo lwakho