Isisombululo se-colitis? Masifunde ngeVedolizumab!

Ngaba unesifo se -Inflammatory Bowel Disease ( IBD ), imeko apho ulwelo lwamathumbu luvuvukala kwaye lubuhlungu ? Ngabo kuphela abaye bahlangabezana nentlungu abaziyo ukuba kunzima kangakanani ukuphila neemeko ezifana nesifo sikaCrohn okanye i-Ulcerative Colitis . Kodwa ungoyiki, ngokuhambela phambili kwesayensi yezonyango, kuye kwavela unyango olutsha nolusebenzayo lokulawula ezi meko. Namhlanje, siza kuthetha ngelinye lamayeza akhethekileyo, iVedolizumab .

Lithini eli yeza libizwa ngokuba yiVedolizumab? Lithetha...

Ngamafutshane, iVedolizumab liyeza elisetyenziselwa ukunyanga izifo ezithile zamathumbu ezivuthayo , ingakumbi isifo sikaCrohn kunye ne-ulcerative colitis. Ukuba unenye yezi meko, mhlawumbi ukhe weva ngeli yeza, okanye ugqirha wakho usenokuba ulicebisile.

Yintoni kanye kanye le chiza elenzayo? Cinga ngayo, umsebenzi walo ophambili kukunciphisa ukudumba okungeyomfuneko kwinkqubo yakho yokugaya ukutya, oko kukuthi, emathunjini . Ezinye iiseli zenkqubo yethu yokuzikhusela komzimba zinegalelo ekubangeni oku kudumba. I-Vedolizumab iyawathintela loo maseli ukuba angangeni aze onakalise izicubu zamathumbu. Njengomgcini-sango, eli yeza livala indlela yokuba ezo seli zidumba zingene emathunjini. Emva koko ukungakhululeki okuvayo, okufana nentlungu yesisu , urhudo, kunye nokopha, kuyancitshiswa kakhulu kwaye ufumana isiqabu.

Zeziphi izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba usebenzise eli yeza?

Ngaphambi kokuba uqale unyango ngeVedolizumab, kubalulekile ukuxelela iqela lakho lezonyango, kuquka ugqirha wakho kunye nomongikazi, ngezi zinto. Olu lwazi luza kubanceda bagqibe ukuba eli yeza likulungele na, liza kunikwa njani, kunye noko kufuneka ukwazi. Musa ukufihla olu lwazi, kuba lunokuba yingozi kuwe.

• Ngaba unayo nayiphi na i-allergies?Usenokuba une-allergy kwiVedolizumab ngokwayo, okanye kwamanye amayeza, ukutya, iidayi, okanye izithinteli. Ngoko ke cacisa ngaloo nto. Ukuba ukhe waba ne-allergy nakweyiphi na iyeza ngaphambili, sixelele ngayo.
• Ngaba unazo naziphi na izifo okwangoku? Umzekelo, ukuba une-infection enzima efana ne-TB , okanye naluphi na olunye usulelo lwebhaktiriya, i-fungus, okanye i-viral, kufuneka uxelele ugqirha wakho. Ukuba uneempawu ezifana nomkhuhlane, ukukhwehlela, okanye i-phlegm, xelela ugqirha wakho. Oku kungenxa yokuba eli yeza lisenokuchaphazela inkqubo yomzimba yokuzikhusela, nto leyo enokwenza ukuba i-infection ekhoyo ibe mandundu.
• Ngaba unesifo sesibindi? Isibindi sisitho esibaluleke kakhulu emzimbeni wethu. Isibindi sinceda ekugayweni nasekukhupheni amayeza emzimbeni. Ngoko ke, ukuba kukho ingxaki ngesibindi, inokuchaphazela unyango.
• Ngaba usandul’ ukufumana naluphi na ugonyo? Okanye uceba ukufumana naluphi na ugonyo kwixesha elizayo? Ezinye izigonyo, ingakumbi izigonyo eziphilayo, zisenokungahambelani nale yeza. Ngoko ke kufuneka uxelele ugqirha wakho ngaloo nto.
• Ngaba ukhulelwe? Okanye uzama ukukhulelwa? Naliphi na iyeza kufuneka lithathwe ngononophelo olukhulu ngexesha lokukhulelwa. Kufuneka uxoxe ngale nto nogqirha wakho. Nguye oza kugqiba ukuba eli yeza liza kumchaphazela na umntwana okanye akunjalo.
• Ingaba ungumama oncancisayo? Xelela ugqirha wakho ngale nto, kuba amayeza anokudluliselwa kumntwana wakho ngobisi lwebele.
• Ngaba unazo naziphi na iingxaki okanye ubuthathaka ngenkqubo yakho yokuzikhusela komzimba? Olu lwazi lubaluleke kakhulu kuba eli yeza linxulumene nenkqubo yokuzikhusela komzimba.

Ulisebenzisa njani eli yeza?

I-Vedolizumab ayisiyo ipilisi okanye isiraphu onokuyithenga kwikhemesti uze uyithathe ekhaya. Inikwa njenge -intravenous infusion . Inikwa liqela lakho lezempilo esibhedlele okanye kwikliniki ekhethekileyo. Oku kuthetha ukuba ugqirha okanye umongikazi oqeqeshwe kolu hlobo lonyango uya kukunika inaliti. Ngokwesiqhelo kuthatha malunga nesiqingatha seyure ukukunika inaliti. Uya kuhlolwa okwethutyana ngexesha nasemva kwenaliti ukuze kubonwe ukuba unayo nayiphi na imiphumo emibi.

Kwakhona, xa unikwa eli yeza, ikhemesti iya kukunika incwadana yemiyalelo ekhethekileyo (iMedGuide) . Iqulethe ulwazi olubaluleke kakhulu malunga neli yeza, iziphumo ebezingalindelekanga, kunye nezinto ekufuneka uzilumkele. Kufuneka ulifunde ngononophelo elo ncwadana ngalo lonke ixesha ufumana iyeza elitsha. Kuba liqulethe izinto ezininzi ekufuneka uzazi. Ukuba kukho into ongayiqondiyo, buza ugqirha okanye umongikazi wakho.

Ngaba eli yeza linokunikwa abantwana?Okwangoku, eli yeza alivumelekanga ukusetyenziswa ebantwaneni. Ngoko ke, ukuba umntwana wakho unale meko, kungcono ukuthetha nogqirha wabantwana ngayo.

Kuthekani ukuba ngempazamo uthatha amayeza amaninzi kakhulu (ukugqithisa)? Amathuba okuba oku kwenzeke mancinci kakhulu, kuba oku kubonelelwa esibhedlele, phantsi kweliso likagqirha. Nangona kunjalo, kwimeko engaqhelekanga yokuba ucinga ukuba uthathe amayeza amaninzi, fowunela iziko lolawulo lwetyhefu okanye igumbi likaxakeka ngokukhawuleza.

Kubaluleke kakhulu: Eli yeza lelakho kuphela . Musa ukwabelana ngeli yeza nabanye abantu, nokuba baneempawu ezifanayo nezakho. Asinguye wonke umntu ofanelekileyo kwiyeza elifanayo, kwaye akucetyiswa ukuba eli yeza ulinike nabani na ngaphandle kwengcebiso kagqirha.

Wenza ntoni ukuba uphoswe yintlanganiso yamayeza?

Eli yeza lidla ngokunikezelwa kanye kwiiveki ezimbalwa. Ngoko ke, ukuba awukwazi ukuza kujova ngosuku nangexesha elicwangcisiweyo, oko kukuthi , ukuba awukwazi ukugcina idinga lakho, fowunela iqela lakho lezempilo ngoko nangoko ubazise . Kubaluleke kakhulu ukulithatha eli yeza njengoko licwangcisiwe. Kuba kulapho uya kufumana khona uncedo olukhulu kwiyeza. Baza kukuxelela into omawuyenze ngokulandelayo, kwaye banokukwazi ukulihlengahlengisa usuku olutsha.

Ziziphi ezinye izinto ezinokusebenzisana nale mithi?

Xa usela iVedolizumab, amanye amayeza owaselayo anokuchaphazela unyango lwakho. Kungoko ke, kubaluleke kakhulu ukuxelela ugqirha wakho ngawo onke amayeza owaselayo.

I-Vedolizumab inokunxibelelana namayeza alandelayo ngokukodwa:

• Amayeza e-steroid: Umzekelo, amayeza anjenge -prednisone okanye i-cortisone . La ngamanye amaxesha anikwa ukudumba kwamathumbu.
• Izithinteli ze-TNF-alpha: Ezi zikwangamayeza anxulumene nokuzikhusela komzimba. Imizekelo ibandakanya i-natalizumab , i-adalimumab , kunye ne -infliximab . Ukusebenzisa la mayeza kunye ne-vedolizumab kunokunyusa umngcipheko wosulelo.
• Iigonyo: Akucetyiswa ukufumana iigonyo, ingakumbi iigonyo eziphilayo, ngelixa usela eli yeza.

Olu luhlu alubandakanyi yonke into. Ngoko ke, xelela ugqirha wakho ngayo yonke imithi oyinikwe ngugqirha wakho, kunye nayo nayiphi na imithi engagunyaziswanga ngugqirha, imifuno, kunye nezongezo zokutya ozithathayo. Kwakhona xelela ugqirha wakho ukuba uyatshaya, usela utywala, okanye usebenzisa ezinye iziyobisi. Ezi zinokudibana namayeza akho okanye zenze imeko yakho ibe mandundu.

Yintoni omele uyilumkele xa usebenzisa eli yeza?

Iqela lakho lezonyango liza kujonga impilo yakho ngokusondeleyo ngelixa uthatha iVedolizumab. Kubalulekile ukuba uhlolwe rhoqo . Kufuneka uqaphele oku kulandelayo:

• Ukuba iimpawu zakho aziphucuki, okanye ukuba zibonakala zisiba mandundu, xelela ugqirha wakho ngoko nangoko .
• Ekubeni amasosha omzimba wakho esenokutshintsha ngelixa usebenzisa eli yeza, usenokuba sesichengeni sosulelo. Ke ngoko, kungcono ukuhlala kude nabantu abagulayo . Kuphephe ukusondelana nabantu abanomkhuhlane okanye umkhuhlane, kwaye uphephe iindawo ezinabantu abaninzi.
• Ukuba unomkhuhlane, umkhuhlane, umphimbo obuhlungu, ukukhohlela, ezinye iimpawu zomkhuhlane, okanye iintlungu zomzimba , musa ukuzenza amayeza. Musa ukucinga nje ukuba, "Ngumkhuhlane nje." Fowunela ugqirha wakho ngoko nangoko uze ufumane ingcebiso.
• Isilumkiso esibaluleke kakhulu: Kunqabile, kwezinye izigulana, eli yeza linokubangela usulelo olukhulu lobuchopho olubizwa ngokuba yiProgressive Multifocal Leukoencephalopathy (PML) . Oku kunokuba yingozi ebomini. Ke ngoko, ukuba ubona naluphi na utshintsho embonweni wakho (umz., ukubona kabini, ukubona okufipheleyo), utshintsho kwindlela ocinga ngayo (ukudideka, ukulahlekelwa yinkumbulo), ingxaki yokuthetha, ingxaki yokuhamba okanye ukuma, okanye ubuthathaka kwelinye icala lomzimba wakho , xelela iqela lakho lezempilo ngokukhawuleza. Ukuba awukwazi ukunxibelelana nabo, funa unyango olukhawulezileyo ngoko nangoko. Nangona oku kunqabile kakhulu, kubalulekile ukukwazi.

Zithini iziphumo ebezingalindelekanga ezinokubakho zale yeza?

Njengalo naliphi na iyeza, iVedolizumab inokubangela ezinye iziphumo ebezingalindelekanga. Nangona kunjalo, ayinguye wonke umntu ozifumanayo. Abanye abantu bayaphumelela ngeyeza ngaphandle kweziphumo ebezingalindelekanga. Ezinye iziphumo ebezingalindelekanga ziyingozi kwaye kufuneka zixelwe kugqirha wakho ngoko nangoko. Ezinye azibi kakhulu kwaye ziya kuphela emva kweentsuku ezimbalwa.

Iziphumo ebezingalindelekanga ekufuneka uxelele ugqirha wakho ngazo ngoko nangoko:

Ukuba ufumana naziphi na kwezi mpawu, xelela iqela lakho lezempilo ngokukhawuleza:

• Iimpendulo ze-allergy: ukurhawuzelela kwesikhumba, ukurhawuzelela okukhulu, amaqhuqhuva (njenge-eczema), ukudumba kobuso, imilebe, ulwimi, okanye umqala - oku kuyingozi kakhulu kuba kunokubangela ubunzima bokuphefumla.
• Ukudinwa, ukulahlekelwa kukulinganisela okanye ukulungelelaniswa kwezinto, ukudideka okanye ingxaki yokuthetha: Ezi zinokuba ziimpawu zosulelo lobuchopho olubizwa ngokuba yi-PML ekhankanyiweyo ngaphambili.
• Iimpawu zosulelo:Umkhuhlane, ukubanda, ukukhohlela okungapheliyo okanye umphimbo obuhlungu, iintlungu zomzimba, ukudinwa.
• Iimpendulo zokufakwa kwenaliti: Iintlungu zesifuba, ukuphefumla okunzima okanye ukuphefumla nzima, ukuziva ubuthathaka okanye unentloko ebuhlungu, ukuba bomvu kwesikhumba, ukurhawuzelelwa. Oku kunokwenzeka emva nje kokufakwa okanye kungekudala emva koko.
• Iimpawu zokulimala kwesibindi: iintlungu zesisu esingentla ngasekunene, ukungabi namdla wokutya, isicaphucaphu okanye ukuhlanza, indle enombala okhanyayo, umchamo otyheli okanye omdaka omnyama, i-jaundice (ulusu okanye amehlo atyheli), ubuthathaka okanye ukudinwa okungaqhelekanga.

Iziphumo ebezingalindelekanga ukuba ugqirha azikhankanye, kodwa kufuneka zikhankanywe ukuba ziyaqhubeka:

Ezi ziphumo bezingalindelekanga azibi kakhulu. Zihlala ziphela emva kweentsuku ezimbalwa. Nangona kunjalo, ukuba ziyaqhubeka okanye zikukhathaza kakhulu, xelela ugqirha wakho .

• Intloko ebuhlungu
• Ukudinwa
• Intlungu yamalungu
• Isicaphucaphu
• Iimpawu zomkhuhlane eziqhelekileyo - umphimbo obuhlungu, impumlo egobhozayo
• Ukukhwehlela
• Ukuqhambuka kwesikhumba

Olu luhlu alubandakanyi zonke iziphumo ebezingalindelekanga. Ukuba ubona nantoni na engaqhelekanga engekho kolu luhlu, buza ugqirha wakho ngayo. Ungaxela iziphumo ebezingalindelekanga kwi- FDA (Food and Drug Administration) ku-1-800-FDA-1088 eMelika, okanye kwiziphathamandla zempilo ezifanelekileyo ngogqirha wakho eSri Lanka.

Uligcina phi iyeza?

Oku akuyi kuba yingxaki kuwe. Kuba iVedolizumab ayiloyeza onokulithatha uye nalo ekhaya. Liyeza elinikwa esibhedlele okanye eklinikhi kuphela, kwaye ligcinwa apho phantsi kolawulo olufanelekileyo lobushushu . Ngoko ke akufuneki ukhathazeke ngokugcina iyeza.

Okubaluleke kakhulu - umyalezo wokubuyela ekhaya

Kulungile, ngoko ke sithethe kakhulu ngeVedolizumab. Isenokubonakala ngathi liyeza elinzima, kodwa ukuba uliqonda kakuhle kwaye ulandela imiyalelo kagqirha wakho, linokukunceda ufumane isiqabu esihle kwisifo sakho samathumbu esibangelwa kukudumba (IBD).

Ngamafutshane, iVedolizumab liyeza elikhethekileyo elinikwa ngemithambo yegazi kwizifo zokudumba kwamathumbu. Linokukunceda ukulawula iimpawu zakho, lenze ubomi bakho bube lula kancinci, kwaye linciphise iingxaki ezibangelwa sisifo.

Khumbula, kubalulekile ukuba ukhululeke kwaye uthembeke kugqirha wakho ngaphambi nangexesha lonyango lwakho. Ukuba unemibuzo okanye izinto ezikuxhalabisayo, ungoyiki ukubuza. Musa ukucinga ngezinto ezinje, "Ngaba le yinto endifanele ndiyibuze?" "Ugqirha uza kucinga ntoni?" Bakho ukuze bakuncede. Sonke kufuneka sizame ukwaziswa, sifumane unyango olufanelekileyo, kwaye sihlale sisempilweni.

Ndiyathemba ukuba olu lwazi luluncedo! Ndikunqwenelela ukuchacha ngokukhawuleza!

I- Vedolizumab, isifo samathumbu esidumbayo, isifo sikaCrohn, i-ulcerative colitis, isifo samathumbu, amayeza, iziphumo ebezingalindelekanga