Ingabe uvame ukuhlushwa ubuhlungu bamalunga , ubuhlungu bomhlane , noma ubuhlungu obukhulu obuhambisana nokuya esikhathini? Bese sithatha ngokushesha umuthi wokuqeda izinhlungu . Kodwa bewazi ukuthi kunezinhlobo ezahlukene zalezi zinhlungu zobuhlungu? Namuhla sizokhuluma ngohlobo lomuthi wokuqeda izinhlungu oluthatha indawo ekhethekile phakathi kwazo, futhi olusebenza ngendlela ehlukile kancane. Lokho yi -COX-2 inhibitors .
Kalula nje, ziyini lezi zithiyo ze-COX-2?
Ama-COX-2 inhibitors empeleni ayiqembu lemithi eqeda ubuhlungu futhi inciphise ukuvuvukala (ilwa nokuvuvukala). Igama lezokwelapha laleli qembu yi-NSAID, elimelela i-Nonsteroidal Anti-inflammatory Drugs. Imithi efana ne -Ibuprofen , i-Naproxen , ne-Diclofenac ovame ukuzwa ngayo nayo ingeyaleli qembu elibizwa nge -NSAID .
Kodwa-ke, lolu hlobo oluthile, olubizwa ngokuthi ama-COX-2 inhibitors, lusebenza emzimbeni ngendlela ehluke kancane kune-NSAID yendabuko esijwayelene nayo sonke. Ake sibheke ukuthi lowo mehluko uyini.
Lomuthi usebenza kanjani emzimbeni? Kuyindlela emangalisayo kakhulu!
Ukuze siqonde lokhu, sidinga kuqala ukuqonda izinhlobo ezimbili zama-enzyme emizimbeni yethu. Lawa ama-enzyme e-COX-1 kanye ne-COX-2 . Womabili la ma-enzyme akhiqiza amakhemikhali emizimbeni yethu abizwa ngokuthi ama-prostaglandins . Lawa ma-prostaglandins yiwona abangela ubuhlungu, ukuvuvukala (ukuvuvukala), kanye nomkhuhlane.
Cabanga ngalokhu: Kunezisebenzi ezimbili ngaphakathi efektri ebizwa ngokuthi umzimba wethu.
- I-COX-1 (isisebenzi sokuqala): Lesi siyisisebenzi esihle. Senza ama-prostaglandin abangela ubuhlungu nokuvuvukala. Kodwa ngaphezu kwalokho, senza izinto ezimbili ezibaluleke kakhulu . Eyokuqala ukuvikela ulwelwesi lwesisu namathumbu ethu e-asidi yesisu. Eyokuqala ukusiza ngenqubo yokujiya kwegazi.
- I-COX-2 (Isisebenzi 2): Lena yinkinga yangempela. Umsebenzi wayo oyinhloko ukwenza ama-prostaglandin abangela ubuhlungu nokuvuvukala.
Manje bheka, uma sithatha imithi yokubulala izinhlungu (ama-NSAID angakhethi) njenge-Ibuprofen ne-Diclofenac, umuthi uyayekisa zombili lezo zisebenzi. Ngemuva kwalokho, ngenxa yokuthi i-COX-2 iyayekiswa, ubuhlungu nokuvuvukala kuyancishiswa. Kodwa ngenxa yokuthi isisebenzi esihle, okungukuthi i-COX-1, siyayekiswa, ukuzivikela kwesisu kuyalahleka , futhi amathuba okuba ne-gastritis, ukuvuvukala kwesisu, kanye nezilonda ayanda.
Kodwa, lolu hlobo lwemithi olubizwa ngokuthi i-COX-2 inhibitors luhlakaniphe kakhulu. Luya ngqo kumuntu onenkinga, okungukuthi, i-enzyme ye-COX-2 . Luvumela umuntu osebenzayo (i-COX-1) ukuthi enze umsebenzi walo. Ngakho-ke umonakalo esiswini mncane kakhulu. Lena inzuzo enkulu yalolu hlobo lwemithi.
Yiziphi izimo ezisetshenziswa yi-COX-2 inhibitors?
Odokotela batusa lolu hlobo lomuthi ukulawula ubuhlungu obuncane kuya kobuphakathi kanye nokuvuvukala okubangelwa yizimo ezahlukene zezokwelapha.
| Isimo sezokwelapha | Incazelo elula |
|---|---|
| I-Osteoarthritis | Ubuhlungu nokuqina okubangelwa ukuguguleka kwamalunga njengoba siguga. |
| Isifo Samathambo Esibangelwa Yi-Rheumatoid | Isifo esibangela ukuvuvukala nobuhlungu emalungeni ngenxa yokusebenza kwesimiso somzimba sokuzivikela. |
| Isifo Samathambo Sentsha | Isifo samathambo ezinganeni ezincane. |
| I-Ankylosing Spondylitis | Isifo lapho amalunga, ikakhulukazi emgogodleni, evuvukala khona futhi angahlangana ndawonye ngokuhamba kwesikhathi. |
| Ubuhlungu ngesikhathi sokuya esikhathini (i-Dysmenorrhea) | Ubuhlungu obukhulu besisu ngesikhathi sokuya esikhathini. |
| Ukulimala kwesikhashana, njengokulimala kwezemidlalo | Uma kwenzeka ukuklwebheka, ukucindezelwa kwemisipha, njll. |
Ngaphezu kwalokho, udokotela wakho angase akunike lo muthi ezimweni ezifana ne-gout kanye ne-migraine.
Yiziphi izingozi nemiphumela emibi yokusebenzisa ama-COX-2 Inhibitors?
Naphezu kwemiphumela emibi yesisu encishisiwe, ama-COX-2 inhibitors awawona imithi engenazo izingozi ngokuphelele. Kungase kube nezingozi ezithile , ikakhulukazi uma isetshenziswa ngemithamo ephezulu futhi isikhathi eside .
Izingozi Eziyinhloko
- Ukuhlaselwa yinhliziyo kanye nesifo sohlangothi: Kutholakale ukuthi ama-COX-2 inhibitors ahlotshaniswa nengozi ekhulayo kancane yokuhlaselwa yinhliziyo kanye nesifo sohlangothi. Le ngozi inkulu nakakhulu kubantu asebevele benesifo senhliziyo noma izici eziyingozi zaso. Ngenxa yalesi sizathu, amanye ama-COX-2 inhibitors, njenge-`Rofecoxib (Vioxx®)` kanye ne-`Valdecoxib (Bextra®)`, asusiwe emakethe.
- Izinkinga zesisu namathumbu: Nakuba umonakalo wesisu unciphile, awupheli ngokuphelele. Abanye abantu bangase babe nokopha kanye nezilonda .
Imiphumela emibi evamile
| Uhlobo lomphumela ongemuhle | Izimpawu ezingaba khona |
|---|---|
| Uhlelo lokugaya ukudla | Ukuqunjelwa, isifo sohudo, ukuqunjelwa, isicanucanu, ubuhlungu besisu, ubuhlungu besifuba. |
| Inhliziyo nemithambo yegazi | Umfutho wegazi ophakeme, ubuhlungu besifuba, ukuhlaselwa yinhliziyo, isifo sohlangothi. |
| Izinso | Ukwehla kokusebenza kwezinso, ukunqwabelana kwamanzi emzimbeni kanye nokuvuvukala (i-edema). |
| Uhlelo lwezinzwa | Ikhanda elibuhlungu, isiyezi. |
Ubani okungafanele athathe ama-COX-2 Inhibitors?
Udokotela wakho uzobuyekeza umlando wakho wezempilo ophelele ukuze anqume ukuthi lo muthi ukulungele yini. Kufanele ugweme ukuthatha lo muthi uma unezinye zezimo ezilandelayo:
- Uma uke waba nesifo sohlangothi ngaphambili.
- Uma usanda kuba nokuhlinzwa kwe-coronary artery bypass noma usuzokwenziwa ukuhlinzwa .
- Uma unesifo sezinso esibi kakhulu noma isifo sesibindi .
- Uma uke waba nokuhlaselwa yi-asthma ngaphambilini noma ukusabela okukhulu kokungezwani komzimba nenye i-NSAID, i-aspirin, noma i-sulfa antibiotic.
- Uma usezinyangeni ezintathu zokugcina zokukhulelwa .
- Uma ungumama oncelisayo (khuluma nodokotela wakho ngalokhu).
Kufanele ubonane nodokotela ngokushesha nini?
Uma uhlangabezana nanoma yiziphi izimpawu ezilandelayo ngenkathi uthatha lo muthi, ungalibali futhi ngokushesha ubone udokotela wakho noma uye eMnyangweni Wezimo Eziphuthumayo (ETU) wesibhedlela esiseduze.
- Izimpawu zenkinga yesibindi: umchamo omnyama, ukukhathala okukhulu, ukuphuzi kwesikhumba noma amehlo, indle enombala okhanyayo, ukucasuka kwesisu.
- Izimpawu zokopha: ukuhlanza igazi noma ukuhlanza okufana nekhofi, ukuphuma kwegazi esitofini (indle emnyama noma ebomvu), ukuphuma kwegazi emchameni, ukuphuma kwegazi ezinsinini, ukuphuka kwesikhumba okungavamile.
- Izimpawu zenkinga yezinso: ukungakwazi ukuchama, ushintsho enanini lomchamo okhiqizwayo, ukukhuluphala ngokuzumayo.
- Izimpawu zokungezwani komzimba okukhulu: ukuqubuka kwesikhumba noma amaqhubu, ukulunywa, ubunzima bokuphefumula, ukuvuvukala kobuso, izindebe, noma ulimi.
- Izimpawu zokuhlaselwa yinhliziyo: ubuhlungu besifuba, ukuphelelwa umoya, ubuhlungu obusakazeka emhlathini noma ehlombe.
- Izimpawu zesifo sohlangothi: ukungazweli ohlangothini olulodwa lomzimba, ubunzima bokukhuluma, ukugoba kobuso.
Umlayezo Wokuya Nawe Ekhaya
- Ama-COX-2 inhibitors ayiqembu elikhethekile lemithi engalimazi kakhulu isisu kunemithi yokubulala izinhlungu evamile (ama-NSAID). Izinhlobo ezisetshenziswa kakhulu eSri Lanka yi -Celecoxib kanye ne-Etoricoxib.
- Lezi azinazo nhlobo izingozi, ikakhulukazi njengoba zingandisa ingozi yokuhlaselwa yinhliziyo kanye nesifo sohlangothi.
- Ungalokothi usebenzise lo muthi ovela ekhemisi ngaphandle kwencwadi kadokotela.
- Sebenzisa njalo umthamo ophansi kakhulu onconywe udokotela wakho, isikhathi esifushane kakhulu .
- Uma unezimo ezifana nesifo senhliziyo, isifo sezinso, isifo sesibindi, noma isifo sohudo, kubalulekile ukutshela udokotela wakho ngaphambi kokuthatha lo muthi.
- Hlala uqaphele izimpawu eziyisixwayiso ezishiwo ngenhla. Uma kuvela izinkinga, funa iseluleko sezokwelapha ngokushesha.
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