Ingabe nawe unekhala elicijile? Ingabe ulahlekelwa yiphunga nokunambitha? Ingabe uhlala unekhala eligobhozayo? Lokhu akuyona nje umkhuhlane, kodwa yisimo esibizwa ngokuthi i-Chronic Rhinosinusitis ene-Nasal Polyps (CRSwNP) . Nakuba abantu abaningi bevame ukuthola impumuzo ekufakweni kwamakhala noma emithini yomlomo, abanye abantu bakuthola kunzima kakhulu ukulawula izimpawu zabo ngalezi zindlela zokwelapha. Kodwa ungakhathazeki, ngokuthuthuka kwesayensi yezokwelapha, manje sekunezindlela ezintsha nezisebenzayo zokwelapha izimo ezinjalo. Namuhla sizokhuluma ngokwelashwa okukhethekile okunjalo, i-Dupixent.
Umuthi i-Dupixent usebenza kanjani ku-CRSwNP?
Kalula nje, ama-polyp asekhaleni yizimila ezincane ezakheka olwelwesini lwama-air sac (ama-sinuses) ngaphakathi noma eduze kwekhala lethu. Imbangela eyinhloko yalokhu yi -sinusitis engapheli . Lokhu kwenzeka lapho ikhala kanye nezimbobo zama-sinus kuvuvukala futhi kuvuvukala isikhathi esingaphezu kwezinyanga ezintathu. Lokhu kuvuvukala okuqhubekayo yikho okubangela ukuba ama-polyp akheke.
Esikhathini esiningi, la ma-polyp awabangeli zimpawu. Kodwa njengoba ekhula, angaqala ukuvimba ukusebenza okuvamile kwekhala kanye nemigodi yama-sinus. Cabanga ngakho njengepayipi lamanzi eliyeka ukugeleza lapho okuthile kubhajwa kulo.
Lokhu kungabangela izimpawu ezifana nokuminyana kwamakhala, ikhala eligelezayo njalo, ukuthimula, futhi ikakhulukazi ukulahlekelwa iphunga nokunambitha . Futhi, lapho i-mucus (phlegm) ingakwazi ukuphuma kahle emigodini yama-sinus, inganqwabelana, ibangele ubuhlungu kanye nokutheleleka.
Umgomo oyinhloko wokwelashwa lapha ukunciphisa ukuvuvukala ekhaleni nasemathunjini e-sinus, okuzonciphisa ulwelwesi futhi kunikeze impumuzo ebalulekile ezimpawini.
Isithako esisebenzayo ku-Dupixent yi -dupilumab . Sisebenza ngokuvimba amaprotheni amabili (`interleukin-4` kanye ne-`interleukin-13`) athumela izimpawu ezibangela ukuthi amasosha omzimba wethu asabele ngokweqile futhi abangele ukuvuvukala. Uma la maprotheni evalekile, ukuvuvukala nokungakhululeki ekhaleni nasema-sinuses kuncipha kakhulu.
Ingabe ukhona umuntu onalesi simo ongakwazi ukusebenzisa i-Dupixent?
Iningi labantu abane-CRSwNP baqale belashwe nge-nasal spray. Lolu uhlobo lomuthi olubizwa ngokuthi i-corticosteroid. Uma ungakwazi ukulawula izimpawu zakho ngemva kokusebenzisa lesi spray izinyanga ezimbalwa, udokotela wakho angase akuncomele ukwelashwa okuhlukile.Udokotela angase akunike iphilisi le-corticosteroid lesikhathi esifushane. Abanye abantu bangadinga nokuhlinzwa ukuze kususwe iqhubu.
I-Dupixent iyindlela enhle kubantu abaye bazama zonke lezi zinto, okuhlanganisa izifutho zamakhala, amaphilisi, kanye nokuhlinzwa, kodwa basenezimpawu ezinzima. Lokhu kusho ukuthi ivame ukusetshenziswa njengokwelashwa komugqa wesibili noma wesithathu.
Izifundo ngokusebenza kahle kwe-Dupixent (LIBERTY Studies)
Kwenziwe izivivinyo ezimbili ezinkulu zezokwelapha, ezibizwa ngokuthi i-LIBERTY, ukuze kutholakale ukuthi lo muthi uphephile futhi usebenza kahle kangakanani. Bonke abahlanganyeli kulezi zivivinyo basebenzise i-nasal spray yansuku zonke kodwa basabhekene nezimpawu. Ngaphezu kwalokho, ama-76% abo ayeselahlekelwe ngokuphelele noma ingxenye yemizwa yawo yokuhogela.
Kulezi zifundo, i-Dupixent iqhathaniswa ne-placebo, umuthi obukeka njengomuthi kodwa empeleni ungenaso isithako esisebenzayo. Imiphumela yalinganiswa ngemva kwezinyanga eziyi-6.
| Izinzuzo ezivezwe ucwaningo | Incazelo |
|---|---|
| Usayizi we-nasal septum | Labo abathatha i-Dupixent izinyanga eziyisithupha babenezinhlayiya ezimbalwa kakhulu kanye nezinhlayiya ezimbalwa kunalabo abathatha i-placebo. Imiphumela yaba yinto efanayo ngonyaka olandelayo. |
| Izimpawu zokuminyana kwamakhala | Labo abathatha i-Dupixent babenezimpawu ezincane kakhulu zokuminyana kwamakhala kanye nekhala eligobhozayo kunalabo abathatha i-placebo. Lokhu kwaqhubeka unyaka wonke. |
| Inzwa yokuhogela | Phakathi kwalabo abanenkinga yokuhogela, labo abathathe i-Dupixent babenesimo sokuhogela esithuthukisiwe kakhulu uma kuqhathaniswa nalabo abathathe i-placebo. |
Isetshenziswa kanjani i-Dupixent?
I-Dupixent iwumjovo owuketshezi ojovwa ngaphansi kwesikhumba njalo emavikini amabili , ngokuvamile ethangeni, esiswini, noma engalweni engenhla.
Lokhu kuza ngedivayisi efana nepeni eligcwalisiwe ongazijova ngayo ekhaya. Ngakho-ke asikho isidingo sokukhathazeka ngezinaliti noma amasirinji. Kodwa khumbula, udokotela wakho noma umhlengikazi uzokukhombisa ukuthi ungajova kanjani kuqala. Kubaluleke kakhulu ukulandela leyo miyalelo ngqo.
Kuthatha isikhathi esingakanani ukubona imiphumela evela ku-Dupixent?
Uma lo muthi usebenza kahle kuwe, ungase ubone ukuthuthuka okuncane ekuzweleni kwakho iphunga phakathi nesonto lokuqala. Kungathatha amasonto ambalwa noma inyanga noma amabili ukuthi ezinye izimpawu, njengokuminyana kwamakhala, ziphele.
Kubaluleke kakhulu: Ungalokothi uyeke ukuphuza i-Dupixent noma eminye imithi yalesi simo ngaphandle kokukhuluma nodokotela wakho, noma ngabe izimpawu zakho sezithuthuke kakhulu. Ukwenza kanjalo kungabangela ukuthi izimpawu zakho zibuye.
Imiphumela emibi nezinkinga ngeminye imithi
Umphumela ovame kakhulu we-Dupixent ukusabela kwesikhumba endaweni yokujova . Lokhu kungafaka phakathi ukubomvu, ubuhlungu, ukuvuvukala, noma ukuphuka lapho kujovwe khona. Indlela engcono kakhulu yokugwema lokhu ukushintshanisa izindawo zokujova. Futhi, gwema ukujova esikhumbeni esiphukile, esilimele, noma esilimele.
Lezi akuzona zonke imiphumela emibi engaba khona. Uma unezimpawu ezikukhathazayo, qiniseka ukuthi ukhuluma nodokotela wakho ngazo.
Eminye imithi kanye nemigomo
- Eminye imithi: Ngaphambi kokuthi uqale i-Dupixent, kubaluleke kakhulu ukutshela udokotela wakho ngayo yonke imithi oyithathayo (ikakhulukazi imithi ye-asthma), amavithamini, ngisho nemithi yamakhambi.
- Imijovo: Eminye "imijovo ephilayo" akufanele inikezwe ngenkathi uthatha i-Dupixent. Ngakho-ke uma kufanele uthole noma yimiphi imijovo maduze, tshela udokotela wakho ngaphambi kokuqala ukwelashwa.
Ingabe kukhona okufanele kucatshangelwe lapho uthatha i-Dupixent?
I-Dupixent akuyona umuthi ongawuthola kalula ekhemisi elivamile. Ihlukaniswa ngokuthi "umuthi okhethekile." Lokhu kusho ukuthi ingatholakala kuphela ezibhedlela ezithile ezinkulu noma emakhemisi akhethekile.
Lokhu kwelashwa kungabiza kakhulu. Ngakho-ke, kubaluleke kakhulu ukukhuluma nodokotela wakho ngalokhu ngaphambi kokuqala ukwelashwa futhi waziswe ngokucacile ngezindleko kanye nezindlela zokukuthola ezweni lethu.
Umlayezo Wokuya Nawe Ekhaya
- I-Dupixent iyindlela entsha yokwelapha i-rhinosinusitis engapheli kanye ne-sinusitis (CRSwNP). Ngokuvamile inikezwa abantu abanezimpawu ezinzima ezingazange zilawulwe ezinye izindlela zokwelapha (izifutho zamakhala, amaphilisi, ukuhlinzwa).
- Lokhu kusebenza ngokuvimbela izimpawu zesistimu yomzimba ezibangela ukuvuvukala, kunciphisa ukuvuvukala ekhaleni nasema-sinuses.
- Lona umjovo ojovwa ngaphansi kwesikhumba njalo emavikini amabili. Kubalulekile ukuthi uqale ufunde ukuthi ungajova kanjani ngendlela efanele kudokotela noma umhlengikazi.
- Gwema ukuyeka ukwelashwa nganoma yisiphi isizathu ngaphandle kweseluleko sikadokotela wakho. Ukwenza kanjalo kungabangela ukuthi izimpawu zibuye.
- Kubaluleke kakhulu ukwazisa udokotela wakho ngayo yonke eminye imithi, amavithamini, kanye nemijovo oyithathayo.
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