Ngaba nawe unempumlo exineneyo? Ngaba uphelelwa livumba nencasa? Ngaba uhlala unempumlo egobhozayo? Ezi asizozifo nje kuphela, kodwa yimeko ebizwa ngokuba yiChronic Rhinosinusitis eneNasal Polyps (CRSwNP) . Nangona abantu abaninzi behlala befumana isiqabu kwii-spray zempumlo okanye amayeza omlomo, abanye abantu bakufumanisa kunzima kakhulu ukulawula iimpawu zabo ngolu hlobo lonyango. Kodwa ungakhathazeki, ngokuhambela phambili kwesayensi yezonyango, ngoku kukho iindlela ezintsha nezisebenzayo zokunyanga ezo meko. Namhlanje siza kuthetha ngonyango olulodwa olukhethekileyo, iDupixent.
Isebenza njani iyeza iDupixent kwi-CRSwNP?
Ngamafutshane, ii-polyps zeempumlo zizinto ezincinci ezikhula kwiinwebu zomoya (ii-sinuses) ngaphakathi okanye ezijikeleze impumlo yethu. Isizathu esiphambili soku yi -sinusitis engapheliyo . Oku kwenzeka xa impumlo kunye ne-sinus zidumbile kwaye zivuvukala kangangeenyanga ezingaphezu kwe-3. Oku kudumba okuqhubekayo yikona okubangela ukuba ii-polyps zenzeke.
Uninzi lwexesha, ezi polyps azibangeli zimpawu. Kodwa njengoko zikhula, ziqala ukuvala ukusebenza okuqhelekileyo kwempumlo kunye nemingxuma ye-sinus. Cinga ngayo njengombhobho wamanzi oyekayo ukuhamba xa into ibambeka kuyo.
Oku kunokubangela iimpawu ezifana nokuxinana kweempumlo, impumlo evuza rhoqo, ukuthimla, ingakumbi ukulahlekelwa yivumba nencasa . Kwakhona, xa i-mucus (phlegm) ingakwazi ukuphuma kakuhle kwimingxunya ye-sinus, inokuqokelelwa, ibangele iintlungu kunye nosulelo.
Injongo ephambili yonyango apha kukunciphisa ukudumba empumlweni nakwimingxunya ye-sinus, okuya kunciphisa i-mucus kwaye kunike isiqabu esikhulu kwiimpawu.
Isithako esisebenzayo kwiDupixent yidupilumab . Isebenza ngokuthintela iiproteni ezimbini (`interleukin-4` kunye ne`interleukin-13`) ezithumela imiqondiso ebangela ukuba inkqubo yomzimba wethu yokuzikhusela iphendule ngokugqithisileyo kwaye ibangele ukudumba. Xa ezi proteni zivaliwe, ukudumba kunye nokungonwabi empumlweni nakwiisinuses kuncipha kakhulu.
Ngaba kukho umntu onayo le meko angayisebenzisa iDupixent?
Uninzi lwabantu abane-CRSwNP baqala ngokunyangwa nge-spray yempumlo. Olu luhlobo lweyeza elibizwa ngokuba yi-corticosteroid. Ukuba ubusebenzisa esi spray kangangeenyanga ezimbalwa kwaye iimpawu zakho azilawuleki, kusenokuba lixesha lokuba ucinge ngogqirha wakho.Ugqirha angakunika ipilisi ye-corticosteroid yexesha elifutshane. Abanye abantu banokufuna utyando ukuze kususwe iqhuma.
I-Dupixent lukhetho olufanelekileyo kubantu abaye bazama zonke ezi zinto, kuquka izitshizi zeempumlo, iipilisi, mhlawumbi notyando, kodwa baseneempawu eziqatha. Oku kuthetha ukuba idla ngokusetyenziswa njengonyango lwesibini okanye lwesithathu.
Izifundo malunga nokusebenza kakuhle kweDupixent (LIBERTY Studies)
Kwenziwe iimvavanyo ezimbini ezinkulu zeklinikhi, ezibizwa ngokuba yi-LIBERTY, ukuze kuqinisekiswe ukuba eli yeza likhuselekile kwaye lisebenza kangakanani na. Bonke abathathi-nxaxheba kwezi zilingo basebenzise i-spray yempumlo yemihla ngemihla kodwa basaphethwe ziimpawu. Ukongeza, ama-76% abo ayelahlekelwe ngokupheleleyo okanye kancinci kukuva ivumba.
Kolu phononongo, iDupixent ithelekiswe ne-placebo, iyeza elalifana neyeza kodwa lingenazo izithako ezisebenzayo. Iziphumo zalinganiswa emva kweenyanga ezi-6.
| Iingenelo ezityhilwe luphando | Inkcazo |
|---|---|
| Ubungakanani be-nasal septum | Abo bathathe iDupixent kangangeenyanga ezi-6 babene-moles ezimbalwa kakhulu kunye ne-moles ezimbalwa kunabo bathathe i-placebo. Iziphumo zazifana kunyaka olandelayo. |
| Iimpawu zokuxinana kwempumlo | Abo bathathe iDupixent babeneempawu ezimbalwa kakhulu zokuxinana kweempumlo kunye nempumlo egobhozayo kunabo bathathe i-placebo. Oku kwahlala unyaka wonke. |
| Imvakalelo yokuvumba | Phakathi kwabo banengxaki yokuvumba, abo bathathe iDupixent babenendlela yokuvumba ephucuke kakhulu xa kuthelekiswa nabo bathathe i-placebo. |
Isetyenziswa njani iDupixent?
I-Dupixent yinaliti engamanzi efakwa phantsi kolusu rhoqo emva kweeveki ezimbini , ngesiqhelo ethangeni, esiswini, okanye engalweni engentla.
Oku kuza kwisixhobo esifana nepeni esizalisiweyo onokuzitofa ekhaya. Ngoko ke akukho mfuneko yokukhathazeka ngeenaliti okanye iisirinji. Kodwa khumbula, ugqirha wakho okanye umongikazi uza kukubonisa indlela yokuyitofa kuqala. Kubaluleke kakhulu ukulandela loo miyalelo ngqo.
Kuthatha ixesha elingakanani ukubona iziphumo ezivela kwiDupixent?
Ukuba eli yeza liyasebenza kuwe, ungabona ukuphucuka okuncinci kwindlela oziva ngayo ivumba kwiveki yokuqala. Kungathatha iiveki ezimbalwa okanye inyanga okanye ezimbini ukuba ezinye iimpawu, ezinje ngokuxinana kweempumlo, ziphele.
Kubaluleke kakhulu: Ungaze uyeke ukusebenzisa iDupixent okanye naliphi na elinye iyeza lale meko ngaphandle kokuthetha nogqirha wakho, nokuba iimpawu zakho ziphucuke kakhulu. Ukwenza njalo kunokubangela ukuba iimpawu zakho zibuye.
Iziphumo ebezingalindelekanga kunye neengxaki ngamanye amayeza
Eyona miphumo ixhaphakileyo yeDupixent kukusabela kwesikhumba kwindawo efakwe inaliti . Oku kunokuquka ukuba bomvu, iintlungu, ukudumba, okanye ukukrweleka apho inaliti inikwe khona. Eyona ndlela ingcono yokuphepha oku kukujikeleza iindawo ezifakelwe inaliti. Kwakhona, kuphephe ukufaka inaliti eluswini oluphukileyo, olunamanxeba, okanye olwenzakeleyo.
Ezi azizo zonke iziphumo ebezingalindelekanga ezinokubakho. Ukuba uneempawu ezikukhathazayo, qiniseka ukuba uthetha nogqirha wakho ngazo.
Amanye amayeza kunye nezitofu
- Amanye amayeza: Ngaphambi kokuba uqale iDupixent, kubaluleke kakhulu ukuxelela ugqirha wakho ngawo onke amayeza owasebenzisayo (ingakumbi amayeza e-asthma), iivithamini, kwanemithi yezityalo.
- Iigonyo: Ezinye "iigonyo eziphilayo" akufuneki zinikwe ngelixa uthatha iDupixent. Ngoko ke ukuba uza kufumana naluphi na ugonyo kungekudala, xelela ugqirha wakho ngaphambi kokuba uqale unyango.
Ngaba kukho naziphi na izinto ezikhethekileyo ekufuneka ziqwalaselwe xa usebenzisa iDupixent?
I-Dupixent ayiloyeza onokulifumana lula kwikhemesti eqhelekileyo. Ihlelwa njenge "yeza elikhethekileyo." Oku kuthetha ukuba inokufumaneka kuphela kwizibhedlele ezithile ezinkulu okanye kwiikhemesti ezikhethekileyo.
Olu nyango lunokuba lubiza kakhulu. Kungoko ke, kubaluleke kakhulu ukuthetha nogqirha wakho ngale nto ngaphambi kokuba uqale unyango kwaye waziswe ngokucacileyo ngexabiso kunye neendlela zokulufumana kwilizwe lethu.
Umyalezo Wokuya Ekhaya
- I-Dupixent lunyango olutsha lwe-rhinosinusitis engapheliyo kunye ne-sinusitis (CRSwNP). Idla ngokumiselwa abantu abaneempawu ezinzima ezingakhange zilawulwe zezinye iindlela zonyango (izitshizi zempumlo, iipilisi, utyando).
- Oku kusebenza ngokuthintela imiqondiso yenkqubo yomzimba yokuzikhusela ebangela ukudumba, kunciphisa ukudumba empumlweni nakwiisinuses.
- Le yinaliti efakwa phantsi kwesikhumba rhoqo emva kweeveki ezimbini. Kubalulekile ukuqala ngokufunda indlela yokuyifaka ngokuchanekileyo kugqirha okanye kumongikazi.
- Kuphephe ukuyeka unyango nangasiphi na isizathu ngaphandle kwengcebiso kagqirha wakho. Ukwenza njalo kunokubangela ukuba iimpawu zibuye.
- Kubaluleke kakhulu ukwazisa ugqirha wakho malunga nawo onke amanye amayeza, iivithamini, kunye nemithi yokugonya oyithathayo.
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