Ngaba nawe unengxaki yegazi? Makhe sithethe nge-CMML (Chronic Myelomonocytic Leukemia)!

Ngaba wakha weva ngesifo esibizwa ngokuba yi-'CMML' okanye i-Chronic Myelomonocytic Leukemia ? Mhlawumbi akunjalo. Kuba luhlobo olungaqhelekanga lomhlaza wegazi. Kodwa kubaluleke kakhulu ukuba sikuqaphele oku. Kuba kuchaphazela indlela umzimba wethu ovelisa ngayo igazi. Masithethe ngale nto ngokulula, ngendlela onokuyiqonda.

Yintoni iCMML? Masiyiqonde ngokulula!

Ngamafutshane, umongo wakho wethambo – inxalenye ethambileyo emathanjeni akho – yiyo eyenza igazi. Umntu one-CMML unemveliso ephezulu kakhulu yohlobo lweeseli ezimhlophe zegazi ezibizwa ngokuba zii-monocytes . Ezi monocytes ezingaqhelekanga zigquma iiseli ezibomvu zegazi eziphilileyo, iiplatelets , kunye nezinye iiseli ezimhlophe zegazi eziphilileyo esizidingayo. Cinga ngayo njengokhula emyezweni olugquma imithi enempilo.

Oogqirha babeka le meko njenge-Myeloproliferative neoplasm/Myelodysplastic syndrome (MPN/ MDS ). Nangona oku kunokubonakala ngathi yindibaniselwano yamagama enzima, kuthetha oku:

• I-Myeloproliferative neoplasm (MPN): Oku kwenzeka xa umongo wakho wethambo wenza uninzi kakhulu lohlobo olunye lweeseli zegazi. Xa kuveliswa uhlobo olunye kakhulu, ibhalansi yegazi iyaphazamiseka kwaye igazi lingasebenzi kakuhle.
• I-Myelodysplastic syndrome (MDS): Le yimeko apho iiseli zegazi eziveliswa ngumongo wakho wethambo ziba zingaqhelekanga kwaye zimile kakubi . Ngokukodwa, endaweni yeeseli zegazi eziphilileyo nezivuthiweyo, zivelisa iiseli ezingavuthwanga ezibizwa ngokuba zii-blast cells.

I-CMML ngamanye amaxesha inokukhula kancinci kakhulu. Kodwa ngamanye amaxesha inokukhula ngokukhawuleza nangokuqatha. Ugqirha wakho uza kukuchazela ngonyango olunokulawula ukukhula kwayo.

Zithini iimpawu zeCMML? Ngaba nawe unazo ezi?

Iimpawu zeCMML azisoloko zibonakala. Ngamanye amaxesha uvavanyo lwegazi luphawu lokuqala. Nokuba iimpawu zibonakala, zihlala zibonakala kancinci kancinci. Jonga ukuba ezi mpawu zivakala ziqhelekile na kuwe:

• Ukuziva udiniwe kwaye ubuthathaka ngalo lonke ixesha: Oku kungenxa yokuncipha kweeseli ezibomvu zegazi, okubangelwa yi -anemia .
• Ukugula rhoqo kunye nezifo:Oku kungenxa yokuncipha kweeseli ezimhlophe zegazi, okubizwa ngokuba yi-neutropenia.
• Ukopha rhoqo kwempumlo, okujika kube luhlaza okwesibhakabhaka nokuba kukho imivumbo emincinci: Oku kungenxa yokuncipha kweeplatelets, okubizwa ngokuba yi-thrombocytopenia.
• I-Splenomegaly : Ukwandiswa kwe-spleen, ekwicala eliphezulu lasekhohlo lesisu sakho.
• I-Hepatomegaly : Ukwanda kwesibindi.
• Ukunciphisa umzimba ngendlela engachazekiyo.
• Ukubila ebusuku.
• Intlungu yamathambo.
• Ifiva.

Khumbula, ayinguye wonke umntu onezi mpawu one-CMML. Kodwa ukuba ezi mpawu ziyaqhubeka, kungcono ukubona ugqirha.

Ngaba kukho isizathu esithile se-CMML?

Abaphandi abakayazi kakuhle into ebangela i -CMML. Nangona kunjalo, bafumanise utshintsho oluninzi lwezakhi zofuzo olunxulunyaniswa nesi sifo. Ukuba ufunyaniswe une-CMML, kusenokwenzeka ukuba unezakhi zofuzo ezingaphezu kwesinye. Ezinye zezona zakhi zofuzo zixhaphakileyo ziquka:

• `TET2`
• `SRSF2`
• `ASXL1`
• `RAS` (le yeyona ixhaphakileyo)

Ugqirha wakho uza kukuxelela okungakumbi ngale jini.

Ngubani osengozini enkulu yokuhlaselwa yi-CMML?

Kukho izinto ezininzi ezinobungozi ezinokuchaphazela uphuhliso lwe-CMML:

• Ubudala: Umngcipheko wokufumana esi sifo uyanda njengoko ukhula. Ubudala obuqhelekileyo bokuxilongwa buphakathi kweminyaka engama-73 ukuya kwengama-75 ubudala. Oku kuthetha ukuba isiqingatha sabo bafunyenwe benale sifo bancinci kunoko, kwaye esinye isiqingatha sikhulile.
• Isini: I-CMML ixhaphake kakhulu kumadoda kunakwabasetyhini.
• Unyango lomhlaza lwangaphambili: Malunga nomntu omnye kwabalishumi abafumana i-CMML bakha bafumana i-chemotherapy okanye i-radiation yomhlaza. Kodwa oogqirha banika olu nyango kuphela ukuba iingenelo zonyango zingaphezulu komngcipheko wokuba nomhlaza kwixesha elizayo.

Ziziphi ezinye iingxaki ezinokwenzeka kule meko?

Malunga nabantu ababini kwabalishumi abane-CMML baya kuba nomnye umhlaza wegazi onzima obizwa ngokuba yi-acute myeloid leukemia (AML). Thetha nogqirha wakho malunga nomngcipheko wakho wokuba ne-AML ngokusekelwe kwisifo sakho kunye nezinto ezinokubangela umngcipheko.

Oogqirha bayixilonga njani i-CMML?

Ugqirha wakho uza kukubuza ngeempawu zakho aze athathe imbali yakho yezonyango. Emva koko uza kwenza iimvavanyo ezininzi ukujonga iiseli zakho zegazi. Ezi mvavanyo zingabandakanya:

• Ubalo lwegazi olupheleleyo (CBC): Ukuba inani lee-monocytes liphezulu kakhulu (i-monocytosis), isenokuba luphawu lwe-CMML.
• I-smear yegazi engaphandle: Ukuba ii-monocytes zibonakala zingahambelani okanye zingavuthwanga (ii-blast cells) xa zijongwa phantsi kwe-microscope, oku kungaba luphawu lwe-CMML.
• I-Bone Marrow Biopsy: Ngamanye amaxesha ugqirha unokufuna ukuthatha isampuli encinci yomongo aze awuvavanye kwilebhu ukuze abone ukuba kukho ii-monocytes ezingaqhelekanga.
• Uvavanyo lwemfuza: Oogqirha bakhangela notshintsho lwemfuza oluhambelana neminye imihlaza yegazi. Oku kubavumela ukuba bakhuphe ezinye izifo ezineempawu ezifanayo kunye neziphumo zovavanyo lwegazi.

Zithini izigaba zeCMML?

Oogqirha bagqiba ukuba i-CMML isasazeke kangakanani, okanye ukuba ingakanani na (umhlaza oqhubekayo), ngokusekelwe kwinani leeseli eziqhumayo egazini lakho nakwi-bone marrow. La manqanaba mabini ngala:

• I-CMML-1: Zingaphantsi kwe-4 kwiiseli ezili-100 egazini lakho eziziiseli zokuqhuma. Zingaphantsi kwe-9 kwiiseli ezili-100 kwi-bone marrow yakho eziziiseli zokuqhuma.
• I-CMML-2: Phakathi kweeseli ezi-5 ne-19 kwi-100 egazini lakho kukho iiseli eziqhumayo. Phakathi kweeseli ezili-10 ne-19 kwi-100 kwi-bone marrow yakho kukho iiseli eziqhumayo.

Kukule nqanaba apho ugqirha wakho eya kugqiba ukuba loluphi unyango olufanelekileyo nolusebenzayo kuwe.

Ziziphi iindlela zonyango ze-CMML?

Okokuqala, ungadinga unyango ukuqinisekisa ukuba uneeseli zegazi ezisempilweni ezaneleyo. Oku kungabandakanya amayeza okunyusa inani leeseli zegazi lakho okanye utofelo-gazi rhoqo. Oku kungaba yinxalenye yonyango lokuthomalalisa iimpawu.

Ezinye iindlela zonyango ezijolise ngqo kwi-CMML zezi:

• Ukufakelwa kweeseli ze-allogeneic stem: Olu lolona nyango lunokunyanga ngokupheleleyo i-CMML. Nangona kunjalo, alufanelekanga kuye wonke umntu. Lunokubangela iingxaki ezisongela ubomi ezifana nesifo se-graft-versus-host.
• Unyango lweKhemotherapy: Amayeza eKhemotherapy ayayimisa ukukhula okungalawulekiyo kwee-monocytes. Oku kunokunceda ekunciphiseni iimpawu. Oku kusebenzisa amayeza afana neHydroxyurea kunye neeHypomethylating agents (HMA).
• Uvavanyo lweklinikhi:Ukuba ezinye iindlela zonyango azincedi, ugqirha wakho unokucebisa ukuba uthathe inxaxheba kuvavanyo lwezonyango. Uvavanyo lwezonyango okwangoku luphanda ukusebenza kakuhle konyango olutsha (umz., unyango olujoliswe kulo, unyango lwe-immunotherapy) lwe-CMML.

Ndifanele ndimbone nini ugqirha?

Kuya kufuneka ubone ugqirha wakho rhoqo (ngesiqhelo kube kanye ngenyanga ukuya kube kanye kwiinyanga ezintandathu). Kubaluleke kakhulu ukuba ugcine la madinga. Ngexesha lala madinga, ugqirha wakho uya kukubuza ngeempawu zakho, enze uvavanyo lwegazi, ajonge ukuba unyango lwakho lusebenza kakuhle kangakanani, aze enze naluphi na utshintsho olufunekayo.

Okwangoku, ukuba ufumana naziphi na iziphumo ebezingalindelekanga nezinzima ezivela kunyango lwakho , thetha nogqirha wakho ngoko nangoko . Ugqirha wakho uza kukuxelela ukuba zeziphi iimpawu ekufuneka uziqaphele, kuxhomekeke kunyango olufumanayo.

Yintoni onokuyilindela xa uphila nale meko?

Umyinge wobomi bomntu ofunyaniswe ene-CMML umalunga nonyaka omnye ukuya kwemithathu. Kwakhona, "umyinge" lixabiso eliphakathi. Oku kuthetha ukuba isiqingatha sabantu sinokuba nexesha elifutshane lokuphila kunye nesiqingatha sobomi obude. Nangona kunjalo, kukho izinto ezininzi ezimisela ikamva lakho. Ezi ziquka:

• Iziphumo zovavanyo lwegazi: Ubalo lweeseli zakho zegazi lunokunika izikhokelo malunga noqikelelo lwakho. Ubalo lwakho lwe-monocyte, i-blast cell, kunye ne-platelet zizinto ezibalulekileyo. Inqanaba lakho le-hemoglobin likwalixabiso elibalulekileyo eliza kuhlolwa ngugqirha wakho rhoqo.
• Utshintsho lwemfuza: Ezinye iinguqulelo zemfuza, umzekelo utshintsho kwi-'ASXL1` gene, zinxulunyaniswa noqikelelo olubi ngakumbi.
• Ukuphindaphindwa kotofelo-gazi: Ngaphandle kokuba udinga utofelo-gazi rhoqo ukuze ubuyisele iiseli zakho zegazi, isiphumo sakho sihlala silungile.

Ingqikelelo yakho ikwaxhomekeke ekubeni imeko yakho iqhubekela phambili ibe yi-'AML' (i-acute myeloid leukemia). Oku kunokwenzeka ngakumbi ukuba une-'CMML-2'.

Ndingenza ntoni ukuze ndihlale ndiphilile kwaye ndomelele?

Ukuba une-CMML, enye yezona zinto zilungileyo onokuzenza kukuthatha uxanduva lwempilo yakho ngazo zonke iindlela onokuthi uzisebenzise . Ngeli xesha, kubalulekile ukutya ukutya okunesondlo kwaye ulale ngokwaneleyo. Ukulinganisela phakathi kokusebenza kunye nokuphumla ngokwaneleyo nako kubalulekile. Ukunxibelelana nabanye abaphila nomhlaza yindlela entle yokulwa neemvakalelo zokuba wedwa. Thetha nogqirha wengqondo onamava okusebenza nezigulane zomhlaza.

Umhlaza ungenza umntu azive engenakuzinceda, kodwa khumbula, usalawula ubomi bakho.Kwaye kukho unyango olunokukunceda.

Ukuphila neCMML akulula. Isiphumo sakho sixhomekeke kwizinto ezininzi ezikungqongileyo. Cela ugqirha wakho akuchazele ukuba zeziphi ezi zinto kunye nendlela ezichaphazela ngayo ikamva lakho. Qonda iindlela zakho zonyango ukuze uqiniseke ukuba unyango olukhethayo luya kuhlangabezana neenjongo zakho.

Umyalezo obalulekileyo onokuwuthatha ekhaya

I-CMML yimeko enzima kakhulu. Kodwa ukuba uyazi ngayo, sebenzisana nogqirha wakho, ufumane unyango olufanelekileyo, kwaye wenze utshintsho oluhle kwindlela ophila ngayo, ungazama ukuphila kakuhle nale meko. Ungaze ulahle ithemba. Usapho lwakho, abahlobo, kunye noogqirha bakho ukukunceda. Awuwedwa. Ukuba unemibuzo okanye iinkxalabo, ungoyiki ukubuza ugqirha wakho. Lilungelo lakho.

` I-CMML, i-Chronic Myelomonocytic Leukemia, umhlaza wegazi, i-Bone Marrow, ii-Monocytes, iimpawu, unyango