Ingabe eminye yemithi oyisebenzisayo iyawuthinta ubuchopho? (Ake sifunde ngemithi ye-Anticholinergic)

Uma uvula ikhabethe lakho lemithi ekhaya, cishe uzothola enye yalezi zinhlobo zemithi. Sikhuluma ngeminye yemithi esetshenziselwa ukungezwani komzimba, ukucindezeleka, ubuhlungu obungapheli, isicanucanu, noma ukuqwasha. Lena yimithi ebesilokhu siyisebenzisa amashumi eminyaka. Kodwa ucwaningo olusha lubonisa ukuthi ukusetshenziswa kwesikhathi eside kwale mithi kungase kungabi kuhle kangako empilweni yethu yobuchopho. Kungase kwandise ngisho nengozi yokuthola i-dementia , isifo sokulahlekelwa yinkumbulo. Ngakho ake sibheke ukuthi iyini le mithi yokulwa ne-cholinergic, ukuthi ithinta kanjani ubuchopho, nokuthi ungayiphatha kanjani ngokuphephile.

Iyini ngempela le mithi yokulwa ne-cholinergic?

Kalula nje, le mithi ingahlukaniswa ngezigaba ezimbili eziyinhloko. Isigaba sokuqala yileyo esiyisebenzisa ngamabomu ukuze sifinyelele umphumela wokulwa ne-cholinergic. Isigaba sesibili yileyo enikezwa enye injongo eyinhloko, kodwa inomphumela oqinile wokulwa ne-cholinergic njengomphumela oseceleni. Ithebula elingezansi libonisa ezinye zezindlela ezivamile zokusebenzisa le mithi.

Le mithi ithinta kanjani ubuchopho bethu?

Kulula kakhulu. Uma le mithi yokulwa ne-cholinergic ingena ebuchosheni, ivimba ikhemikhali ebizwa ngokuthi i-acetylcholine . Le acetylcholine iyi-neurotransmitter ebalulekile ekusebenzeni kwenani elikhulu lama-neurons ebuchosheni. Cabanga ngobuchopho bakho njengehhovisi elikhulu leposi. I-Acetylcholine iyisithunywa esibaluleke kakhulu kuyo. Yilokho okusiza ukugcina izinkumbulo, ukugcina ulwazi kwimemori yesikhathi esifushane, nokuluhlela lube yizinkumbulo zesikhathi eside. Ngakho lokho okwenziwa yile mithi ukuphazamisa umsebenzi walowo sithunywa. Uma ingawuvimbeli ngokuphelele, inciphisa kakhulu umsebenzi walawo ma-neurons.

Yimiphi imiphumela yokusebenzisa lokhu okungaba nayo ekusebenzeni kobuchopho?

Ucwaningo lubonisa ukuthi le mithi ayilungile kakhulu emakhono akho okukhumbula nokucabanga. Ikakhulukazi, uma uyisebenzisa isikhathi eside, kuba nzima kakhulu ukuguqula imiphumela. Ake sihlukanise le ngozi ibe yizikhathi ezintathu. 1. Umphumela osheshayo: Ngisho noma uthatha lo muthi kanye, ungase ube nezinkinga zokukhumbula. Asicabangi ukuthi ukuwuthatha kanye kuzodala umonakalo ohlala njalo. Kodwa ngisho nokusetshenziswa kwesikhathi esifushane kungabangela izinkinga zokukhumbula. 2. Umphumela wesikhathi eside wesikhathi esifushane: Cabanga ukuthi ubulokhu uthatha lo muthi izinyanga eziningana . Uma kunjalo, ngemva kokuyeka umuthi, kungathatha izinyanga eziningana ukuthi imiphumela ememori inyamalale ngokuphelele. Ngokuvamile, emitholampilo, amakhono okukhumbula nokucabanga esigulini ahlolwa kabusha okungenani izinyanga ezintathu ngemva kokuyeka umuthi onjalo. 3. Imiphumela yesikhathi eside: Ubufakazi obuqongelelwe emashumini eminyaka busikisela ukuxhumana phakathi kwale mithi yokulwa ne-cholinergic kanye ne-dementia , ikakhulukazi isifo i-Alzheimer's .

Ubani osengozini enkulu yale miphumela?

Izinto ezimbili eziyinhloko zithinta lokhu.

• Ukuguga : Njengoba siguga, siya ngokuya sizwela kakhulu emiphumeleni emibi yanoma yimuphi umuthi. Ngokungafani nalapho sisebancane, imizimba yethu ithatha isikhathi eside ukululama njengoba siguga. Ngakho-ke, sidinga ukuqaphela kakhulu ngemithi yethu. Lokhu kuyiqiniso ikakhulukazi ngemithi yokulwa ne-cholinergic.

• Ukuthambekela kwezakhi zofuzo : Abanye abantu bathambekele kwezakhi zofuzo ekuhlaselweni yisifo i-Alzheimer's . Lokhu kungenxa yohlobo lwezakhi zofuzo olubizwa ngokuthi i-ApoE4 . Ucwaningo luthole ukuthi abantu abanalesi sakhi sofuzo basengozini enkulu yokulahlekelwa yinkumbulo lapho bethatha imithi yokulwa ne-cholinergic.

Ucwaningo olulodwa luthole ukuthi abantu abangaphezu kweminyaka engu-55 abasebenzisa umuthi onamandla wokulwa ne-cholinergic ngesilinganiso esincane esinconywayo sansuku zonke iminyaka emi-3 esikhathini esiyiminyaka eyi-10 babenengozi ekhulayo engu-50% yokuba ne-dementia.

Ngakho-ke yini okufanele yenziwe ngabantu abasebenzisa lo muthi?

Into ebaluleke kakhulu ukuthi ungayeki ukuthatha noma yimiphi imithi udokotela wakho ayikunikezile. Ukwenza kanjalo kungenza isimo sakho sibe sibi kakhulu. Cabanga nje ukuthi ngokuzumayo uba nokusabela okukhulu kokungezwani komzimba futhi udinga ukuthatha imithi ngaleso sikhathi. Ukuyithatha kanye akuyona into enkulu. Inkinga ukuthi uyisebenzisa njalo futhi isikhathi eside. Okufanele ukwenze ukukhuluma ngokukhululekile nodokotela wakho ngemithi oyithathayo. "Dokotela, ingabe lo muthi engiwuthathayo unemiphumela yokulwa ne-cholinergic? Ingabe kufanele ngiqhubeke nokuwuthatha? Ingabe kukhona ezinye izinketho kimi?" Zibuze. Sekukonke, uma ukhathazekile ngempilo yobuchopho bakho, kungcono ukuyeka imithi enemiphumela yokulwa ne-cholinergic ngangokunokwenzeka.

Yiziphi ezinye izindlela ezingasetshenziswa esikhundleni salomuthi?

Ngenhlanhla, namuhla sinezinye izindlela eziphephile zokuxazulula eziningi zalezi zimo.

Izinkinga zokungalali

Indlela engcono kakhulu yokwenza lokhu ukusungula imikhuba emihle yokulala. Lala ngesikhathi esifanayo nsuku zonke. Yeka ukubuka ifoni noma i-TV yakho ngaphambi kokulala. Uma ungakwazi ukulala kungakapheli imizuzu eyi-15 yokulala, vuka wenze okunye endaweni emnyama ngaphandle kwefoni yakho imizuzu eyi-15 ngaphambi kokulala. Uma kudingeka, khuluma nodokotela wakho mayelana nokusebenzisa into efana ne -melatonin .

Ukukhathazeka Nokucindezeleka

Kuneminye imithi eminingi engenayo imiphumela yokulwa ne-cholinergic kulezi zimo. Isibonelo, imithi efana ne - Duloxetine ingasetshenziswa kokubili ekucindezelekeni kanye nobuhlungu.Futhi iyithuluzi elinamandla kakhulu.

Ubunzima bokulawula umchamo

Manje sekukhona imithi yesizukulwane esisha yalokhu futhi engenazo izingozi zokulwa ne-cholinergic. I-Mirabegron ingenye yemithi enjalo.

Ubuhlungu besikhathi eside

Ukwelashwa ngokomzimba kufanele kube yisisekelo sokwelashwa kwezimo eziningi zobuhlungu obungapheli. Kunobufakazi bokuthi ukwelashwa ngokomzimba kunganciphisa ubuhlungu ngempumelelo kakhulu kunemithi.

Ukungezwani komzimba

Kunezinhlobo eziningi ezintsha zama-antihistamine atholakala emakhemisi. Izibonelo zifaka phakathi i-Cetirizine , i-Fexofenadine , ne -Levocetirizine . Kodwa-ke, qaphela uma uthenga imithi yokukhwehlela nomkhuhlane ekhemisi ene-suffix ethi "DM" ekugcineni kwegama. Ngokuvamile iqukethe i-diphenhydramine . I-Anticholinergic, imithi, impilo yobuchopho, i-dementia, ukulahlekelwa inkumbulo, ukukhohlwa, imiphumela emibi, imiphumela emibi, i-Alzheimer's